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膽囊結石病致病基因的定位研究
...值(NPL)分別爲1.77(P=0.05)和1.92(P=0.04),參數分析優勢對數值(LOD)分別爲1.84和2.07。D3S1266位點的LOD值爲1.35。D11S902位點傳遞不平衡檢驗,P值爲0.0027。高發病年齡組D3S1266位點的LOD值由1.35上升到2.71,高甘油三酯組D9S1682位點的LOD值由2.07上...
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腹腔鏡卵巢打孔術治療耐藥性多囊卵巢綜合徵15例分析
...米芬的PCOS患者應用腹腔鏡對卵巢進行單極電凝打孔術(LOD),術後出現排卵,並相應的獲得妊娠。1資料與方法1.1一般資料選擇2002年9月~2006年10月陽江市第三人民醫院不孕症門診治療的PCOS患者,在月經週期或黃體酮撤退性出血...
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NovelGenomicLociInfluencingPlasmaHomocysteineLevels
...tedusingtheSIMWALK2softwareprogram.22Weconsideredmultipointlogarithmofodds(LOD)scores3.00asstatisticallysignificantevidenceoflinkage,2.00assuggestiveevidence,and1.30astentativeevidenceoflinkage.23ThesemultipointLODscorethresholdscorrespondtogenome-wideprobabilityvaluesof0.0001,0.001,and0.007respecti...
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AtherosclerosisSusceptibilityLociIdentifiedFromaStrainIntercrossofApolipoproteinE-DeficientMiceviaaHigh-DensityGenomeScan
...eEMalgorithmwasusedforintervalmappingwithinther/qtlsoftware,whichcalculatedLODscores(logoftheoddsratio)foreachphenotypeacrossthemousegenomeateverySNPpositionandin2-MbintervalsinregionswheremarkerSNPswerenotpresent.Lesionsizewasanalyzedbeforeandafterlog10transformation,whichnormalizesthedistributiona...
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Neuromedinß:astrongcandidategenelinkingeatingbehaviorsandsusceptibilitytoobesity
...31).ToidentifyregionofpromisinglinkageorQTL,weusedP0.0023orlogarithmofodds(LOD)1.75forbothlinkagemethods.Thislevelrepresents,onaverage,onefalsepositivelinkagesignalpergenomescanof400markers(32).Otherinterestingregions(suggestive)arereportedifP0.01orLOD1.17.Achi-squaredtestwasappliedtoevaluatewhether...
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QuantitativeTraitLocusMappingofGenesThatRegulatePhospholipidTransferActivityinSM/JandNZB/BlNJInbredMice
...inmicefedchow(Pltpq1andPltpq2)werefoundonchromosomes3(34cM,logarithmofodds[LOD]3.5)and10(66cM,LOD4.1);twoadditionalQTLinmicefedatherogenicdiet(Pltpq3andPltpq4)werefoundonchromosomes9(56cM,LOD4.5)and15(34cM,LOD5.0);andoneQTL(Pltiq1)fortheinducibilityofPLTPactivitywasfoundonchromosome4(70cM,LOD3.7).Se...
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TheMexican-AmericanCoronaryArteryDiseaseFamilyStudy
...trongestevidenceoflinkagewasfoundonchromosome2atD2S2944(logarithmoftheodds[LOD]=3.08).Othersuggestivelinkageswerealsofoundonchromosome6atD6S1022toD6S2410(LOD=2.21)andchromosome13atD13S796toD13S895(LOD=1.34).Conclusions—TheseresultsshowthatthereisastronggeneticeffectonCIMTintheseMexicanAmericanCADf...
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藥物分析實驗數據處理
...B)/加入量A×100%回收率的RSD一般應爲2%以內。3.檢測限(LOD)是指分析方法能夠從背景信號中區分出藥物時,所需樣品中藥物的最低濃度,無需定量測定。LOD是一種限度檢驗效能指標,它既反映方法與儀器的靈敏度和噪音的大小...
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Sweettastepreferencesarepartlygeneticallydetermined:identificationofatraitlocusonchromosome
...tandsuggestivelinkageonchromosome2p22forsaturatedfatintake[logarithmofodds(LOD)2.62].Ouraimwastodeterminetheproportionofthegeneticfactorscontributingtothesweetnessperceptionofaqueoussolutionsandsweetfoodpreferencesinapopulationrandomlyselectedintermsofsweettastepreference-relatedphenotypes.Ifatraitw...
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EatingbehaviorintheOldOrderAmish:heritabilityanalysisandagenome-widelinkageanalysis
...videnceforlinkageofrestraintscoresto2chromosomalregions,nearmarkersD3S1304[LOD(logofodds)=2.5,P=0.0003]andD6S276(LOD=2.3,P=0.0006).WepreviouslyreportedthatD3S1304islinkedtoalocusinfluencingpercentagebodyfatinthissamepopulation(LOD=1.6),suggestingthatthisbehavioralphenotypemaybesecondarytoobesity.The...
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AQuantitativeTraitLocusonChromosome16qInfluencesVariationinPlasmaHDL-CLevelsinMexicanAmericans
...ingevidenceforaquantitativetraitlocus(QTL),withapeakmultipointlogoftheodds(LOD)=3.73(P=0.000034).Subsequentpenetrancemodel-basedlinkageanalysis,incorporatinggenotypesatthemarkerlocusnearestthemultipointpeak(D16S518)intothesegregationmodel,detectedlinkagewiththepreviouslydetectedmajorlocus(LOD=2.73,P...
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QuantitativeTraitLociAnalysisforPlasmaHDL-CholesterolConcentrationsandAtherosclerosisSusceptibilityBetweenInbredMouseStrainsC57BL/6Jand129S1/
...edbysixloci:Hdlq14andHdlq15onchromosome1(peakscM80andcM104,logarithmofodds[LOD]5.3and9.7,respectively);Hdlq16onchromosome8(cM44,LOD2.6);Hdlq17onchromosome9(cM24,LOD2.9);Hdlq18onchromosome12(cM20,LOD5.9);andHdlq19onchromosome2(cM90),whichinteractedwithHdlq15.Atherosclerosissusceptibilitywasaffectedby...
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AGenomeSearchforGeneticDeterminantsThatInfluencePlasmaFibrinogenLevels
...nerabletodeviationsfrommultivariatenormality,givinginflatedlogarithmofodds(LOD)scoresifthedistributionofthetraitpresentshighlevelsofkurtosis.29However,levelsoffibrinogenintheGAITindividualsexhibitedakurtosisof0.42,whichdoesnotaffectthedistributionofLODscores.Thus,thestandardnominalPvaluesforLODscore...
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QuantitativeTraitLocusMappingofGeneticModifiersofMetabolicSyndromeandAtherosclerosisinLow-DensityLipoproteinReceptor-DeficientMice
...smainsulinconcentrationsweredetectedonchromosomes1(females;logarithmofodds[LOD]=2.9)and13(femalesandmales;LOD=4.3).BodyweightQTLswerefoundonchromosomes8(males;LOD=3.4)and13(males;LOD=2.9).Anatherosclerosislocuswasdetectedonchromosome2(femalesandmales;LOD=3.9),and2QTLsinfluencingHDL-Clevelsweredetect...
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一個原發性痛風家系致病易感基因染色體定位
...的染色體區段。結果發現在微衛星引物D4S1572處獲得最大LOD值(θ=0.00時LOD=1.50),表明該痛風家系的致病基因與該位點連鎖。由此,研究者得出結論,由於D4S1572位於4q25,因此該家系致病基因位於4q25附近。作者:
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一個精神分裂症多發家系染色體候選區域的連鎖分析
...在染色體11q23.2-24.2區域獲得3個連續高的多點非參數分析LOD值,在D11s925處獲得的峯值爲4.33(P=0.016),超過顯著性連鎖的閾值。與D11s925相鄰的D11s898及D11s4151在多點非參數分析中的LOD值分別爲1.57和3.82。對¨號染色體上的6個微衛星標誌...
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銀屑病遺傳與基因研究進展
...以引起銀屑病發病,說明還存在其他的致病基因,而且用lod積分分析或用同胞配對法進行的家系基礎上連鎖研究並沒有提供確切的證據來支持在HLA位點上或附近存在一個主要的銀屑病致病基因。對銀屑病高遺傳性的研究表明易感...
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Mapping,GeneticIsolation,andCharacterizationofGeneticLociThatDetermineResistancetoAtherosclerosisinC3HMice
...ionQTLs,thepresentcross,onachowdiet,revealedasinglemajorlocusonchromosome9(lod=5.0,Ath29*),andasuggestivelocusonchromosome4(lod=2.6,Ath8).QTLsforplasmaHDL,totalcholesterol,andtriglyceridelevelswerefoundonchromosome1overtheApoA2gene.NeitherofthelesionQTLswereassociatedwithdifferencesinplasmalipidleve...
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體內藥物分析方法的設計與評價
...出有關化合物的最小量”。常用最低檢測限(Limitofdetection,LOD)或最低檢測量(Limitofquantification;LOQ)來表示。LOD範圍在ng(10-9g)~10-18g。⑷專屬性或選擇性(SpecificityorSelectivity):是指測定的信號(響應)是屬於被測藥物所特有的。若有幹...
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哮喘與ADAM33基因的關係研究新進展
...兩個峯值,一個是靠近標記位點D20S906,優勢對數評分(LOD)爲2.94,另一個是標記位點D20S482(12.1cM區域),優勢對數評分(LOD)也爲2.94。而D20S482與哮喘及氣道高反應性(bronchialhyper-responsiveness,BHR)相關的LOD值增加爲3.93,說明20p13存在...
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加強人體器官捐獻規範化管理,提高全民器官捐獻意識*
...的方法主要包括增加腦死亡器官捐獻(DBD)、活體器官捐獻(LOD)、心臟死亡器官捐獻(DCD)等,其中增加器官捐獻是主要途徑。然而在我國,目前各種類型的器官捐獻面臨諸多現實困難。 2.1DBD現狀 2009年衛生部制訂了《腦死亡...
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推拿與電針結合治療面神經麻痹40例臨牀觀察
...用疏密波,分別接陽白與太陽、牽正與地倉。每次30min,lOd爲1個療程。 1.2.2推拿治療取穴:患側陽白、四白、睛明、攢竹、地倉、下關、太陽、水溝、承漿、翳風、迎香、顴髎,雙側合谷及額肌、眼輪匝肌、頰肌、咀嚼肌。...
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GenomewideScreenforPulmonaryFunctionin200FamiliesAscertainedforAsthma
...ceforlinkageofpre-andpostbronchodilatorFEV1%VCwasobtainedforchromosome2q32(LOD,4.9,increasingto6.03withadditionalfine-mappingmarkers,and3.2,respectively).Linkageexistedforchromosome5qforpre-andpostbronchodilatorVC(likelihoodofdisease[LOD],1.8and2.6,respectively).Resultsforpre-andpostbronchodilatorFE...
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Quantitativetraitlocusdeterminingdietarymacronutrientintakesislocatedonhumanchromosome2p
...aturatedfatintakewasfoundonchromosome2p22nearmarkerD2S1346[logarithmofodds(LOD)=2.62].Intakesoftotalcalories,fat,protein,andmonounsaturatedfatwerealsosuggestivelylinkedtothesamemarker.Asignificantlinkagesignalonchromosome2p22forleptinconcentrationsandfatmasswaslocalizedinthispopulation,soweusedlepti...
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中西醫結合治療慢性支氣管炎急性發作期的療效觀察
...質。對照組僅給予頭孢他定,靜脈滴注,每日l次,連續lod;觀察組在此基礎上給予痰熱清注射液20ml加入5%葡萄糖注射液250ml,靜脈滴注,每日l次,連續lod。1.4觀察指標觀察並記錄用藥10d後,觀察組和對照組患者臨牀症狀和體...
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ALocusonChromosome2InfluencesLevelsofTissueFactorPathwayInhibitor
...52(P0.0001),withnoevidenceforsharedhouseholdeffects.Inthegenomescreen,only1LODscore2wasobserved.Onchromosome2q,themaximummultipointLODscorewas3.52nearmarkerD2S1384.ThisisnearthestructuralgeneforTFPI,whichislocatedat2q32.Infollow-upassociationanalyses,marginalevidenceofassociation(P=0.04)wasobservedw...
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高效毛細管電泳法分析D苯丙氨酸與DN乙酰苯丙氨酸的對映體雜質含量
...inElmer343,USA). 自制磺化β環糊精(sulfatedβcyclodextrin,SβCD)由陝西師範大學化學系李保林教授惠贈;其它試劑均爲分析純.對照品:光學純的D苯丙氨酸、外消旋苯丙氨酸(上海化學試劑二廠);光學純的DN...
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頂空固相微萃取氣相色譜法測定水中有機氯化合物
...ercialimportpolydimethylsiloxane(PDMS)fiber.ResultsLimitsofdetection(LOD)ofthemethodwerebelow35.3ng/Landrelativestandarddeviations(RSD)werenothigherthan11.8%(n=3);linearityregressioncoefficients(R)werelessthan0.990;recoveriesrangedfrom71.5to115.5%.ConclusionThesensitivityofsol-ge...
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微液液提取或固相萃取法淨化、氣相色譜質譜聯用檢測葡萄酒中19種農藥多殘留
...在83.3%~116.7%之間(四蟎嗪爲43%)。SPE法的最低檢出限(LOD)0.001~0.01mg/kg之間,定量檢出限(LOQ)爲0.005~0.05mg/kg,相對標準偏差小於10%;MLLE法爲LOD在0.02~0.10mg/kg,LOQ爲0.06~0.30mg/kg,相對標準偏差小於14%。所有目標化合物均存...
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遺傳流行病學
...色體上相距很遠。重組分數越小,兩位點相距越近。 lodscore方法假設在已知的遺傳模型和某一θ值(0~0.5)下,計算觀察家系的似然度(likelihood)與θ=0.5時似然度的比值的對數(lod值),最大lod值下的θ值是最可能的重組分數值。若l...