SerumparaoxonaseactivityisdecreasedintheactivestageofBeh?et’sdisease
...ctsoflipidperoxidationinducedbyreactiveoxygenspeciesinpatientswithBeh?et’sdisease(BD)intheactivestage.Methods:SerumMDAlevelsandPON1levelsweremeasuredspectrophotometricallyin16patientswithBDintheactivestageofthediseaseandin15healthysubjectswhoconstitutedthecontrolgroup.Results:IntheBDgroup,median(r...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第10期ResponsetoallegationsandsomeconsiderationsoninterferontreatmentinBeh?et’sdisease
...omandhalukd@hacettepe.edu.trAcceptedforpublication13May2003Keywords:Beh;et;sdisease;interferonKotteretalrefertosomeproblems,suchasfabricationofauthorship,possiblydata,andethicaltransgressions,1inourarticlepublishedintheLancet.2However,theydosowithoutknowingthecurrentfactsaboutanongoingprocess.Theyci...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第2期5,10-MethylenetetrahydrofolatereductaseC677TgenepolymorphisminBeh?et’spatientswithorwithoutocularinvolvement
...reasedserumlevelsofhomocysteine(Hcy)havebeenreportedinpatientswithBeh?et’sdisease(BD)withanestablishedriskfactorforvascularinvolvement.Recently,theauthorsdemonstratedthatelevatedHcylevelsareassociatedwithocularinvolvementinsuchpatients.Ontheotherhand,elevatedlevelsofHcycanresultfromgeneticerrors.I...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第12期DiagnosisandtreatmentofParkinsondisease:moleculestomedicine
...ficanteffectofrTMS(approximately20%improvementonthemotorUnifiedParkinson’sDiseaseRatingScale[UPDRS]).Otherlargestudieshavefailed,promptingconcernregardingthestandardizationoftechnique.Inaddition,ameasurableplaceboeffect,asdetectedbyPETscan,canbeseenwithrTMSthatmaybeconfoundingstudyresults(S43).Awe...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第7期OxidativestressandAlzheimerdisease
...tificationofcerebrospinalfluidF2-isoprostaneconcentrationsasabiomarkerofthisdisease.PROTEINGLYCATIONANDALZHEIMERDISEASEGlycationphenomenahavebeenheldresponsibleformanyage-relatedpathologies.Glycationofproteinsstartsasanonenzymaticprocesswiththespontaneouscondensationofketoneoraldehydegroupsofasugarw...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第2期Alzheimerdisease:protectivefactors
...lsarecolocalizedwithperivasculardepositsofamyloid-betaproteininAlzheimer‘sdiseasebrain.Stroke1997;28:194850.NetlandEE,NewtonJL,MajochaRE,TateBA.Indomethacinreversesthemicroglialresponsetoamyloidbeta-protein.NeurobiolAging1998;19:2014.McGeerPL,RogersJ.Anti-inflammatoryagentsasatherapeut...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第2期EvidenceofaRoleforLactadherininAlzheimer??sDisease
...minedlactadherinexpressioninbrainsectionsofpatientswithorwithoutAlzheimer??sdiseaseandstudieditsroleinthephagocytosisofamyloidß-peptide(Aß).CellsinvolvedinAlzheimer??sdisease,includingvascularsmoothmusclecells,astrocytes,andmicroglia,showedatime-relatedincreaseinlactadherinproductionincu...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第3期VitaminEandAlzheimerdisease:thebasisforadditionalclinicaltrials
MichaelGrundman1FromtheAlzheimer‘sDiseaseCooperativeStudy,DepartmentofNeurosciences,UniversityofCalifornia,SanDiego.2SupportedbytheNationalInstitutesofHealth(grantU01AG10483).3AddressreprintrequeststoMGrundman,Alzheimer‘sDiseaseCooperativeStudy,9500GilmanDrive0949,LaJolla,CA,92093-0949.E-m...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第2期Mycobacteriumaviumsubsp.paratuberculosis,GeneticSusceptibilitytoCrohn‘sDisease,andSardinians:theWayAhead
...asperformedtodeterminewhatproportionofpeopleinSardiniawithorwithoutCrohn‘sdiseasewereinfectedwithMycobacteriumaviumsubspeciesparatuberculosisandhadapreponderanceofallelicvariantsofNod2,anintracellularproteininvolvedinCrohn‘sdiseasesusceptibility.GeneticanalysisoftheallelesoftheNOD2/CARD15gene(in...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期DysfunctionofTGF-?signalinginAlzheimer’sdisease
...poorlyunderstoodpathologicreactionthatresultsinthedevelopmentofAlzheimer’sdisease(AD).Despiteintensivestudy,thereisnoconsensusastohowA?accumulationcausesneurodegenerationinAD.InthisissueoftheJCI,Tesseuretal.reportthattheexpressionofTGF-?typeIIreceptor(T?RII)byneuronsisreducedveryearlyinthecourseof...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第11期