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抗體依賴的病毒感染增強作用
...生明顯影響,這種現象稱爲抗依賴的病毒感染增強作用(ADE)。 1.ADE的類型 ADE有兩種形式,一種是由FcR介導的ADE(FcR-ADE),涉及到病毒、抗體和細胞表面的FcR。這種形式對於HIV來說又可分爲兩種,一種是FcR介導的CD4依賴...
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InVivoActionsofAngiopoietinsonQuiescentandRemodelingBloodandLymphaticVesselsinMouseAirwaysandSkin
...lativelylong-termandsustainedcirculatingexpressionofeachangiopoietinusinganadenoviraldeliverysystem.Twoweeksaftertreatment,weobservedtrachealbloodandlymphaticvascularenlargement,andlymphaticfilopodiaformation,withAng2.Co-treatmentwithAng2attenuatedAng1-inducedtrachealbloodandlymphaticremodeling.Inth...
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全球致死性藥物不良事件八年內增長近3倍
...1998~2005年收集的藥物不良事件報告顯示——8年,致死性ADE增長近3倍 近年來,世界各國的藥物不良事件(ADE)呈逐漸增加的態勢,由ADE引發的致死事件大有愈演愈烈之勢。近日,美國醫療安全協會(InstituteforSafeMedicationPractice...
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Isoform-DependentCholesterolEffluxFromMacrophagesbyApolipoproteinEIsModulatedbyCellSurfaceProteoglycans
...oform-specificdifferenceinitsfunctionforcholesteroleffluxfromcholesterol-loadedRAW264.7cells,amurinemacrophagecelllinethatlacksendogenousapoEexpression.MethodsandResults—WhenhumanapoEwasexpressedinRAW264.7cells,apoE2reducedcellulartotalcholesterol(TC)andesterifiedcholesterol(EC)levelssignificantly...
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AdenovirusVectorE4GeneRegulatesConnexin40and43ExpressioninEndothelialCellsviaPKAandPI3KSignalPathways
...seases.Infectionofendothelialcells(ECs)withfirst-generationE1/E3-deletedE4+adenovirus(AdE4+)selectivelymodulatesthesurvivalandangiogenicpotentialofECsbyasofyetunrecognizedmechanisms.WeshowherethatAdE4+vectorspotentiateCxexpressioninECsinvitroandinmousehearttissue.InfectionofECswithAdE4+,butnotAdE4eC...
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藥物不良反應監測研究--回顧與展望
...計學家DavidFinney於1965年首先提出,強調對藥物不良事件(ADE)而非ADR的報道,“處方事件監測”中的“事件”完全改變了最初的概念,即凡確認爲ADR的症狀以及懷疑爲ADR的症狀或因發現症狀而到醫院就診等都包含在“事件”之列,...
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FXR1P與Btf相互作用的鑑定
...司。 1.1.2主要試劑酵母SD培養基,SD/-His/-Leu/-Trp,SD/-Ade/-His/-Leu/-Trp培養基,X-β-半乳糖苷(X-gal)等購自Clontech公司;醋酸鋰購自Sigma公司;其他試劑均國內購買。 1.2方法 1.2.1藍色克隆文庫質粒的分離通過文庫篩選我們...
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癲癇藥物治療進展
...和血漿蛋白結合,唑尼沙胺、拉莫三嗪、奧卡西平等新型ADE與血漿蛋白結合率均低於傳統ADE。(3)單藥使用半衰期長,多數僅日需1~2次口服,只有加巴噴丁半衰期短,需多次給藥。(4)在體內不會代謝,從腎排泄,爲線性藥...
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乙型肝炎病毒抗原與金屬硫蛋白相互作用的研究
...酵母Y187進行配合、雙雜交,在營養缺陷培養基(SD/Trp-Leu-His-Ade)上及X-αgal藍白斑雙重篩選與肝細胞蛋白結合的蛋白編碼基因,進一步用網織紅細胞裂解物體外翻譯、蛋白間免疫共沉澱實驗證實其相互作用的可靠性。該研究成功地篩選...
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SciTranslMed:殺死登革病毒的人源抗體
...體。此外,E蛋白還可能引起抗體依賴的增強感染作用(ADE)。C蛋白可能在蛋白質和RNA的相互作用中發揮作用。M蛋白與病毒感染能力的強弱有關。登革病毒可分爲4個血清型,與其他B組蟲媒病毒如乙型腦炎病毒可交叉免疫反應。...
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Pneumoniabeforeantibiotics
...,USA.0-8018-8327-X(hardcover).UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,USA.E-mail:ar127@columbia.edu(A.J.Ratner);weiser@mail.med.upenn.edu(J.N.Weiser)Streptococcuspneumoniae(thepneumococcus)wasfirstisolatedbyPasteurandSternbergin1880andshortlythereafterwasrecognizedasthemos...
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美國研究生物質糖類先進生物化學轉化爲可再生燃料和化學品方法
...dbiofuelsthatwillbeabletoreplacegasolineordieselwithoutrequiringspecialupgradesorchangestothevehicleorfuelinginfrastructure.ThisannouncementispartoftheObamaAdministration‘scontinuingcommitmenttoacceleratingRDtodevelopamoresustainabletransportationsystem,lowerourdependenceonforeignoil,andgrowAmeric...
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AdenosineinhibitsENaCviacytochromeP-450epoxygenase-dependentmetabolitesofarachidonicacid
【摘要】Weusedthepatch-clamptechniquetoexaminetheeffectofadenosineonepithelialsodiumchannel(ENaC)activityinratcorticalcollectingduct(CCD).ApplicationofadenosineinhibitsENaCactivity,andtheeffectofadenosinewasmimickedbycyclohexyladenosine(CHA),anA1adenosine-receptoragonistthatreducedchannelactivit...
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關於啓用藥品生產許可證登記表和醫療機構製劑許可證登記表填報軟件的通知
...ads/details.aspx?displaylang=zh-cnfamilyid=9ad000f2-cae7-493d-b0f3-ae36c570ade8作者:食藥監安函[2005]61號
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乙型肝炎病毒受體介導侵入細胞機制的研究現狀
...表面也有分佈,可能對病毒侵入肝細胞也有意義。 2.3ADE作用(抗體依賴的感染增強作用)簡而言之病毒的ADE作用就是病毒顆粒與抗體或補體結合形成複合物後反而利用了細胞膜上的抗體Fc段受體或補體受體附着於細胞膜上,...
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FDA授予羅氏單抗藥物GA101治療CLL優先審查資格
...mia(CLL)AnnouncementfollowsFDABreakthroughTherapyDesignationforGA101inCLLFDAdecisionontheGA101BiologicsLicenseApplication(BLA)isexpectedbytheendof2013Roche(SIX:RO,ROG;OTCQX:RHHBY):RochetodayannouncedthattheU.S.FoodandDrugAdministration(FDA)hasacceptedthecompany‘sBiologicsLicenseApplication(BLA)for...
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DengueandDengueVaccines
...hereisnear-universalagreementamongpolicymakersinSoutheastAsiancountriesthatadenguevaccineisurgentlyneeded[4].ThissenseofurgencyissharedbytheUSmilitaryandtheWorldHealthOrganization[5].Akeyfactdrivingdenguevaccinedevelopmentisthataprimaryinfectionwith1serotypemayinducelong-termprotectiveimmunitytorein...
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酵母雙雜交體系的新發展
...報告基因。如PJ69-4A[14]具有三個報告基因:GAL1-HIS3、GAL2-ADE2和GAL7-LacZ,GAL1、GAL2、GAL7都有可被Ga14BD識別的特異序列,且特此之間各不相同,使三種報告基因能同時產生假陽性反應的機率明顯下降。其中GAL2-ADE2,經對照實驗檢測爲...
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拜耳亞洲藥物警戒:跨國安全報告需求缺失
...協作將會得到增強。 問:亞洲藥品不良反應/事件(ADR/ADE)報告的安全數據庫的要求和電子投遞是多種多樣的。製藥公司和監督管理部門建立一個可爲亞洲患者服務的綜合藥物警戒系統需採取哪些措施? JDelumeau:日本具有...
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淺議如何預防中藥注射劑引起的藥品不良反應
...不適,及時告訴陪護者或醫務人員,採取搶救措施,避免ADE(藥品不良事件)事件發生。中藥過敏史者,最好慎用,避免再次損害。 臨牀使用過程中,注意以上幾個原則,就能預防ADR事件對我們的傷害!倡導合理用藥,警惕&ldquo...
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心肌缺血預適應在急性心肌梗死中的作用
...。參考文獻1MurryCE,JenningRB,ReimerKA.Preconditioningwithischemia:adeˉlayofiethalcellinjuryinischemicmyocardium.Circulation,1986,74(2):1124.2Braunwald.陳灝珠主譯.心臟病學.第五版.北京:人民衛生出版社,1999,1100.作者單位:300202天津河西醫院作者:周...
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OutcomeandSevereHemorrhagicComplicationsofIntravenousThrombolysisWithTissuePlasminogenActivatorinVeryOld(80Years)StrokePatients
...variablesandcounts(percentage)forcategoricalvariables.GroupcomparisonsweremadeusingtheMann–WhitneyUtestforcontinuousvariablesandFisherexacttestforcategoricalvariables;forcorrelations,Spearmanrankcorrelationswereused.Toidentifyindependentpredictorsoffavorableoutcomeanddeath,logisticregressionanalys...
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Long-TermandSustainedCOMP-Ang1InducesLong-LastingVascularEnlargementandEnhancedBloodFlow
...chanismoflong-lastingvascularenlargement.WefoundthatCOMP-Ang1administeredbyadenoviralvectorinducedlong-lastingvascularenlargementandincreasedtrachealbloodflow.Incontrast,short-termadministrationofCOMP-Ang1recombinantproteininducedtransientvascularenlargementthatspontaneouslyreversedwithinamonth.Inbo...
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登革熱及登革出血熱
...制。稱抗體信賴性感染增強現象(Antibody-dependentenhancement,ADE),導致登革出血熱發生。有人發現Ⅱ型登革病毒株有多個與抗體依賴性感染增強現象有關的抗源決定簇,而其他型病毒株則無這種增強性抗原決定簇,故Ⅱ型登革病毒...
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S-Adenosylmethionine:molecular,biological,andclinicalaspectsanintroduction
...armacy,UniversityofSouthernCalifornia,LosAngeles.2PresentedatthesymposiumS-Adenosylmethionine(SAMe):fromMolecularMechanismtoClinicalImplications,heldinSantaBarbara,CA,March710,2001.3AddressreprintrequeststoCSLieber,BronxVAMedicalCenter(151-2),130WestKingsbridgeRoad,Bronx,NY10468.E-mail:lieberc...
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Leopardspotretinalpigmentationininfancyindicatingaperoxisomaldisorder
...esinneonataladrenoleucodystrophyhadonlybeenpublishedin1978).Noreferencewasmadetotheperoxisomes(peroxisomalabnormalitieswerefirstidentifiedinneonataladrenoleucodystrophyin1982).Thepatientdiedwithoutadefinitediagnosisat5yearsofagebutnecropsyrevealedanenlargedcirrhoticliver,adrenalcorticalatrophy,andwh...
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鈀(Ⅱ)配合物抗癌活性研究進展
...四核環狀生物結構模式。最近,筆者以Pd(phen)Cl2和腺嘌呤(ade)反應,獲得生物配合物單晶,晶體分子結構顯示,ade以N3、N9與Pd(Ⅱ)離子橋聯配位,形成雙核配合物[43]。這些工作對深入理解鈀(Ⅱ)配合物與DNA的作用機制提供了有...
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壓縮空氣致大腸損傷
...reatmentofonepatientwithCICAwasreported,whilealiteraturesreviewofCICAwasmade.ResultsThepatientwashealedbyoperation.ConclusionThehistoryisimportanttothediagnosisofCICA.Thekeyofsavinglifeisthedecompressionperitoneocentesisintime.Thelocaltreatmentofcolorectalinjurydependsonroutineofcolorectalinjurytr...
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奎的平治療成人與兒童精神分裂症的療效比較
...auscherJ,etal.Quetiapine:aneffectiveantipsychoticinfirstepisodeschizophreniadespiteonlytransientlyhighdopamine2receptorblockade.JClinPsychiatry,2002,63(10):992.3姚輝,侯剛,王筱蘭,等.奎的平治療精神分裂症臨牀觀察.臨牀精神醫學雜誌,2003,13(4):221.4高誠忠,高至勝...
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NHE8mediatesamiloride-sensitiveNa+/H+exchangeacrossmosquitoMalpighiantubulesandcatalyzesNa+andK+transportinreconstitutedproteoliposomes
...iletheinsectisstillbloodfeeding(4)butneithertheprocessnoritsregulationisyetadequatelyunderstoodatthemolecularlevel.Ithasbeenpostulatedthatthefeedingactivatesasyetunidentifiedmechanoreceptor(s)inthegut,whichinturnpromptthereleaseofneurosecretoryfactorsfromthebrainthatactivatesignalingpathwaysthatregu...