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Scenesse獲批准成爲治療遺傳性疾病的新方法
...e,與紅細胞生成protoporPHyria防止光毒性首先在成人醫學(EPP)。 在暴露於陽光之後,EPP患者會感覺到暴露於陽光的皮膚有一種刺痛感,延長暴露可導致一種令人傷殘的疼痛,隨後出現紅腫。Scenesse計數器疾病的影響,從而影...
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抗紫外線疫苗即將面世可助日光過敏者防曬
...疫苗”之稱的它,除了能防癌外,還能有效用於那些患有EPP(對自然光過敏)的人。自然光的正常照射,往往使他們的皮膚起泡、灼傷,“疼痛難忍”。 通過將穀粒大小的植物插入患者腰部,並複製人體對紫外線及有害輻射的...
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“紫外線疫苗”即將面世可幫助日光過敏者“防曬”
...疫苗”之稱的它,除了能防癌外,還能有效用於那些患有EPP(對自然光過敏)的人。自然光的正常照射,往往使他們的皮膚起泡、灼傷,“疼痛難忍”。通過將穀粒大小的植物插入患者腰部,並複製人體對紫外線及有害輻射的天然...
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GC-2050氣相色譜儀
...處理系統,並配有通用打印機端口(HOST、USB、SPP、ECP、EPP),使GC9160氣相色譜依具有 單機可完成圖譜顯示、數據分析、結果打印的獨特功能。 自我診斷功能,能顯示故障部位。 觸摸式鍵盤,方便使用者對各項操作...
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馬來西亞推動使用生物潤滑油
...從2011年開始將資本支出激勵性補貼(根據入口點計劃6,即EPP6)發放給那些有意進一步從事棕櫚油下游業務的公司。這些補貼用於生產附加值更高的棕櫚油衍生物,比如表面活性劑、農業化學品、生物多元醇、生物潤滑油、甘油衍...
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不穩定骨盆骨折的損傷控制
...1]。2.8骨盆填塞腹膜外填塞技術(extraperitonealpelvicpacking,EPP)成功應用於膀胱和骶骨周圍間隙的止血。採用骨盆C型鉗或外固定支架提供骨盆後環的即時穩定性,提供了骨盆填塞的機械穩定性和骨折復位而減少骨折出血。骶骨周圍...
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MonitoringofCytomegalovirusInfectioninSolid-OrganTransplantRecipientsbyanUltrasensitivePlasmaPCRAssay
...enefitofanultrasensitiveplasma-basedPCRassayforrenaltransplantrecipients.Thepp65CMVantigen(pp65Ag)assayusingleukocyteswasemployedasaroutinetestforthemonitoringofCMVin23transplantrecipients.Wecomparedthepp65antigenemiawiththeCMVloadquantifiedbyanultrasensitivePCR(US-PCR)withalimitofdetectionof20CMVDN...
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Heme-regulatedeIF2kinasemodifiesthephenotypicseverityofmurinemodelsoferythropoieticprotoporphyriaand?-thalassemia
...eofHRIin2mousemodelsofhumanrbcdisorders,namelyerythropoieticprotoporphyria(EPP)and?-thalassemia.Inbothcases,lackofHRIadverselymodifiesthephenotype:HRIdeficiencyexacerbatesEPPandrenders?-thalassemiaembryonicallylethal.ThisstudyestablishestheprotectivefunctionofHRIininheritedrbcdiseasesinmiceandsugges...
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Understandingglobinregulationin?-thalassemia:it’sassimpleas,?,,
...RIdeficiencyisalsoshowntoincreasetheseverityoferythropoieticprotoporphyria(EPP),adiseasecharacterizedbydefectivehemesynthesis.NormalHRIactivityisshowninEPPtopreventthemoresevereaccumulationofbothfree-andfree?-globinchains,whichformerythroidcellinclusionsandaretoxictocells.ThisisdocumentedinHRI–/...
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InfluenceoftriacylglycerolstructureonthepostprandialresponseoffactorVIItostearicacidrichfats
...iacylglycerolwascollectedbyfinger-prick1,2,4,and5hpostprandiallyintoamicro-Eppindorftubecontaining1mgdipotassiumEDTA.Thebloodsampleswereprocessedwithin1hofcollection.AnalyticmethodsPlasmatriacylglycerolandtotalandHDL-cholesterolconcentrationsweremeasuredbyenzymaticassayaspreviouslydescribed(2).Plasm...
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SensitiveEDTA-BasedMicrobiologicalAssaysforDetectionofMetallo--LactamasesinNonfermentativeGram-NegativeBacteria
...microbiology.Clin.Microbiol.Rev.3:219-226.Khler,T.,M.Michea-Hamzehpour,S.F.Epp,andJ.C.Pechere.1999.CarbapenemactivitiesagainstPseudomonasaeruginosa:respectivecontributionsofOprDandeffluxsystems.Antimicrob.AgentsChemother.43:424-427.Lee,K.,Y.Chong,H.B.Shin,Y.A.Kim,D.Yong,andJ.H.Yum.2001.ModifiedHodge...
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SrcFamilyKinaseInhibitorsBlockAmphiregulin-MediatedAutocrineErbBSignalinginNormalHumanKeratinocytes
...iveininhibitingwoundclosure,withmarkedinhibitionbyaslittleas0.2ePD173953or5ePP1.Aspreviouslydemonstrated(Stolletal.,2003),U0126alsoinhibitedwoundclosure,demonstratingeffectivenessatconcentrationsaslowas2e.ItwassurprisingthatlowdosesofbothSFKIsproducedalong-lastinginhibitionofNHKproliferationandmigra...
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ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
FromUniversityHospitalHamburg-Eppendorf(M.B.,A.E.,J.H.,B.B.,H.G.,M.M.,F.R.),Hamburg,Germany;andtheCollegeofPhysiciansandSurgeonsofColumbiaUniversity(R.R.),NewYork,NY.CorrespondencetoDrFranzRinninger,UniversityHospitalHamburg-Eppendorf,DepartmentofMedicine,Martinistrasse52,20246Hamburg,Germany.E-mail...
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MRImagingoftheMetacarpophalangealJointsoftheFingersPartI.ConventionalMRImagingandMRArthrographicFindingsinCadavers1
...chmentsandbodiesofthepalmarplates(PPs),therecessesofthedistalattachmentofthePP,andthedeeptransversemetacarpalligament(DTML).3.Theextensorhoodformedbythefollowing:radialandulnarsagittalbands,transversefibersoftheinterosseoustendinouspartoftheextensorhoodontheradialandulnarsides(Fig2),andfibrousconnec...
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CellCycleSignalingbyEndothelin-1RequiresSrcNonreceptorProteinTyrosineKinase
...wellplates.Cells,serumstarvedfor24hinDMEM/0.5%FBSfor24,werepretreatedwith10ePP2orPP3for1hbeforeaddingeither100nMendothelin-1or20%FBS.CellswerefixedandstainedforBrdUincorporationasdescribedabove.WesternBlotting.WesternblottingforPTyrSrc(416)andcyclinD1inHMCswasperformedasreportedpreviouslybyuswithmin...
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NuclearLocalizationofNADPH:Cytochromec(P450)ReductaseEnhancestheCytotoxicityofMitomycinCtoChineseHamsterOvaryCells
...ygenradicalsandotheroxygen-derivedspecies,inFreeRadicalsinBiologyandMedicinepp23eC85,ClarendonPress,Oxford,UK.HodnickWFandSartorelliAC(1993)ReductiveactivationofmitomycinCbyNADH:cytochromeb5reductase.CancerRes53:4907eC4912.HoeyBM,ButlerJ,andSwallowAJ(1988)ReductiveactivationofmitomycinC.Biochemistry...
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ExpressionandPhosphorylationoftheNa-PumpRegulatorySubunitPhospholemmaninHeartFailure
.../L):50Tris,1dithiothreitol(DTT),1MnCl2,and2Uproteinphosphate1a(PP1a)plus0.1ePP2a.ImmunoblotsHomogenatesandcelllysates(30eprotein/lane)weresize-fractionatedonSDS-PAGE(10%forNa/K-ATPase;15%forPLM,12%forimmunoprecipitations).Proteinsweretransferredto0.20-enitrocellulose(NaVO3wasaddedtothetransferbuffer...
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DetectionofPseudomonasaeruginosaProducingMetallo--LactamasesinaLargeCentralizedLaboratory
...monasaeruginosa.Clin.Infect.Dis.37:26-32.Kohler,T.,M.Michea-Hamzehpour,S.F.Epp,andJ.C.Pechere.1999.CarbapenemactivitiesagainstPseudomonasaeruginosa:respectivecontributionsofOprDandeffluxsystems.Antimicrob.AgentsChemother.43:424-427.Lagatolla,C.,E.A.Tonin,C.Monti-Bragadin,L.Dolzani,F.Gombac,C.Bearzi,...
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SrcFamilyKinaseActivityIsRequiredforMurineEmbryonicStemCellGrowthandDifferentiation
...pendentofthepresenceofLIF.ThenextSFKinhibitortestedwasthepyrazolo-pyrimidinePP2,anotherbroad-spectruminhibitorofSFKactivity(Hankeetal.,1996).AsshowninFig.4A,strongSFKinhibitionwasobservedinEScellsaftertreatmentwith5μMPP2,withnearlycompleteinhibitionat10μM.AsobservedwithSKI-1,partialinhibitionofSFK...
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第四節 石蠟包埋組織的DNA提取及其應用
...的paget細胞是來源於腺癌細胞而不是表皮的角質層細胞。EPP中的paget細胞也來源於腺癌細胞,但這種腺癌細胞與MPD中的腺癌細胞不同,因爲兩者基因表達不同。 3.遺傳病的基因診斷遺傳病的回顧性家族調查,可通過石蠟包埋...
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DomainsNecessaryforG12BindingandStimulationofProteinPhosphatase-2A(PP2A):IsG12aNovelRegulatorySubunitofPP2A?
...orminganA-Ccoreenzyme.BsubunitsreversiblyinteractwiththecoreenzymetoregulatePP2Afunction,andotherproteinscanmimic(replace)Bsubunits.WedemonstratedpreviouslyG12stimulationofPP2AphosphataseactivityinvitroandinCOScells(Zhuetal.,2004).ManysignalingpathwaysshareinvolvementofG12andPP2A,althoughuntilrecent...
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第二節 脂質代謝
...物(IPP及DPP)縮合成15C的焦磷酸法呢酯(farnesylpyrophosfhate,EPP)。二分子15C焦磷酸法呢酯在內質網鯊烯合酶(squalenesynthase)的作用下,再縮合,還原即生成30C的多烯烴-鯊烯(squalene)。圖1-3膽固醇合成代謝圖 (3)膽固醇的合成。鯊烯...
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Methylmercury-InducedIncreaseofIntracellularCa2+IncreasesSpontaneousSynapticCurrentFrequencyinRatCerebellarSlices
...mentcausedalargeandtransientincreasebeforeeventualsuppressionoffrequencyofMEPPsatneuromuscularpreparations(Juang,1976;AtchisonandNarahashi,1982).TimestoonsetofincreasesinMEPPfrequencywereapproximately30to40minand5to15min,respectively,afterMeHgexposureto20and100µMMeHg(AtchisonandNarahashi,1982)...
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MolecularApproximationsbetweenResidues21and23ofSecretinandItsReceptor:DevelopmentofaModelforPeptideDockingwiththeAminoTerminusoftheSe
...es37to122.Themodelswerethencompletedbyattachingmissinghydrogens,assigningECEPP/3atomtypesandcharges(Nemethyetal.,1992),followedbyregularizationtoimposeidealcovalentgeometriesonallbondanglesandbondlengths.EighthundredandthreeNMRrestraintswereconvertedtoICM-readableformatandwereimposedonthemodelsusing...
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Myastheniagravis:past,present,andfuture
...eAChRionchannelopening,permittinginfluxofNa+intothemusclefiber.TheresultingEPPactivatesvoltage-gatedNa+channelsatthebottomofthefolds,leadingtofurtherNa+influxandspreadingoftheactionpotentialalongthemusclefiber.Otherproteins,includingRapsyn,MuSK,andagrin,whichareinvolvedinAChRclustering,arealsopresen...
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MCP-1contributestomacrophageinfiltrationintoadiposetissue,insulinresistance,andhepaticsteatosisinobesity
...oxyl-terminaltails.Proc.Natl.Acad.Sci.U.S.A.91::2752-2756.Schweickart,V.L.,Epp,A.,Raport,C.J.,andGray,P.W.2000..CCR11isafunctionalreceptorforthemonocytechemoattractantproteinfamilyofchemokines.J.Biol.Chem.275::9550-9556.Lu,D.etal.2005..CloningandfunctionalcharacterizationoftherabbitC-Cchemokinerecep...
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Proteinphosphatase2AisanegativeregulatorofIL-2productioninpatientswithsystemiclupuserythematosus
...chasAlzheimerdisease(41)andOpitzBBB/Gsyndrome(42).WepresentdatathatintroducePP2AasanovelregulatoroftheIL2promoteractivityandIL-2production.WereportherethattheproteinandcatalyticactivityofPP2AisincreasedinpatientswithSLEbutnotinpatientswithRAandthatitisresponsible,atleastinpart,forthedecreasedproduct...