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美國生命治療公司啓動肝穩定性臨牀試驗
...將有20家來自美國和歐洲的領先肝臟學術機構會參與此次SILVER(StabilizationInLiVERdisease)研究。SILVER治療方案要求入組病人患有慢性肝病,並且根據終末期肝病評分模型(MELD)的標準,最近曾有過急性發作,並出現過慢加急肝衰竭現象...
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美國生命治療公司啓動肝穩定性臨牀試驗
...將有20家來自美國和歐洲的領先肝臟學術機構會參與此次SILVER(StabilizationInLiVERdisease)研究。SILVER治療方案要求入組病人患有慢性肝病,並且根據終末期肝病評分模型(MELD)的標準,最近曾有過急性發作,並出現過慢加急肝衰竭現象...
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Science熱議,夢魘照進現實?
...cience雜誌消息,美國知名學府普林斯頓大學的遺傳學家LeeSilver與AnneMorriss成立了一家名爲GenePeeks的公司。該公司旨在依據父母的DNA預測其虛擬後代的患病風險,以提高父母懷上健康後代的機率。該公司的計劃於十月三日被公佈在...
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交流診療技術推動足踝外科發展——全國足踝部疾病診斷及治療研討學習班在京舉辦
...療採用各種第一蹠骨截骨術恢復正常的IMA爲主,同時進行Silver軟組織手術;對於PASA(近端關節固定角)增大,其他角正常的,治療以恢復正常PASA爲主,適宜採用Reverdin或者Austin,同時加用Silver軟組織手術;對於單純的HVA(拇外翻角)...
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Nature重大成果:癱瘓康復或指日可待
...究的高級研究員、凱斯西儲大學醫學院神經科學教授JerrySilver說:“對於數百萬的人們有可能在某一天能夠重獲脊髓損傷過程中喪失的運動能力,我們感到非常的興奮。”每年,有成千上萬的人因脊髓損傷而癱瘓。損傷擠壓並切...
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美國發現脂肪儲存重要基因
...方法。 美國紐約艾伯特#8226;愛因斯坦醫學院的DavidL.Silver博士說,因爲在所有的真核細胞生命中,從最簡單的酵母到最複雜的人類,細胞內脂肪滴儲存脂肪的能力都是最基本的過程,所以我們試圖尋找編碼與脂肪儲存相關蛋...
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PNAS驚人發現:以癌克癌,循環腫瘤細胞“再立功”
...,並揭示了在小鼠模型中的檢測結果。通過向血液中注射silver-bullet對抗癌症一直是科學家們的研究方向之一。這種silver-bullet能夠在身體內移動,直到找到腫瘤;當它們發揮功效時,bullet會打開,利用化學物質攻擊腫瘤。這種方法...
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美髮現自閉症新生物標誌物
近期,南佛羅里達大學精神病學系和Silver兒童發展中心的研究小組在《美國實驗生物學學會聯合會雜誌》上發表研究報告\AberrantT-lymphocytedevelopmentandfunctioninmiceoverexpressinghumansolubleamyloidprecursorprotein-α:implicationsforautism\稱:與泛自...
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科學家用基因工程與實驗動物追溯人類進化
...不過,通過該努力,Wray和杜克大學發育神經生物學家DebraSilver,觀察了人類調控元件HARE5是如何改變小鼠的。研究顯示,攜帶人類HARE5的小鼠胚胎形成的大腦大了12%。“HARE5可以很容易地成爲人類大腦如何擴展的重要部分。”俄亥...
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氧療與手術切口感染
...岱明.現代感染病學.上海:上海醫科大學出版社,1998,36-55.4SilverⅠ.TissuePO2changesinacuteinflammation.AdvExpMedBiol,1978,94:769-774.5KlebanoffS.Oxygenmetabolismandthetoxicpropertiesofphagocytes.AmInternMed,1980,93:480-489.6HuntT,LinseyM,GrislisG,etal.Theeffectofdifferingambiento...
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EndogenousIRBPcanbedispensableforgenerationofnaturalCD4+CD25+regulatoryTcellsthatprotectfromIRBP-inducedretinalautoimmunity
...athol.65:152–160.Avichezer,D.,R.S.Grajewski,C.C.Chan,M.J.Mattapallil,P.B.Silver,J.A.Raber,G.I.Liou,B.Wiggert,G.M.Lewis,L.A.Donoso,andR.R.Caspi.2003.Animmunologicallyprivilegedretinalantigenelicitstolerance:majorroleforcentralselectionmechanisms.J.Exp.Med.198:1665–1676.Liou,G.I.,Y.Fei,N.S.Peachey...
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Roleof2-integrinsforhomingandneovascularizationcapacityofendothelialprogenitorcells
...isandarteriogenesis.Nat.Med.6:389–395.Asahara,T.,T.Murohara,A.Sullivan,M.Silver,R.vanderZee,T.Li,B.Witzenbichler,G.Schatteman,andJ.M.Isner.1997.Isolationofputativeprogenitorendothelialcellsforangiogenesis.Science.275:964–967.Shi,Q.,S.Rafii,M.H.Wu,E.S.Wijelath,C.Yu,A.Ishida,Y.Fujita,S.Kothari,R.M...
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Functionaldisruptionof4integrinmobilizesbonemarrow–derivedendothelialprogenitorsandaugmentsischemicneovascularization
...ciationgrant(0430135NtoG.Qin).ReferencesAsahara,T.,T.Murohara,A.Sullivan,M.Silver,R.vanderZee,T.Li,B.Witzenbichler,G.Schatteman,andJ.M.Isner.1997.Isolationofputativeprogenitorendothelialcellsforangiogenesis.Science.275:964–967.Rafii,S.,andD.Lyden.2003.Therapeuticstemandprogenitorcelltransplantatio...
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NatureCommunications:缺血壞死心肌交感神經支配或能重建
...igmapeptide,ISP),一直被CaseWesternReserveUniversity神經科學的Silver教授用於脊髓修復的研究。他與同事從事心臟病研究的Habecker教授交流時發現心肌“疤痕”與脊髓損傷有共同之處-脊髓損傷和有神經損傷的心肌都存在一種蛋白多糖的...
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低氧血癥和高血糖症對正常貓視網膜pH的影響
...thalmol.2005Dec;123(12):1684-90.41美國埃文斯通西北大學的Padnick-SilverL博士及其同事研究了急性低氧血癥和高血糖症對視網膜pH的影響以瞭解高血糖症在正常完整貓視網膜中誘導的變化。研究人員在血氧正常(動脈血氧分壓[PaO2]=114.5±7.9m...
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輸卵管妊娠治療後的生殖狀態
...娠率分別爲49.3%和53.0%;再次異位妊娠率爲9.9%和14.8%。在Silver等[12]的一項前瞻性研究中,輸卵管切除與保留術後的宮內妊娠率分別爲53.8%和60.0%;再次異位妊娠率爲7.7%和18.3%。結果表明,保守術後的宮內妊娠率至少不低於輸卵...
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研究發現負責在細胞中儲存脂肪的基因
...。在最新的研究中,美國艾伯特·愛因斯坦醫學院的DavidSilver和同事發現了兩個將脂肪打包成脂滴的關鍵基因,分別爲FIT1和FIT2。這兩個基因彼此有50%的相似之處,它們編碼的蛋白質長度超過200個氨基酸,且這種蛋白不與任何其它...
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老年人母外翻畸形圍手術期處理
...cBride手術+第Ⅰ蹠骨基底截骨+第Ⅱ趾趾間關節成形術1足,Silver手術2足,Austin手術1足(圖1)。圖1主要手術方式圖1a.Keller手術;圖1b.Keeller手術+Ⅰ蹠骨基底截骨;圖1c.Keller手術+Ⅰ蹠骨基底截骨+Ⅱ趾蹠趾和趾間關節成形術;圖1d.McBr...
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HistonedeacetylaseactivityisessentialfortheexpressionofHoxA9andforendothelialcommitmentofprogenitorcells
....Blood.102:2555–2561.Asahara,T.,H.Masuda,T.Takahashi,C.Kalka,C.Pastore,M.Silver,M.Kearne,M.Magner,andJ.M.Isner.1999.Bonemarroworiginofendothelialprogenitorcellsresponsibleforpostnatalvasculogenesisinphysiologicalandpathologicalneovascularization.Circ.Res.85:221–228.Kalka,C.,H.Masuda,T.Takahashi,...
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RetinalchangesinjuvenileXlinkedretinoschisisusingthreedimensionalopticalcoherencetomography
...kedrecessiveretinaldisorder,thecharacteristicfunduscopicfindingsofwhichareasilver-greyretinalreflex,fovealretinoschisis,andperipheralretinoschisis.Electroretinograms(ERGs)typicallyrecordareducedb-waveamplitudewithrelativepreservationofthea-waveamplitude.Visualacuity(VA)usuallydeterioratesslowlyuntil...
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銀杏葉提取物無助於預防癡呆請勿隨意服用
...ancementARandomizedControlledTrialPaulR.Solomon,PhD;FelicityAdams,BA;AmandaSilver,BA;JillZimmer,BA;RichardDeVeaux,PhDJAMA.2002;288:835-840.ContextSeveralover-the-countertreatmentsaremarketedashavingtheabilitytoimprovememory,attention,andrelatedcognitivefunctionsinaslittleas4weeks.Theseclaims,however...
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阿希米治療細菌性陰道病40例臨牀分析
...用婦產科雜誌,1998,14(2):88. [3]DEMLINGRH,DESANTIL.Effectsofsilveronwoundmanagement[J].Wounds,2001,13(1SupplA):115. [4]NEDAM,TERAIY.Silver——Newmagicinmedicine[J].ScienceDigest,1978,5(5):193. [5]DIBROVP,DZIOBAJ,GOSINKKK,etal.Chemiosmoticmechanismofantimicro...
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腦出血中西醫結合治療新進展
...導耐受、抑制補體活化等正在進一步研究之中。3討論3.1Silver[21]等在加拿大《醫學郵報》中說:“多學科合作是現代卒中治療的標誌”。隨着影像、外科、內科學及祖國醫學的現代化發展,綜合治療是當今腦出血治療的基本有...
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EvaluationofaNewSelectiveEnrichmentBrothforDetectionofGroupBStreptococciinPregnantWomen
...tionofStreptococcusagalactiaeinpregnantwomen.J.Clin.Microbiol.40:4329-4331.Silver,H.M.,andJ.Struminsky.1996.AcomparisonoftheyieldofpositiveantenatalgroupBstreptococcuscultureswithdirectinoculationinselectivegrowthmediumversusprimaryinoculationintransportmediumfollowedbydelayedinoculationinselectiveg...
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AnewcardiacMASTerswitchfortherenin-angiotensinsystem
...tensinsystem:conceptual,oraregulatorofcardiacfunction?Circ.Res.85::643-650.Silver,R.B.etal.2004..Mastcells:auniquesourceofrenin.Proc.Natl.Acad.Sci.U.S.A.101::13607-13612.Mackins,C.J.etal.2006..Cardiacmastcell–derivedreninpromoteslocalangiotensinformation,norepinephrinerelease,andarrhythmiasinische...
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ChromograninA:asurprisinglinkbetweengranulebiogenesisandhypertension
...ispositiontohypertension.ReferencesBlaschko,H.,Comline,R.S.,Schneider,F.H.,Silver,M.,andSmith,A.D.1967..Secretionofachromaffingranuleprotein,chromogranin,fromtheadrenalglandaftersplanchnicstimulation.Nature.215::58-59.Kim,T.,Tao-Cheng,J.-H.,Eiden,L.E.,andLoh,Y.P.2001..ChromograninA,an“on/off“swi...
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TheimmuneparadoxofsarcoidosisandregulatoryTcells
...granulomatousreactions.J.Immunol.161:6413–6420.Forman,J.D.,J.T.Klein,R.F.Silver,M.C.Liu,B.M.Greenlee,andD.R.Moller.1994.SelectiveactivationandaccumulationofoligoclonalV-specificTcellsinactivepulmonarysarcoidosis.J.Clin.Invest.94:1533–1542.Grunewald,J.,C.H.Janson,A.Eklund,M.Ohrn,O.Olerup,U.Persso...
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SpecimenStorageinTransportMediumandDetectionofGroupBStreptococcibyCulture
...ococcaldisease.RevisedguidelinesfromCDC.Morb.Mortal.Wkly.Rep.51(RR11):1-22.Silver,H.M.,andJ.Strumminsky.1996.AcomparisonoftheyieldofpositiveantenatalgroupBStreptococcuscultureswithdirectinoculationinselectivegrowthmediumversusprimaryinoculationintransportmediumfollowedbydelayedinoculationinselective...
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ApproachestoBacterialRNAIsolationandPurificationforMicroarrayAnalysisofEscherichiacoliK1InteractionwithHumanBrainMicrovascularEndothelialC
...onalandcomparativegenomicsofpathogenicbacteria.Curr.Opin.Microbiol.5:20-26.Silver,R.P.,W.Aaronson,A.Sutton,andR.Schneerson.1980.ComparativeanalysisofplasmidsandsomemetaboliccharacteristicsofEscherichiacoliK1fromdiseasedandhealthyindividuals.Infect.Immun.29:200-206.Stins,M.F.,P.V.Nemani,C.Wass,andK.S...
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DodevelopingBcellsneedantigen
...6:2005–2010.Hayakawa,K.,M.Asano,S.A.Shinton,M.Gui,D.Allman,C.L.Stewart,J.Silver,andR.R.Hardy.1999.PositiveselectionofnaturalautoreactiveBcells.Science.285:113–116.Lopez-Carvalho,T.,andJ.F.Kearney.2004.DevelopmentandselectionofmarginalzoneBcells.Immunol.Rev.197:192–205.Lucas,A.H.,andD.C.Reason....