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單體素氫質子磁共振波譜研究口腔頜面部惡性腫瘤
...學空間(MEDcyber.com)5月18日消息,單體素氫質子磁共振(1HMR)波譜能爲口腔頜面部軟組織惡性腫瘤的診斷提供有益信息。口腔頜面部的惡性腫瘤以癌爲常見,肉瘤較少。癌腫中絕大多數爲鱗狀細胞癌,其次爲腺性上皮癌,還有基底...
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毛細血管血血糖和靜脈血漿血糖相關性分析
...整羣抽樣與隨機抽樣相結合的方法,在青島市6區市抽出3647名常住居民,測定其空腹外周毛細血管血血糖和靜脈血漿血糖,應用統計學方法進行數據處理。結果居民的空腹靜脈血漿血糖高於外周毛細血管血血糖,差異有顯著性(t...
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Conditionalgeneexpressioninrenalcollectingductepithelialcells:useoftheinducibleCre-loxsystem
...enhancedgreenfluorescentprotein(eGFP)-taggedhumanmineralocorticoidreceptor(hMR)inthealdosterone-responsiveRCCD2cellline(8).MATERIALSANDMETHODSCellCultureRCCD2cellswereculturedonpetridishesthathadbeencoatedwithrattypeIcollagen,aspreviouslydescribed(8).Cellswereculturedinadefinedmediumthatcontained1:1...
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TargetedSkinOverexpressionoftheMineralocorticoidReceptorinMiceCausesEpidermalAtrophyPrematureSkinBarrierFormationEyeAbnormalitiesandAlopeci
...MRspecificallytokeratinocytesoftheepidermisandhairfollicle(HF).ExpressionofhMRthroughoutgestationresultedinearlypostnataldeaththatcouldbepreventedbyantagonizingMRsignaling.DTmiceexhibitedprematureepidermalbarrierformationatembryonicday16.5,reducedHFdensityandepidermalatrophy,increasedkeratinocyteapo...
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SolubleGuanylylCyclaseActivationWithHMR1766AttenuatesPlateletActivationinDiabeticRats
...tarrats.After2weeks,treatmentwitheitherplaceboortheguanylylcyclaseactivatorHMR1766(10mg/kgtwicedailybygavage)wasinitiated.Twoweekslater,invivoplateletactivationandinvitroplateletreactivitywereassessed.ChronictreatmentwithHMR1766enhancedNO/cGMP-mediatedsignalinginplateletsfromdiabeticratsdeterminedby...
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深圳公明區職業病危害情況調查
...工總數94069人,其中接觸有害因素的16767人。作業崗位數3647家,接觸勞動者16767人(男6040人,女10727人)。有害因素主要爲有機溶劑(苯系物、正己烷、三氯乙烯等)、粉塵、噪聲與鉛等,塑料製品業、傢俱製造業、金屬製品業...
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國產格列美脲治療2型糖尿病的療效觀察
...紀80年代由德國HoechstAG藥廠開發成功,1995年被美國FDA批准HMR公司的Amaryl作爲2型糖尿病臨牀用藥在美國上市。Amaryl作爲進口藥物,價格昂貴,國人難以支付。目前國內已出現了國產的格列美脲,並已在臨牀上應用,但其臨牀研究...
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ChlamydophilapneumoniaeandMycoplasmapneumoniae
...ayeEN,Collart-DutilleulV,Maridonneau-PariniI,Diu-HercendA.ThenewketolideHMR3647accumulatesintheazurophilgranulesofhumanpolymorphonuclearneutrophils.AntimicrobAgentsChemother1999;43:2457–2462.PhamGiaH,RoederV,NamourF,SultanE,LenfantB.HMR3647achieveshighandsustainedconcentrationsinwhitebloodcellsinm...
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Benefitsandrisksofantiobesityagents
...olicResearchGroup,VeteransAdministrationMedicalCenter,UniversityofKentucky(HMR)WeightManagementProgram,UniversityofKentuckyLexington,KYDearSir:Aftersuccessfulweightloss,long-termweightmaintenanceisdifficultandoftennotsuccessful(1).Whereasrecentstudies(1,2)indicatethatlong-termweightmaintenanceafterv...
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細胞計數與存活測試
...hrosinbluish(SigmaE-9259)及0.05grampreservativemethyl paraben(SigmaH-3647)溶於100mlCa++/Mg++freesaline 2.3.血球計數盤及蓋玻片(Hemocytometerandcoverslip) 2.4.計數器(counter) 2.5.低倍倒立顯微鏡 2.6.粒子計數器(Coultercounter,CoulterElectronics) 3...
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HbeAg陰性乙型肝炎病毒感染機理的研究進展
...8 2.YunCH,etal.JVirol,1992;66:4073 3.ChenIH,et,al.JVirol,1995;69:3647 4.SatoS,etal.AnnalInternalMed.1995;122:241 5.OkamotoH,etal.JVirol,1994;68:8102 6.LaskusT,etal.Gastrocenterology,1995;109:1618 7.MoriyamaK,etal.Virology,1996;226:269 8.ScaglioniPP,etal.Virology,19...
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ProteinKinaseGTransmitstheCardioprotectiveSignalFromCytosoltoMitochondria
...chemicalswerefromSigmaChemicalCo.KT5823,TPP+,andcpt-cGMPwerefromCalbiochem.HMR1098wasagiftofDrHeinrichEnglertofSanofisAventis(Frankfurt,Germany).CyclicGMPproteinkinase1(PKG)waspurifiedfrombovinelung.15PKCisozyme-specificpeptideantagonistsV1-2(EAVSLKPT)16andV1-1(SFNSYELGSL)17weresynthesizedwithapurit...
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緩慢激活延遲整流鉀通道(IKs)的研究進展*
...IKs對甲磺酸鹽類有抵抗作用,但可被色原烷醇類(293B、HMR-1556),吲哚帕胺,硫噴妥鈉,異丙酚和地西泮(L-768、673,L735、821或L-7)選擇性阻斷[15~17]。此外,色原烷醇類對於開放通道的阻斷作用具有對映選擇性,(-)3R,4S-2...
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Effectofacutedietarystandardizationontheurinary,plasma,andsalivarymetabolomicprofilesofhealthyhumans
...t,DivisionofClinicalandMolecularMedicine,TrinityCollege,Dublin,Ireland(MCW,HMR,andMJG),andtheUCDSchoolofBiomolecularandBiomedicalSciences,UCDConwayInstituteofBiomolecularandBiomedicalResearch,UniversityCollegeDublin,Belfield,Dublin,Ireland(LBandJPGM)2SupportedbytheIrishResearchCouncilforScience,Engi...
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不明原因骨痛病人骨顯像檢查結果分析
...droutinenuclidewholebodyboneimaging.AnanalysiswasdonebycombinationwithMR,CT,andXray.ResultsOfthe247patients,201werepositiveinimaging(81.4%).Thecommoncausesofbonepainaremetastasisofthemalignancy,intervertebraldiscprotrusion,hyperosteosis,andosteoporosis.ConclusionBoneimagingisofgreatervaluei...
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CellularMechanismofCalcium-MediatedTriggeredActivityintheHeart
...hepreparationtoaCCDvideocamera.ExperimentalProtocolIn12wedgesfrom12animals,HMR1556(7eol/L),aselectiveIKschannelblocker,24andIsoproterenol(0.2eol/L),a-adrenergicstimulant,wereadministeredsimultaneouslytoenhancecalciumentry.Thismodelhasbeenshownpreviouslytobeassociatedwithtriggeredactivityinsinglecell...
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10951例育齡婦女生殖健康狀況分析
...療,取得了明顯成效。2結果普查結果顯示:生殖道感染3647例,發病率爲33.3%,佔首位。其中各種陰道炎2380例,佔21.7%(滴蟲性陰道炎、念珠菌性陰道炎、老年性陰道炎、細菌性陰道炎);慢性宮頸炎976例,佔8.9%;慢性盆腔炎及...
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Photorhabdusasymbiotica,aPathogenEmergingonTwoContinentsThatProvesthatThereIsNoSubstituteforaWell-TrainedClinicalMicrobiologist
...ofPhotorhabdusluminescensfrominfectedhumansinAustralia.J.Clin.Microbiol.37:3647-3653.作者:AliceS.Weissfeld,RhondaJ.Halliday,DawnE.Si
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SelectingBcellsandplasmacellstomemory
...rginalzoneBcellsharboringaprediversifiedimmunoglobulinrepertoire.Blood.104:3647–3654.Bernasconi,N.L.,E.Traggiani,andA.Lanzavecchia.2002.MaintenanceofserologicalmemorybypolyclonalactivationofhumanmemoryBcells.Science.298:2199–2202.Hauser,A.E.,G.F.Debes,S.Arce,G.Cassese,A.Hamann,A.Radbruch,andR.A....
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促紅細胞生成素對缺血再灌注心臟的心肌保護作用
...4MAP激酶)、白屈菜赤鹼(PKC)以及K+通道阻滯劑優降糖、HMR1098,5-HD和Paxilline所阻斷;在應用EPO之前(2.3±0.9nmol/min/g)和15min之後(2.4±1.9nmol/min/g)心臟所釋放的硝酸鹽及亞硝酸鹽沒有差別;而L-NAME和L-NMA則對EPO的保護作用沒有影...
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BrothMicrodilutionandDiskDiffusionTestsforSusceptibilityTestingofPasteurellaSpeciesIsolatedfromHumanClinicalSpecimens
...H.Gerardo,M.Hudspeth,andC.V.Merriam.1998.ActivitiesofHMR3004(RU64004)andHMR3647(RU66647)comparedtothoseoferythromycin,azithromycin,clarithromycin,roxithromycin,andeightotherantimicrobialagentsagainstunusualaerobicandanaerobichumanandanimalbitepathogensisolatedfromskinandsofttissueinfectionsinhumans....
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DodevelopingBcellsneedantigen
...ginalzoneBcellsharboringapre-diversifiedimmunoglobulinrepertoire.Blood.104:3647–3654.Kraus,M.,M.B.Alimzhanov,N.Rajewsky,andK.Rajewsky.2004.SurvivalofrestingmatureBlymphocytesdependsonBCRsignalingviatheIgalpha/betaheterodimer.Cell.117:787–800.Wedemayer,G.J.,P.A.Patten,L.H.Wang,P.G.Schultz,andR.C....
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OntheMechanismofActionof9-O-ArylalkyloximeDerivativesof6-O-Mycaminosyltylonolide,aNewClassof16-MemberedMacrolideAntibiotics
...獻】AckermannGandRodloffAC(2003)Drugsofthe21stcentury:telithromycin(HMR3647)-thefirstketolide.JAntimicrobChemother51:497-511.[Abstract/FreeFullText]BerisioR,HarmsJ,SchluenzenF,ZarivachR,HansenHAS,FuciniP,andYonathA(2003)Structuralinsightintotheantibioticactionoftelithromycinagainstresistantmutants...
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提高產後訪視質量促進母嬰健康(附3922例臨牀分析)
...534例,中專或高中以上1623例,初中及以下1765例。初產婦3647例,經產婦275例。1.2方法1.2.1組織管理和人員配備城區孕產婦系統管理協作組的產後訪視,由本院院後服務中心產後訪視組8名醫務人員負責,設組長1人。按每10萬人口配...
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針對新靶點開發抗腫瘤藥物
...試驗中顯示出良好的抗腫瘤活性。 Flavopiridol(L86-8275,HMR1275)是CDK2和CDK4的雙重抑制劑,阻止細胞的G2/M過渡以及細胞從G1期進入S期。Ⅰ、Ⅱ期臨牀數據顯示,Flavopiridol對RCC的反應率良好,腫瘤體積的減小程度高於50%。 UCN-01...
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BreakthroughDisseminatedAspergillusustusInfectioninAllogeneicHematopoieticStemCellTransplantRecipientsReceivingVoriconazoleorCaspofunginProphy
...ceptibilitytestingofCandida[sic]species.Antimicrob.AgentsChemother.46:3644-3647.Gene,J.,A.Azon-Masoliver,J.Guarro,G.DeFebrer,A.Martínez,C.Grau,M.Ortoneda,andF.Ballester.2001.CutaneousinfectioncausedbyAspergillusustus,anemergingopportunisticfungusinimmunosuppressedpatients.J.Clin.Microbiol.39:1134-1...
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DisseminationofSalmonellaentericasubsp.entericaSerovarTyphimuriumvar.CopenhagenClonalTypesthroughaContractHeifer-RaisingOperation
...lmonellaisolatesfromfoodanimalsandgroundmeat.Antimicrob.AgentsChemother.45:3647-3650.作者:NarasimhaV.Hegde,MichelleL.Cook,DavidR.Wol
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脂肪肝危險因素Logistic迴歸分析
...56名。研究對象一般資料見表1,其中男8309例(69.5%),女3647例(30.5%),按年齡段分成5組,其中20~29歲組2703例(22.6%),30~39歲組4135例(34.6%),40~49歲組2112例(17.7%),50~59歲組1074例(9.0%),60歲以上組1932例(16.2%)。表...
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SmallorganswithahighmetabolicrateexplainlowerrestingenergyexpenditureinAfricanAmericanthaninwhiteadults
...andbrain)andthereforealowerproportionofbodymassashigh-metabolic-rate(HMR)tissuesthandowhites.Ifthishypothesisprovestobetrue,thenthepreviouslyreportedlowerREEinAfricanAmericansmaybeexplainedtotallyorinpartbydifferencesinthecompositionofthebodysFFMcompartment.SUBJECTSANDMETHODSSubjec...
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雌激素對腦缺血的神經保護作用機制
...004,5(6):411-419. 10VogelvangTE,MijatovicV,KenemansP,etal.HMR3339,anovelselectiveestrogenreceptormodulator,reducestotalcholesterol,low-densitylipoproteincholesterol,andhomocysteineinhealthypost-menopausalwomen.FertilSteril,2004,82(6):1540-1549. 11TomirnotoH,Ak...