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磷酸哌喹
藥物名稱磷酸哌喹藥物別名磷酸喹哌,抗矽14英文名稱PiperaquinePhosp說 明片劑:0.2g、0.25g、0.5g。本品爲糖衣片,除去糖衣後顯白色或淡黃色。功用作用本品抗瘧作用與氯喹相類似。 哌喹影響伯氏瘧原蟲紅內期裂殖體的超...
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哌喹
藥物名稱哌喹藥物別名磷酸哌喳,抗矽-14,13228R.P.)英文名稱Piperaquine說 明片劑:每片含磷酸喹250mg。功用作用本品的抗瘧作用與氯喹相類似。口服吸收後貯存於肝臟,以後緩慢釋放進入血液,故作用持久。主要用於瘧疾症...
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CD14的結構和功能
CD14的結構和功能免疫學雜誌2000年第1期第16卷綜述與講座作者:趙虎 周庭銀 孔憲濤單位:趙虎(第二軍醫大學長征醫院免疫中心,上海200003);周庭銀(第二軍醫大學長征醫院免疫中心,上海200003);孔憲濤(第二軍醫大學...
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14-3-3蛋白
14-3-3蛋白(pdf)【摘要】14-3-3是一個在真核生物中廣泛表達的酸性蛋白家族,主要以同源/異源二聚體形式存在,通過磷酸化絲/蘇氨酸作用與靶蛋白或靶蛋白的兩個結構域結合。七種不同亞型的高度保守的14-3-3蛋白與人類細胞中多...
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CD14+CD34lowCellsWithStemCellPhenotypicandFunctionalFeaturesAretheMajorSourceofCirculatingEndothelialProgenitors
...pheralblood(PB)derivefromtheadhesion-relatedselectionincultureofasubsetofCD14+cells,which,whenassessedbythehighly-sensitiveantibody-conjugatedmagnetofluorescentliposomes(ACMFL)technique,werefoundtoexpressCD34.TheseCD14+CD34lowcellsrepresentedavariableproportionatindividuallevelofCD14+cells,rangingfr...
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Excentralcleavageofß-caroteneinvivoinahealthyman
...8).Hoffman-LaRoche(Basel,Switzerland)donatedtheall-trans[10,10‘,11,11‘-14C]-ß-caroteneusedinthestudy.3Reprintsnotavailable.AddresscorrespondencetoAJClifford,3147MeyerHall,OneShieldsAvenue,DepartmentofNutrition,UniversityofCalifornia,Davis,CA95616-8669.E-mail:ajclifford{at}ucdavis.edu.ABSTRA...
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High-andlow-affinitytransportofL-leucineandL-DOPAbytheheteroaminoacidexchangersLAT1andLAT2inLLC-PK1renalcells
...ThepresentstudyexaminedthefunctionalcharacteristicsoftheinwardandoutwardL-[14C]DOPAandL-[14C]leucinetransportersinLLC-PK1cells.UptakewasinitiatedbytheadditionofHanks‘mediumwithagivenconcentrationofL-[14C]DOPAorL-[14C]leucine.Saturationexperimentswereperformedincellsincubatedfor6minwith0.25µM...
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Fn14IsUpregulatedinCytokine-StimulatedVascularSmoothMuscleCellsandIsExpressedinHumanCarotidAtheroscleroticPlaques
...mplicatedinthepathogenesisofatherosclerosis.WehaveanalyzedtheexpressionofFn14anditsligandTWEAKincarotidatheroscleroticplaquesanditspotentialmodulationbyatorvastatininvivo.Furthermore,wehavestudiedwhetherproinflammatorycytokinesregulateFn14expressioninhumanaorticsmoothmusclecells(hASMCs)incultureaswe...
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UpregulatedExpressionof14-3-3ProteinsinAstrocytesFromHumanCerebrovascularIschemicLesions
...ischemia.Thepurposeofthisstudywastoinvestigatewhetheranabnormalexpressionof14-3-3proteins,anoveltypeofmolecularchaperones,occursinhumangrayandwhitematterischemiclesions.Methods—Wepreparedformalin-fixed,paraffin-embeddedsectionsfrom33autopsiedbrains,consistingof7normalcontrols,4caseswithcerebralthr...
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PolymorphismsintheCD14GeneAssociatedwithPulmonaryFunctioninFarmers
...ienceairwayobstruction,whichmaybeattributableinparttoendotoxininhalation.CD14isareceptorforendotoxin.MaterialsandMethods:BasedonourfindingsofincreasedcirculatingCD14associatedwiththeCD14/eC159Tallele,wehypothesizedthatcarriersofthisallelewouldhavedecreasedlungfunctionamongendotoxin-exposedindividual...
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RelationshipsamongCD14andCC16Genotypes,PlasmaLevels,andSeverity
...tswithstablediseaseandhavenotdefinedmechanismsimportantduringacuteasthma.CD14andCC16eachplayakeyroleinbiologicallyimportantinflammatorypathwaysandthegeneofeachhasafunctionalpromoter-regionpolymorphism.Objectives:Thisstudywasdesignedtodeterminetheinfluenceofthesepolymorphismsonplasmalevelsoftheirprod...
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IdentificationandCharacterizationofaNewTubulin-BindingTetrasubstitutedBrominatedPyrrole
...ibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylicacidethylester(JG-03-14)andfoundthatitisapotentmicrotubuledepolymerizer.JG-03-14causedadose-dependentlossofcellularmicrotubules,formationofaberrantmitoticspindles,accumulationofcellsintheG2/Mphaseofthecellcycle,andBcl-2phosphorylation.Theseevents...
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InhibitionofTNFreceptor1internalizationbyadenovirus14.7Kasanovelimmuneescapemechanism
...Cologne,UniversityofCologne,Cologne,Germany.AbstractTheadenoviralproteinE3-14.7K(14.7K)isaninhibitorofTNF-inducedapoptosis,butthemolecularmechanismunderlyingthisprotectiveeffecthasnotyetbeenexplainedexhaustively.TNF-mediatedapoptosisisinitiatedbyligand-inducedrecruitmentofTNFreceptor–associateddea...
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DifferentialHealingActivitiesofCD34+andCD14+EndothelialCellProgenitors
...atetheirinvivoeffects.MethodsandResults-HumanCD34+primitiveprogenitorsandCD14+monocyticprogenitorswereinjectedlocallyintotheischemiclimbsofdiabeticmice.CD14+celltherapyimprovedhealingandvesselgrowth,althoughnotasrapidlyoreffectivelyasCD34+celltreatment.Westernblotanalysisrevealedthatcelltherapymodul...
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TowardtheDevelopmentofanAntidisease,Transmission-BlockingIntranasalVaccineforGroupAStreptococcus
...ventGASinfection,aconformationallyconstrainedandminimallyconservedpeptide,J14,fromtheMproteinofGAShasbeendefined.Inthepresentstudy,J14wasformulatedwithbacterialoutermembraneproteins(proteosomes)andthenintranasallyadministeredtooutbredmicewithoutadditionaladjuvant.SuchimmunizationledtohightitersofJ14...
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碳-14-呼氣試驗對胃幽門螺旋桿菌的療效分析
【摘要】目的探討碳-14-呼氣試驗(簡稱14C-UBT)指導藥物治療Hp具有臨牀應用價值。方法經胃鏡和首次14C-UBT檢查均爲陽性的胃潰瘍(26例)、淺表性胃炎(69例)、萎縮性胃炎(33例)患者共計128例,將這些患者分爲3組:A組爲患...
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可溶性CD14和HCMV感染與冠心病病情變化關係
【摘要】 目的探討可溶性CD14(sCD14)和人鉅細胞病毒(HCMV)感染與冠心病(CHD)病情變化的關係。方法應用ELISA法測定120例CHD病人血清sCD14和HCMVIgG的濃度,其中急性心肌梗死(AMI)、不穩定型心絞痛(UAP)和穩定型心絞痛...
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ProtectionofEndothelialSurvivalbyPeroxisomeProliferator-ActivatedReceptor-Mediated14-3-3Upregulation
...ticactionofcPGI2andL-165041.OurresultsshowforthefirsttimethatPGI2stimulated14-3-3expressionviaPPARactivation.cPGI2andL-165041inducedbindingoafPPARtoPPARresponseelementslocatedbetween-1426and-1477of14-3-3promoterregion,therebyactivating14-3-3promoteractivityandproteinexpression.Upregulationof14-3-3pr...
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中國研究者對原發性肝癌p14ARF基因CpG島甲基化研究
...中華普通外科雜誌》2007年第22卷第11期中國研究者探討了p14ARF基因啓動子區CpG島甲基化與原發性肝細胞肝癌發生、發展的關係。研究者採用逆轉錄-聚合酶鏈式反應(RT-PCR)檢測42例原發性肝癌組織及癌旁組織中p14ARFmRNA的表達,同...
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OppositelydirectedH+gradientfunctionsasadrivingforceofratH+/organiccationantiporterMATE
...edtoexistinHEK-rMATE1cells,andthetransportofvariousorganiccationsincluding[14C]tetraethylammoniumwasstimulatedinintracellularacidifiedHEK-rMATE1cellsbutnotmockcells.Thetransportof[14C]tetraethylammoniuminmembranevesiclesfromHEK-rMATE1cellsexhibitedtheovershootphenomenononlywhentherewasanoutwardlydir...
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Afeasibilitystudyquantifyinginvivohuman-tocopherolmetabolism
...epartmentofAgriculture,ARS,BHNRC,Beltsville,MD(JAN)2Supportedbygrantno.DKRO148307,NationalCenterforResearchResourcesgrantno.RR13461fromtheNationalInstitutesofHealth,Contractno.W-7405-Eng-48fromtheUSDepartmentofEnergy(toLawrenceLivermoreNationalLaboratory),andHoffmannLaRoche.Hoffmann-LaRochedonatedth...
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Pathogenicroleforskinmacrophagesinamousemodelofkeratinocyte-inducedpsoriasis-likeskininflammation
...hagesandgranulocytesfromtheskinofmicewithepidermis-specificdeletionofIKK2(K14-Cre-IKK2fl/flmice).Eliminationofskinmacrophagesbysubcutaneousinjectionofclodronateliposomeswasaccompaniedbyinhibitionofgranulocytemigrationintotheskinandresultedinadramaticattenuationofpsoriasis-likeskinchanges.Thehyperpro...
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胃內酸化消除質子泵抑制劑對14C-尿素呼氣試驗假陰性的研究
【摘要】目的觀察胃內酸化是否即刻消除質子泵抑制劑對14C-尿素呼氣試驗假陰性。方法35例需質子泵(PPI)治療的Hp陽性潰瘍型功能性消化不良病人口服PPI治療7天,第6天行第二次14C-UBT檢測,第7天用改良14C-UBT檢測,即對正服用PP...
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Community-WideOutbreaksofClonallyRelatedCTX-M-14-Lactamase-ProducingEscherichiacoliStrainsintheCalgaryHealthRegion
...57(55%)ofthestrainswerepositiveforblaCTX-MgenesfromtheCTX-M-IIIgroup(CTX-M-14-like).Theobjectiveofthisstudywastoinvestigatethemolecularepidemiologyofthesestrains.The-lactamaseswerecharacterized,andthegeneticrelatednessoftheisolateswasanalyzedbydigestinggenomicDNAwiththerestrictionendonucleaseXbaIand...
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嚴重燒傷早期大鼠肺泡巨噬細胞CD14的表達及調控*
【摘要】目的探討嚴重燒傷對大鼠肺泡巨噬細胞(AM)CD14膜蛋白(CD14)和mRNA基因表達變化的影響,以及抗CD14抗體對AM產生腫瘤壞死因子α(TNF-α)和白介素6(IL-6)的調控作用。方法20%Ⅲ度燒傷大鼠檢測早期外周血內毒素(LPS)...
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化症回生片
...,壁厚,有時一邊菲薄。 草酸鈣簇晶甚大,直徑80~140μm。 無定形團塊淡黃棕色,包埋有細小方形結晶。 花粉粒呈圓形或橢圓形,直徑64~80μm,外壁呈刺狀,有萌發孔三個。 (2)取本品2片,研細,加甲醇20ml,超聲...
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EnhancedLevelsofOxidizedLow-DensityLipoproteinPrimeMonocytestoCytokineOverproductionviaUpregulationofCD14andToll-LikeReceptor4inUnstableA
...itylipoprotein(oxLDL)contributestocytokineoverproductionviaupregulationofCD14andtoll-likereceptor-4(TLR-4)expressiononcirculatingmonocytesofunstableangina(UA)patients.MethodsandResults—ExpressionofCD14andTLR-4oncirculatingmonocytes,andtheconcentrationofplasmaoxLDL,(interleukin)-6,IL-1beta,IL-8...
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14C-尿素呼氣試驗診斷幽門螺旋桿菌感染的研究
【摘要】目的探討14C-尿素呼氣試驗在診斷幽門螺旋桿菌(Hp)感染中的價值。方法對88例因上腹不適進行胃鏡檢查的患者。於胃竇取黏膜組織進行組織學檢測,作爲標準對照,同時進行14C-尿素呼氣試驗(14C-UBT)。結果14C-UBT靈敏度爲90....
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DifferentialEffectsofGq,G14,andG15onVascularSmoothMuscleCellSurvivalandGeneExpressionProfiles
...yUniversitySchoolofMedicine,Atlanta,GeorgiaAbstractGqfamilymembers(Gq,G11,G14,andG15/16)stimulatephospholipaseC(PLC)andinositollipidsignalingbutdiffermarkedlyinaminoacidsequenceandtissuedistributionpredictingunappreciatedfunctionaldiversity.Toexaminefunctionaldifferences,wecomparedthesignalingproper...
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手術中圍肝門部血管急症的治療要點
...急症的治療方法和臨牀療效。方法對10餘年來筆者治療的14例手術中圍肝門部血管急症患者的臨牀資料進行了綜合分析。結果本組中惡性腫瘤7例(50.0%),良性病變7例(50.0%)。手術中圍肝門部血管急症屬醫源性12例(85.7%),創...