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MouseStrain–SpecificDifferencesinVascularWallGeneExpressionandTheirRelationshiptoVascularDisease
...int.Fordetails,pleaseseeonlineMethods,11availableathttp://atvb.ahajournals.org.DataProcessingArrayimageacquisitionandfeatureextractionwasperformedusingtheAgilentG2565AAMicroarrayScannerandfeatureextractionsoftwareversionA.6.1.1.NormalizationwasperformedusingaLOWESSalgorithm,andDye-normalizedsignalsw...
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“Images“ofnutritioninmedicaleducationandprimarycare
...s.TheMSOPrecommendsthatmedicalschoolfacultyspecifytheattributesappropriateforgraduatingstudentstohaveandadoptlearningobjectivesforthecurriculumconsistentwiththoseattributes(10).Thechallengeformedical-nutritioneducatorsistonotgetlostinthecurrentcurriculumreform.Thisisparticularlyimportantforthosewhop...
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ShearStressInhibitsSmoothMuscleCell–InducedInflammatoryGeneExpressioninEndothelialCells
...ealthResearchInstitutes,Miaoli350,Taiwan,RepublicofChina.E-mailjjchiu@nhri.org.twAbstractObjectives—Vascularendothelialcells(ECs)areinfluencedbyshearstressandneighboringsmoothmusclecells(SMCs).Weinvestigatedtheinflammation-relevantgeneexpressioninEC/SMCcoculturesunderstaticconditionandinresponseto...
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Interleukin-18andMacrophageMigrationInhibitoryFactorAreAssociatedWithIncreasedCarotidIntima-MediaThickening
...ed(Figure1Aversus1B;FiguresIandII,availableonlineathttp://atvb.ahajournals.org).Aspreviouslyreported,intimaformationwasgreatestinFVBandSJL(Figure1Cand1D).MorphometricanalysisofleftcarotidcompartmentsafterligationisshowninFigure1Eto1H.LumendiametersignificantlydecreasedafterligationinbothC3H/FandC3H/...
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TrendsinbloodfolateandvitaminB-12concentrationsintheUnitedStates,1988–
...obridgethetransitionfromoldtonewquality-controlmaterial,analyzedWorldHealthOrganizationreferencematerialwhenavailable(RBCfolateandserumvitaminB-12),andcontinuouslyparticipatedinproficiencytestingprogramsoftheCollegeofAmericanPathologists.Long-termCVsforeach2-ypostfortificationperiodwere4–7%for...
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PorphyromonasgingivalisBacteremiaInducesCoronaryandAorticAtherosclerosisinNormocholesterolemicandHypercholesterolemicPigs
...dintenselocalandsystemicinflammationandthevirulencepropertiesofthecausativeorganisms.16–21Porphyromonasgingivalishasbeenstronglyassociatedwithadultperiodontitis.ThisbacteriaisaGram-negative,nonmotile,obligateanaerobethatcaninvadeandinfectepithelium,endothelium,andvascularsmoothmusclecells22–29an...
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非代謝綜合徵人羣的血尿酸水平的研究
...consensusworld-widedefinitionofthemetabolicsyndrome[OL].http://www.idf.org/webcast/pdf/IDF_Backgrounder_1.pdf. [3]王中心,蘇麗.福州市區代謝綜合徵情況的調查[J].中華高血壓雜誌,2007,15(2):128~131. [4]楊敬源,黃文湧,楊星,等.貴陽市城區...
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VacuolarandplasmamembranestrippingandautophagiceliminationofToxoplasmagondiiinprimedeffectormacrophages
...ovideaninterfacethroughwhichtheparasiteacquiresnutrientsfromthehostcytosolforgrowthandreplicationandaltersinnateimmunesignaling(5,6).TheformationofanonfusogenicPVhasbeenclassicallyviewedasanadaptivemechanismforintracellularsurvivalbyapicomplexanparasites,allowingparasiteevasionoflysosomaldestruction...
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Gettingnutritioneducationintomedicalschools:acomputer-basedapproach
...rriculumhasbeenwidelyrecognized(28)andtheurgencyofthisissuehasledmanyorganizationstocallforchangeinmedicalschoolcurricula(1,3,6,913).Thefederalgovernmentdecreedthatnutritioneducationbeanintegralcomponentofmedicaleducation[theNationalNutritionMonitoringandRelatedResearchAct(14)mandatestha...
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IncreasedGoodpastureAntigen-BindingProteinExpressionInducesTypeIVCollagenDisorganizationandDepositofImmunoglobulinAinGlomerularBasementMembr
...ritischaracterizedbyelevatedGPBP,glomerularbasementmembrane(GBM)collagendisorganizationandexpansion,anddepositsofIgAondisruptedGBM.TransgenicoverexpressionofhumanGPBP(hGPBP)innon-lupus-pronemicetriggeredsimilarglomerularabnormalitiesincludingdepositsofIgAonacapillaryGBMthatunderwentdissociation,inth...
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ContinuingMedicalEducationinnutrition
...).Nutritioninclinicalcare.Washington,DC:ILSIPress.Internet:http://www.ilsi.org/Press/NCC/(accessed12February2006).Continuingmedicaleducation.AmJClinNutr2005;82:11459.RobertWoodJohnsonFoundation.Continuingprovidereducationonobesity.apanelreviewofexistingprograms.Internet:http://www.rwjf.org/res...
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NPC方案治療中晚期非小細胞肺癌296例臨牀分析
...。4周爲1個療程,連用2個療程以上。結果CR12例,PR123例,NC128例,PD33例,總有效率(CR+PR)爲45.6%,中位緩解期爲8.5個月,中位生存期爲13個月,1年生存率52.7%(156/296)。毒副作用:骨髓抑制佔89.5%,三到四度佔41.4%,脫髮95.3%。靜...
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MultilocusSequenceTypingSchemeThatProvidesBothSpeciesandStrainDifferentiationfortheBurkholderiacepaciaComplex
...ymorphicDNA(RAPD),andBOX-PCR(5);howthesemethodsareappliedisdependentupontheorganismsbeinginvestigatedandthequestionsbeingaddressedbythestudy.ThePCR-basedtechniques,suchasBOX-PCRandRAPD,arehighlydiscriminatorybutnotalwayseasilytransferablebetweendifferentlaboratories.PFGEisalsonotalwaysatransferablet...
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Neutrophil-derivedleukotrieneB4isrequiredforinflammatoryarthritis
...imen(seeSupplementalMaterialsandmethodsandFig.S1,availableathttp://www.jem.org/cgi/content/full/jem.20052371/DC1).Consistentwithourgeneticobservations,oraladministrationofthe5-LOinhibitoreffectivelypreventsinductionofarthritis(Fig.3,AandB).Histologically,5-LOinhibitor–pretreatedmicedisplaylittleev...
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TheNationalInstituteofBiomedicalImagingandBioengineering:HistoryStatusandPotentialImpact1
...alindividualswhoheldleadershippositionsinanumberofscientificandprofessionalorganizationsoverthelast3decadesofthe20thcentury. QUESTFORAHOMEFORBIOMEDICALIMAGINGANDBIOENGINEERINGATNIHTopABSTRACTINTRODUCTIONQUESTFORAHOME...LEGISLATIVEACTIONSANDNIH...ESTABLISHMENTOFNIBIBIS...STATUTORYAUTHORITIESOFNIBIB...
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TheNationalInstituteofBiomedicalImagingandBioengineering:History,Status,andPotentialImpact1
...alindividualswhoheldleadershippositionsinanumberofscientificandprofessionalorganizationsoverthelast3decadesofthe20thcentury. QUESTFORAHOMEFORBIOMEDICALIMAGINGANDBIOENGINEERINGATNIHTopABSTRACTINTRODUCTIONQUESTFORAHOME...LEGISLATIVEACTIONSANDNIH...ESTABLISHMENTOFNIBIBIS...STATUTORYAUTHORITIESOFNIBIB...
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TheScurfymutationofFoxP3inthethymusstromaleadstodefectivethymopoiesis
...ctioninthethymusandTcell–dependentautoimmunediseases.Thus,inthehuman,DiGeorgesyndromecanleadtoautoimmunediseases(1–5);thymomaiscommonlyassociatedwithmyastheniagravis(6,7),whereasthymichypoplasiaisassociatedwithautoimmunehemolyticanemiaandjuvenilepemphigoid(8).Thediabetes-proneBBratshaveseveredef...
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EssentialroleoftheTcell–specificadapterproteinintheactivationofLCKinperipheralTcells
...ofwild-typeLNTcellswithCD3/CD28antibodies(Fig.S1,availableathttp://www.jem.org/cgi/content/full/jem.20051637/DC1).Thissuggeststhat,althoughTSAdisrequiredforLCKactivationinvivo(Fig.3,CandD),TSAdisnotsufficientforfullLCKactivationandthatfullLCKactivationinvivomaydependonTSAdcooperationwithotherfactors...
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阻塞性睡眠呼吸暫停綜合徵與頸圍相關性的研究
【摘要】目的探討頸圍(NC)與阻塞性睡眠呼吸暫停綜合徵(OSAS)的關係。方法對239例經多導睡眠圖(PSG)監測確診爲OSAS的男性患者按頸圍分A、B、C三組,記錄各組呼吸暫停和低通氣指數(AHI)、年齡及體重指數(BMI)。在年...
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Human1typeIVcollagenNC1domainexhibitsdistinctantiangiogenicactivitymediatedby1?1integrin
...TownNationalResearchHospital,Omaha,Nebraska,USA.2DepartmentofBiomedicalSciences,CreightonUniversitySchoolofMedicine,Omaha,Nebraska,USA.3DepartmentofBiochemistryandMolecularBiology,UniversityofNebraskaMedicalCenter,Omaha,Nebraska,USA.4CenterforMatrixBiology,DepartmentofMedicine,BethIsraelDeaconessMed...
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NF-κB導致高脂飼養大鼠大血管病變
...傷的可能機制。研究者將45只Wistar雄性大鼠隨機分爲對照(NC)、高脂飼養(HF)和抗氧化劑N-乙酰半胱氨酸干預(HF+NAC)3組,飼養11周測定血糖、胰島素、血脂以及體重的變化,處死大鼠,測定內臟脂肪含量、主動脈組織形態學改變,並...
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Asymmetricallymphoidandmyeloidlineagecommitmentinmultipotenthematopoieticprogenitors
...inabilityofFlt3hiVCAM-1+MPPstogiverisetoCMPsimplicatesanalternativepathwayforGMlineagedifferentiationindependentofCMPsinvivo.Ourresultssuggestthatthedivergenceofthelymphoidandmyeloidlineagesduringearlyhematopoiesisoccursasymmetricallyatdistinctprogenitorstages.RESULTSANDDISCUSSIONPurificationofFlt3l...
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RapidPerfusionandNetworkRemodelinginaMicrovascularConstructAfterImplantation
...heprocessbywhichperfusionpathwaylengthandvesselsegmentnumberareincreasedandorganizedintoafunctionalvascularbed.Innormalsituations,thiseffectiveincreaseinvesseldensitydeliversmorebloodtothetissue,facilitatingtissuegrowthand/orincreasedtissueactivity.1,2Consequently,vascularizationisaprimarycomponento...
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應用高葡萄糖鉗夾技術評價高甘油三酯血癥人羣胰島素分泌和胰島素敏感性
...指數相匹配的正常糖耐量、正常血脂者12名(正常對照組,NC組),應用高葡萄糖鉗夾技術評價胰島β細胞功能及胰島素敏感性。結果HTG組和NC組在鉗夾過程中胰島素呈雙相分泌,第一時相胰島素分泌均於4~6min達到高峯,在10~30min...
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AssociationsbetweenmarkersofsubclinicalatherosclerosisanddietarypatternsderivedbyprincipalcomponentsanalysisandreducedrankregressionintheM
...icipatingMESAinvestigatorsandinstitutionscanbefoundathttp://www.mesa-nhlbi.org.Theauthors‘responsibilitieswereasfollowsJAN:analyticdesign,dataanalysis,andmanuscriptpreparation;LMS:criticalreviewofthemanuscript;MBS:dataanalysisandcriticalreviewofthemanuscript;NSJ,RGB,andAGB:dataacquisitionand...
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動脈粥樣硬化性腦梗死患者載脂蛋白B基因多態性與血脂水平分析
...採用聚合酶鏈式反應技術檢測了85例ACI患者及56例正常人(NC)的apoB基因多態性。結果 (1)NC組X-X+基因型血漿TC水平明顯高於X-X-基因型(P<0.001);ACI組與NC組少見E+E-或E-E-基因型,血漿TG水平明顯高於E+E+基因型(P<0.02)。(2)X-X-基因型個...
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ExtendedMultilocusSequenceTypingSystemforCampylobactercoli,C.lari,C.upsaliensis,andC.helveticus
...glyA,pgm,andtkt);however,adkandpgiweresubstitutedforaspAandgltAinC.lariandforgltAandpgminC.upsaliensis.MultipleC.coli(n=57),C.lari(n=20),C.upsaliensis(n=78),andC.helveticus(n=9)isolates,representingbothclinicalandenvironmentalsources,weretyped.Allfourspeciesweregeneticallydiverse:themajority(80%)oft...
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糖尿病一級親屬脂聯素和瘦素與胰島素抵抗的相關性
...究者選取153例糖耐量正常者,其中無家族史的正常對照(NC)者41例,單純父親爲糖尿病的一級親屬36例,單純母親爲糖尿病的一級親屬45例,雙親均爲糖尿病的一級親屬31例。測定所有受試者血脂、血糖、胰島素、瘦素、脂聯素。結...
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DietarypatternsareassociatedwithbiochemicalmarkersofinflammationandendothelialactivationintheMulti-EthnicStudyofAtherosclerosis(MESA)
...icipatingMESAinvestigatorsandinstitutionscanbefoundathttp://www.mesa-nhlbi.org.JANwasresponsibleforthedataanalysisandmanuscriptpreparation.LMSwasinvolvedinthedataanalysisandcriticalreviewofthemanuscript.EJM-D,NSJ,andDMHwereinvolvedinthedataacquisitionandmanuscriptreview.DRJwasinvolvedinthedataacquis...
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Womenwithlowironstoresabsorbironfromsoybeans
...il,CHORI,5700MartinLutherKing,JrWay,Oakland,CA94609.E-mail:etheil{at}chori.org.ABSTRACTBackground:Worldwide,30%ofthepopulation,agreaterproportionofwhomarewomenandchildren,isirondeficient.Soybeansareamajorsourceofnonhemeironinmanyhumandiets,butinformationonironbioavailabilityisstillconflicting.Becaus...