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(月扁)(piān)病
(月扁)(piān)病 古病名。指患處赤脈卒起如編繩。且見有疼痛者。(月扁),脈隱起如辮繩也。(《集韻》)。《肘後備急方》卷五:“皮肉卒腫起,狹長赤痛名(月扁)。”該病多因久勞,或熱氣盛時爲冷溼所折,致...
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黃(王扁)
黃(王扁) 明代醫生。字楚祥。儀真(今江蘇儀徵)人。少喪父,從母習儒。既而思曰:“醫,仁術也。苟精之,亦足以濟世。窮研《素問》、《難經》等,醫術益精,以醫聞名於淮、揚間。正統初(1436年),徵爲太醫,...
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黃(王扁)
黃(王扁) 明代醫生。字楚祥。儀真(今江蘇儀徵)人。少喪父,從母習儒。既而思曰:“醫,仁術也。苟精之,亦足以濟世。窮研《素問》、《難經》等,醫術益精,以醫聞名於淮、揚間。正統初(1436年),徵爲太醫,...
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EmergencyAdministrationofAbciximabforTreatmentofPatientsWithAcuteIschemicStroke
...tPA.3RecurrentocclusionmightbesecondarytoprocoagulanteffectsofrtPA,andtherapiestocounteracttheseactionsareneeded.4Hence,thereisaneedforreperfusionagentsthatcouldbesafelyadministeredinalongertimewindow.Activationofplateletsisakeycomponentofacutethromboembolismandexperimentalstudiesalreadydemonstratet...
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駢(pián)產
駢(pián)產 駢,指並列或一對。駢產即雙生。詳該條。作者:
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Regulationofphosphatidylinositol3–kinasebypolyisoprenylphosphatesinneutrophil-mediatedtissueinjury
...CenterofExperimentalTherapeuticsandReperfusionInjury,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA021152DepartmentofChemistry,UniversityofSouthernCalifornia,CA90089Neutrophilsplayacentralroleinhostdefense,inflammation,andtissueinjury.Recentfindingsindicateanovelroleforpolyisoprenylpho...
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SafetyandEfficacyofMechanicalEmbolectomyinAcuteIschemicStroke
...ork,NYOregonHealthScienceUniversity(H.L.L.,G.M.N.),PortlandSaintLuke’sHospital(T.G.,M.M.R.),KansasCity,MoHartfordHospital(I.E.S.),Hartford,ConnDepartmentofRadiology(R.T.H.),UniversityofCalifornia,SanFranciscoRiversideMethodistHospital(R.F.B.),Columbus,OhiotheDepartmentofRadiology(M.P.M.),StanfordU...
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Pioglitazonemitigatesrenalglomerularvascularchangesinhigh-fat,high-calorie-inducedtype2diabetesmellitus
...beingfedahigh-fat-caloriediet,andanincreaseinPPARactivitywasinducedbyaddingpioglitazone(Pi)tothediet.Miceweregroupedasfollows:normalcaloriediet(N),D,N+Pi,andD+Pi(n=6/group).Theglomerularfiltrationrate(GFR),renalarterybloodflowandpressure,andplasmaglucoseweremeasured.Renalglomeruliandpreglomerularart...
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ProtectionfromangiotensinII–mediatedvasculotoxicandhypertensiveresponseinmicelackingPI3K
...el,Switzerland4DipartimentodiMedicinaSperimentaleePatologia,UniversitàLaSapienzadiRoma,00161Roma,ItalyHypertensionaffectsnearly20%ofthepopulationinWesterncountriesandstronglyincreasestheriskforcardiovasculardiseases.Inthepathogenesisofhypertension,thevasoactivepeptideoftherenin-angiotensinsystem,an...
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抗逆轉錄病毒與骨量減少及骨質疏鬆的流行
...:HIV-陽性vsHIV-陰性;ART-治療vsART-未治療;蛋白酶抑制劑(PI)-治療vsPI-未治療,採用隨機效應模型產生混合OR和置信區間。結果可見,在所有的37篇研究中,有20篇研究符合入選標準。在884例HIV感染患者中,67%出現BMD減低,其中15%患...
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江浙滬地區漢族人羣9個STR座位遺傳多態性研究
...g平衡(P0.05)。其多態信息量(Polymorphisminformationcontent,PIC)均大於0.7201,雜合度(heterozygosity,H)均大於0.7296,個體識別力(powerofdiscrimination,DP)均大於0.7903,非父排除率(probabilityofpaternityexclusion,PE)均大於0.5306。隨機個...
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Phosphatidylinositol3,4,5-trisphosphate:anearlymediatorofinsulin-stimulatedsodiumtransportinA6cells
【摘要】InsulinstimulatessodiumtransportacrossA6epithelialcellmonolayers.Activationofphosphatidylinositol3-kinase(PI3-kinase)wassuggestedasanearlystepintheinsulin-stimulatedsodiumreabsorption(Ref.35).ToestablishthatthestimulationofthePI3-kinasesignalingcascadeiscausingstimulationofapicalepitheli...
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Centralcontrolofrenalsodium-phosphate(NaPi-2)transporters
【摘要】Regulationofphosphate(Pi)reabsorptionoccursthroughtheup-anddownregulationoftherenaltype-IIsodiumPicotransporters(NaPi-2).Recently,renalNaPi2-typeexpressionhasbeenidentifiedinareasofthebrain.ThepresentstudydeterminedwhetherbrainNaPi-2isregulatedbydietaryPiandwhetherthebehavioralandrenalad...
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LuminalflowinduceseNOSactivationandtranslocationintheratthickascendinglimb.II.RoleofPI3-kinaseandHsp9
...WefoundthataugmentingluminalflowinduceseNOSactivationandtranslocationtotheapicalmembraneofTHALs(OrtizPA,HongNJ,andGarvinJL.AmJPhysiolRenalPhysiol287:F274-F280,2004).Inothercells,eNOSactivationbyshearstressismediatedbyphosphatidylinositol3-OHkinase(PI3)-kinase.WehypothesizedthatluminalflowinduceseNOS...
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CardiacSarcoplasmicReticulumCalciumReleaseandLoadAreEnhancedbySubcellularcAMPElevationsinPI3K-DeficientMice
...,Austria.AbstractWerecentlyshowedthatphosphoinositide-3-kinase-eCdeficient(PI3KeC/eC)micehaveincreasedcardiaccontractilitywithoutchangesinheartsizecomparedwithcontrolmice(ie,PI3K+/+orPI3K+/eC).Inthisstudy,weshowthatPI3KeC/eCcardiomyocyteshaveelevatedCa2+transientamplitudeswithabbreviateddecaykinetic...
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Magnesiumrequirements:newestimationsformenandwomenbycross-sectionalstatisticalanalysesofmetabolicmagnesiumbalancedata
...qualtomagnesiumintake(M)]atmagnesiumintakesof165mg/d[95%predictioninterval(PI):113,237mg/d;Y=19.8+0.880M],2.36mg·kg1·d1(95%PI:1.58,3.38mg·kg1·d1;Y=0.306+0.870M),or0.075mg·kcal1·d1(95%PI:0.05,0.11mg·kcal1·d1;Y=0.0...
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IntestinalNa-PicotransporteradaptationtodietaryPicontentinvitaminDreceptornullmice
...ntestinalNa+-dependentphosphatetransportadaptationtovariablelevelsofdietaryPi.Therefore,thegoalofthecurrentstudywastoassessNa+-dependentPicotransportactivityintransgenicmicetodeterminewhethervitaminDisanessentialmediatorofthisprocess.Intestinalbrush-bordermembrane(BBM),Na+-dependentPicotransportacti...
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氨基酸分子的模糊聚類分析
【摘要】本文選用氨基酸分子的相對分子量、pI值、疏水性值以及保守性值這四個參數,利用模糊聚類的方法,對20種氨基酸分子進行了分類。通過對分類結果的分析,有助於我們研究蛋白質的相似性問題。【關鍵詞】氨基酸;...
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資深PI最新文章解析信號通路
來自新加坡分子與細胞生物學研究院,癌症與發育細胞生物學部的研究人員獲得了YAP-TEAD4複合物在YAP因子N端結構域相互作用,以及在TEAD4C端結構域與YAP相互作用的晶體結構,從中研究人員認爲YAP中的PXXΦP片段是與TEAD4相互作用...
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PI3K-AktPathwaySuppressesCoagulationandInflammationinEndotoxemicMice
...issuefactor(TF).Inthisstudy,weanalyzedtheroleofthephosphoinositide3-kinase(PI3K)-Aktpathwayintheactivationofcoagulationandtheinnateimmuneresponseinamousemodelofendotoxemia.MethodsandResults—WortmanninandLY294002wereusedtoinhibitthePI3K-Aktpathway.WefoundthatwortmannininhibitedLPS-inducedAktphospho...
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Adenovirus-MediatedIntraarterialDeliveryofPTENInhibitsNeointimalHyperplasia
...Durham,NC27710.E-mailcdkontos@duke.eduAbstractObjective—Phosphoinositide(PI)3-kinasepromotesvascularsmoothmusclecell(VSMC)responsesnecessaryforneointimalhyperplasia.Werecentlydemonstratedthattheinositol3-phosphatasePTENisexpressedinVSMCsandthatitsoverexpressioninhibitsthesecellularresponses.Thepur...
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Inhibitionofphosphatidylinositol3-kinasestimulatesactivityofthesmall-conductanceKchannelintheCCD
...WeusedWesternblottingtoexaminetheexpressionofphosphatidylinositol3-kinase(PI3K)intherenalcortexandoutermedullaandemployedthepatch-clamptechniquetostudytheeffectofPI3KontheROMK-likesmall-conductanceK(SK)channelsinthecorticalcollectingduct(CCD).LowKintakeincreasedtheexpressionofthe110-kDa-subunit(p110...
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納洛酮對重型顱腦損傷腦血流動力學及顱內壓的影響
...壓監護儀監測顱內壓。結果治療組腦血流動力學Vs、Vm、PI值在納洛酮治療3天后與對照組相比明顯改善(P<0.05);治療組在第3天后平均顱內壓明顯低於對照組(P<0.05)。結論大劑量納洛酮能夠改善重症顱腦損傷引起的腦血流動...
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PredictorsofHIVDrug-ResistanceMutationsinaLargeAntiretroviral-NaiveCohortInitiatingTripleAntiretroviralTherapy
...ishColumbia,Canada.Methods.Allplasmasampleswithplasmavirusloads(pVLs)1000copies/mLcollectedduringthefirst30monthsoffollow-upweregenotypedfordrugresistance.Theprimaryoutcomemeasurewastimetothefirstdetectionofmajordrug-resistancemutation(s).Coxproportionalhazardregressionwasusedtoidentifyfactorssignif...
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PI3Kintegratestheactionofinsulinandleptinonhypothalamicneurons
...shington,USA.AbstractCentralcontrolofenergybalancedependsontheabilityofproopiomelanocortin(POMC)oragouti-relatedprotein(Agrp)hypothalamicneuronstosenseandrespondtochangesinperipheralenergystores.Leptinandinsulinhavebeenimplicatedascirculatingindicatorsofadiposity,butitisnotclearhowchangesintheirleve...
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蛋白質組鑑定技術
...Phospho或Fluoroimagers,對圖象進行數字化.併成爲以象素(pixels)爲基礎的空間和網格.其次,在圖象灰度水平上過濾和變形,進行圖象加工,以進行斑點檢測.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意義的區域與背景分...
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蛋白質組鑑定技術
...Phospho或Fluoroimagers,對圖象進行數字化.併成爲以象素(pixels)爲基礎的空間和網格.其次,在圖象灰度水平上過濾和變形,進行圖象加工,以進行斑點檢測.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意義的區域與背景分...
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蛋白質組鑑定技術
...Phospho或Fluoroimagers,對圖象進行數字化.併成爲以象素(pixels)爲基礎的空間和網格.其次,在圖象灰度水平上過濾和變形,進行圖象加工,以進行斑點檢測.利用Laplacian,Gaussian,DOG(differenceofGaussians)opreator使有意義的區域與背景分...
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PAR1,butNotPAR4,ActivatesHumanPlateletsthroughaGi/o/Phosphoinositide-3KinaseSignalingAxis
...wthatPAR1couplestoGi/oinhumanplateletsandactivatesphosphoinositide-3kinase(PI3K).PI3KactivationregulatesplateletintegrinIIb3activationandplateletaggregationandpotentiatesthePAR1-mediatedincreaseinintraplateletcalciumconcentration.PI3KinhibitorseliminatedtheseeffectsdownstreamofPAR1,buttheyhadnoeffec...
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CilostazolProtectsAgainstBrainWhiteMatterDamageandCognitiveImpairmentinaRatModelofChronicCerebralHypoperfusion
...dimmunohistochemistryfor4-hydroxy-2-nonenal(HNE),glutathione-S-transferase-pi(GST-pi),ionizedcalcium-bindingadaptormolecule1,phosphorylatedCREB(p-CREB),Bcl-2,andcyclooxygenase-2(COX-2)wereanalyzedatbaselineandat3,7,14,21,and28daysafterhypoperfusion.Result—Cilostazolsignificantlyimprovedspatiallear...