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PPAR-ligandamelioratesacuterenalfailurebyreducingcisplatin-inducedincreasedexpressionofrenalendonucleaseG
...ulesincisplatin-treatedmice.PretreatmentofPPAR-wild-typemicewithPPAR-ligandWY-14643reducedsignificantlycisplatin-inducedincreasedproteinexpressionandenzymeactivityofEndoGandpreventedthenucleartranslocationofmitochondrialEndoG.MorphologicalexaminationoftubularinjuryinthePPAR-wild-typemicethatreceived...
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ModulationofPPARExpressionandInflammatoryInterleukin-6ProductionbyChronicGlucoseIncreasesMonocyte/EndothelialAdhesion
...invascularcells,soweexaminedPPAR-associatedsignalinginEC.AknownPPARagonist,Wy14,643,preventedglucose-mediatedIL-6productionbyECandreducedglucose-mediatedmonocyteadhesionby40%.HG-culturedHAEChada50%reductioninexpressionofPPARcomparedwithcontrolEC.PrimaryaorticECisolatedfromPPARknockout(KO)miceshowedi...
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PPARligandprotectsduringcisplatin-inducedacuterenalfailurebypreventinginhibitionofrenalFAOandPDCactivity
...owreportontheeffectsofperoxisomeproliferator-activatedreceptor-(PPAR)ligandWy-14643(WY)ontheabnormalitiesofmediumchainfattyacidoxidationandpyruvatedehydrogenasecomplex(PDC)activityinkidneytissueofcisplatin-treatedmice.CisplatincausesasignificantreductioninmRNAlevelsandenzymeactivityofmitochondrialme...
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ModulationofReceptorPhosphorylationContributestoActivationofPeroxisomeProliferatorActivatedReceptorbyDehydroepiandrosteroneandOtherPeroxisome
...,PPARcanbeactivatedwithperoxisomeproliferators(PP),suchasfibratedrugs(e.g.,Wy-14643,clofibrate),nonfibratedrugs(nafenopin),fattyacids,chlorinatedcompounds,nonsteroidalanti-inflammatorydrugs,andendogenoussteroids,suchasdehydroepiandrosterone(DHEA)(EscherandWhali,2000).MostPPserveasligandsfortherecept...
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FenofibricAcid,anActiveFormofFenofibrate,IncreasesApolipoproteinA-I–MediatedHigh-DensityLipoproteinBiogenesisbyEnhancingTranscriptionofATP-Bi
...iptionofthegeneofapolipoproteinA-I(apoA-I)intheliver.13–15APPARactivator,Wy14643,wasshowntoupregulatethegeneofATP-bindingcassettetransporterA1(ABCA1)16thatmediatesandrate-limitsbiogenesisofHDLbytheinteractionofhelicalapolipoproteinandcells.17–20ABCA1expressionisenhancedbyloadingcholesteroltocell...
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ConstitutiveExpressionofPeroxisomeProliferator-ActivatedReceptor-RegulatedGenesinDwarfMice
...dthosealteredbythePP4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thioaceticacid(WY-14,643)in+/dwmice.Thegenesincludedthoseinvolvedin-and-oxidationoffattyacids(Acox1,Cyp4a10,Cyp4a14)andthoseinvolvedinstressresponses(thechaperonin,T-complexprotein1)andcardiovasculardisease(fibrinogen).Thelevelsofsomeofthes...
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ReciprocalandCoordinateRegulationofSerumAmyloidAVersusApolipoproteinA-IandParaoxonase-1byInflammationinMurineHepatocytes
...orafterexposuretotheperoxisomeproliferator-activatedreceptor-(PPAR)ligands(WY-14643andfenofibrate).Consistentwiththesefindings,thebasallevelofSAAwasincreased,whereasapoA-IandPON-1decreasedinprimaryhepatocytesfromPPAR-deficientmiceascomparedwithwild-typemice.Moreover,neitherWY-14643norfenofibratehada...
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ExpressionofHemeOxygenase-1inHumanVascularCellsIsRegulatedbyPeroxisomeProliferator-ActivatedReceptors
...umans.28,29ThereforewedeterminedtheinfluenceofligandsspecificforeitherPPAR(Wy-14,643andfenofibrate)orPPAR(rosiglitazoneandtroglitazone)onHO-1expressioninvascularcells.Westernblotanalysis(Figure1A)andimmunofluorescence(Figure1B)demonstratedthatbothPPARandPPARligandsinducedHO-1expressioninhumanumbilic...
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PeroxisomeProliferator-ActivatedReceptorAgonistsIncreaseNitricOxideSynthaseExpressioninVascularEndothelialCells
...Raction,inhibitedthefenofibrate-inducedupregulationofeNOSproteinexpression.WY14643andbezafibratealsoincreasedeNOSproteinlevels,whereasrosiglitazonedidnot.TransienttransfectionexperimentsusinghumaneNOSpromoterconstructshowedthatfenofibratefailedtoenhanceeNOSpromoteractivity.ActinomycinDstudiesdemonst...
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細胞內脂肪堆積和β細胞增殖的關係
...05)。高濃度的Glu使細胞內脂肪堆積增加15%~92%。TriacsinC或Wy14643能減少13%~54%的脂肪堆積,同時緩解FA對細胞增殖的抑制作用48%~71%。FA刺激CPT-1基因的表達,Glu對其有劑量依賴性的抑制,20mmol/LGlu使CPT-1基因的表達減少50%(P<0.05)。...
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雪佛龍與惠好組建生物燃料合資公司
雪佛龍(CVX)與惠好公司(WY)週五宣佈組建了一家合資公司,以開發將纖維素基生物量,或非食品原料轉化爲低碳生物燃料的技術。 雙方任命來自雪佛龍的MichaelBurnside爲這家名爲CatchlightEnergyLLC的合資公司的首席執行官,並任命...
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HepaticPGC-1βOverexpressionInducesCombinedHyperlipidemiaandModulatestheResponsetoPPARActivation
...hesetwocoactivatorsinpotentiatingthelipidloweringpropertiesofthePPARagonistWy14,643(Wy).MethodsandResults—C57BL/6micewerefedchoworHFDandtransducedwithadenovirusesencodingPGC-1orPGC-1β.Onchow,hepaticPGC-1βoverexpressioncausedseverecombinedhyperlipidemiaincludingelevatedplasmaapolipopr...
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Cardiac7-transmembrane-spanningdomainreceptorportfolios:diversify,diversify,diversify
...diacresponsetopressureoverload.J.Clin.Invest.116::1005-1015.doi:10.1172/JCI22811.ALLHATCollaborativeResearchGroup.Majorcardiovasculareventsinhypertensivepatientsrandomizedtodoxazosinvschlorthalidone.JAMA.283::1967-1975.Bryson,C.L.etal.2004..Riskofcongestiveheartfailureinanelderlypopulationtreatedwit...
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XG501型500mAX線機故障維修2例
...焦,測燈絲初極電壓僅爲40V左右:從而懷疑磁飽和穩壓器WY有問題,測磁飽和穩壓器輸入端101、102兩端交流電壓爲220V左右,斷開磁飽和穩壓器輸出端142,測空載輸出端電壓僅爲60V(正常值220V左右),焊下穩壓器2只並聯的4μF/1...
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RegulationofMouseHepatic-Amino-β-Carboxymuconate--SemialdehydeDecarboxylase,aKeyEnzymeintheTryptophan-NicotinamideAdenineDinucleotidePathway,by
...SDmRNAlevelsweregovernedbyHNF4anddownregulatedbyactivationofPPARbytheligandWy-14,643([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]aceticacid]),asrevealedbystudieswithhepaticHNF4-nullmiceandPPAR-nullmice,respectively.TransienttransfectionandelectrophoreticmobilityshiftanalysesshowedanHNF4bindingsitei...
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crusade研究-對不穩定性心絞痛患者進行快速危險分層可以減輕早期實施ACCAHA指南的不良結果嗎
...idelinesUpdateSitesWhoHaveSubmitted=486AK(0)WA(8)OR(5)CA(36)ID(0)NV(3)MT(0)WY(0)CO(8)NM(2)ND(1)SD(2)NE(4)KS(3)OK(8)TX(17)MN(4)IA(4)MO(12)AR(4)LA(8)WI(5)MI(24)MIUT(1)AZ(9)HI(1)IL(15)IN(9)KY(8)TN(15)MS(7)AL(11)GA(15)FL(33)SC(6)NC(13)VA(16)OH(30)WV(3)PA(39)NY(36)MD(13)ME(1)VT(1)NH(2)NJ(10)MA(11)CT(8)DE...
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InhibitionofSmoothMuscleProliferationbyUrea-BasedAlkanoicAcidsviaPeroxisomeProliferator-ActivatedReceptor-DependentRepressionofCyclinD
...purchasedfromCellSignalingTechnologyandSantaCruzBiotechnology,respectively.Wy14,643andPDGF-BBwerepurchasedfromBiomolandUpstateBiotechnology,respectively.RadioactivecompoundswereobtainedfromPerkinElmer.HumanaorticandcoronaryarterySMCswerepurchasedfromCambrexandmaintainedinSmGM-2medium.Allexperimentsu...
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Anti-inflammatoryeffectoffibrateprotectsfromcisplatin-inducedARF
...philinfiltrationinthecorticomedullaryregion.Pretreatmentofwild-typemicewithWY-14,643,afibrateclassofPPARligands,beforecisplatinsignificantlysuppressedcisplatin-inducedupregulationofcytokine/chemokineexpression,preventedneutrophilaccumulation,andamelioratedrenaldysfunction.Incontrast,treatmentwithPPA...
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X光機的仟伏與毫安的關係以及如何調整毫安的誤差
...阻)圖3上海機械廠XG-200型X射線機燈絲初級電路 〗圖中wy爲磁飽和穩壓器;KHB·爲空間電荷補償器;XJB爲小焦點燈絲變壓器;DJB爲大焦點燈絲改變變壓器;TW爲透視mA可調電阻;TY爲各mA檔可調電阻可變電阻上裝有各毫安檔的可移動...
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AntiatherogenicPropertiesofFibrates
...aprocessdependentonactivationoftheLXRpathway.TheexperimentalPPAR-activator,Wy14643,haspreviouslybeenshownalsotoupregulatetheABCA1geneinaprocessapparentlyrelatedtoactivationoftheLXRpathway.13ThestudybyArakawaetal10representsthefirstevidencethatsuchupregulationoftheABCA1geneispromotedbyfibricacidsderi...
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高電位交變場配合早期康復訓練治療腦卒中足內翻療效觀察
...次40分鐘。④使用皇城公司研製的“健得福第5代XN-2001-WY型心腦血管治療儀。偏癱患者仰臥位,屈髖、屈膝或端坐位,雙足脫襪、分開放置,與肩同寬,置於高電位交變場治療牀或治療平臺上,雙足必須緊貼檯面,若不能,他...
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Arandomizedfactorialstudyoftheeffectsoflong-termgarlicandmicronutrientsupplementationandof2-wkantibiotictreatmentforHelicobacterpyloriinf
...slehi1FromtheBeijingInstituteforCancerResearch,Beijng,China(LZ,YW,KP,JM,andWY);theBiostatisticsBranch,DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,Bethesda,MD(MHG,LMB,andRM);andWakunagaofAmericaCoLtd,MissionViejo,CA(HA)2Supportedbycontractno.NO1-CP-71103fromtheNationalCancerInstit...
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PPARs與動脈粥樣硬化研究新進展(基金項目)
...,其中PUFA與PPARα的親和力最高。具有降脂作用的化合物WY-14643和臨牀上已廣泛使用的貝特類降脂藥(Fibrate)爲其合成配體。PPARβ配體的結構介於PPARα和PPARγ配體之間而更類似於PPARα的配體。花生四烯酸經環氧合酶、脂氧合酶作...
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Salt-sensitivehypertensionisassociatedwithdysfunctionalCyp4a10geneandkidneyepithelialsodiumchannel
...e,VanderbiltUniversity,Nashville,Tennessee,USA.2DepartmentofPharmacology,NewYorkMedicalCollege,Valhalla,NewYork,USA.3DepartmentofBiochemistry,VanderbiltUniversity,Nashville,Tennessee,USA.4VeteransAffairsHospital,Nashville,Tennessee,USA.5DepartmentofBiochemistry,UniversityofTexasSouthwesternMedicalCe...
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關於認可湖北醫療器械質量檢測中心對一次性使用無菌注射器等產品和項目檢測資格的通知
...新消痛灸Q/WSZ002-200539醫用滴注敷貼全項目醫用滴注敷貼Q/WY002-200240一次性使用衛生腹被全項目一次性使用衛生腹被Q/KF006-20041手術薄膜全項目手術薄膜Q/SHW001-199842一次性使用吸氧管全項目一次性使用吸氧管Q/ZXCY005-200143N-S高能磁伸...
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過氧化物酶體增殖物激活受體與動脈粥樣硬化
...子表達[3]。內皮細胞表達PPAR,PPARα激動劑非諾貝特和WY14643通過抑制核因子-κB降低細胞因子誘導血管細胞粘附分子-1的表達,從而減少單核細胞粘附到內皮細胞上,而PPARγ激動劑沒有這一作用。而Simon等報道PPARα和PPARγ激動劑...
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重型顱腦損傷患者腦組織氧分壓變化及早期應用氧合液對其變化的影響
...位患者每日可輸注500~1500ml氧合液(醫用無菌充氧器ylh-wy-1型深圳英利華醫藥科技發展有限公司生產),5~10天爲1個療程。 1.2腦組織氧分壓監測使用德國GMS公司腦組織氧分壓監測系統(LICOX2型GMP)進行監測。其氧分壓探針是...
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新的腦膜炎疫苗可以讓嬰兒有比較好的免疫力
...的青少年都需接種腦膜炎雙球菌四價糖共軛疫苗(血清型ACWY),不過,目前核準的疫苗對嬰兒的免疫力差,而嬰兒的發病率卻是最高,因此發展出這種新的四價腦膜炎雙球菌糖共軛疫苗(MenACWY)。 有別於目前的疫苗,MenACWY...
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PPARinhibitsvascularsmoothmusclecellproliferationunderlyingintimalhyperplasiabyinducingthetumorsuppressorp16INK4a
.../129mSMCs(B)resumedgrowthatT0innormalGM.TheindicatedconcentrationsofGW7647,Wy14,643(10μM),orvehicle(Me2SO)wereaddedinthenormalGM.CellswereharvestedattheindicatedtimesformeasureofDNAcontent(expressedasarbitraryunits).Valuesarethemean±SEMoftriplicatepointsfromasingleexperiment(n=3/timepoint),whichwa...
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HumanadrenalglandssecretevitaminCinresponsetoadrenocorticotrophichormone
...nsibilitiesareasfollowsJLD,JG,andML:studyconceptanddesign;SJP,JLD,RC,WY,DAP,andML:datacollectionandanalysisandinterpretationofresults;SJPandML:writingofthemanuscript;andallauthors(exceptJLD,whoisdeceased)reviewedthefinalmanuscript.Thefundingsourcehadnoroleinstudydesign,collection,analysisandin...