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HyperlipidemiaPromotesOsteoclasticPotentialofBoneMarrowCellsExVivo
...WG.StatisticalMethods,seventhedition.Ames,IA:IowaStateUniversityPress;1980:191–193.Lamon-FavaS,SadowskiJA,DavidsonKW,O’BrienME,McNamaraJR,SchaeferEJ.Plasmalipoproteinsascarriersofphylloquinone(vitaminK1)inhumans.AmJClinNutr.1998;67:1226–1231.ParhamiF,JacksonSM,TintutY,LeV,BalucanJP,TerritoM,De...
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VirulenceinMiceofPneumococcalClonalTypeswithKnownInvasiveDiseasePotentialinHumans
...ure2C).However,at168hafterchallenge,colony-formingunitsofsomeotherclones(ST1917F,ST30714,ST16219F,andST42519F)couldalsoberecoveredfromlungtissueofmicethatdidnothaveclinicalsymptoms(figure2C).TheinvasiveST30714isolatecausedpneumoniain20%ofmice,whereasthecarrierST55514isolatedidnotcausepneumoniainanym...
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RoleofType1THelperCellsintheResolutionofAcuteStreptococcuspneumoniaeSinusitis:AMouseModel
DepartmentofSurgery,SectionofOtolaryngologyHeadandNeckSurgery,DepartmentofPathologyDepartmentofMedicine,SectionofPulmonaryandCriticalCare,TheUniversityofChicago,Chicago,IllinoisBackground.Weexaminedtheimportanceoftheadaptiveandinnateimmuneresponsesintheresolutionofanacutebacterialsinusinfectioninmic...
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UptakeofLeishmaniamajorbydendriticcellsismediatedbyFcreceptorsandfacilitatesacquisitionofprotectiveimmunity
...ceptorisrequiredtosustaininfectioninmurinecutaneousleishmaniasis.J.Exp.Med.191:1063–1068.Sacks,D.L.,P.A.Scott,R.Asofsky,andF.A.Sher.1984.Cutaneousleishmaniasisinanti-IgM-treatedmice:enhancedresistanceduetofunctionaldepletionofaBcell-dependentTcellinvolvedinthesuppressorpathway.J.Immunol.132:2072...
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Anti-IL-23therapyinhibitsmultipleinflammatorypathwaysandamelioratesautoimmuneencephalomyelitis
...1oftheTcellepitopesthatarisesduringdiseaserelapseisdirectedagainstPLP178–191(33).ThereforewetestedTcellresponsestoPLP139–151andPLP178–191duringinitialEAE(day11)anddiseaserelapse(day30).Miceweretreatedwithanti–IL-23p19orcontrolmAbsjustbeforediseaseonset.Draininglymphnode(DLN)cellsandCNS-infil...
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TCellAccumulationinBCellFolliclesIsRegulatedbyDendriticCellsandIsIndependentofBCellActivation
...gandtoThelpercelltype2differentiationinexperimentalleishmaniasis.J.Exp.Med.191:375–380.Rogers,P.R.,J.Song,I.Gramaglia,N.Killeen,andM.Croft.2001.OX40promotesBcl-xLandBcl-2expressionandisessentialforlong-termsurvivalofCD4Tcells.Immunity.15:445–455.Schulz,O.,D.A.Edwards,M.Schito,J.Aliberti,S.Manick...
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TCellAccumulationinBCellFolliclesIsRegulatedbyDendriticCellsandIsIndependentofBCellActivation
...gandtoThelpercelltype2differentiationinexperimentalleishmaniasis.J.Exp.Med.191:375–380.Rogers,P.R.,J.Song,I.Gramaglia,N.Killeen,andM.Croft.2001.OX40promotesBcl-xLandBcl-2expressionandisessentialforlong-termsurvivalofCD4Tcells.Immunity.15:445–455.Schulz,O.,D.A.Edwards,M.Schito,J.Aliberti,S.Manick...
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ChronicImmuneReactivityAgainstPersistingMicrobialAntigenintheVasculatureExacerbatesAtheroscleroticLesionFormation
...ithantibodiesagainstβ-gal(MPBiomedicals,),CD8(cloneYTS169.4.2),CD4(YTS191.1.2),orF4/80(BiomedicalsAG,cloneBM8)followedbygoatanti-ratIg(CaltagLabs)andalkalinephosphatase-labeleddonkeyanti-goatIg(JacksonImmunoResearchLabs).AlkalinephophatasewasvisualizedbyusingAS-BIphosphate/NewFuchsin,andsection...
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Nonneutralizingantibodiesbindingtothesurfaceglycoproteinoflymphocyticchoriomeningitisvirusreduceearlyvirusspread
...ation-enhancedphagocytosisoffoot-and-mouthdiseasevirus.Immunology.65:187–191.Aasa-Chapman,M.M.,S.Holuigue,K.Aubin,M.Wong,N.A.Jones,D.Cornforth,P.Pellegrino,P.Newton,I.Williams,P.Borrow,andA.McKnight.2005.Detectionofantibody-dependentcomplement-mediatedinactivationofbothautologousandheterologousvir...
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Platelet,NotEndothelial,P-SelectinIsRequiredforNeointimalFormationAfterVascularInjury
...onplateletsandcanmediateplatelet-endothelialinteractioninvivo.JExpMed.2000;191:1413–1422.vonHundelshausenP,WeberKS,HuoY,ProudfootAE,NelsonPJ,LeyK,WeberC.RANTESdepositionbyplateletstriggersmonocytearrestoninflamedandatheroscleroticendothelium.Circulation.2001;103:1772–1777.MankaD,ForlowSB,Sanders...
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Pertussistoxininhibitsneutrophilrecruitmenttodelayantibody-mediatedclearanceofBordetellapertussis
...edtoprotectionafterhouseholdexposuretoBordetellapertussis.Vaccine.16::1907-1916.Long,S.S.,Welkon,C.J.,andClark,J.L.1990..Widespreadsilenttransmissionofpertussisinfamilies:antibodycorrelatesofinfectionandsymptomatology.J.Infect.Dis.161::480-486.Leef,M.,Elkins,K.L.,Barbic,J.,andShahin,R.D.2000..Protec...
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BlockadeoftheFas/FasLSystemImprovesPneumococcalClearancefromtheLungswithoutPreventingDisseminationofBacteriatotheSpleen
MedicalResearchServiceoftheVeteransAffairsPugetSoundHealthCareSystem,andDivisionsofPulmonaryandCriticalCareMedicineandAllergyandInfectiousDiseases,DepartmentofMedicine,UniversityofWashingtonSchoolofMedicine,SeattleLillyResearchLaboratories,EliLillyandCompany,Indianapolis,IndianaBackground.TheFas/Fas...
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MastCell-DerivedTumorNecrosisFactorCanPromoteNerveFiberElongationintheSkinduringContactHypersensitivityinMice
...euronsbyCGRP-mediatedmucosalmastcelldegranulation.AmJPhysiol2004,287:G178-G191BudaiD,LarsonAA:RoleofsubstancePinthemodulationofC-fiber-evokedresponsesofspinaldorsalhornneurons.BrainRes1996,710:197-203OidaH,NambaT,SugimotoY,UshikubiF,OhishiH,IchikawaA,NarumiyaS:Insituhybridizationstudiesofprostacycli...
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PathologyandprotectioninnephrotoxicnephritisisdeterminedbyselectiveengagementofspecificFcreceptors
...ctrolyteandHypertensionDivision,TheUniversityofPennsylvania,Philadelphia,PA19104Introductionofheterologousanti–glomerularbasementmembraneantiserum(nephrotoxicserum,NTS)intopresensitizedmicetriggerstheproductionofIgGanti-NTSantibodiesthatarepredominantlyIgG2bandtheglomerulardepositionofpathogenicim...
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Urokinase-TypePlasminogenActivatorReceptorRegulatesLeukocyteRecruitmentduringExperimentalPneumococcalMeningitis
DepartmentofNeurology,KlinikumGrosshadern,Ludwig-MaximiliansUniversity,Munich,GermanyTissue-typeplasminogenactivator(tPA)andurokinase-typeplasminogenactivator(uPA)havebeensuggestedtoplayanimportantroleininflammatorydiseases.IncreasedlevelsoftPA,uPA,uPAreceptor(uPAR),andtheirinhibitor,plasminogenacti...
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MonoclonalAntibody-MediatedCD00ReceptorSignalingSuppressesMacrophageActivationandTissueDamageinExperimentalAutoimmuneUveoretinitis
.../neuroncellsurfaceantigenOX2bindstoaligandonmacrophages.EurJImmunol1997,27:1911-1918BarclayAN,WrightGJ,BrookeG,BrownMH:CD200andmembraneproteininteractionsinthecontrolofmyeloidcells.TrendsImmunol2002,23:285-290NathanC,MullerWA:Puttingthebrakesoninnateimmunity:aregulatoryroleforCD200?NatImmunol2001,2:...
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SuppressionoftumorformationinlymphnodesbyL-selectin–mediatednaturalkillercellrecruitment
...2000.Differentialtumorsurveillancebynaturalkiller(NK)andNKTcells.J.Exp.Med.191:661–668.Smyth,M.J.,M.Taniguchi,andS.E.Street.2000.Theanti-tumoractivityofIL-12:mechanismsofinnateimmunitythataremodelanddosedependent.J.Immunol.165:2665–2670.Takeda,K.,M.J.Smyth,E.Cretney,Y.Hayakawa,N.Yamaguchi,H.Yagi...
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CriticalfunctionofBmx/Etkinischemia-mediatedarteriogenesisandangiogenesis
...458.HeilM.andSchaperW.2005.Cellularmechanismsofarteriogenesis.EXS.94:181–191.TamagnoneL.,etal.1994.BMX,anovelnonreceptortyrosinekinasegeneoftheBTK/ITK/TEC/TXKfamilylocatedinchromosomeXp22.2.Oncogene.9:3683–3688.QiuY.,RobinsonD.,PretlowT.G.,KungH.J.1998.Etk/Bmx,atyrosinekinasewithapleckstrin-homo...
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ImmunolocalizationofproteinkinaseCisoenzymes,I,II,,andinmousekidney
...ependentand-independentPKCisoenzymesinrenalischemia.BiochemBiophysResCommun191:1124-1130,1993.LeitgesM,MayrM,BraunU,MayrU,LiC,PfisterG,Ghaffari-TabriziN,BaierG,HuY,andXuQ.ExacerbatedveingraftarteriosclerosisinproteinkinaseC-nullmice.JClinInvest108:1505-1512,2001.LeitgesM,PlomannM,StandaertML,Bandyop...
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ImmaturemonocytesacquireantigensfromothercellsinthebonemarrowandpresentthemtoTcellsaftermaturingintheperiphery
...omalcompartmentsofdendriticcellsisregulatedbyinflammatorystimuli.J.Exp.Med.191:927–936.Schmid,H.,R.Sauerbrei,G.Schwarz,E.Weber,H.Kalbacher,andC.Driessen.2002.ModulationoftheendosomalandlysosomaldistributionofcathepsinsB,LandSinhumanmonocytes/macrophages.Biol.Chem.383:1277–1283.Authier,F.,B.I.Pos...
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TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...asticcoexpressionofactivationreceptorsonmurinenaturalkillercells.J.Exp.Med.191:1341–1354.Gosselin,P.,L.H.Mason,J.Willette-Brown,J.R.Ortaldo,D.W.McVicar,andS.K.Anderson.1999.InductionofDAP12phosphorylation,calciummobilization,andcytokinesecretionbyLy49H.J.Leukoc.Biol.66:165–171.Arase,H.,E.S.Mocar...
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CCChemokineReceptorExpressionbyBLymphocytesIsEssentialfortheDevelopmentofIsolatedLymphoidFollicles
...emokineresponseprofilesduringBcelldifferentiationandmaturation.JExpMed2000,191:1303-1318KrzysiekR,LefevreEA,BernardJ,FoussatA,GalanaudP,LouacheF,RichardY:RegulationofCCR6chemokinereceptorexpressionandresponsivenesstomacrophageinflammatoryprotein-3alpha/CCL20inhumanBcells.Blood2000,96:2338-2345WangC,...
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TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...asticcoexpressionofactivationreceptorsonmurinenaturalkillercells.J.Exp.Med.191:1341–1354.Gosselin,P.,L.H.Mason,J.Willette-Brown,J.R.Ortaldo,D.W.McVicar,andS.K.Anderson.1999.InductionofDAP12phosphorylation,calciummobilization,andcytokinesecretionbyLy49H.J.Leukoc.Biol.66:165–171.Arase,H.,E.S.Mocar...
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照射時間延長對小鼠Lewis肺癌MMP9和Ecad表達影響
...reedimensionalconformaldosedistributions[J].JJpnSocTherRadiolOncol,2000,12:191193. [3]CHANGSX,CULLIPTJ,DESCHESNEKM.Intensitymodulationdeliverytechniques:“step&shoot”mlCautosequenceversustheuseofamodulator[J].MedPhys,2000,27:948949. [4]李曉麗,劉希光,程熙國,等.照射...
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Iron,zinc,andcopperconcentrationsinbreastmilkareindependentofmaternalmineralstatus
...rationsofiron,zinc,andcopperandmaternalmineralstatus.Design:Milksamplesfrom191SwedishandHonduranmotherswerecollectedat9mopostpartum.Iron,zinc,andcopperconcentrationsweremeasuredbyatomicabsorptionspectrometry.Bloodsamplesfrommotherswereanalyzedforplasmazincandcopperand4indexesofironstatus:hemoglobin,...
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RoleofDioxinResponseElementandNuclearFactor-BMotifsin2,3,7,8-Tetrachlorodibenzo-p-dioxin-MediatedRegulationofFasandFasLigandExpression
...erconstructswithorwithoutNF-Bmotifs.WedesignatedtheseconstructsFasL231,FasL191,andFasL324basedonthesizeoftherespectivePCR-amplifiedfragments.TheprimersusedtogeneratevariousfragmentsofmouseFasLpromoterareshowninTable1.Fordirectionalcloning,allupstreamprimersincludedSacIrestrictionsiteanddownstreampri...
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BacterialPeptidoglycan-AssociatedLipoprotein:ANaturallyOccurringToll-LikeReceptor2AgonistThatIsShedintoSerumandHasSynergywithLipopolysaccha
DepartmentofPathology,BostonUniversityMedicalCenter,DepartmentsofAnesthesiaandPediatrics,HarvardMedicalSchool,andDepartmentsofAnesthesiaandCriticalCare,PediatricsMedicineInfectiousDiseaseUnit,MassachusettsGeneralHospital,BostonDivisionofPulmonaryandCriticalCareMedicine,UniversityofMarylandSchoolofMe...
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HydronephrosisassociatedwithantiurothelialandantinuclearautoantibodiesinBALB/c-Fcgr2b–/–Pdcd1–/–mice
...modificationofpositiveselectioninthethymusofPD-1–deficientmice.J.Exp.Med.191:891–898.Fukuyama,H.,F.Nimmerjahn,andJ.V.Ravetch.2005.TheinhibitoryFcgammareceptormodulatesautoimmunitybylimitingtheaccumulationofimmunoglobulinG+anti-DNAplasmacells.Nat.Immunol.6:99–106.Prokunina,L.,C.Castillejo-Lopez...
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造血幹細胞在皮膚移植中誘導特異性免疫耐受的研究
...ctionbyreleaseofdonor-specific,solubleHLAclassI.HumanImmunol,1994,40:191. 7NostrozaJ,MunozP,EspinozaR,etal.QuantitationofsolubieHLAclassIheterodimersandβ2-microglobulininpatientswithactivepulmonarytuberculosis.HumanImmunol,1994,40:179. (收稿日期:2004-08-30) ...
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Cell-derivedanaphylatoxinsaskeymediatorsofantibody-dependenttypeIIautoimmunityinmice
...eircapacitytointeractinvivowiththelow-affinityFcgammareceptorIII.J.Exp.Med.191::1293-1302.Schiller,C.etal.2000..MouseFcRIIisanegativeregulatorofFcRIIIinIgGimmunecomplex-triggeredinflammationbutnotinautoantibody-inducedhemolysis.Eur.J.Immunol.30::481-490.Ahmed,S.S.etal.1995..Fcreceptorsinliversinusoi...