-
第七節 非感染性心內膜炎
...鎖緣可見一些2~4mm大的粗糙疣狀血栓沉積物。 3.Lбffler纖維增生性壁性心內膜炎(endocarditisparietalisfibroplasticaLöffler)頗爲少見,幾乎只見於男性。特點雖幾乎只侵犯心壁內膜,好發於左心室並累及心尖區,但從不侵犯瓣...
-
AnalysisofPromoterRegionsRegulatingBasalandInterleukin-4-InducibleExpressionoftheHumanCB1ReceptorGeneinTLymphocytes
...lum:animmunohistochemicalstudy.NeurosciLett396:113-116.[CrossRef][Medline]BörnerC,HölltV,andKrausJ(2006)Cannabinoidreceptortype2agonistsinducetranscriptionoftheµ-opioidreceptorgeneinJurkatTcells.MolPharmacol69:1486-1491.[Abstract/FreeFullText]BörnerC,HölltV,SebaldW,andKrausJ(2007)Transcriptiona...
-
Interactionoftheμ-OpioidReceptorwithSynaptophysinInfluencesReceptorTraffickingandSignaling
...6:285-306.[CrossRef][Medline]KochT,BrandenburgLO,LiangY,SchulzS,BeyerA,SchröderH,andHölltV(2004)PhospholipaseD2modulatesagonist-inducedmu-opioidreceptordesensitizationandresensitization.JNeurochem88:680-688.[CrossRef][Medline]KochT,BrandenburgLO,SchulzS,LiangY,KleinJ,andHölltV(2003)ADPribosylatio...
-
限制型心肌病
...非浸潤性限制型心肌病中,有心肌心內膜纖維經與Löffler心內膜炎二種,前者見於熱帶,後者見於溫帶,實際相似。心臟外觀輕度或中度增大,心內膜顯著纖維化與增厚,以心室流入道與心尖爲主要部位,房室瓣也可被波及,...
-
限制型心肌病
...非浸潤性限制型心肌病中,有心肌心內膜纖維經與Löffler心內膜炎二種,前者見於熱帶,後者見於溫帶,實際相似。心臟外觀輕度或中度增大,心內膜顯著纖維化與增厚,以心室流入道與心尖爲主要部位,房室瓣也可被波及,...
-
CorticalGlutamatergicNeuronsMediatetheMotorSedativeActionofDiazepam
...pfulcommentsonthemanuscript.【參考文獻】BarnardEA,SkolnickP,OlsenRW,MöhlerH,SieghartW,BiggioG,BraestrupC,BatesonAN,andLangerSZ(1998)InternationalUnionofPharmacology.XV.Subtypesof-aminobutyricacidAreceptors:classificationonthebasisofsubunitstructureandfunction.PharmacolRev50:291-313.[Abstract/...
-
DimerizationRegionofSolubleGuanylateCyclaseCharacterizedbyBimolecularFluorescenceComplementationinVivo
...o.WO0119780.2001March22BeckerEM,WunderF,KastR,RobyrC,HoenickaM,GerzerR,SchröderH,andStaschJP(1999)Generationandcharacterizationofastablesolubleguanylatecyclase-overexpressingCHOcellline.NitricOxide3:55–66.[CrossRef][Medline]BenderATandBeavoJA(2006)Cyclicnucleotidephosphodiesterases:molecularregul...
-
MolecularBasisfortheAntiproliferativeEffectofAgmatineinTumorCellsofColonic,Hepatic,andNeuronalOrigin
...430.[Abstract/FreeFullText]KribbenB,HellerJ,TrebickaJ,SauerbruchT,BrüssM,GöthertM,andMolderingsGJ(2004)Agmatine(decarboxylatedarginine),amodulatoroflivercellhomeostasisandproliferation.Naunyn-Schmiedeberg‘sArchPharmacol369:160-165.[CrossRef][Medline]LiG,RegunathanS,BarrowCJ,EshraghiJ,CooperR,and...
-
TheEffectofLowpHonBreastCancerResistanceProtein(ABCG2)-MediatedTransportofMethotrexate,7-Hydroxymethotrexate,MethotrexateDiglutamate,FolicAc
...ns.CancerRes52:4441-4447.[Abstract/FreeFullText]BreedveldP,ZelcerN,PluimD,SönmezerÖ,TibbenMM,BeijnenJH,SchinkelAH,vanTellingenO,BorstP,andSchellensJHM(2004)MechanismofthepharmacokineticinteractionbetweenMTXandbenzimidazoles:potentialroleforbreastcancerresistanceproteininclinicaldrug-druginteractio...
-
SalicylateBlocksLipolyticActionsofTumorNecrosisFactor-inPrimaryRatAdipocytes
...idelipasein3T3-L1adipocytes.MolCellEndocrinol240:43-49.[CrossRef][Medline]MöhligM,FreudenbergM,BobbertT,RistowM,RochlitzH,WeickertMO,PfeifferAF,andSprangerJ(2006)Acetylsalicylicacidimproveslipid-inducedinsulinresistanceinhealthymen.JClinEndocrinolMetab91:964-967.[Abstract/FreeFullText]NewmanWPandBr...
-
ComparativeStudyofortho-andmeta-NitratedInhibitorsofCatechol-O-methyltransferase:InteractionswiththeActiveSiteandRegioselectivityofO-Methylat
...thanesulfonicacid;RMSd,root-mean-squaredeviation.【參考文獻】BäckströmR,HonkanenE,PippuriA,KairisaloP,PystynenJ,HeinolaK,NissinenE,LindenIB,MännistöPT,andKaakkolaS(1989)Synthesisofsomenovelpotentandselectivecatechol-O-methyltransferaseinhibitors.JMedChem32:841-846.[CrossRef][Medline]Bonif...
-
PhoneutrianigriventerToxin1:ANovel,State-DependentInhibitorofNeuronalSodiumChannelsThatInteractswithμConotoxinBindingSites
...notoxinsasprobesofvoltagegatedsodiumchannels.Toxicon44:117–122.[Medline]LönnendonkerU(1989a)BindingoftetrodotoxinandsaxitoxintoNa+channelsatdifferentholdingpotentials:fluctuationmeasurementsinfrogmyelinatednerve.BiochimBiophysActa985:161–167.[Medline]LönnendonkerU(1989b)Use-dependentblockofsod...
-
EvidenceforDirectRegulationofMyocardialNa+/H+ExchangerIsoform1PhosphorylationandActivityby90-kDaRibosomalS6Kinase(RSK):EffectsoftheNovel
...ne;CONT,control.【參考文獻】AkerS,SnabaitisAK,KonietzkaI,vandeSandA,BönglerK,AvkiranM,HeuschG,andSchulzR(2004)InhibitionoftheNa+/H+exchangerattenuatesthedeteriorationofventricularfunctionduringpacing-inducedheartfailureinrabbits.CardiovascRes63:273-282.[Abstract/FreeFullText]AlvarezBV,PérezN...
-
InVivoOxidativeDamageinRatsIsAssociatedwithBarbiturateResponsebutNotOtherCytochromeP450Inducers
...essinalcoholicpatients.AlcoholAlcohol35:98-103.[Abstract/FreeFullText]EkströmGandIngelman-SundbergM(1989)RatlivermicrosomalNADPH-supportedoxidaseactivityandlipidperoxidationdependentonethanol-induciblecytochromeP-450(P-450IIE1).BiochemPharmacol38:1313-1319.[CrossRef][Medline]EkströmG,vonBahrC,andI...
-
DivergentActivitiesofHumanGlutathioneTransferasesintheBioactivationofAzathioprine
...tlungandliver.BiochimBiophysActa582:67-78.[Medline]OdlindB,HartvigP,LindströmB,LönnerholmG,TufvesonG,andGrefbergN(1986)Serumazathioprineand6-mercaptopurinelevelsandimmunosuppressiveactivityafterazathioprineinuremicpatients.IntJImmunopharmacol8:1-11.[CrossRef][Medline]PembleS,SchroederKR,SpencerSR,...
-
CB1ReceptorAntagonismIncreasesHippocampalAcetylcholineRelease:SiteandMechanismofAction
...ence98:253-262.[CrossRef][Medline]KatonaI,SperlághB,MaglóczkyZ,SánthaE,KöfalviA,CzirjákS,MackieK,ViziES,andFreundTF(2000)GABAergicinterneuronsarethetargetsofcannabinoidactionsinthehumanhippocampus.Neuroscience100:797-804.[CrossRef][Medline]KöfalviA,RodriguesRJ,LedentC,MackieK,ViziES,CunhaRA,an...
-
Rimonabant:JustanAntiobesityDrug?CurrentEvidenceonItsPleiotropicEffects
...JPharmacolExpTher277:586–594.[Abstract/FreeFullText]CotaD,MarsicanoG,TschöpM,GrüblerY,FlachskammC,SchubertM,AuerD,YassouridisA,Thöne-ReinekeC,OrtmannS,etal.(2003)Theendogenouscannabinoidsystemaffectsenergybalanceviacentralorexigenicdriveandperipherallipogenesis.JClinInvestig112:423–431.[Cross...
-
AtomicForceMicroscopyRevealstheStoichiometryandSubunitArrangementofthe4β3GABAAReceptor
...iolChem276:38934-38939.[Abstract/FreeFullText]BarnardEA,SkolnickP,OlsenRW,MöhlerH,SieghartW,BiggioG,BraestrupC,BatesonAN,andLangerSZ(1998)InternationalUnionofPharmacology.XV.Subtypesof-aminobutyricacidAreceptors:classificationonthebasisofsubunitstructureandreceptorfunction.PharmacolRev50:291-313.[A...
-
BioactivationofNitroglycerinbyAscorbate
...ndglutathione.ArchBiochemBiophys330:219-228.[CrossRef][Medline]HinzBandSchröderH(1998)VitaminCattenuatesnitratetoleranceindependentlyofitsantioxidanteffect.FEBSLett428:97-99.[CrossRef][Medline]IgnarroLJ,BarryBK,GruetterDJ,EdwardsJC,OhlsteinEH,GruetterCA,andBaricosWH(1980)Guanylatecyclaseactivationb...
-
ACommonRegulatoryRegionFunctionsBidirectionallyinTranscriptionalActivationoftheHumanCYP1A1andCYP1A2Genes
...bindingAhreceptor.Science(WashDC)268:722-726.[Abstract/FreeFullText]FinnströmN,ThörnM,LööfL,andRaneA(2001)IndependentpatternsofcytochromeP450geneexpressioninliverandbloodinpatientswithsuspectedliverdisease.EurJClinPharmacol57:403-409.[CrossRef][Medline]FisherJM,WuL,DenisonMS,andWhitlockJPJr(1990...
-
IdentificationofaNovelLigandBindingResidueArg38(1.35)intheHumanGonadotropin-ReleasingHormoneReceptor
...ndconformation.MolPharmacol60:1280-1287.[Abstract/FreeFullText]GründkerC,VölkerP,andEmonsG(2001)Antiproliferativesignalingofluteinizinghormone-releasinghormoneinhumanendometrialandovariancancercellsthroughGproteinalpha(I)-mediatedactivationofphosphotyrosinephosphatase.Endocrinology142:2369-2380.[A...
-
PhosducinandPhosducin-likeProteinAttenuateG-Protein-CoupledReceptor-MediatedInhibitionofVoltage-GatedCalciumChannelsinRatSympatheticNeurons
...cellularsignaling.DevCell4:295-305.[CrossRef][Medline]MüllerS,StraubA,SchröderS,BauerPH,andLohseMJ(1996)InteractionsofphosducinwithdefinedGprotein-subunits.JBiolChem271:11781-11786.[Abstract/FreeFullText]NagaiT,SawanoA,ParkES,andMiyawakiA(2001)Circularlypermutedgreenfluorescentproteinsengineeredto...
-
MutationalDisruptionofaConservedDisulfideBondinMuscarinicAcetylcholineReceptorsAttenuatesPositiveHomotropicCooperativitybetweenMultipleAllost
...s.MolPharmacol35:652-660.[Abstract/FreeFullText]PrillaS,SchrobangJ,EllisJ,HöltjeHD,andMohrK(2006)Allostericinteractionswithmuscarinicacetylcholinereceptors:complexroleoftheconservedtryptophanM4222Trpinacriticalclusterofaminoacidsforbaselineaffinity,subtypeselectivity,andcooperativity.MolPharmacol70...
-
InVitroandinVivoNuclearFactor-BInhibitoryEffectsoftheCell-PenetratingPenetratinPeptide
...NFreceptorinternalization.JCellSci118:3339-3351.[Abstract/FreeFullText]FülöpL,PenkeB,andZarándiM(2001)Synthesisandfluorescentlabelingofbeta-amyloidpeptides.JPeptSci7:397-401.[CrossRef][Medline]GhibaudiE,BoscoloB,InserraG,LaurentiE,TraversaS,BarberoL,andFerrariRP(2005)Theinteractionofthecell-penet...
-
TheInvestigationalAnticonvulsantLacosamideSelectivelyEnhancesSlowInactivationofVoltage-GatedSodiumChannels
...ilepsy.EpilepsyRes47:217-227.[CrossRef][Medline]BeyreutherB,CallizotN,andStöhrT(2006)Antinociceptiveefficacyoflacosamideinaratmodelforpainfuldiabeticneuropathy.EurJPharmacol539:64-70.[CrossRef][Medline]BeyreutherBK,FreitagJ,HeersC,KrebsfaengerN,ScharfeneckerU,andStöhrT(2007)Lacosamide:areviewofpre...
-
IdentificationoftheAtypicalL-TypeCa2+ChannelBlockerDiltiazemandItsMetabolitesAsGhrelinReceptorAgonists
...chemia/reperfusioninjury.BiochemPharmacol67:565-574.[CrossRef][Medline]TschöpM,SmileyDL,andHeimanML(2000)Ghrelininducesadiposityinrodents.Nature407:908-913.[CrossRef][Medline]UchidaY(1976)Effectofdiltiazem,anewanti-Caagent,onleftventricularfunctioninpatientswithandwithoutanginapectoris.Astudyusingu...
-
N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide(ICA-27243):ANovel,SelectiveKCNQ2/Q3PotassiumChannelActivator
...oacidsintherathippocampusinvitro.EpilepsyRes22:167-173.[CrossRef][Medline]LöscherWandSchmidtD(1994)Strategiesinantiepilepticdrugdevelopment:isrationaldrugdesignsuperiortorandomscreeningandstructuralvariation?EpilepsyRes17:95-134.[CrossRef][Medline]MainMJ,CryanJE,DupereJR,CoxB,ClareJJ,andBurbidgeSA(...
-
AntieosinophilicActivityofOrazipone
...onwithIL-5.JAllergyClinImmunol98:S207-S215.[CrossRef][Medline]AhoP,BäckströmR,KoponenA,LindenI-B,LottaT,LönnbergK,PippuriA,andPohtoP(2001),inventors;OrionPharma,assignee.Substituteddiketonesandtheiruse.U.S.patent6,201,027.2001March13.BonnyC,ObersonA,NegriS,SauserC,andSchorderetDF(2001)Cell-permea...
-
CombinedEffectsofSulindacandSuberoylanilideHydroxamicAcidonApoptosisInductioninHumanLungCancerCells
...seoligodeoxynucleotidesandsiRNA.CancerLett232:243-254.[CrossRef][Medline]GröschS,TegederI,NiederbergerE,BrautigamL,andGeisslingerG(2001)COX-2independentinductionofcellcyclearrestandapoptosisincoloncancercellsbytheselectiveCOX-2inhibitorcelecoxib.FASEBJ15:2742-2744.[FreeFullText]JinHO,YoonSI,SeoSK,L...
-
TheNeurosteroidsDehydroepiandrosteroneSulfateandPregnenoloneSulfateInhibittheUNC-49GABAReceptorthroughaCommonSetofResidues
...sofGABA(A)receptors.BrainResBrainResRev37:91–97.[CrossRef][Medline]DemirgörenS,MajewskaMD,SpivakCE,andLondonED(1991)Receptorbindingandelectrophysiologicaleffectsofdehydroepiandrosteronesulfate,anantagonistoftheGABAAreceptor.Neuroscience45:127–135.[CrossRef][Medline]EtterA,CullyDF,LiuKK,ReissB,V...