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科學家完成肺孢子菌全基因組測序
...條件下獲得P.jirovecii細胞,所以無法獲得其基因組DNA,但是Hauser及其同事採取了另外一種方法.他們從肺孢子菌肺炎患者中收集支氣管肺泡灌洗液,通過免疫共沉澱的方法收集P.jirovecii細胞,通過隨機引物擴增獲得混合的DNA雙鏈,這些DNA...
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Single-Nucleotide-PolymorphismMappingofthePseudomonasaeruginosaTypeIIISecretionToxinsforDevelopmentofaDiagnosticMultiplexPCRSystem
...educedvirulenceinamousemodelofacutelunginfection(11),afindingalsoreportedbyHauseretal.(22).Clinically,isolatesthatsecreteExoUinvitroweremorelikelytohavecausedseverepneumoniainmechanicallyventilatedpatients(21).GiventheevidencethatthetoxinsoftheTTSSareimportantforthedeterminationofstrainvirulenceandp...
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醫生用幹細胞製造女性生殖器
...率四千分一兩名女子所患的罕見疾病Mayer-VonRokitansky-Kuster-HauserSyndrome(MRKHS)，每4,000至5,000名新生女嬰，有一人會患有此病。患者一般會擁有正常的乳房、卵巢和子宮，但沒有陰道，不能進行性行爲或生育。此前，醫學界會利用皮...
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GenotypicStudyofPneumocystisjiroveciiinHumanImmunodeficiencyVirus-PositivePatientsinThailand
...numberofribosomalRNAgenesinPneumocystiscarinii.J.Eukaryot.Microbiol.41:88S.Hauser,P.M.,P.Francioli,J.Bille,A.Telenti,andD.S.Blanc.1997.TypingofPneumocystiscariniif.sp.hominisbysingle-strandconformationpolymorphismoffourgenomicregions.J.Clin.Microbiol.35:3086-3091.Helweg-Larsen,J.,C.H.Lee,S.Jin,J.Y.H...
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芯片技術在醫學實驗室應用展望
...量。生物芯片在HIV檢測及相關研究中也發揮了一定作用。Hauser等［8］應用DNA芯片技術在艾滋病患者出現抗體反應之前檢測艾滋病病毒，對該病的早期診斷意義重大。2.3在腫瘤診斷中的應用腫瘤的發生發展往往涉及到較多基因的...
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Intraoperativevisualexperiencesofcataractpatientscanbebothpleasantandunpleasant
...dicherry,India4LionsAravindInstituteofCommunityOphthalmology,Modurai,India5Hauser-RossEyeInstitute,Sycamore,IL,USA6AcademicDepartmentofAnaesthesia,TheJamesCookUniversityHospital,UKCorrespondenceto:DrKah-GuanAuEongAlexandraHospital378AlexandraRoadSingapore,Singapore159964;kah_guan_au_eong@alexhosp.co...
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先天性無陰道
...管細小，卵巢發育及功能正常常爲特徵的Rokitansky-Kustner-Hauser綜合徵病人爲最多見。睾丸女性化（雄激素不敏感綜合徵）病人較爲少見。很少數爲真性兩性畸形或性腺發育不全者。【診斷】絕大多數先天性牆角陰道病人在正常陰...
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先天性無陰道
...管細小，卵巢發育及功能正常常爲特徵的Rokitansky-Kustner-Hauser綜合徵病人爲最多見。睾丸女性化（雄激素不敏感綜合徵）病人較爲少見。很少數爲真性兩性畸形或性腺發育不全者。臨牀表現絕大多數先天性牆角陰道病人在正常陰...
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先天性無陰道繼發陰道外翻一例
...管、卵巢及外生殖器發育正常，稱之爲Meyer-Rokitausky-Kuster-Hauser-Syndrome(MRKH)綜合徵。正常情況下女性胚胎髮育過程中副中腎管頭端發育成輸卵管，中、尾端發育成子宮及陰道上段。雙側副中腎管中、尾段發育時相互融合，縱隔消失...
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基因芯片技術及其在臨牀檢驗醫學中的應用
...，這也是基因芯片技術被首次應用於臨牀實踐。1998年，Hauser等［7］人應用DNA芯片技術在艾滋病患者出現抗體反應前檢測艾滋病病毒，對此病的早期診斷十分重要;同年，Kimizuka［8］與Affymetrix公司合作生產了新一代的診斷試劑盒...
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癲癇患者95例的臨牀類型、腦電圖及CT分析
...齡與病因的關係本研究中15歲以下兒童癲癇特發性多見，Hauser認爲出生時神經缺陷是小兒癲癇的最重要的病因［3］;老年人以繼發性癲癇爲主，其病因以腦血管病最多，其次是腦腫瘤、腦外傷、一氧化碳中毒、代謝性腦病等［4］...
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腫瘤的抗體治療
...tastaticbreastcancer.JClinOncol，2002，20:719-726.8DandachiN，DietzeO，Hauser-KronbergerC.Chromogenicinsituhyˉbridization:anovelapproachtoapracticalandsensitivemethodforthedetechionofHER2oncogeneinarchivalhumanbreastcarcinoma.LabInvest，2002，82:1007-1014.9HerbstRS，HongWK.IMC-C225，ananti-...
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髕骨不穩定的診治現狀
...良好療效，但術後併發症較高。 (2)髕韌帶止點移位術(Hauser法)：將髕韌帶連同脛骨結節的骨片向遠側和內側移位固定，通常與外側鬆解和股內側肌前移術聯合應用。適用於髕骨脫位復位後伸屈不受影響，高位髕骨，脛骨結節已...
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InfectionbyChlamydophiliaaviuminanElderlyCoupleWorkinginaPetShop
...001.Chlamydialinfection,p.1075-1084.InE.Braunwald,A.S.Fauci,D.L.Kasper,S.L.Hauser,D.L.Longo,andJ.L.Jameson(ed.),Harrison‘sprinciplesofinternalmedicine,14thedition,vol1.McGraw-Hill,NewYork,N.Y.Wang,S.P.,andJ.T.Grayston.1970.ImmunologicrelationshipbetweengenitalTRIC,lymphogranulomavenereum,andrelate...
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Blimp-1isrequiredformaintenanceoflong-livedplasmacellsinthebonemarrow
...ofplasmacelldevelopment.Nat.Rev.Immunol.5:230–242.Hoyer,B.F.,K.Moser,A.E.Hauser,A.Peddinghaus,C.Voigt,D.Eilat,A.Radbruch,F.Hiepe,andR.A.Manz.2004.Short-livedplasmablastsandlong-livedplasmacellscontributetochronichumoralautoimmunityinNZB/Wmice.J.Exp.Med.199:1577–1584.Silverman,G.J.,andS.Weisman.2...
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陰道成形圍手術期20例的臨牀護理分析
...分重要。【關鍵詞】RKH;陰道成形;護理 Rokitansky-Kustner-Hauser綜合徵：指胚胎在發育期間受到內在或外界因素阻擾，亦可能由於基因突變引起副中腎管發育異常。先天性無陰道的患者通常都具有46XX染色體核型，常合併無子宮或...
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抑鬱症的研究進展
...感反應。抑鬱症的發生與額葉功能性和器質性損害有關。Hauser等指出［4］，老年抑鬱症病人比正常老年人的額葉體積小（220±31）ml∶（250±3.1）ml，P0.01，顯示老年抑鬱症病人有額葉萎縮的相對特異性，有人用核磁共振（MRI）研...
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腺病毒載體介導的遺傳病基因治療研究和應用進展
...毒等）載體，將功能性營養蛋白的cDNA導入肌肉細胞內。Hauser等[7]在轉基因mdx小鼠中，分別轉移6.3kb的一段基因和cDNA全基因，證實可以部分或全部糾正小鼠的病理症狀，小鼠的肌肉力量可以恢復。1993年，Vincent等[8]最早通過缺失E1...
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SelectingBcellsandplasmacellstomemory
...calmemorybypolyclonalactivationofhumanmemoryBcells.Science.298:2199–2202.Hauser,A.E.,G.F.Debes,S.Arce,G.Cassese,A.Hamann,A.Radbruch,andR.A.Manz.2002.ChemotacticresponsivenesstowardligandsforCXCR3andCXCR4isregulatedonplasmablastsduringthetimecourseofamemoryimmuneresponse.J.Immunol.169:1277–1282.Z...
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CorynebacteriumulceransinanImmunocompromisedPatientwithDiphtheriaandHerDog
...i.2003.CorynebacteriumulceransdiphtheriainJapan.Emerg.Infect.Dis.9:752-753.Hauser,D.,M.R.Popoff,M.Kiredjian,P.Boquet,andF.Bimet.1993.PolymerasechainreactionassayfordiagnosisofpotentiallytoxinogenicCorynebacteriumdiphtheriaestrains:correlationwithADP-ribosylationactivityassay.J.Clin.Microbiol.31:2720...
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自閉症的病因研究進展
...象，並由此假設顳葉功能障礙可能是一個重要發病因素(Hauser);患者的胼胝體和下後區體積明顯小於正常的對照組(Piven);小腦神經元的廣泛減少(Williams);小腦發育不良或過度增生(Courchesne);大腦皮質代謝呈瀰漫性減弱(Sherman);腦血流灌...
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DihydropteroateSynthaseandNovelDihydrofolateReductaseGeneMutationsinStrainsofPneumocystisjiroveciifromSouthAfrica
...4.Nahimana,A.,M.Rabodonirina,G.Zanetti,I.Meneau,P.Francioli,J.Bille,andP.M.Hauser.2003.AssociationbetweenaspecificPneumocystisjirovecidihydropteroatesynthasemutationandfailureofpyrimethamine/sulfadoxineprophylaxisinhumanimmunodeficiencyvirus-positiveand-negativepatients.J.Infect.Dis.188:1017-1023.Ri...
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ImprovementofLymeBorreliosisSerodiagnosisbyaNewlyDevelopedRecombinantImmunoglobulinG(IgG)andIgMLineImmunoblotAssayandAdditionofVlsEandD
...iaburgdorferipathogenicforhumans.Int.J.Med.Microbiol.293(Suppl.37):172-173.Hauser,U.,G.Lehnert,R.Lobentanzer,andB.Wilske.1997.InterpretationcriteriaforstandardizedWesternblotsforthreeEuropeanspeciesofBorreliaburgdorferisensulato.J.Clin.Microbiol.35:1433-1444.Heikkil,T.,I.Seppl,H.Saxen,J.Panelius,H.Y...
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EarlyImmuneResponsetotheComponentsoftheTypeIIISystemofPseudomonasaeruginosainChildrenwithCysticFibrosis
...sis.Pediatrics100:E2.Feltman,H.,G.Schulert,S.Khan,M.Jain,L.Peterson,andA.R.Hauser.2001.PrevalenceoftypeIIIsecretiongenesinclinicalandenvironmentalisolatesofPseudomonasaeruginosa.Microbiology147:2659-2669.FitzSimmons,S.C.1993.Thechangingepidemiologyofcysticfibrosis.J.Pediatr.122:1-9.Frank,D.W.1997.Th...
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多胎妊娠
...。2.年齡及產次：年齡對單卵雙胎髮生率的影響不明顯。Hauser等發現單卵雙胎髮生率在20歲以下婦女爲3‰,＞40歲者爲4.5‰。雙卵雙胎髮生率隨年齡的增長顯著升高，在15～19歲年齡組僅2.5‰，而30～34歲組上升至11.5‰。產次增加，...
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AntibodiesfromPatientswithMelioidosisRecognizeBurkholderiamalleibutNotBurkholderiathailandensisAntigensintheIndirectHemagglutinationAssay
...worth,A.Cronin,B.Crossett,P.Davis,D.DeShazer,T.Feltwell,A.Fraser,Z.Hance,H.Hauser,S.Holroyd,K.Jagels,K.E.Keith,M.Maddison,S.Moule,C.Price,M.A.Quail,E.Rabbinowitsch,K.Rutherford,M.Sanders,M.Simmonds,S.Songsivilai,K.Stevens,S.Tumapa,M.Vesaratchavest,S.Whitehead,C.Yeats,B.G.Barrell,P.C.Oyston,andJ.Park...
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MEF2Asequencevariantsandcoronaryarterydisease:achangeofheart?
...nearly-andlate-settlementpopulationsofFinland.Am.J.Hum.Genet.67::1481-1493.Hauser,E.R.etal.2004..Agenomewidescanforearly-onsetcoronaryarterydiseasein438families:theGENECARDStudy.Am.J.Hum.Genet.75::436-447.Francke,S.etal.2001..Agenome-widescanforcoronaryheartdiseasesuggestsinIndo-Mauritiansasusceptib...
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美國科學家用人體自身細胞培養出人造陰道
...管細小，卵巢發育及功能正常常爲特徵的Rokitansky-Kustner-Hauser綜合徵病人爲最多見。睾丸女性化（雄激素不敏感綜合徵）病人較爲少見。很少數爲真性兩性畸形或性腺發育不全者。臨牀表現1、青春期前無明顯異常表現，常被忽視...
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FatalReactivationofPostnatalCytomegalovirusInfectionwithRapidEmergenceofGanciclovirResistanceinanInfantafterAllogeneicStemCellTransplantati
...L97protein.J.Med.Virol.65:70-76.Michel,D.,K.Wunderlich,M.Michel,T.Wasner,I.Hauser,M.Just,W.Hampl,andT.Mertens.2003.Fastgenotypicidentificationandestimationofganciclovir-resistantcytomegalovirusfromclinicalspecimens.Monogr.Virol.24:160-170.Pinkel,D.1998.Differentiatingjuvenilemyelomonocyticleukemiafr...
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VariationsinemmTypeamongGroupAStreptococcalIsolatesCausingInvasiveorNoninvasiveInfectionsinaNationwideStudy
...ealisolatesandtheirrelationshiptoinvasiveisolates.J.Infect.Dis.185:915-920.Hauser,A.R.,D.L.Stevens,E.L.Kaplan,andP.M.Schlievert.1991.MolecularanalysisofpyrogenicexotoxinsfromStreptococcuspyogenesisolatesassociatedwithtoxicshock-likesyndrome.J.Clin.Microbiol.29:1562-1567.Helweg-Larsen,J.,J.S.Jensen,T...
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苯甲基季銨鹽用氨基鈉（或氨基鉀）處理時得到苯甲基三級胺：苯甲基硫Yilide重排生成（2-甲基苯基）-二甲硫醚：一般認爲反應先是發生[2,3]s 遷移，然後互變異構得到重排產物：[1]M.Sommelet, Compt.Rend. 205,56（1937）[2]W.Wittig,R.MangoldandG.Felletschin, Ann. 560,116（1948）[3]C.R.Hauser,D.N.vanEenam, J.Amer.Chem.Soc. 78,5698（1956）[4]J.F.Bunnett, Quart,Rev. 12,15（1938）[5]C.K.Ingold, StructureandMechanisminOrganicChemistry（CornellUnivers ...
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