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輸血相關人類嗜T淋巴細胞病毒感染
1流行病學人類嗜T淋巴細胞病毒Ⅰ型和Ⅱ型(HTLV-Ⅰ/Ⅱ)是上世紀70年代末和80年代初首先發現的感染人類的逆轉錄病毒,由細胞介導傳播。HTLV-Ⅰ在體內主要感染CD4+T淋巴細胞。母乳、精液、血液中存在CD4+T淋巴細胞,所以HTLV-Ⅰ...
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海南省無償獻血人羣HTLV-Ⅰ/Ⅱ血清抗體陽性率調查
【摘要】目的瞭解海南省無償獻血者血清中抗-HTLV-Ⅰ/Ⅱ陽性率。方法用ELISA法篩查獻血者血清抗-HTLV-Ⅰ/Ⅱ,初篩陽性者經ELISA法雙孔複檢,複檢呈陽性的標本再用蛋白印跡試驗(WesternBlot)進行確認。結果11000名海南省無償獻血...
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中國東北地區HTLV-1的前病毒DNA測定及其意義
摘要:目的瞭解我國東北的HTLV-1的流行情況及病毒特徵。方法從2002年起在東北地區共採取了941份標本,用免疫熒光法進行了血清抗體的檢測,經PCR擴增及Southern雜交鑑定。結果發現3例HTLV-1陽性感染病人,陽性率0.3%,沒有發現HTLV-2...
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人類T淋巴細胞病毒Ⅰ及Ⅱ型感染的檢測
...的工作提出寶貴的意見和建議。 人類T淋巴細胞病毒(HTLV)-Ⅰ與成人T淋巴細胞白血病(ATL)感染有關,HTLV-Ⅱ和T細胞性毛細胞白血病(THCL)感染有關。在世界許多地區均有HTLV-Ⅰ或(和)Ⅱ感染,並在某些地區流行的報道,流行...
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6-2-11RNA腫瘤病毒與人類T細胞白血病
...它們分離到人類T細胞白血病病毒(humanT-cellleukemiavirus,HTLV)。這種病毒在電鏡下呈C型病毒顆粒形態,有芽生現象,浮力密度爲1.16g/ml,含有高分子量的RNA和逆轉錄酶,表明其屬於RNA腫瘤病毒。 1977年日本學者Uchiyama等報道...
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ProvirusLoadIsLowerinHumanTLymphotropicVirus(HTLV)IICarriersthaninHTLV-ICarriers:AKeyDifferenceinViralPathogenesis
...NationalCancerInstituteFrederick,Frederick,MarylandHumanTlymphotropicvirus(HTLV)IandHTLV-IIarecloselyrelatedretroviruses[1].InadditiontoHTLV-Iassociatedmyelopathy(HAM),HTLV-IisassociatedwithadultTcellleukemia(ATL).SomeevidencesuggeststhatHTLV-IImaybeassociatedwithaHAM-likeneuropathy[2],buttheinciden...
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HumanTLymphotropicVirusTypeI(HTLV-I)ProviralLoadinCerebrospinalFluid:ANewCriterionfortheDiagnosisofHTLV-IAssociatedMyelopathy/TropicalSpa
...talierUniversitairedeFort-de-France,MartiniqueHumanTlymphotropicvirustypeI(HTLV-I)associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP)isassociatedwithaccumulationofHTLV-IinfectedTcellsinthecentralnervoussystem(CNS).However,dataonHTLV-IproviralloadintheCNSattheasymptomaticstagearestilllacking.Wem...
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HelminthicInfectionDown-RegulatesType1ImmuneResponsesinHumanTCellLymphotropicVirusType1(HTLV-1)CarriersandIsMorePrevalentinHTLV-1Carrie
...tionalInstitutesofHealth,Bethesda,MarylandHumanTcelllymphotropicvirustype1(HTLV-1)infectionisassociatedwithanexacerbatedtype1immuneresponseandsecretionofhighlevelsofproinflammatorycytokines.Incontrast,helminthicinfectioninducesatype2immuneresponse.Inthepresentstudy,thecytokineprofileinHTLV-1carriers...
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AProspectiveStudyofSexualTransmissionofHumanTLymphotropicVirus(HTLV)IandHTLV-II
...d.Cross-sectionalstudiessupportsexualtransmissionofhumanTlymphotropicvirus(HTLV)I/II;however,prospectiveincidencedata,particularlyforHTLV-II,arelimited.Methods.Acohortof85HTLV-positive(30withHTLV-Iand55withHTLV-II)blooddonorsandtheirstable(6months)heterosexualsexpartnerswerefollowedbiannuallyoverthe...
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白血病病毒研究的重大發現
...了一種叫做HBZ的蛋白質。HBZ由人類I型T細胞白血病病毒(HTLV-1)製造(HTLV-1是一種反轉錄病毒,是HIV的遠房親戚)。這項研究表明HBZ能夠提升HTLV-1病毒在動物寄主中產生一種持續性感染的能力。美國俄亥俄州立大學綜合中心和獸...
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HTLV-1propelsuntransformedCD4+lymphocytesintothecellcyclewhileprotectingCD8+cellsfromdeath
...titutesofHealth,Bethesda,Maryland,USA.AbstractHumanTcellleukemiavirustype1(HTLV-1)infectsbothCD4+andCD8+lymphocytes,yetitinducesadultTcellleukemia/lymphoma(ATLL)thatisregularlyoftheCD4+phenotype.HereweshowthatinvivoinfectedCD4+andCD8+Tcellsdisplayedsimilarpatternsofclonalexpansionincarrierswithoutma...
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Ataxonluxury:HTLV-IinfectionofCD4+CD25+Tregs
...nrevisitedbyYamanoetal.,whodemonstratethathumanTcelllymphotropicvirustypeI(HTLV-I)infectionofCD4+CD25+TregsinpatientswithHTLV-I–associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP)resultsinadecreaseinFOXP3mRNAandproteinexpression.ThisleadstotheinabilityofHTLV-I–infectedCD4+CD25+Tregstoinhibi...
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AdultTcellleukemia:ataleoftwoTcells
...niaMedicalSchool,Norfolk,Virginia,USA.AbstractHumanTcellleukemiavirustype1(HTLV-1)istheetiologicagentforthedevelopmentofanaggressivehematologicneoplasiatermedadultTcellleukemia/lymphoma(ATLL).AlthoughthevirusinfectsTcellsubsetsthatdisplayeitherCD4orCD8cellsurfacemarkers,theleukemiccellisexclusivelyo...
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中國人皮膚型成人T細胞白血病/淋巴瘤一例報道
...酶鏈反應分別檢測患者外周血中嗜人T淋巴細胞病毒Ⅰ型(HTLV-Ⅰ)抗體和淋巴樣細胞的HTLV-Ⅰ前病毒DNA。結果此例患者的皮膚損害多形,除表現丘疹、斑塊外,併發生皰壁緊張或鬆弛的大皰。組織病理檢查示表皮下水皰,皰底真皮...
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病毒捕手:尋找下一個HIV
...爾夫博士的“嫌疑犯”名單上已經列出了一批新的病毒:HTLV-3、HTLV-4、猴泡沫病毒……它們與HIV同屬於逆轉錄病毒,正蠢蠢欲動地往人類身上遷徙。逆轉錄病毒的危險之處在於,它能把該病毒的基因物質注入被感染細胞的DNA,所...
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ReplytoHisadaetal.
...ohortsandfoundthatproviralloadwasupto1log10higherinhumanTlymphotropicvirus(HTLV)IcarriersthaninHTLV-IIcarriers.Replicationofthisfindingstrengthenstheconclusionthatthemagnitudeofproviralloadmayexplainthedifferencesinpathogenesisbetweenthe2retrovirusesdifferencesthatexistdespitethesimilargeneticsequen...
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HumanTLymphotropicVirusTypeIIInfectionandHumoralResponsestoPneumococcalPolysaccharideandTetanusToxoidVaccines
...niversityofMinnesota,MinneapolisInfectionwithhumanTlymphotropicvirustypeII(HTLV-II)hasbeenlinkedtoanincreasedincidenceofbacterialpneumonia.TodeterminewhetherHTLV-IIinfectionisassociatedwithimpairedhumoralimmuneresponses,weimmunizedacohortofHTLV-IIinfectedsubjectsandmatcheduninfectedcontrolsubjectswi...
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科學家在非洲發現新的逆轉錄病毒
...人員已將這兩種病毒命名爲人類淋巴T細胞病毒3型和4型(HTLV-3、HTLV-4)。目前,他們還不知道這兩種病毒對人類危害究竟有多大,但早先發現的其他類型人類淋巴T細胞病毒能引起嚴重的免疫系統疾病。因此,他們認爲這兩種...
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Virus-induceddysfunctionofCD4+CD25+TcellsinpatientswithHTLV-I–associatedneuroimmunologicaldisease
...TcellpopulationinpatientswithhumanTcelllymphotropicvirustypeI–associated(HTLV-I–associated)myelopathy/tropicalspasticparaparesis(HAM/TSP)hasbeenshowntobeamajorreservoirforthisvirus,itwasofinteresttodeterminewhetherthefrequencyandfunctionofCD4+CD25+TregsinHAM/TSPpatientsmightbeaffected.Inthesecel...
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TheClonalExpansionofHumanTLymphotropicVirusType1InfectedTCells:AComparisonbetweenSeroconvertersandLong-TermCarriers
...erCenter,BostonBackground.TheclonalexpansionofhumanTlymphotropicvirustype1(HTLV-1)infectedTcellsisconsideredtobeimportantforthemaintenanceofinfection.However,theprocessbywhichtheclonalityofHTLV-1infectedTcellsisestablishedisnotunderstood.Methods.HTLV-1clonalityin4adultseroconverterswasanalyzedbyinve...
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RoleofNeuronalInterferon-intheDevelopmentofMyelopathyinRatsInfectedwithHumanT-CellLeukemiaVirusType
【摘要】HumanT-cellleukemiavirustype1(HTLV-1)isthecausativeagentofnotonlyadultT-cellleukemiabutalsoHTLV-1-associatedmyelopathy/tropicalspasticparaparesis(HAM/TSP).AmongtheratstrainsinfectedwithHTLV-1,chronicprogressivemyelopathy,namedHAMratdisease,occursexclusivelyinWKAHrats.Inthepresentstudy,we...
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AIDS相關病毒與非白血性白血病及Raf信號傳導的關係
...多病毒與AIDS的關係並不大,例如:人T細胞白血病病毒1(HTLV-1),,乙型肝炎病毒(HBV),丙型肝炎病毒(HCV)和人皰疹病毒(HHV-6)。在這些病毒中,HTLV-1與非白血性白血病有着在病因學上的聯繫。近期的觀察發現EBV,HBV,HCV和KSHV可能與某...
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醫學微生物學-反轉錄病毒複習題
...制需依賴RNA的RNA多聚酶3.含有反轉錄酶和整合酶的病毒A.HTLVB.HAVC.登革熱病毒D.HHVE.EBV4.除哪項外,下列病毒都能通過性接觸傳播A.HIVB.HCVC.HSV-2D.HPVE.HTLV5.HIV侵犯的主要細胞是:A.T細胞B.CD8細胞C.CD4細胞D.B細胞E.T細胞和B細胞6.HIV的...
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類風溼關節炎的主要病因探討
...毒後,在神經異常出現的同時,可引起四肢關節炎。成人HTLV-1可引起HTLV-1伴隨的關節炎。把HTLV-1基因轉染給小鼠,則該小鼠就會出現慢性增殖性滑膜炎。這進一步說明病毒與關節炎發病有關。1.2與細菌的關係細菌感染可引起無菌...
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去白細胞輸血的臨牀應用進展
...體,如鉅細胞病毒(MCV)、人類T淋巴細胞白血病病毒(HTLV-Ⅰ/Ⅱ)和人類免疫缺陷病毒(HIV)等,輸血可能導致這些病毒經血傳播及潛伏病毒的激活。通過各種物理、化學方法去除血液成分中的白細胞,在防止輸血不良反應及...
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我國研製出白血病病毒診斷試劑
...專家鑑定認爲,該試劑是“人類T淋巴細胞白血病病毒(HTLV)重組抗原及抗體診斷試劑盒的研製”項目研究取得的重要成果,也是中國自主研究出的第一個HTLV(白血病)篩查試劑,不僅填補了國內空白,也達到國際領先水平。該...
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第十七章 免疫缺陷
...。麻疹病毒和人類親淋巴細胞病毒(humanTlymphotropicvirus-1,HTLV-1)感染CD4+細胞。HIV和HTLV-1使TH細胞惡變爲成熟T細胞白血病/淋巴瘤。結核桿菌和許多真菌的慢性感染常導致免疫缺陷。寄生蟲感染如非洲慢性瘧疾感染兒童其T細胞功能...
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6-2-8RNA腫瘤病毒與動物白血病
...機理尚未搞清。應該指出,BLV與人類T細胞白血病病毒(HTLV)之間在某些方面相似,如兩者的逆轉錄酶的活性均需Mg2+參與;最初的HTLV是從人類皮膚型淋巴瘤或皮膚型白血病細胞分離的,而BLV注射綿羊能誘發產生皮膚型白血病或...
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淋巴瘤
...淋巴瘤有關,即EB病毒和人類T細胞淋巴瘤/白血病病毒(HTLV-1)。EB病毒已發現與非洲兒童的Burkitt淋巴瘤有密切的病因關係,EB病毒DNA已從Burkitt淋巴鎦的細胞核中提取出來。但發生於非洲以外地區的同類型淋巴瘤則未發現與EB...
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第五屆全國血細胞診斷學術會議紀要
...科大學報道9例成人T細胞白血病/淋巴瘤(ATL),其中7例患者HTLV-1抗體陽性,表明HTLV-1亦是我國ATL的病因。本病治療效果及預後均差。山東德州市人民醫院和中國醫學科學院血液學研究所報道10例慢性粒-單核細胞白血病(CMML),認爲CMML是...