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17-β雌二醇對卵巢去勢大鼠海馬區tau蛋白Alzheimer樣磷酸化的影響
...化的影響。方法18只雌性成年SD大鼠隨機分爲卵巢去勢組(OVX組)、卵巢去勢+17-β雌二醇組(OVX+17-βE2組)和假手術組(Sham-OVX組),OVX組和OVX+17-βE2組動物卵巢切除後10天起分別皮下注射生理鹽水0.1ml/d、17-β雌二醇20μg/(kg·d)。Sham-OVX組動物...
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Gonadalsteroidregulationofrenalinjuryinrenalwraphypertension
...inRWdiseaseseverityinmale(M)andfemale(F),castrated(Cast),andovariectomized(OVX)ratsandafterdihydrotestosterone(DHT)and17-estradiol(E2)treatment.MalecastrationattenuatedtheseverityofRW-inducedglomerulosclerosis(GS)[GSindex(GSI):RW-M,2.1±0.2;RW-Cast,1.3±0.2;RW-Cast+DHT,2.4±0.4],meanglomerularvolume...
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不同劑量雌激素對去勢大鼠血脂代謝的影響
...方法選用日齡120天雌性SD大鼠,隨機分爲2組:去卵巢組(OVX組)和假去卵巢組(Sham組),OVX組於術後60天再隨機分爲4組皮下注射不同劑量雌激素。於第10次注射雌激素後第2天全部動物均取血,離心分離血清,用酶法測定血脂,...
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染料木素和17β-雌二醇對去卵巢大鼠松質骨微結構的作用
...研究目的是觀察染料木素和小劑量17β-雌二醇對去卵巢(OVX)大鼠松質骨微結構的作用。方法採用90只7月齡SD大鼠被隨機分爲基線組、OVX組、假手術(SHAM)組、小劑量17β-雌二醇干預組(10μg·kg^-1·d^-1,EST組)和染料木素干預組...
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鋁致Alzheimer病對尿中微量元素排出的影響
...SD大鼠29只,隨機分爲卵巢假切組(sham組)、卵巢切除組(ovx組)、卵巢切除合併慢性鋁中毒組(ovx+AL3+組)、卵巢切除合併慢性鋁中毒及尼爾雌醇灌胃組(ovx++AL3++E2組)。收集24的尿液,採用日本島津ICPQ-1012型電感耦合等離子體發射...
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實驗性骨質疏鬆模型骨組織中核因子表達特徵及其意義
...小鼠隨機分假手術對照組(CON組)和去卵巢骨質疏鬆模型組(OVX組),術後第12周測量全身骨密度後處死,取股骨下端用ABC免疫組織化學、原位雜交方法測定骨組織中核因子的蛋白含量及表達水平並進行細胞定位。結果OVX組與CON組相比...
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在去卵巢誘導骨質疏鬆的大鼠中,鍼灸對骨密度的治療和預防作用
...中國天津的醫生合作,對在去卵巢誘導骨質疏鬆的大鼠(OVX)中,鍼灸在它們骨密度的治療和預防作用方面進行了研究,並對不同鍼灸部位在脛骨、股骨或脊椎上是否有不同的治療效果進行了評價。研究選取了35只雌性SD大鼠,...
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IschemicNeuroprotectionWithSelective-OpioidReceptorAgonistIsGenderSpecific
...etofreperfusionandcontinuedfor22hours.Inthesecondexperiment,ovariectomized(OVX)femaleratsweretreatedwithvehicleorBRL.Infarctvolumeinthecortexandcaudoputamen(CP)complexwasassessedbytriphenyltetrazoliumchloridestainingat72hoursafterMCAO.ResultsInfarctvolume(percentageofipsilateralstructure;mean±SEM)w...
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他莫西芬對大鼠子宮內膜增殖和凋亡的影響
...手術組(SHAM組)、假手術+TAM組(SHAM+TAM組)、去勢手術組(OVX組)、去勢手術+TAM組(OVX+TAM組),每組10只,用藥28天后,處死大鼠取子宮進行形態學檢查,PCNA抗原免疫組化分析及TUNEL凋亡檢測。結果他莫西芬可以使去勢大鼠子宮溼...
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雌激素對雙側穹隆-海馬傘切斷及去勢大鼠腦源性神經營養因子表達的影響
...建立4個模型組:穹隆-海馬傘切斷組(FF組)、卵巢切除組(OVX組)、卵巢切除加穹隆-海馬傘切斷組(OF組)和對照組,然後再建立OF組同時給予雌二醇(E2)治療組(OF+E2組)和雙側穹隆-海馬傘切斷加卵巢切除對照組,每組5只。E2劑量爲1mg/kg,...
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IL-6在絕經後骨質疏鬆症發病機制中的作用研究進展
...作一綜述。1藥理研究王寶利等[2]爲了研究尼爾雌醇對OVX大鼠IL-6mRNA表達水平的影響,探討絕經後骨質疏鬆的分子細胞學機制。將30只3月齡雌性Wistar大鼠隨機分成三組,每組10只,即OVX組、假手術組和尼爾雌醇組。對OVX組和尼爾...
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續斷對去勢大鼠骨量和血清IGF-Ⅰ的影響ˇ
...標的影響。方法12月齡雌性SD大鼠隨機分爲空白對照組(OVX)、雌激素對照組(OVX+E)、續斷1、2、3組(OVX+X1、X2、X3),卵巢切除後7天開始給藥,術前和3個月後2次檢測骨量,然後處死大鼠,檢測血清IGF-Ⅰ、ALP、Ca和P。結果空白...
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17-Estradiolreplacementimprovesrenalfunctionandpathologyassociatedwithdiabeticnephropathy
...inwomenandmen.Thisstudyexaminedtheeffectsofestrogendeficiencybyovariectomy(OVX)andreplacementwith17-estradiol(OVX+E2)onrenalfunctionandpathologyinthenondiabetic(ND)andstreptozotocin(STZ)-induceddiabetic(D)ratkidneysfor12wk.Diabeteswasassociatedwithanincreaseinurinealbuminexcretion(UAE;ND,0.39±0.03;...
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EstrogenTreatmentAbrogatesNeointimaFormationinHumanC-ReactiveProteinTransgenicMice
...cularinjuryintheCRPtgmouse.MethodsandResults—Intact(INT)orovariectomized(OVX)CRPtgandNTG,treatedwithE2orvehicle,hadtheirrightcommoncarotidarteryligated.ResultantneointimaformationwasexaggeratedinCRPtgcomparedwithNTG,whetherINTorOVX,butwaspreventedinbothgenotypesbyE2.ExpressionofhumanCRPprotein(imm...
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性激素紊亂對新生小鼠下頜骨內部結構的影響
...影響。他們分析了施行睾丸切除術(ORX)或卵巢切除術(OVX)的新生小鼠下頜骨的內部結構。40只5日齡C57BL/6J小鼠分別接受ORX、OVX和假手術。手術後8周,對每隻小鼠的下頜骨進行組織形態測定分析,應用外周骨定量斷層掃描儀(...
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激素替代對猴宮骶韌帶和圓韌帶生物力學特性的影響
...外科醫師學院的VardyMD博士及其同事研究了卵巢切除術(OVX)和共軛馬雌激素加宮安黃體酮(CEE/MPA)或乙炔基雌二醇加炔諾酮(EE/NA)對絕經後(PMP)猴宮骶韌帶(USL)及圓韌帶(RL)生物力學特性的影響。在這項隨機三盲安慰劑...
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降鈣素對骨性關節炎中軟骨作用的研究進展
...現爲輕度的浸潤和蛋白多糖的丟失,出現軟骨潰爛。但是OVX模型還是代表早期或者破壞性不強的疾病的,因此,OVX模型適合作爲關節炎早期的研究〔18〕。汪韜等〔19〕對OVX大鼠進行研究,結果表明CT能阻止骨量的丟失,阻止椎間...
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甲狀旁腺激素治療去勢大鼠顱骨缺損的研究
...monefragment134onbloodCa2+,PO43-andPTHconcentrationinovariectomizedrats(OVX).MethodsTwentyfour6monthWistarratsweredividedinto3groupsrandomly,sham,OVXandOVXtreatedbyPTH134.TheBoneMineralDensityof6ratsselectedrandomlywerevaluedandconfirmedosteoporosismodels.Theotherswith8mmdefectinskullwer...
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米索前列醇對去勢後大鼠早期骨丟失的保護
...theinfluenceofmisoprostolonbonemineraldensity(BMD)inovariecˉtomized(OVX)rats.Methods30femaleWistarratsaged90dweredividedinto3groups:Sham,OVX,OVX+misoprostolwith10ratsineachgroup.TheOVX+misoprostolgroupwastreatedorally2mg/(kg·d)misoprostolafter28days.Allratsweresacrificedfortreatmen...
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再灌注早期應用雌二醇對缺血鼠心肌的保護作用
...,採用Langendorff離體鼠心臟灌注模型,將30只雌性卵巢切除(OVX)大鼠隨機均分爲3組。缺血再灌注組(I-R組)用K-H液預灌注15min,常溫停灌30min,恢復K-H液再灌注30min;0.1%二甲基亞碸組(D組)和5μmol/LE2組(E組)從再灌注第6min起改用含相應藥液的...
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再灌注早期應用雌二醇對缺血鼠心肌的保護作用
...,採用Langendorff離體鼠心臟灌注模型,將30只雌性卵巢切除(OVX)大鼠隨機均分爲3組。缺血再灌注組(I-R組)用K-H液預灌注15min,常溫停灌30min,恢復K-H液再灌注30min;0.1%二甲基亞碸組(D組)和5μmol/LE2組(E組)從再灌注第6min起改用含相應藥液的...
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局部注射緩釋型bBMP對去勢綿羊椎體骨骼影響的研究
...松椎體骨強度的局部治療方法。研究者採用卵巢切除法(OVX)對6只成年雌性綿羊去勢,低鈣飼養1年後,經雙能X線吸收骨密度測量儀檢測後確定建立骨質疏鬆模型。採用拉丁方設計方案,通過經椎弓根注射途徑,分別在每隻動物...
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Lipidstandardizationofserumfat-solubleantioxidantconcentrations:theYALTAstudy
...analyzedasadependentvariableonlipoproteincharacteristicsbytheuseofaseriesofmodels.Model1containedonlyplasmatotalcholesterolasanindependentvariable.Model2hadonlyplasmaLDLcholesterol;model3hadplasmatotalcholesterolandVLDLcholesterol;model4hadplasmaLDL,HDL,andVLDLcholesterolsimultaneously.Notethatbecau...
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Associationbetweendietaryglycemicindex,glycemicload,andbodymassindexintheInter99study:isunderreportingaproblem?
...sweredefinedasthosehavinganEI/BMR1.14.UnivariateandmultiplelinearregressionmodelswereusedtotestforassociationsbetweenGI,GL,andBMI.Theconfoundersweresex,age,smoking,physicalactivity,alcoholintake,andenergyintake.Allanalyseswereconductedon1)theentirepopulationand2)asubsampleexcludingLERs.Results:Inthe...
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ATNFreceptorlooppeptidemimicblocksRANKligand-inducedsignaling,boneresorption,andboneloss
...fcharacteristicrepeatedcysteine-richdomains(CRDs)(25).Mutagenesis,molecularmodelingstudies,andcrystalstructuresofp55typeITNFR/TNF-?(22)andTRAIL/deathreceptor5(23,24)complexesindicatethatTNFRmembershave2ligandcontactsurfacesatconservedlocations(CRD2andCRD3intheTNFR).Whilethelocationsandgeneralnatureo...
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LowfolatestatusisassociatedwithimpairedcognitivefunctionanddementiaintheSacramentoAreaLatinoStudyonAging
...tisticalanalysisMultiplelinearregressionanalyseswereusedtobuild4statisticalmodelstodescribetheassociationsbetweenRBCfolateconcentration(independentvariable)andeachofthecognitivefunctiontestinstruments(dependentvariables)before(model1)andafteradjustmentforconfoundingbyhomocysteinealone(model2),byhomo...
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Relationsoftotalphysicalactivityandintensitytofitnessandfatnessinchildren:theEuropeanYouthHeartStudy
...er4consecutivedays(2weekdaysandatleast1weekendday)withanactivitymonitor(MTImodelWAM7164;ManufacturingTechnologyInc,Shalimar,FL,formerlyknownasComputerScienceandApplicationsInc)attachedontherighthip.Atleast3daysofrecording,withaminimumof10hregistrationperday,wassetasaninclusioncriterion.TotalPA(alsoc...
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Weight,shape,andmortalityriskinolderpersons:elevatedwaist-hipratio,nothighbodymassindex,isassociatedwithagreaterriskofdeath
...intilesbysex-specificquintilesandrelatedtomortalityriskbyusingCoxregressionmodels.Three-wayinteractionsweretestedbetweeneachanthropometricvariable(BMI,WHR,andWC)withsexandcurrentsmokingstatusforall-causeandcirculatorymortality.Allmodelswereadjustedforthelineareffectsofheightandage,whichwasconsidered...
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LipidprofilesinadolescentFilipinos:relationtobirthweightandmaternalenergystatusduringpregnancy
...ationduringpregnancyhaslong-termeffectsonlipidmetabolisminoffspringinanimalmodels(7,8),fewstudiesinhumanshaveinvestigatedthepossibleroleofmaternalnutritionduringpregnancyintheserelations(9).Ofthe3studiesofcholesterolthatincludedmarkersofmaternalnutritionalstatusduringpregnancy,poormaternalnutritiona...
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LongitudinalmeasuresofcirculatingleptinandghrelinconcentrationsareassociatedwiththegrowthofyoungPeruvianchildrenbutarenotaffectedbyzinc
...oreandafterthefeedingwithanelectronicinfantbalancewith5gprecision(BabyScalemodel231;Seca,Hamburg,Germany).Childrenwhowerenotbreastfeedingwerefedthetypicalnon-humanmilksubstituteusedinthiscommunity(reconstitutedevaporatedorpowderedcowmilk),andtheamountsofmilkandwaterwereweighedwithanelectronicbalance...