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Chemical-BasedTranslationalInductionofLuciferaseExpression:AnEfficientToolforinVivoScreeningofProteinFarnesylationInhibitors
...onate(mevalolactone),andtamoxifenwerefromSigma-Aldrich(St.Louis,MO);ICI182,780wasfromTocrisCooksonInc.(Bristol,UK);PBPEwassynthesizedinourlab(Poirotetal.,2000);andestradiolwasfromSteraloids(London,UK).TransientTransfectionsandTreatments.G418selectedclones(producingR17-eIF-4G-CVLS)weretransientlytran...
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EstrogenReceptorAntagonistFulvestrant(ICI182,780)InhibitstheAnti-InflammatoryEffectofGlucocorticoids
...-inducedpleurisy).Inparticular,wehaveinvestigatedwhetherfulvestrant(ICI182,780),aselectiveER-antagonist,isabletoattenuatethewellknownanti-inflammatoryeffectofdexamethasone(DEX),asyntheticglucocorticoid,inovariectomizedrats.WeshowthatICI182,780,aselectiveER-antagonist,reversestheanti-inflammatoryacti...
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DelayofPostnatalMaturationSensitizestheMouseProstatetoTestosterone-InducedPronouncedHyperplasia
...on,andtreatmentswithinhibitorsofestrogenaction,aromataseinhibitor,andICI182780furtherexacerbatedtestosterone-inducedhyperplasticgrowth.However,theactivationofestrogenreceptor(ER)-ßwithaspecificagonist,DPN,preventedthedevelopmentofprostatichyperplasiaandinflammationintestosterone-treatedLuRKOmi...
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TheAntiestrogenTamoxifenActivatesBKChannelsandStimulatesProliferationofMCF-7BreastCancerCells
...ordedinthepresenceoftheselectiveestrogenreceptorantagonistfaslodex(ICI-182,780;1µM).Atthesingle-channellevel,tamoxifensignificantlyincreasedtheopenprobabilityoftheBKchannelby46.2±10.1%(n=4)withoutchangingitsunitaryconductance.Moreover,weshowherethatthestimulationofBKchannelactivitybytam...
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NeuroprotectiveEffectsof17-EstradiolandNonfeminizingEstrogensagainstH2O2ToxicityinHumanNeuroblastomaSK-N-SHCells
...againstH2O2insult.Moreover,theestrogenreceptorantagonistfulvestrant(ICI182,780)didnotblockeffectsof17-E2,butincreasedcellsurvivalandbluntedintracellularCa2+increases.However,theseestrogensfailedtoreducecytosolicreactiveoxygenspecies,evenatconcentrationsashighas10µM.Inconclusion,estrogensexertp...
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報告稱轉基因作物可促進農業持續、有利且高速發展
...相當於從大氣層中減少了177億kg的二氧化碳,或者相當於780萬量汽車一年的排放量。 減少殺蟲劑的使用(1996-2009)總量爲3.93億kg(-8.7%),從而也降低了除草劑和殺蟲劑對環境的影響,與非轉基因相比,轉基因作物使用量減...
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LimitedRedundancyinPhosphorylationofRetinoblastomaTumorSuppressorProteinbyCyclin-DependentKinasesinAcuteLymphoblasticLeukemia
...erredserine612,whichwasinhibitedbyp16INK4a,andfascaplysin.Incontrast,serine780andserine795wereefficientlyphosphorylatedbyCDK4butnotbyCDK2.Thedatasuggestthattheredun-dancyinphosphorylationofRBbyCDK2andCDK4inNalm-6extractsislimited.Serine612phosphorylationbyCDK4alsooccurredinextractsofchildhoodacutely...
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慢性非結石性膽囊炎780例超聲診斷
...、高熱、黃疸[1],易誤診。筆者就近一年來超聲檢查780例慢性膽囊炎病例資料總結如下。1資料與方法1.1一般資料本組患者共780例,男465例,女315例,年齡30~75歲。1.2儀器與方法應用PHILIPS彩超診斷儀,探頭頻率12~3MHz。囑受...
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2008年歐盟生物柴油產量爲780萬噸
據歐洲生物燃料局表示,2008年歐盟生產了780萬噸生物柴油,遠遠高於2007年的570萬噸。 德國產量爲280萬噸,低於2007年的290萬噸。法國180萬噸,高於2007年的87.2萬噸。意大利59.5萬噸,高於07年的36.3萬噸。比利時27.7萬噸,高於07...
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780例受血者輸血前傳染性指標檢測的臨牀意義
...指標檢測的臨牀意義。方法採用酶聯免疫吸附(ELISA)法對780例輸血前患者進行乙型肝炎表面抗原(HBsAg)、丙型肝炎病毒抗體(抗-HCV)、艾滋病病毒抗體(抗-HIV)檢測,用梅毒血清學(TRUST)法檢測梅毒抗體。結果780例受血者中HBsAg的陽性...
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2019年全球生物塑料產能有望達到約780萬噸
...將在2014年170餘萬噸的基礎上增長360%,至2019年有望達到約780萬噸。該協會與德國研究機構IfBB和諾瓦研究院合作編輯的數據表明,生物基聚乙烯和生物基聚對苯二甲酸乙二酯將成爲這一增長的主要動力。IfBB即德國漢諾威應用科學...
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金嗓靈系列治療780例聲嘶療效觀察
...的觀察金嗓靈系列治療聲嘶的結果,探討其機制。方法對780例聲嘶患者,其中資料完整320例,分別用金嗓靈系列(治療組)和玄甘合劑(對照組)進行治療並做療效對比。結果金嗓靈系列有效率95%,玄甘合劑有效率79%。結論金嗓...
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RaloxifenerelaxesratintrarenalarteriesbyinhibitingCa2+influx
...nitro-L-argininemethylester,charybdotoxinplusapamin,indomethacin,orICI-182,780didnotmodifytheeffectofraloxifene.RaloxifenecausedsimilarrelaxationsinringscontractedbyU-46619andhighK+.Nifedipineattenuatedthepotencyofraloxifene.RaloxifenereducedCaCl2-inducedcontractions.K+(80mM)stimulatedanincreaseinVS...
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經導管射頻消融治療780例室上性心動過速的護理
...治療室上性心動過速(SVT)的臨牀護理。方法回顧性分析780例室上性心動過速患者RFCA治療及護理的資料。結果消融成功率:房室折返性心動過速(AVRT)97.5%,房室結內折返性心動過速(AVNRT)96.7%,預激綜合徵100%。消除320例患者...
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GinsenosideRe,aMainPhytosterolofPanaxginseng,ActivatesCardiacPotassiumChannelsviaaNongenomicPathwayofSexHormones
...igma-Aldrich;SH-6andPP2werepurchasedfromMerck(Darmstadt,Germany),andICI182,780andnilutamidewerepurchasedfromTocris(Ellisville,MO).StocksolutionsofE2(5mM),DHT(5mM),andmifepristone(10mM)werepreparedinethanol;thoseforE-4031(5mM),SMTC(5mM),andL-NIO(1mM)indistilledwater;andthosefornisoldipine(10mM),SH-6(...
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青少年心理健康知曉率780例調查研究
...學高一、高二兩個年級及淞誼中學初一、初二兩個年級共780例中學生統一採用青少年心理健康知識知曉率調查問卷進行調查,問卷共20項。當場發放當場回收,對所有數據輸入電腦進行相關數理統計分析。結果青少年對心理衛生...
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AgonistsofToll-likeReceptors2and4ActivateAirwaySmoothMuscleviaMononuclearLeukocytes
...valofeosinophilsinresponsetolipopolysaccharide.AmJRespirCellMolBiol2000;23:780eC787.MacKenzieA,WilsonHL,Kiss-TothE,DowerSK,NorthRA,SurprenantA.Rapidsecretionofinterleukin-1betabymicrovesicleshedding.Immunity2001;15:825eC835.MorathS,StadelmaierA,GeyerA,SchmidtRR,HartungT.Syntheticlipoteichoicacidfrom...
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TamoxifenandRaloxifeneDifferinTheirFunctionalInteractionswithAspartate351ofEstrogenReceptor
...lagonists,haveashortersidechainthanthefullantiestrogensICI164,384andICI182,780.Tamoxifenandraloxifeneareestrogenagonistsinbone,andtamoxifenbutnotraloxifeneisestrogenicintheuterusofovariectomizedratsormice(Greseetal.,1997).BothSERMscontainalkylaminoethoxysidechains,withdifferenttertiaryaminesubstitue...
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腹部手術後早期機械性腸梗阻的中西醫結合治療(附780例臨牀報告)
...1982年1月~2005年1月間,共收治腹部手術後機械性腸梗阻780例。現將1982~1990年和1991~2005年兩個時期單純西醫治療和中西醫結合治療結果進行比較,就其治療體會提出一點看法。 1資料與方法 1.1一般資料術後3周內發生的...
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靜脈抽血患者穿刺點護理行爲的調查
...者對穿刺點護理知識的瞭解情況。方法採用問卷調查法對780例醫院靜脈抽血患者進行調查。結果患者對血管的保護意識差,缺乏對穿刺點的護理知識,主要集中在按壓時間、按壓方法上。結論護理人員應加強對醫院患者的健康教...
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EstrogensCross-Talkto1b-AdrenergicReceptors
...takingplaceduring15min)andwereblockedbytheestrogenreceptorantagonistICI182,780(faslodex).Likewise,inhibitorsofphosphoinositide3-kinase[wortmanninand2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one(LY294002)]andofproteinkinaseC[staurosporine,3-[1-[3-(amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-i...
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EstrogenIncreasesMitochondrialEfficiencyandReducesOxidativeStressinCerebralBloodVessels
...mec.Thiseffectwasblockedbytheestrogenreceptorantagonistfulvestrant(ICI-182,780,Faslodex)butwasunaffectedbyinhibitorsofnitric-oxidesynthaseorphosphoinositide-3-kinase.Nuclearrespiratoryfactor-1protein,aprimaryregulatorofnucleargene-encodedmitochondrialgenes,wassignificantlyincreasedbylong-termestroge...
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Randomizedcontrolledsafetyandefficacytrialof2vitaminAsupplementationschedulesinTanzanianinfants
...atthesametimeasroutinevaccinationininfantsaged13mo.Design:Werecruited780newborninfantsandtheirmotherstoarandomizeddouble-blindcontrolledtrialinIfakarainsouthernTanzania.Inonegroup,mothersreceived60000µgvitaminApalmitateshortlyafterdelivery,andtheirinfantsreceived7500µgatthesametimeas...
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尿激酶靜脈溶栓治療急性心肌梗死纖溶系統的變化及臨牀意義
...。方法觀察32例首次急性心肌梗死(AMI)患者的尿激酶(UK)靜脈溶栓治療前後血漿UK抗原、組織纖溶酶原激活物(t-PA)抗原、纖溶酶原激活物(PA)活性、纖溶酶原激活物抑制物(PAI)活性、纖溶酶活性和纖維蛋白原抗原的變化...
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Caseselectioninmacularrelocationsurgeryforagerelatedmaculardegeneration
...8:1499.BlandJM,AltmanDG.Someexamplesofregressiontowardsthemean.BMJ1994;309:780.BlandJM,AltmanDG.Statisticalmethodsforassessingagreementbetweentwomethodsofclinicalmeasurement.Lancet1986;1:307–10.MachemerR,SteinhorstUH.Retinalseparation,retinotomy,andmacularrelocation:II.Asurgicalapproachforage-rela...
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EstrogenReducesAngiotensinII–InducedNitricOxideSynthaseandNAD(P)HOxidaseExpressioninEndothelialCells
...fectsofE2ontheAIIresponseswerenotinhibitedbytheE2receptorantagonistICI-182,780.Conclusions—AIIstimulationofendothelialcellsincreasesexpressionofNAD(P)HoxidaseandNOS,whichmaycontributetooxidativestress,asevidencedbyperoxynitriteformation.E2inhibitstheseAIIeffects,possiblythroughreducedAT1Rexpressio...
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Tissueoxygenandhemodynamicsinrenalmedulla,cortex,andcorticomedullaryjunctionduringhemorrhage-reperfusion
...bsolutevalue.Low-energy(2mW)laserlightfromasolid-statediodelaseroperatingat780nm(withinthevisibleredlightspectrum)isguidedtothemeasurementsiteviaanopticalfiber.Anidenticaladjacentfiberreceivestheback-scatteredlightfromthetissueandtransmitsittotwoindependentphotodetectors.Opticalmixingoflightscattere...
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醫護人員專業資格和縮寫Medicalqualificationabbreviations
...學院院士FBCOFellowofBritishCollegeofOphthalmicOpticians(Optometrists)(UK)英國視光師學院院士FBOAFellowofBritishOpticalAssociation(UK)英國視覺協會院士FChSFellowofSocietyofChiropodists(UK)手足病醫生協會院士FCOphthFellow,CollegeofOpthalmologistsofHongKong香港眼科醫學...
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Erlotinib,anEffectiveEpidermalGrowthFactorReceptorTyrosineKinaseInhibitor,Inducesp27KIP1Up-RegulationandNuclearTranslocationinAssociationwit
...echnology),monoclonalantibodytoRb,andpolyclonalantibodiestop-RbSer795andSer780(CellSignalingTechnology,Danvers,MA),monoclonalantibodiestoE2F1(KH95;CellSignalingTechnology),andpolyclonalantibodiestoSKP2,p-p27KIP1Thr178(SantaCruzBiotechnology),polyclonalanti-Sp1antibody(PEP-2;SantaCruzBiotechnology),p...
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扶復康口服液的毒性研究
...死亡。用孫瑞亢法測得LD50及其(P=0.95)可信限爲(7504.0±780.0)mg/kg。結論扶復康正常劑量無毒性反應。 【關鍵詞】扶復康;小鼠急性毒性實驗 扶復康口服液是由複方中藥提取的一種新的抗癌針劑,經初步臨牀觀察,該藥...