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抗胃食管反流外科治療的遠期療效觀察
...管反流外科治療的遠期療效。研究者1988年11月至2004年1月手術治療129例胃食管反流病(GERD)，分別採用Nissen手術(65例)、賁門斜行套疊術(39例)、Belsey4號手術(17例)、Toupet手術(3例)、Thal手術(1例)、Dor手術(4例)等6種方法治療。116例得到...
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惠州地區地中海貧血調查
...詞】地中海貧血；檢出率；血紅蛋白 SurveyofincidenceofthalassemiainHuizhouArea. WUYuan-zhong,YUXiao-yan,DINGFa-ying,etal. (HuizhouMunicipalCentralPeople’sHospital,Huizhou516001,Guangdong,P.R.China) Abstract:ObjectiveTosurveytheprevalenceofthalassemiainHu...
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Confocalmicroscopyofthecorneainnephropathiccystinosis
1AnteriorSegmentDivision,DepartmentofOphthalmology,KingKhaledEyeSpecialistHospital,Riyadh,KingdomofSaudiArabia2PediatricOphthalmologyandStrabismusDivision,DepartmentofOphthalmology,KingKhaledEyeSpecialistHospital,Riyadh,KingdomofSaudiArabiaKeywords:confocalmicroscopy;cornea;nephropathiccystinosisCys...
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糖尿病心血管疾病的非降脂治療與臨牀評價
...ransplantn=64n=72n=80n=142n=149n=925n=43n=43PositiveETTPositiveAngiography(thal201)36%24%9%31%30%12.1%65%40%58%55%9%11%9%12.1%5.3%6.4%——35%43%IndicationsforCardiacTestinginDiabeticPatientsTypicaloratypicalcardiacsymptomsRestingECGsuggestiveofischemiaorinfarctionPeripheralorcarotidocclusivearteri...
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多囊卵巢綜合徵中西醫結合診療淺議
...監測排卵，排卵率達89.7%，6個月的累計妊娠率爲68.5%。3.4手術治療3.4.1腹腔鏡手術適用於嚴重PCOS對促排卵治療無效者。在腹腔鏡下對多囊卵巢用電凝或激光技術穿刺打孔，每側卵巢打孔4個爲宜，既能獲得90%排卵率和70%妊娠率，又...
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多發性骨髓瘤治療新突破
...、8、11,馬法蘭(Mel)0.15mg/kgd1~4,Dex12mg/m2d1~4、d17~20,沙利度胺(Thal)100mg/d,28天一週期]的VMDT方案治療復發/難治性MM的Ⅱ期臨牀試驗結果。該研究共有31例患者入組,其中20例爲難治性復發患者,至報告時有25例患者可評價治療反應,14例(56%)達...
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SuperoxideenhancesNa-K-2Clcotransporteractivityinthethickascendinglimb
...ichiganABSTRACTSuperoxide(O2)enhancesNareabsorptionbythethickascendinglimb(THAL).NaabsorptioninthissegmentinvolvestheNa-K-2Clcotransporter,Kchannel,andNa-K-ATPase.WehypothesizedthatO2stimulatesNaClabsorptionprimarilybyenhancingNa-K-2Clcotransport.First,wemeasuredsteady-stateintracellularNa(Nai)andch...
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廣東順德地區β-地中海貧血流行病學調查
...因突變；流行病學調查 Epidemiologicalinvestigationofβ-thalassemiainShundeAreaofGuangdong. XIEJian-min,LIANGYu-quan,WUSu-qin. ShundeDistrictFirstPeople’sHospitalofFoshanCity,Foshan528300,Guangdong,P.R.China Abstract：ObjectiveToinvestigatethecarryingrateandfre...
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LuminalflowinduceseNOSactivationandtranslocationintheratthickascendinglimb.II.RoleofPI3-kinaseandHsp9
...nthase(eNOS)regulatesNaClabsorptionbythethickascendinglimboftheloopofHenle(THAL).WefoundthataugmentingluminalflowinduceseNOSactivationandtranslocationtotheapicalmembraneofTHALs(OrtizPA,HongNJ,andGarvinJL.AmJPhysiolRenalPhysiol287:F274-F280,2004).Inothercells,eNOSactivationbyshearstressismediatedbyph...
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食管裂孔疝（外科）
...，而非食管運動障礙所致。長時pH監測法：以前作過食管手術的病人，合併其他疾病者，懷疑有返流引起吸入性肺炎或患“心絞痛”的病人，爲其使用24hpH連續監測可提供寶貴的診斷資料。作系列標準的食管功能試驗測定後，pH電...
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環境雌激素的研究進展
...tylphenol）和壬基酚（4-Nonylphenol）等;（5）酞酸酯類（PAEsphthalates）:其中DEP，DMP和DOP已被我國確定爲環境優先控制污染物［3］。（6）金屬化合類:目前以三丁基錫研究較多。 （7）其它環境激素類。 2EEs對人體健康的危害和...
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EvaluationofRibotypingasaToolforMolecularTypingofYersiniapseudotuberculosisStrainsofWorldwideOrigin
...ndY.enterocoliticaInfectionsinSheepinAustralia.J.Clin.Microbiol.30:712-715.Thal,E.1973.ObservationsonimmunityinYersiniapseudotuberculosis.Contrib.Microbiol.Immunol.2:190-195.Toyokawa,Y.,Y.Ohtomo,T.Akiyama,K.Masuda,M.Kasai,S.Kaneko,andT.Maruyama.1993.LargescaleoutbreakofYersiniapseudotuberculosissero...
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Bonecalciumturnoverduringpregnancyandlactationinwomenwithlowcalciumdietsisassociatedwithcalciumintakeandcirculatinginsulin-likegrowthfac
...analyses.JCKwasresponsiblefortheconceptionandfundingofthestudyandassistedwithallaspectsofthestudyimplementationandanalysisandwiththemanuscriptpreparation.Noneofthestudyauthorshadanypersonalorfinancialaffiliationswiththesupporterofthisresearch.REFERENCESReceivedforpublicationJuly25,2005.Acceptedforpu...
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Endothelinstimulatesendothelialnitricoxidesynthaseexpressioninthethickascendinglimb
...Endothelin-1(ET-1)acutelyinhibitsNaClreabsorptionbythethickascendinglimb(THAL)byactivatingtheETBreceptor,stimulatingendothelialnitricoxidesynthase(eNOS),andreleasingnitricoxide(NO).Innonrenaltissue,chronicexposuretoET-1stimulateseNOSexpressionviatheETBreceptorandactivationofphosphatidylinositol3-kin...
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ClonalSpreadofaVancomycin-ResistantEnterococcusfaeciumStrainamongBloodstream-InfectingIsolatesinItaly
...trophoresis:criteriaforbacterialstraintyping.J.Clin.Microbiol.33:2233-2239.Thal,L.,S.Donabedian,B.Robinson-Dunn,J.Chow,L.Dembry,D.Clewell,D.Alshab,andM.Zervos.1998.Molecularanalysisofglycopeptide-resistantEnterococcusfaeciumisolatescollectedfromMichiganhospitalsovera6-yearperiod.J.Clin.Microbiol.36:...
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Ahigh-saltdietstimulatesthickascendinglimbeNOSexpressionbyraisingmedullaryosmolalityandincreasingreleaseofendothelin-1
...TAhigh-saltdietincreasesrenalendothelin(ET)productionandthickascendinglimb(THAL)endothelialnitricoxidesynthase(eNOS)expression.ETstimulatesTHALeNOSexpressionviaETBreceptors.Thetonicityoftherenalmedullaishighlyvariable,andhyperosmolalitystimulatesET-1synthesisbyendothelialcells.Wehypothesizedthatahig...
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CharacterizationofVancomycin-ResistantEnterococcusfaeciumIsolatesfromBroilerPoultryandPigFarmsinEnglandandWales
...EFisolateswereselectedbytheircolonymorphologyandcolor(purple-pinkcolonieswithalighterhalo),subcultured,andstoredat–70°C.TheidentityofthepresumptiveE.faeciumisolateswasconfirmedbyreal-timePCR.AmplificationwasperformedinaLightCyclerinstrument(RocheDiagnosticsUKLtd.,Lewes,UnitedKingdom)inglasscapill...
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腎綜合徵出血熱流行病學研究進展
...和捷克的Tula病毒宿主爲歐洲的普通田鼠。帶Thottapalayan和THAL的宿主動物僅在南亞和東南亞分佈［27］。日本HV的宿主爲棕背平鼠、褐家鼠、黑家鼠和大林姬鼠［17］。歐洲DOB病毒宿主爲黑線姬屬和黃頸姬鼠［26］。我國HFRS疫源地監...
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Aminoglycoside-InducedDegenerationofAdultSpiralGanglionNeuronsInvolvesDifferentialModulationofTyrosineKinaseBandpNeurotrophinReceptorSignali
...ionindegeneratingSGNs,concomitantwithatemporaldeclineofSGNdensityintheRosenthal??scanalwherethesemolecularchangesoccur.Coincidentally,theproportionofdegeneratingneuronsexpressingphosphorylatedc-Jun,atargetofp75NTR-mediatedpathway,27,28isincreased,whereasthereisaconversedeclineintheproportionofneuron...
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ThalidomideasaPotentInhibitorofNeointimalHyperplasiaAfterBalloonInjuryinRatCarotidArtery
...isoneofthemainpathogenesesofneointimalhyperplasiaaftercoronaryintervention.Thalidomide,becauseofitspotentantiinflammatoryandimmunomodulatoryproperties,isbeingre-evaluatedinseveralclinicalfields.Therefore,weexaminedwhetherthalidomidetherapyaffectsneointimalformation.MethodsandResults—InmaleSprague-...
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Regulationofthickascendinglimbtransport:roleofnitricoxide
...ecteffectsofnitricoxide(NO)onindividualtransportersofthethickascendinglimb(THAL)cell.NOdirectlyinhibitsNa+-K+-2Cl-cotransportandNa/Hexchangers(NHE1/3).NOinhibitstheNa+-K+-ATPasepumpbyreactingwithO2-andformingOONO-.TheeffectofNOoninwardlyrectified(ROMK)channelsremainscontroversial.(-),Inhibition;(?),...
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RenewalofMuralThrombusReleasesPlasmaMarkersandIsInvolvedinAorticAbdominalAneurysmEvolution
...emedia,andahigherlevelofimmuno-inflammationintheadventitia.6Thiscontrastswithalowerlevelofproteaseactivitieswithinthethrombus-exposedarterialwallascomparedwiththewallnotexposedtothrombusactivity.7Themuralthrombusisenrichedwithplasminogen-plasmin,3andfibrinolysispredominatesintheabluminalpartofthethr...
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MiceDeficientfortheTypeIITransmembraneSerineProteaseTMPRSS/hepsinExhibitProfoundHearingLoss
...eobtainedandstainedwithhematoxylinandeosin.Thecross-sectionalareaoftheRosenthal??scanal,osseousspirallamina,andtectorialmembranefromthemiddleturnweredeterminedusingamorphometricprogram(AxioVisionLE,Hallbergmoos,Germany).Thesameprogramwasalsousedtomeasurethelongestverticaldistancebetweenthedorsalandv...
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BK-1subunit:immunolocalizationinthemammalianconnectingtubuleanditsroleinthekaliureticresponsetovolumeexpansion
...l.(41)demonstratedflow-activatedeNOSandNOproductioninthethickascendinglimb(THAL).WeandothersshowedthatBKareactivatedbytheNO-cGMP-proteinkinaseGpathway(1,51,52)andthatthisactivationrequiresthepresenceofaBK-1orBK-2subunit(22,61).Weobservednearlyadoublingoftheopenprobability(PO)oncGMPadditioninanexpres...
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ImpairmentofFunctionalCapillaryDensitybutNotOxygenDeliveryintheHamsterWindowChamberduringSevereExperimentalMalaria
...ribundcomparedwithuninfectedcontrols,butthislevelwasmarkedlyhigherthanthelethalthreshold.Nonecroticcellslabeledwithpropidiumiodideweredetectedinmoribundanimalsonday10afterinfection.Wethereforeconcludethatlossoffunctionalcapillariesratherthantissuehypoxiaisamajorlethaleventinseveremalaria.-----------...
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PharmacologicalTargetingofAdipocytes/FatMetabolismforTreatmentofObesityandDiabetes
...persons.Additionalconsiderationstothetherapeuticuseofleptinaretherathershorthalf-lifeofthepeptideinhumans(25min)(Kleinetal.,1996),thehighcostofproduction,andtheneedforinjections,allfactsthatmaketheuseofleptinintheclinicproblematicforroutineusage.Theseconsiderationsalsoapplytoadiponectinandretinolbin...
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InhibitionofNa-K-ATPaseinthickascendinglimbsbyNOdependsonO2-andisdiminishedbyahigh-saltdiet
...nhancesnitricoxide(NO)-inducedinhibitionoftransportinthethickascendinglimb(THAL).LongexposurestoNOinhibitNa-K-ATPaseinculturedcells.WehypothesizedthatNOinhibitsTHALNa-K-ATPaseafterlongexposuresandahigh-saltdietwouldaugmentthiseffect.Ratsdrankeithertapwateror1%NaClfor7-10days.Na-K-ATPaseactivitywasas...
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手術室醫院信息系統的建立與應用體會
【摘要】目的建立手術室醫院信息系統(HIS)，以保證圍手術期患者管理和手術部的安全運轉，達到信息及時準確傳遞及手術相關的統計工作的目的。方法在醫院信息系統運行中逐步優化和完善手術申請、手術安排、手術登記、手...
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優化手術室業務流程提升手術檯利用率
【摘要】 目的找出目前手術室工作的流程中存在的問題，根據問題優化手術室工作流程，提高工作效率。方法運用業務流程再造的技術和方法，對原有的第一臺手術不能按時開始、連臺手術間隔時間太長等不合理的工作流程...
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接臺手術的護理問題及對策分析
【摘要】探討手術室接臺手術中存在的護理問題，加強接臺手術中的護理。根據所存在的護理問題，進行相應的對策分析，確保手術患者的安全。【關鍵詞】接臺手術;護理問題;對策分析隨着手術量的不斷增加，手術室手術的接...
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心氣虛，則脈細；肺氣虛，則皮寒；肝氣虛，則氣少；腎氣虛，則泄利前後；脾氣虛，則飲食不入。
關於Thal-AshcraftandBoix-Ochod手術
Thal-AshcraftandBoix-Ochod手術用於胃食管反流的治療。目前研究認爲胃食管反流病（gastroesophagealrefluxdisease，GERD）是一種多因素促成的原發性上消化道運動障礙性疾病。由於食管下端括約肌（loweresophagealsphincter，LES）功能失調，胃內容物進入食管，導致患者出現症狀及食管黏膜病變。1歲以內主要表現爲溢奶或嘔吐，一般9～24個月好轉。兒童期表現與成人類似，最常見症狀爲反酸，呃逆，燒心，胸痛，咳嗽，氣喘，夜間呼吸暫停及複發性肺炎，氣管痙攣，咽喉炎。有相當長的時間GERD不被認識，因而得不到合理治療。嚴重者可出現吞嚥困難，發展成Barrett食管。自20世紀60年代起至今，對GERD的病因、病理、生理學方面的研究有了新的認識。認爲引起GERD的病理、生理學因素有：食管酸清除率降低，食管下端括約肌張力降低，胃酸水平增高。 ...
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