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心肌梗死後室性期前收縮與心臟性猝死的預測
爲探討心肌梗死後室性期前收縮(以下簡稱VPC)與心臟性猝死的關係,預測可能發生的致命危險,以求及早防治,我們對9年來我院收治的124例心肌梗死患者進行定期監測,並作了隨訪,現將結果報道如下。 1臨牀資料 1.1...
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胺碘酮在室性心律失常中的應用
...0~76歲。入選標準:(1)患者有慢性心衰病史,LVEF40%,且VPC10/h;(2)排除竇性心動過緩、竇房阻滯、束支傳導阻滯及其他高度傳導障礙者(安置起搏器者除外);排除各種原因引起的低血壓者(收縮壓90mmHg);排除甲狀腺功能障礙...
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Selectivesphingosine1-phosphate1receptoractivationreducesischemia-reperfusioninjuryinmousekidney
...lydecreasedwithFTY-720treatment.TheprotectiveeffectofFTY-720wasreversedwithVPC-44116,aselectiveS1P1receptorantagonist.Furthermore,SEW-2871,aselectiveS1P1agonist,significantlydecreasedplasmacreatinineinadose-responsemannerwithamaximalreductionof70%withadoseof10mg/kg.Analysisofkidneysbylightmicroscopy...
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比索洛爾治療充血性心力衰竭併發室性心律失常臨牀觀察
...能(NYHA)Ⅲ~Ⅳ級,左心室射血分數0.4;頻發室性早搏(VPC)34例,陣發性室性心動過速(PVT)2例,合併Ⅰ度房室傳導阻滯2例。無Ⅱ度以上房室傳導阻滯、病態窒房結綜合徵、竇性心動過緩及QTc0.50者,無嚴重的肺部疾病和肝病...
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胺碘酮治療充血性心力衰竭併發室性心律失常臨牀觀察
...能(NYHA)Ⅲ~Ⅳ級,左心室射血分數0.40;頻發室性早搏(VPC)36例,陣發性室性心動過速(PVT)2例,合併Ⅰ度房室傳導阻滯2例。無Ⅱ度以上房室傳導阻滯、病態竇房結綜合徵、竇性心動過緩及QTc0.50s、嚴重肺部疾病和肝病、甲狀...
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重組逆轉錄病毒載體介導基因轉移的現狀及思考
...障的存在,使得向腫瘤部位注射的外源性病毒生產細胞(VPC)可長期存活。理想的基因轉染方法是在腫瘤局部環境中連續不斷的提供載體質粒來轉染周圍的腫瘤細胞,基於這一構想,有學者在基因治療腫瘤的實驗中建立了將腫瘤...
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RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?
...o-(2-octadec-9-enoylamino-3-[4-(pyridine-2-ylmethoxy)-phenyl]-propyl)ester(VPC32183).Signaltransductionthroughp42/44mitogen-activatedproteinkinase(MAPK),p38MAPK,andRhokinaseisinvolvedinLPA-mediatedcytokinesecretion,whereasLPA-inducedcellmotilityrequiresp38MAPKandRhokinasebutnotp42/44MAPK.Treatmentof...
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SphingosineKinase-DependentActivationofEndothelialNitricOxideSynthasebyAngiotensinII
...lresponsesamountedto2.6±0.2mN/mmsegmentlength.DMS(10µmol/L)andVPC23019(10µmol/L)hadnoinfluenceonthepretensionofthepreparations.PreincubationofthevesselswithDMS(10µmol/L)hadnosignificanteffectonthepotencyorefficacyofKClorphenylephrine(Figure1Aand1B).However,DMSinducedaleftwar...
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Synthesisoflong-chainpolyunsaturatedfattyacidsinpretermnewbornsfedformulawithlong-chainpolyunsaturatedfattyacids
...uteofMaternal-InfantileSciences,PolytechnicUniversityofMarche,Ancona,Italy(VPC);theDepartmentofPediatrics,UniversityofPadua,Padua,Italy(MS,GV,andPEC);theLaboratoryofBiochemistry,ErasmusUniversity,Rotterdam,Netherlands(IL);theDepartmentofGynecology,PerinatologyandChildHealth,LaSapienzaUniversity,Rome...
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胺碘酮治療器質性心臟病併發室性心律失常或心房顫動的臨牀觀察
...間期的改變,本組30例入選患者的心功能均改善1級,頻繁VPC8例的治療有效率90%,2例PVT也被終止,且心功能迅速改善;房顫治療有效率90%,無效10%;心室率自(97.57±14.46)/min減至(62.5±9.25)/min,P0.01;Q-T間期從(398.6±21)ms延長...
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肥厚性梗阻型心肌病誤診1例分析
...浮腫至膝關節。ECG:陣發性房顫、房撲,Ⅱ°Ⅰ型AVB,頻發VPC,Ⅱ°Ⅱ型SAB。X-線胸片示心影增大。入院後心髒彩超示:(1)左房內徑明顯增大,左室內徑正常,左室室間隔於二尖瓣水平以下至乳頭肌水平明顯肥厚約21mm,左室側壁...
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等離子體技術及臨牀應用
...割(PK)模式;另一種是在腹腔鏡下操作的脈衝凝血切割(VPC)模式。當等離子體能量控制器輸出切割能量時,因工作點能量集中,高聚焦,作用侷限,因此切割精確;同時因適中的電壓及電流,靶組織表面溫度在40℃~70℃[2]。...
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30例老年患者心臟性猝死前動態心電圖分析
...CHD)and≥3gradeventriculararrhythmia(ventricularprematurecomplexes,VPC)intheCSDgroupwerehigherthaninthecontrolgroup(P0.05);②TheincidenceofatrialfibrillationintheCSDgroupwerehigherthaninthecontrolgroup(P0.05);③Theincidenceofmyocardialischemia(MI)andpersistencedepressionofSTse...
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Sphingosine-1-PhosphatePreventsTumorNecrosisFactor-–MediatedMonocyteAdhesiontoAorticEndotheliuminMice
...eS1P1/S1P3Gireceptorsignaling.14Someaortasweretreatedfor4hourswith10μmol/LVPC23019aS1PreceptorantagonistwithaKiforS1P1of25nM;themoleculeis50-foldlesspotentinblockingS1P3,butisinactiveatS1P2.15Aortaswereincubatedwithfluorescentlylabeledmousemonocytesaspreviouslydescribed.16InjectionofSEW2871entirely...
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BroadlyReactiveNestedReverseTranscription-PCRUsinganInternalRNAStandardControlforDetectionofNorovirusesinStoolSamples
...ththenumberoflatexbeads(LB)counted(LBC)pergridandthenumberofvirionscounted(VPC)pergrid,usingtheequationadaptedfromthatdescribedbyMitterederetal.(27),v=(VPC/LBC)x(4.73x1013LBml–1/LBd)x3/μ,whereLBdisthedilutionfactoroflatexbeadsinthemixtureforthegridandμistheconcentrationfactorofthefecalsampleafte...
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DifferentiallocalizationofmammalianLin-7(MALS/Veli)PDZproteinsinthekidney
...ceptortyrosinekinase,Let-23,onthebasolateralmembraneofvulvaprogenitorcells(VPC).NullmutationsinLin-7,Lin-2,orLin-10causetheLet-23receptortobecomemislocalizedtotheapicalmembraneanddisruptVPCdevelopment.StudiestodeducethemechanismrevealedthatLin-7servestheprimaryroleinlocalizingLet-23.Thissmallprotein...
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Invivodeterminationofdiffusivetransportparametersinasuperfusedtissue
...)andsolutionintheperitonealcavity(PC;CPC)aresampled,andtheperitonealvolume(VPC)aremeasured.Themasstransferareacoefficient(MTAC),whichcombinesallofthediffusivetransportprocessesintoasingle“lumped“parameter,characterizesthesolutetransportinthemembranemodel.Thefollowingequationillustratestheuseofth...
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InSilicoPredictionofPregnaneXReceptorActivatorsbyMachineLearningApproache
...bonds(nrot),molecularconnectivityandgeometry(3C,4PC,5CH,6CH,1v,2v,3vP,3vC,4vPC,6vCH,dis1,dis2,dis3,etc.),molecularflexibility(),electrotopologicalstatesorEstates[Scar,Shet,Shal,S(1),S(5),S(12),S(13),S(16),S(18),Tcent,Tradi,Tdiam,Tiwie,etc.],molecularsurfacearea(polarmolecularsurfacearea,Sapc,Sanc,Sa...
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Regulationofcalciumsignalingbypolycystin-
...undinpre-medialGolgiandtheER,bycellgradientanalysis.Whilefull-lengthandD511VPC2wereconfinedtopre-medialGolgimembranes,theL703XPC2partiallytranslocatedtotheplasmamembraneasexpectedfromthelossoftheERretentionsignal(77).ReconstitutedERmembranesfromLLC-PK1cellsoverexpressingwild-typePC2butnotnaïvem...