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Serotoninandcentralnervoussystemfatigue:nutritionalconsiderations
...rcisecarbohydratesbranched-chainaminoacidsserotonindopaminetryptophanINTRODUCTIONResearchintheareaoffatiguehasfocusedprimarilyonperipheralfatigue,whichinvolvesreductionsintheabilityofmuscletoperformworkbecauseofimpairmentsanywherealongthechainofcommandfromneuromusculart...
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TheTwo-StateDimerReceptorModel:AGeneralModelforReceptorDimers
...oncavedownwardScatchardplots.Analysisofagonist/antagonistcompetitiondatafordopamineD1receptorsusingthetwo-statedimerreceptormodelhasalsobeenperformed.Althoughfittingtothetwo-statedimerreceptormodelwassimilartothefittingtothe“two-independent-sitereceptormodel“,theformerissimpler,andadiscriminatio...
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DifferentialActivationofAdenylateCyclaseandReceptorInternalizationbyNovelDopamineD1ReceptorAgonists
...choolofPharmacy,WestLafayette,Indiana(D.E.N.)AbstractStructurallydissimilardopamineD1receptoragonistswerecomparedwithdopamineintheirabilitytoactivateadenylatecyclaseandtointernalizehemagglutinin-taggedhumanD1receptorsinastablytransfectedhumanembryonickidneycellline.ThirteendopamineD1receptoragonists...
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Roleof20-HETEinD1/D2dopaminereceptorsynergismresultingintheinhibitionofNa+-K+-ATPaseactivityintheproximaltubule
...boliteofcytochromeP-450(CYP),asapossiblemediatorofNa+-K+-ATPaseinhibitionbydopamine(DA).TheaimofthisstudywastoinvestigatetheintracellularmechanismsinvolvedinthiseffectandtoelucidatetheDAreceptorassociatedwiththe20-HETEpathwayintheratkidney.DA(10-5M)inhibitedNa+-K+-ATPaseactivityinmicrodissectedtubul...
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MultipleIndependentFunctionsofArrestinsintheRegulationofProtease-ActivatedReceptor-2SignalingandTrafficking
...edonthestabilityofthereceptor-arrestininteraction.Likewise,theC-tailoftheD1dopaminereceptorisalsonotrequiredforrapidarrestinassociationanddesensitization(Kimetal.,2003).TheregulationofPAR1desensitizationbyarrestinsisindependentofreceptorphosphorylation(Chenetal.,2004),andourdatawithPAR2C-tailmutants...