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腹膜後纖維化引起的尿路梗阻
腹膜後纖維化(retroperitonealfibrosis,RPF)系腹膜後結締組織廣泛纖維化,壓迫血管、神經、胃腸道和輸尿管出現臨牀症狀,其中輸尿管周圍發生纖維化粘連,壓迫上尿路引起腎積水和腎功能衰竭最爲常見。我院1986年以來共收治腹膜後...
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結核桿菌復甦因子體外刺激結核病人血淋巴細胞增殖的試驗研究
...蘇的蛋白質,研究表明[1]結核分枝桿菌復甦因子蛋白質(Rpf)亞單位疫苗在小鼠試驗中有很高的免疫反應,除RpfC外,均能誘導產生抗體IgG1和IgG2α、γ-IFN、IL-10、IL-12,促進T細胞增殖。因此,我們應用Rpf刺激結核病人血淋巴...
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妊高徵患者腎功能檢測及臨牀意義
...統變化較大,腎臟略增大,腎血漿流量(renalplas-maflow,RPF)及腎小球濾過率(glomerularfiltrationrate,GFR)於妊娠早期均增加,整個妊娠期間維持高水平,RPF比非孕時約增加35%,GFR約增加50%。代謝產物Urea、Cr、UA等排泄增多,血中濃...
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梗阻性腎病
...快慢而定。急性慢性GFR下降,近端腎小管壓力可以正常,RPF改變可以不十分明顯,加上對側RPF可能可以代償性上升,其機制可能是腎-明反射被激活所致。慢性發生的單側輸尿管梗阻一般輸尿管內壓力不如急性者爲高,近端腎小...
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RenalfunctionmeasurementsfromMRrenographyandasimplifiedmulticompartmentalmodel
...sproposedformeasurementofsixfunctionalparametersthatincluderenalplasmaflow(RPF)andGFR.CompleteModel:SevenCompartmentsThefullmulticompartmentalmodel(Fig.1)dividesthevascular-nephronunitintosevencompartments:theintrarenalarteriesandglomerularvessels(A),vasarectaandveins(V),proximalconvolutedtubule(P),...
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體外循環的抗凝與拮抗
...輸血:2.應用魚精蛋白代用品如重組的血小板因子4(rPF4)和抗肝素靈,PF4儲存與血小板2顆粒中,是天然的肝素結合蛋白。rPF4與魚精蛋白之比>3:1才使ACT延長,抗肝素靈>5:1使ACT延長。但目前臨牀尚未使用。...
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梗阻性腎病
...快慢而定。急性慢性GFR下降,近端腎小管壓力可以正常,RPF改變可以不十分明顯,加上對側RPF可能可以代償性上升,其機制可能是腎-明反射被激活所致。慢性發生的單側輸尿管梗阻一般輸尿管內壓力不如急性者爲高,近端腎小...
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Exogenous5‘-nucleotidaseimprovesglomerularautoregulationinThy-1nephriticrats
...redetermined.Inthefirstseriesofexperiments,autoregulationofrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)wasimpairedinnephriticrats.Inresponsetoareductioninbloodpressure(98±2to80±1mmHg),bothRPF(4.17±0.63to3.20±0.45ml·min-1·gkidneywt-1,P0.05,n=6)andGFR(0...
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肥胖人的腎臟疾病有何特點?
...動物實驗發現,其單位時間內尿排泄量減少,腎血流量(RPF)、腎小球濾過值(GFR)均減少;肥胖引起的腎臟損害的形態學改變是腎臟脂肪含量的增加,重量增加,體積增大;組織學的檢查發現,腎小管、腎小球的基底膜常有明顯的...
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凝血、抗凝與拮抗
...血和輸血;2)應用魚精蛋白代用品如重組的血小板因子4(rPF4),PF4儲存於血小板a顆粒中,是天然肝素結合蛋白,rPF4與肝素之比>3:1才使ACT延長。抗肝素靈在>5:1才使ACT延長。但目前臨牀尚未使用。 (七)魚精蛋白過敏反應...
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LS9公司商業規模驗證生產可再生柴油
...業規模驗證生產可再生柴油。新的“可再生石油工廠”(RPF)於2010年生產5萬~10萬加侖超清潔柴油(UltraCleanDiesel),這一生產規模將確認該公司超清潔柴油(UltraCleanDiesel)技術的可行性。一旦驗證規模試驗完成,LS9公司將快速將該...
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ModelingGFRtrajectoriesindiabeticnephropathy
...riaormacroalbuminuria(17)envisagedphysiologicalstudies[GFR,renalplasmaflow(RPF),etc.]occurringevery6mo.Thisfrequencyofsamplingwasaccomplishedinaboutone-halfofthepatientsforthefirst4yr.Intheremainingone-halfofthesubjects,thefirstfollow-upstudywas1yrafterthebaselinestudies,withthestudyfrequencyincreas...
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Adaptivehyperfiltrationintheagingkidneyaftercontralateralnephrectomy
...ologicalevaluation.AllsubjectsunderwentadeterminationofGFR,renalplasmaflow(RPF),andpreglomerularvascularpressures,accordingtoaprotocolapprovedbytheInstitutionalReviewBoardofStanfordUniversitySchoolofMedicine.Initially,bloodwassampledfordeterminationofplasmaoncoticpressure().Urinewasvoidedspontaneous...
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Hepatocytegrowthfactorinducesanendothelin-mediateddeclineinglomerularfiltrationrate
...ontentweredeterminedbyliquidscintillationcounting,andGFRandrenalplasmaflow(RPF)werecalculatedbythestandardformulas(23).Sixgroupswerestudied(seeTable1).Ratsreceivedeithernopretreatment,theETA/ETBreceptorblockerbosentan(200mg/kg)bygavage1hbeforethestudy,ortheANGIIreceptorantagonistcandesartan(5mg/kg),...
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對慢性腎功能衰竭實驗動物模型的改進
...後尿白蛋白顯著增加,菊粉廓清率(Cin)、腎血漿流量(RPF)減少。如並用腎切除法,單個腎單位的蛋白量明顯增加,收縮壓(SBP)升高,Cin降低,腎小球明顯肥大,有初期的腎小球硬化。長期的實驗,腎小球硬化更嚴重,局竈...
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黃芪注射液並用貝那普利治療早期糖尿病腎病的療效觀察
...尿微量白蛋白的排出,使糖尿病大鼠升高的腎血漿流量(RPF)、腎小球濾過率(GFR)明顯降低,並使腎皮質、髓質內升高的一氧化氮合成酶(iNOS)基因表達明顯下調,從而部分糾正DN早期的腎臟高濾過、高灌注。另據報道,黃芪...
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Thedynamicsofglomerularfiltrationinthepuerperium
...armicrocirculation(30,47,49,50).Thesecondisanelevatedrateofrenalplasmaflow(RPF)(3,14,18,52).Anensuinghyperperfusionofglomerulibluntstheextenttowhichtheaxialproteinconcentrationandoncoticpressurecanincreasealongtheglomerularcapillariesduringfiltrateformation(11).Incontrasttothegravidstate,thereisscan...
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黃芪和卡託普利聯合治療糖尿病早期腎病的療效觀察
...芪在不影響糖尿病血糖、血壓的情況下,可使早期升高的RPF、GFR部分下降[6],從而降低尿蛋白的排出。卡託普利爲ACE抑制劑,可控制血壓,阻滯腎內血管緊張素2的生成,相對優勢地擴張腎小球出球小動脈,降低腎小球囊內壓...
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RenalHemodynamicInflammatoryandApoptoticResponsestoLipopolysaccharideinHO-C/CMice
...ance(RVR)wasdeterminedastheratioofmeanarterialpressure:RBF.Renalplasmaflow(RPF)wascalculatedbyRBFx(100Chematocrit)/100.FiltrationfractionwascalculatedasGFR/RPF.mRNAExpressionbyQuantitativeReal-TimeReverseTranscriptase-PolymeraseChainReaction(RT-PCR)Foranalysisofgeneexpression,totalRNAwasextractedfro...
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第八章 尿的生成和排出--第一節 腎的功能解剖和腎血流量
...皮質的血流量。圖8-5腎血流量和腎小球濾過率的自身調節RPF:腎血漿流量GFR:腎小球濾過率 關於自身調節的機制,有人提出肌源學說來解釋。此學說認爲,當腎灌注壓增高時,血管平滑肌因灌注壓增加而受到牽張刺激,這使...
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黃芪注射液並用貝那普利治療早期糖尿病腎病的臨牀療效
...尿微量白蛋白的排出,使糖尿病大鼠升高的腎血漿流量(RPF)、腎小球濾過率(GFR)明顯降低,並使腎皮質、髓質內升高的一氧化氮合成酶(iNOS)基因表達明顯下調,從而部分糾正DN早期的腎臟高濾過、高灌注。另據報道[6]...
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InhibitionofRas/ERK1/2signalingprotectsagainstpostischemicrenalinjury
...ofinulin[arterial-venous/arterialconcentration(A-V/A)x100];renalplasmaflow(RPF)wascalculatedbytheratioglomerularfiltrationrate(GFR)/filtrationfraction(FF),andrenalbloodflowbycorrectionofRPFbyhematocrit[RBF=RPF/(1-Hct)/100];renalvascularresistances(RVR)wereestimatedbytheexpressionRVR=MAP/RBF,whereMAP...
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不同亞型注意缺陷多動障礙兒童威斯康星卡片分類測驗研究
...lgroup,theADHDgroupshowedsignificantlylessinthescoresofresponseserrors(Re),Rpf,perseverativeresponses(Rp),perseverativeerrors(Rpe)andnonperseverativeerrors(nRpe).ThechildrenwithADHDindifferentsubtypesshowedsignificantlylessscoresthanthecontrolgroupinthescoresofReandRfp.Inaddition,thePItypeshoweds...
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Cyclooxygenase-2inhibitionnormalizesarterialbloodpressureinCYP1A1-REN2transgenicratswithinducibleANGII-dependentmalignanthypertension
...8±6vs.136±4mmHg,P0.01).Therewasnodifferenceinrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)betweeninducedandnoninducedrats.NimesulideelicitedalargerdecreaseinMAPinhypertensiverats(188±6to140±8mmHg,P0.01)thaninnormotensiverats(136±4to113±8mmHg,P0.01).Add...
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Shunt-AssociatedMigraineRespondsFavorablytoAtrialSeptalRepair
...chisreportedinTable1.Thecompositetotalscorethusobtainedrangesfrom0to10.AfterPFOclosureinSSorSAandthebaselinevisitinCTRLS,allpatientsweregivenadiaryinwhichtheyhadtomarkthecharacteristicsofeachsubsequentmigraineattackintermsofseverity,duration,andpresenceofauraaswellasthemedicationusedandtheefficacyof...
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中醫藥治療早期糖尿病腎病進展
...素方法分別測定用藥前後腎小球濾過率(GFR)和腎血漿流量(RPF)以及ALB/Cr、RBP/CR、24h尿蛋白定量等。結果:大黃組治療後GFR下降,尿ALB/Cr、24h尿蛋白定量均減少,與治療前及對照組治療後比較均有顯著性差異(P0.05)。實驗研究...
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中晚期子宮頸癌低氧放療並化療的臨牀效果
...顯示,低氧照射對骨髓及外周淋巴細胞的放射防護因子(RPF)分別爲1.48和1.39。說明低氧放療對小鼠骨髓有核細胞及外周淋巴細胞具有一定的保護作用,這爲臨牀上特別是腹盆部大野照射採用低氧放療提供了實驗依據和參數[4]...
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Overexpressionofkidneyneutralendopeptidase(EC3.4.24.11)andrenalfunctioninexperimentalcirrhosis
...dot;h-1PAHfor150mintoassessglomerularfiltrationrate(GFR)andrenalplasmaflow(RPF)atdifferenttimesbymeansoftheirrespectivesteady-stateplasmaclearances(CInandCPAH)(10,30).After90minofinulinplusPAHinfusion(i.e.,oncetheirsteady-stateplasmaconcentrationswerereached)(10),alaparotomywasperformedandtheurinary...
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Short-termnitricoxideinhibitioninducesprogressivenephropathyafterregressionofinitialrenalinjury
...ichmeanarterialpressure(MAP),glomerularfiltrationrate(GFR),renalplasmaflow(RPF),andrenalvascularresistance(RVR)weremeasured.Glomerularhydraulicpressure(PGC)wasdirectlydeterminedbymicropunctureofsuperficialglomeruli.Thedetailsoftheexperimentalproceduresandanalyticaltechniquesutilizedinthesestudiesare...
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Testosteronesupplementationinagingmenandwomen:possibleimpactoncardiovascular-renaldisease
...ewasasimilarincreaseinbloodpressureandreductionineffectiverenalplasmaflow(ERPF)inmenandwomen,butGFRwasmaintainedinmenonly,leadingtoanincreaseinthefiltrationfraction(FF),whichsuggestsanincreaseinglomerularcapillarypressure(48).Inwomen,thereductioninERPFwasassociatedwithaconcomitantreductioninGFR,resu...