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KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues
...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...
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HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
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RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages
...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...
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Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling
...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...
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DifferentialAdditiveEffectsofEndothelialLipaseandScavengerReceptor-ClassBTypeIonHigh-DensityLipoproteinMetabolisminKnockoutMouseModels
...crinologyandMetabolism(K.M.,L.C.),DepartmentsofMedicineandMolecularCellularBiology,BaylorCollegeofMedicine,andSt.Luke’sEpiscopalHospital,Houston,Tex;LawrenceBerkeleyNationalLaboratory(T.F.),Berkeley,Calif;andLipoScience(J.D.O.),Raleigh,NC.CorrespondencetoLawrenceChan,DivisionofEndocrinologyMetabol...
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CholesterylEsterTransferProtein(CETP)ExpressionProtectsAgainstDietInducedAtherosclerosisinSR-BIDeficientMice
...ssionofthehumanCETPtransgeneprotectsagainstdiet-inducedatherosclerosisinSR-BIdeficientmice.MethodsandResults-SR-BIdeficient(-/-)micewerecrossedwithCETPtransgenic(CETPtg)micetoproduceacolonyofSR-BI-/-xCETPtgmiceinaC57Bl/6background.Ageandsexmatchedgroupsofgeneticallymodifiedandwild-typeC57Bl/6micewer...
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HCV蛋白酶抑制劑BI201335有強效抗病毒活性
...林格殷格翰公司研發的丙肝病毒(HCV)NS3/4A蛋白酶抑制劑BI201335,在初治和經治的慢性基因1型丙肝病毒(HCV)感染患者中的優異療效。基因1型的HCV是在所有HCV感染治療中最有挑戰性的基因分型。 丙型肝炎是肝臟感染性疾病...
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MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
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ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
...H.G.,M.M.,F.R.),Hamburg,Germany;andtheCollegeofPhysiciansandSurgeonsofColumbiaUniversity(R.R.),NewYork,NY.CorrespondencetoDrFranzRinninger,UniversityHospitalHamburg-Eppendorf,DepartmentofMedicine,Martinistrasse52,20246Hamburg,Germany.E-mailRinninger@uke.uni-hamburg.deAbstractObjective—High-density...
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Bi-PAP呼吸機通氣治療慢性阻塞性肺疾病合併呼吸衰竭
【摘要】目的研究無創Bi-PAP呼吸機治療慢性阻塞性肺疾病(COPD)合併呼吸衰竭。方法52例患者隨機分爲治療組27例,持續Bi-PAP呼吸機治療;對照組25例,持續低流量吸氧。兩組同時抗感染等常規治療。觀察血氣和臨牀症狀變化。結...
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IncreasedOxidativeStressinScavengerReceptorBIKnockoutMiceWithDysfunctionalHDL
【摘要】Objective—InthecurrentstudytheeffectofdisruptionofSR-BI,aprominentregulatorofHDLmetabolism,ontheactivityoftheHDL-associatedantioxidantenzymesPON1andPAF-AHaswellasinvivooxidativestresswereinvestigated.MethodsandResults—SR-BIdeficiencyresultedin1.4-fold(P0.001)and1.6-fold(P0.01...
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Phosphatidylinositol-3-KinaseRegulatesScavengerReceptorClassBTypeISubcellularLocalizationandSelectiveLipidUptakeinHepatocytes
...ive-Thehigh-densitylipoprotein(HDL)receptorscavengerreceptorClassBtypeI(SR-BI)playsakeyroleinmediatingthefinalstepofreversecholesteroltransport.ThisstudyexaminedthepossibleregulationofhepaticSR-BIbyphosphatidylinositol-3-kinase(PI3K),awellknownregulatorofendocytosisandmembraneproteintrafficking.Meth...
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SR-BI受體基因的G4A位點多態性可能增加腦血管疾病風險
...硬化和腦缺血患者中均發現,B族I型清道夫受體基因(SR-BI,也稱高密度脂蛋白受體)G4AGA+AA患者的高密度脂蛋白也明顯升高,而低密度脂蛋白卻低於GG基因患者。動脈粥樣硬化是一個被廣泛認可的中風獨立危險因素,與脂代謝密...
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實時組織彈性成像與超聲BI-RADS分級法在乳腺腫瘤性疾病診斷中的對比研究
...腺結節的實時組織彈性成像資料進行回顧分析,並與超聲BI-RADS分級法對比,探討兩種方法在乳腺實性結節良惡性鑑別診斷中的價值。方法130例女性乳腺結節患者,常規高頻彩超圖像進行BI-RADS分級[1],而後對實時彈性圖像評分,...
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高密度脂蛋白抗動脈粥樣硬化機制—SR-BI,CD36,PPARgamma的作用
高密度脂蛋白抗動脈粥樣硬化機制—SR-BI,CD36,PPARgamma的作用南華大學心血管疾病研究所易光輝泡沫細胞形成是動脈粥樣硬化發病的核心SR-BI動脈粥樣硬化小型豬SR-BI、CD36和PPARγ表達的變化第一部分Figure1:Themeanbodyweightsofthetwog...
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海南省2007年登革熱媒介伊蚊分佈調查
...)、容器指數(ContainerIndex,CI)、佈雷圖指數(BreteauIndex,BI)等,以房屋指數、容器指數和佈雷圖指數,調查媒介幼蟲密度;以撈取積水容器內蚊幼,調查孳生情況。結果全省BI值最高爲123,最低爲13.3,全省平均BI值37.4;CI值最...
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多菌型麻風聯合化療期滿後麻風菌的活性及復發的研究
...色法檢測麻風菌的活性,抗酸染色(AFB)記錄細菌指數(BI)及形態指數(MI)。結果檢測多菌型麻風患者共29例,其中初治MDT期滿22例,復發MDT期滿7例,共檢出綠染菌4例。抗酸染色查菌陽性者中復發患者平均BI高於初治患者平均...
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Bi-PAP無創鼻罩呼吸機治療慢性阻塞性肺疾病的護理
【摘要】目的探討Bi-PAP無創鼻罩呼吸機治療慢性阻塞性肺疾疾(COPD)呼吸衰竭的護理。方法35例COPD呼吸衰竭患者在常規治療的同時,應用Bi-PAP呼吸機S/T模式輔助通氣治療。結果經無創正壓通氣,31例好轉,4例病情加重予以氣管...
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LymphocytesAreNotRequiredfortheRapidOnsetofCoronaryHeartDiseaseinScavengerReceptorClassBTypeI/ApolipoproteinEDoubleKnockoutMice
FromtheDepartmentofBiology(S.L.K.,M.K.),MassachusettsInstituteofTechnology,Cambridge;andDivisionofCardiologyDepartmentofMedicine(M.H.P.),MassachusettsGeneralHospitalandHarvardMedicalSchool,Boston,Mass.CorrespondencetoMontyKrieger,Room68-483,BiologyDepartment,MassachusettsInstituteofTechnology,Cambri...
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High-DensityLipoproteinPromotesEndothelialCellMigrationandReendothelializationviaScavengerReceptor-BTypeI
...rationinvitroinanitricoxide-independentmannerviascavengerreceptorBtypeI(SR-BI)-mediatedactivationofRacGTPase.ThisprocessdoesnotrequireHDLcargomolecules,anditisdependentontheactivationofSrckinases,phosphatidylinositol3-kinase,andp44/42mitogen-activatedproteinkinases.Rapidinitialstimulationoflamellipo...
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HepaticLipaseDeficiencyDelaysAtherosclerosis,MyocardialInfarction,andCardiacDysfunctionandExtendsLifespaninSR-BI/ApolipoproteinEDoubleKnockou
【摘要】Objective-SR-BI/apolipoprotein(apo)Edoubleknockout(dKO)miceexhibitmanyfeaturesofhumancoronaryheartdisease(CHD),includingocclusivecoronaryatherosclerosis,cardiachypertrophy,myocardialinfarctions,andprematuredeath.Herewedeterminedtheeffectsonthispathologyofhepaticlipase(HL)deficiency,which...
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NabelspeaksupaboutdirectingtheNHLBI
TheNationalHeart,Lung,andBloodInstitute(NHLBI)coversextensiveground,exploringcauses,prevention,therapy,anddiagnosisofdiseasesinvolvingtheheart,blood,bloodvessels,andlung.TheNHLBIalsoresearchessleepdisordersandcoordinatestheNIHWoman’sHealthInitiative.ElizabethNabel,formerlythescientificdirectorofcl...
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勃林格殷格翰啓動肺癌新型第三代表皮生長因子受體抑制劑項目
勃林格殷格翰今天在德國慕尼黑召開的BIO歐洲會議上宣佈啓動一項全球II期試驗,旨在評價BI1482694(HM61713)用於T790M突變陽性非小細胞癌患者的安全性和有效性,此類患者的腫瘤細胞已不再對現有表皮生長因子受體靶向治療產生...
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DualPotentiatingandInhibitoryActionsofaBenz[e]indeneNeurosteroidAnalogonRecombinant122GABAAReceptors
【關鍵詞】Benz[e]indene5µM),BI-2inhibitsreceptorfunctionbyenhancingtheapparentrateofdesensitization.Fromsingle-channelrecordings,weestimatethattheentryrateintotheinhibitedorblockedstate,k+B,is0.50µM-1s-1.Basedonthekineticmechanismofaction,andthefindingthatthiseffectisblockedbythe1V2...
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丹陽市40例麻風病人聯合化療臨牀療效分析
...病人,皮損消退時間爲2個月~3年,平均1.8年。表1MDT前後Bi變化略2.2細菌指數變化23例療前查菌陽性者,MDT前皮膚查菌Bi平均1.77,聯化治療後Bi呈持續下降趨勢,其中療後2年內細菌Bi下降幅度較大,年均下降0.657,高於國外報道,...
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賽萊樂治療42例缺血性腦卒中療效觀察
...萊樂150mg靜脈點滴。療程15天。結束後評定NFD程度、FMA及BI得分的變化,觀察不良反應。結果2例賽萊樂組病人因不良反應退出觀察,餘82例完成觀察。賽萊樂組、對照組的總有效率分別爲83%、62%(P<0.05)。治療後NFD、FMA、BI評分分別...
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中山大學和杜塞爾多夫大學啓動全球糖尿病項目
...博士共同擔任全球協調牽頭人的全球糖尿病項目(項目號BI1245.19和BI1245.20)的研究者會議在南京成功舉行。中山大學附屬第三醫院、復旦大學附屬華山醫院、第二軍醫大學附屬長征醫院、首都醫科大學附屬北京同仁醫院、衛生部...
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穴位敷貼對缺血性中風肢體偏癱患者的療效觀察
...息3天后換取其他穴位再貼。1.6觀察指標參照Barthal指數(BI)評分(表1)。表1Barthal指數(BI)注:*每週少於1次,**每24h少於1次。總積分由0~100分,按其依賴程度分,100分獨立;75~95分輕度依賴;50~70分中度依賴;25~45分重度...
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創(dou)意(bi)發明:古有鑽木取火,今有咀嚼發電
2014年9月18日訊/生物谷BIOON/鑽木取火可以說是人類最早的能量轉換方法之一,可以說這種方法大大加速了人類的進化。可是你是否曾設想過,有一天你可以在公園裏喫漢堡的時候就可以爲你的手機充電?最近,一年一度的搞笑諾...
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中山大學和德國杜塞爾多夫大學共同負責的全球糖尿病項目正式啓動
...博士共同擔任全球協調牽頭人的全球糖尿病項目(項目號BI1245.19和BI1245.20)的研究者會議在南京中山國際會議中心成功舉行。中山大學附屬第三醫院、復旦大學附屬華山醫院、第二軍醫大學附屬長征醫院、首都醫科大學附屬北京...