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PulmonaryHypertension
...erstandingofthediseasewasfirstaddressedbyaconsensusconference(20).IdiopathicPAHisararedisease,affectingapproximatelyonlyoneinonemillionpersonsinthepopulation.Butitisacrueldisease,frequentlyaffectingotherwisenormalyoungwomenwithamediansurvivalof2.8yearswhenuntreated(21).Anepidemicofpulmonaryhypertens...
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SildenafilversusEndothelinReceptorAntagonistforPulmonaryHypertension(SERAPH)Study
...(Table1).AllwereinWHOfunctionalclassIIIandthemajorityofpatientshadidiopathicPAH.Thirteenpatientsassignedtosildenafiland12receivingbosentancompletedtheprotocolandprovideddataforgroupanalysis.OnepatientassignedtosildenafildiedsuddenlyduringWeek14oftreatment.ABNPlevelmeasuredinabloodsamplefromthispatie...
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RatrenalcorticalOAT1andOAT3exhibitgenderdifferencesdeterminedbybothandrogenstimulationandestrogeninhibition
...catedbyanarrowheadandanarrow,respectively.InadditiontothestudiesoftheclassicPAH-transportingproteinsOAT1andOAT3,wehavealsotriedtotestwhethergenderdifferencesattheproteinlevelexistforOAT2,whichtransportsPAHonlyweakly(36,37).Previously,itwasshownthattheexpressionofOAT2-relatedmRNAintheratkidneyisstron...
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腎血管性高血壓
...檢測(即尿量減少25%,尿肌酐增高25%,對氨馬尿酸廓清率CPAH增高50%)其陽性率可提高到72%。Dean並建議收集3次尿標本作測定。若尿量減少、肌酐及PAH濃度增高,則亦可定爲“陽性”,假陰性率可減至8%。㈣放射性核素的應用1.放...