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六、粘附分子與凝血
...乏GPIbα、GPIbβ、GPIX三種分子外,同時還缺乏另一條稱爲GPV的肽鏈。GPV同樣含有LRG序列,其功能還不清楚。GPIb-IX複合物與vWF結合的部位在GPIbα鏈上,位於其N端的第7個LRG重複序列及近膜部分的富含碳水化合物區域之間(圖2-15)。v...
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P-GlycoproteinSubstrateBindingDomainsAreLocatedattheTransmembraneDomain/TransmembraneDomainInterfaces:ACombinedPhotoaffinityLabeling-ProteinHo
...vations).Photolabelingofplasma-membranevesicleswiththeradioactiveanalog[3H]GPV51wasdemonstratedtobehighlyspecificforP-gp,andotherplasmamembraneproteinswerenotlabeledtoanysignificantextent.Inaddition,nonradioactiveGPV51competedwithbindingof[3H]GPV51inaconcentration-dependentmanner(Eckeretal.,2002).Id...
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拜耳亞洲藥物警戒:跨國安全報告需求缺失
...家,收集安全數據以及世衛組織的全球疫苗和免疫計劃(GPV)的參與情況仍舊不太現實。 問:亞洲如何解決假藥事件,標準藥物在藥品安全和藥物警戒上如何才能夠使阻力最小化? JDelumeau:就我個人看,意外不良藥物反應...
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SolublePlateletGlycoproteinVIsaMarkerofThrombosisinPatientsWithIschemicStroke
...eischemicstrokestilllackaninformativebiochemicaltest.SolubleglycoproteinV(sGPV)isanewplasmaticmarkerofthrombosisreleasedfromtheplateletsurfacebythrombin.TheobjectiveofthisprospectivestudywastocomparethelevelsofsGPVinstrokeandcontrolpatients.Methods—Consecutivepatientswithacuteischemicstroke(n=159)...
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基於最優效應的左心室的收縮動力學模型及時變主動作用
...爲線性的狀態方程式:O·a0(t)=-G(RVCaRa+1Ca+1C0)Qa0(t)+GPV(t)CaRa+GU(t)P·(t)=G(R0RVCaRa+R0Ca-RVC0)Qac(t)-GR0/CaRa·PV(t)+GRVU(t)(2)V·(t)=-Qa0(t)P·Va(t)=U(t) 2左心室收縮最優效率 將心臟作爲一個血泵看,...
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激光、消疣湯、干擾素α-2b聯用對尖減少銳溼疣復發的療效觀察
...病率逐漸增加。目前,國內外不少學者報告有6.11.16.18型GPV與CA關係密切[1],肛門及外陰CA的患者其HPV亞臨牀感染相當高[2],且傳播快、易復發,目前尚無確切的單一療法,我們用中西醫結合治療CA,降低複發率,取得較好的...
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1990~1997年全球控制和消除麻疹進展
...sVaccineInitiative(CVI)andWHO‘sglobalprogrammeforvaccinesandimmunization(GPV)-recommendationsfromtheScientificAdvisoryGroupofExperts(SAGE)[R].WER,1998,73:281~288.收稿日期:1999-04-12作者:風清揚
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ACrucialRoleofGlycoproteinVIforPlateletRecruitmenttotheInjuredArterialWallInVivo
...ousecarotidarterythatinhibitionorabsenceofthemajorplateletcollagenreceptor,GPVI,abolishesplatelet–vesselwallinteractionsafterendothelialdenudation.Unexpectedly,inhibitionofGPVIbythemonoclonalantibodyJAQ1reducedplatelettetheringtothesubendotheliumby89%.Inaddition,stablearrestandaggregationofplatele...
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ACrucialRoleofGlycoproteinVIforPlateletRecruitmenttotheInjuredArterialWallInVivo
...ousecarotidarterythatinhibitionorabsenceofthemajorplateletcollagenreceptor,GPVI,abolishesplatelet–vesselwallinteractionsafterendothelialdenudation.Unexpectedly,inhibitionofGPVIbythemonoclonalantibodyJAQ1reducedplatelettetheringtothesubendotheliumby89%.Inaddition,stablearrestandaggregationofplatele...
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WHO關於水痘疫苗的意見書
...衛生使用的疫苗應: 1.符合全球疫苗和免疫規劃(GPV)對疫苗質量政策聲明中規定的質量要求; 2.安全,並對各自目標人羣預防實際疾病有明顯的效果; 3.若用於嬰幼兒,應容易適合國家兒童期免疫計劃的免疫程...
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TheFabFragmentofaNovelAnti-GPVIMonoclonalAntibody,OM4,ReducesInVivoThrombosisWithoutBleedingRiskinRats
【摘要】Background-InhibitionofGPVIhasbeenproposedasausefulantithromboticstrategy;however,invivoproof-of-conceptanimalstudiestargetingGPVIarelacking.Weevaluatedanovelanti-humanGPVImonoclonalantibodyOM4Fabinrats.MethodsandResults-OM4Fabspecificallyinhibitedcollagen-inducedaggregationofratplatelet...
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Two-PhaseAntithromboticProtectionAfterAnti-GlycoproteinVITreatmentinMice
...lplateletagonists,actingthroughdifferentreceptors,amongwhichglycoproteinVI(GPVI)andprotease-activatedreceptors,respectively,aretheessentialones.Inmice,targetingofGPVIwiththemonoclonalantibodyJAQ1inducesdepletionofthereceptorfromcirculatingplatelets,resultinginabolishedcollagenresponsesandlong-lastin...
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第一章 白細胞分化抗原--第一節 白細胞分化抗原的分類
...結合vWFCD42c Pt,Meg22,血小板GPIb-β CD42d Pt,Meg85,血小板GPV CD43OTH71C5,G19-1;(Leukosialin)T,G,Mgp95,SialophorinT細胞活化?與CD54結合 續表3CD常用況隆抗體或代號()主要表達細胞分子量(kDa)和結構功能CD44GRHL1,Hermes,F10-44-2(Pgp-1,ECM-RⅢ)...
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Mindingthegapstopromotethrombusgrowthandstability
...-1(38).LossofPECAM-1expressioninmiceincreasesresponsivenesstocollagenviatheGPVIcollagenreceptor,consistentwithamodelinwhichplateletactivationleadstotyrosinephosphorylationofPECAM-1,allowingSHP-1/2tobindandbringingthephosphatasenearitssubstrates,includingtheFcchainpartnerofGPVI(39,40).Thismaynormally...