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功能食品科學與消化道的生理及功能(一)
...酵促進了細菌的生長(生物量),同時產生短鏈脂肪酸(SCFA)、H2、CO2、CH4。SCFA是細菌發酵的主要終產物,是人和哺乳動物後腸(橫結腸2/3位置以下的結腸)的主要陰離子,包括乙酸、丙酸、丁酸。支鏈脂肪酸如異丁酸/戊酸...
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腹部大手術後早期腸內營養的臨牀應用(附60例報告)
...F在結腸內被細菌發酵後產生短鏈脂肪酸(shortchainfattyacid,SCFA),SCFA爲結腸黏膜上皮細胞生長必需的能量底物,這些SCFA在維持結腸的正常生長,保障結腸黏膜屏障功能的完整性等方面起着重要作用[4,5]。而對一些腸道吸收功能...
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腸功能障礙的治療進展
...鹽、丁酸鹽)、氫氣、二氧化碳、甲烷和水。短鏈脂肪酸(SCFA)易於被結腸黏膜吸收,並作爲能量而利用。據估計,正常人體結腸吸收的SCFA提供每日所需能量的5%~10%,然而,在嚴重吸收不良者或攝高纖維飲食者,由此所獲得的能量可超過...
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降結腸癌一期切除術26例臨牀觀察
...。糞便內的食物纖維經發酵後能產生大量的短鏈脂肪酸(SCFA),SCFA對結腸黏膜,尤其是遠端結腸黏膜的癒合有重要的生理意義[6]。其內的乙酸能增加結腸血液迴流,丁酸能刺激結腸黏膜細胞的增生。Uden等通過鼠的實驗研究...
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降結腸癌一期切除術26例臨牀觀察
...。糞便內的食物纖維經發酵後能產生大量的短鏈脂肪酸(SCFA),SCFA對結腸黏膜,尤其是遠端結腸黏膜的癒合有重要的生理意義[6]。其內的乙酸能增加結腸血液迴流,丁酸能刺激結腸黏膜細胞的增生。Uden等通過鼠的實驗研究...
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危重病人的免疫營養
...維才被細菌酵解,產生乙酸、丙酸和丁酸等短鏈脂肪酸(SCFA),而SCFA是結腸粘膜細胞的主要能量來源,可增加腸粘膜血供,促進腸粘膜細胞的增殖和分化,維護腸絨毛形態結構的完整性,同時改變腸腔內環境、抑制致病菌生長...
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腸道微生態與人體健康
...較輕的慢性肝病和肝硬化患者的臨牀結局。短鏈脂肪酸(SCFAs)是膳食纖維在結腸腔內經細菌發酵的產物,SCFA不僅是腸上皮細胞重要的能量來源,還可影響影響腸黏膜屏障,腸上皮細胞的通透性、氧化應激反應等,對結腸功能和健...
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Excretionofstarchandesterifiedshort-chainfattyacidsbyileostomysubjectsaftertheingestionofacylatedstarches
...a.E-mail:julie.clarke{at}csiro.au.ABSTRACTBackground:Short-chainfattyacids(SCFAs)havearoleinmaintainingbowelhealthandcanassistinthepreventionandtreatmentofcolonicdisease.TheabilityofacylatedstarchestodeliverSCFAstothelargebowelhasbeenshowninanimalstudiesbuthasnotbeenestablishedinhumans.Objective:The...
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Prebioticdigestionandfermentation
...ichiacoli,andClostridiumperfringenswaspoor.Usinggasandshort-chainfattyacid(SCFA)productionasendpoints,WangandGibson(12)showedthatfecalslurriesfermentedoligofructose,alongwithawiderangeofothercarbohydrates,butthatoligofructoseandinulinselectivelystimulatedgrowthofbifidobacteria.Inpurecultureexperimen...
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StudiesontheeffectsofpolydextroseintakeonphysiologicfunctionsinChinesepeople
...diminishedputrefactivemicroflora,enhancedproductionofshort-chainfattyacids(SCFAs),andsuppressedproductionofcarcinogenicmetabolites(eg,indoleandp-cresol)(3,8,10).Therefore,thesafetyandefficacyofpolydextroseasawater-solublebulkingagentandfiberhasbeenwidelyandthoroughlyinvestigated.Themetabolicroutehas...
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Small-bowelabsorptionofD-tagatoseandrelatedeffectsoncarbohydratedigestibility:anileostomystudy
...lorintheileostomybags,thepooledsampleswereanalyzedforshort-chainfattyacids(SCFAs).Inafurtherevaluationafterthemainstudy,2subjects(subjects3and5)wereaskedtoeatprepareddosesof3x5gD-tagatose/dinadditiontotheirnormaldietfor2consecutivedays.Onthethirdday,subjectswereaskedtochangebagsbeforebreakfastandthe...
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Effectsofhigh-resistant-starchbananaflour(RS2)oninvitrofermentationandthesmall-bowelexcretionofenergy,nutrients,andsterols:anileostomystu
...fstarchinresidue,pH,andconcentrationsandyieldsoftotalshort-chainfattyacids(SCFA),acetate,propionate,andbutyrateafterinvitrofermentationofilealeffluentsfor24hinstudyA1Viewlargerversion(9K):FIGURE4..StudyA.Mean(±SEM)concentrationsofbutyricacidduringinvitrofermentationofilealeffluentsobtainedfromi...
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L-Rhamnoseincreasesserumpropionateafterlong-termsupplementation,butlactulosedoesnotraiseserumacetate
...#149;L-rhamnoselactulosefecesINTRODUCTIONShort-chainfattyacids(SCFAs)areproducedbythebacterialfermentationofunabsorbedcarbohydratesinthehumancolon.The3mainSCFAsacetic,propionic,andn-butyricacidsoccurinamolarratioof60:20:20inthecoloniccontentsandfecalmatter(1).Asagroup,theSCFA...
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Consumptionoffermentedandnonfermenteddairyproducts:effectsoncholesterolconcentrationsandmetabolism
...fmicelleformationcombinedwiththeeffectoffermentationonshort-chainfattyacid(SCFA)productionweremechanismsthathadbeenproposedtoexplainthepotentialcholesterol-loweringeffectsoffermenteddairyproducts(15).Theseanimalstudiesallpointtowardacholesterol-loweringactionoffermenteddairyproducts(710,12...
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CD4memoryTcellssurviveandproliferatebutfailtodifferentiateintheabsenceofCD40
...40-deficientenvironmentforatleast18wk(Fig.S2).WhenreimmunizedwithpeptideplusCFAtheyrespondedbyproliferatingjustaswellasmemorycellsinWTmice(Fig.4).However,theywereincapableofdifferentiatingintoIFN-–producingeffectorTcells.Sothecostimulationrequirementsofmemorycellsforcelldivisionarelessstringenttha...