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Moderateddiscussion
PeterFürst,moderatorDrFürst:Iwouldliketoemphasizethat400companiesareinvolvedinmarketingfunctionalfoods.Theyrepresent6%ofthetotalfoodmarket,or$7billion.Sofunctionalfoodsareofenormouscommercialvalue.Arewesatisfiedwiththeexistingdefinitionforfunctionalfood?Shouldwetrytodefinefunctionalfoodsat...
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過氧化物酶體增殖劑激活受體的研究進展和應用前景
...-α/γ雙重激動劑 在體外活性測試中,化合物DRF2725顯示出較高的PPAR-α/γ雙重激動活性。在臨牀研究中,DRF2725也表現出較好的降血糖、血脂作用。DRF2725進入了Ⅲ期臨牀研究,然而,由於在動物試驗中,發現...
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Moderateddiscussion
...polyphenols,andgenisteinandopenthemeetingfordiscussion.Beforewebegin,DrFürstwouldliketomakeacomment.DrFürst:Iwouldliketoraisethequestionofbioavailability,whichisaproblemwhendealingwithphytochemicals.Anovelwaytostudybioavailabilityistheuseofanisolatedratsmallintestine[PlauthM,KremerI,...
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二維和三維四極杆離子阱蛋白質組數據質量的定量比較
...TQ中離子阱由具有雙曲線輪廓的四極杆構成,由其產生的2Drf電場以及不連續DC電壓將用於將離子容納在阱中央的軸向方向。LTQ中在居中的兩個杆上打開一個小口方便離子的射入和被兩個檢測器檢測(LCQ是在端電極上由離子射入口...
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Growth,bonemass,andvitaminDstatusofChineseadolescentgirls3yafterwithdrawalofmilksupplementation
...g,LengHuatFoo,AngelikaTrube,GuanshengMa,XiaoqiHu,XueqinDu,ChrisTCowell,DavidRFraserandHeatherGreenfield1FromtheFacultyofVeterinaryScience,UniversityofSydney,Sydney,Australia(KZ,QZ,LHF,AT,XD,DRF,andHG);theInstituteforNutritionandFoodSafety,ChineseCenterforDiseaseControlandPrevention,Beijing,China(QZ,...
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冠狀動脈造影正常的急性心肌梗死12例臨牀分析
...血管活性物質對冠脈舒縮產生影響。如內皮舒緩因子(EˉDRF)的缺乏或不足可引起冠脈痙攣。現已證明,乙酰膽鹼能誘發內皮功能受損的冠脈痙攣:而正常冠脈乙酰膽鹼可刺激完好的內皮細胞釋放EDRF,使之不會發生痙攣[5]。故...
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PPAR激動劑類抗糖尿病藥研發喜憂參半
...諾德公司在臨牀前研究中發現,PPAR激動劑Ragaglitazar(NN622/DRF2725)可使實驗鼠的尿路膀胱腫瘤發生率增高,因而暫停了其Ⅲ期臨牀研究。2003年,默克公司和日本杏林製藥公司在動物長期毒性實驗中也發現,在研的PPAR-α、γ激動劑MK...
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《免疫學雜誌》1999年(第15卷)目錄索引
...格局的作用 範祖森馬寶驪(220) 中國拉祜族人HLA-DRF的快速DNA分型 洪坤學褚嘉佑衛燦東等(223) 人PBMC中IL-18基因的克隆及在E.coli中的高效表達與純化 杜勇汪濤杜桂鑫等(226) 抗HbsAg抗體Fab段在大腸桿菌中的高...
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山莨菪鹼對乳癌術後皮瓣的保護作用
...血管平滑肌兩種途徑實現的,並且與PGI2(前列環素)、E-DRF(內皮源性舒張因子)和KATP(ATP敏感性鉀通道)開放均有關[4]。所有患者應用山莨菪鹼後均出現顏面頸胸等處皮膚潮紅,正是山莨菪鹼擴張微血管作用的有力證據。...
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QualityofHospitalandOutpatientCareAfterStrokeorTransientIschemicAttack
...atieZuider,Rotterdam,DrR.Saxena,DrE.Thomeer;StFranciscusGasthuis,Rotterdam,DrF.H.Vermeij;TweeStedenZiekenhuis,Tilburg,DrB.P.W.Jansen;StElisabethZiekenhuis,Tilburg,DrP.L.M.deKort;AcademischZiekenhuisMaastricht,Maastricht,DrR.J.vanOostenbrugge.Datacollectionofficers:M.Beijerink,H.Broers,A.vandenDool,H...
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Diaphanous1and2RegulateSmoothMuscleCellDifferentiationbyActivatingtheMyocardin-RelatedTranscriptionFactors
...ndmDia2).22-24Theseproteinsbelongtothesubfamilyofdiaphanous-relatedformins(DRFs)thatalsoincludesDia3andFHOD1.PreviousstudieshavedemonstratedthattheDRFsactaspotentactinandmicrotubulepolymerizingfactorsthatregulateanumberofprocessesincludingcellmigrationanddivision(seeHiggs25andWallaretal26forreviews)...
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PerivascularAdiposeTissueandMesentericVascularFunctioninSpontaneouslyHypertensiveRats
...edvascularresistanceobservedinSHR.【關鍵詞】perivascularadiposetissueADRFmesentericarteriesSHRIntroductionEarlierstudiesuncoveredaparacrineroleforadiposetissueintheregulationofvascularfunction.SoltisandCassis1demonstratedthatperivascularfatsignificantlyattenuatedvascularresponsivenessofaorticri...
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FishoilandantioxidantsalterthecompositionandfunctionofcirculatingmononuclearcellsinCrohndisease
TimothyMTrebble,NigelKArden,StephenAWootton,PhilipCCalder,MarkAMullee,DavidRFineandMikeAStroud1FromtheInstituteofHumanNutrition,SchoolofMedicine(TMT,SAW,PCC,andMAS),theMRCEnvironmentalEpidemiologyUnit(NKA),theMedicalStatistics/SouthamptonStatisticalSciencesResearchInstitute(MAM),andtheDivisionofInfe...
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EtiologyofanemiainpregnancyinsouthMalawi
...gestthatironsupplementationalonewillnotprovidetheoptimalsolution.DISCUSSIONDrFleming:WhydoyouthinkthesepatientshavevitaminB-12deficiency?DrvandenBroek:Itisdifficulttosay.ApaperfromZimbabwebySavage[SavageD,GangaidzoI,LindenbaumJ,etal.VitaminB12deficiencyistheprimarycauseofmegaloblasticanaemiainZimbab...
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ErtiprotafibImprovesGlycemicControlandLowersLipidsviaMultipleMechanisms
...(2001)(-)3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoicacid[(-)DRF2725]:adualPPARagonistwithpotentantihyperglycemicandlipidmodulatingactivity.JMedChem44:2675-2678.McGovernSL,CaselliE,GrigorieffN,andShoichetBK(2002)Acommonmechanismunderlyingpromiscuousinhibitorsfromvirtualandhigh-throughp...