Ouabainmodulationofendothelialcalciumsignalingindescendingvasarecta
...wetestedwhetherouabainmodulatesendothelialcytoplasmiccalciumconcentration([Ca2+]CYT)inratdescendingvasarecta(DVR).Overabroadrangebetween10-10and10-4M,ouabainelicitedbiphasicpeakandplateau[Ca2+]CYTelevations.Blockadeofvoltage-gatedCa2+entrywithnifedipinedidnotaffecttheresponsetoouabainmitigatingagain...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期IntracellularANGIIinducescytosolicCa2+mobilizationbystimulatingintracellularAT1receptorsinproximaltubulecells
...tionofANGIIdirectlyinsinglePTCsincreasesintracellularcalciumconcentration([Ca2+]i)and,ifso,elucidatedthecellularmechanismsinvolved.Changesin[Ca2+]iresponseswerestudiedbyfluorescenceimagingusingtheCa2+indicatorfluo3.ANGII(1nM)wasmicroinjecteddirectlyinthecells,whereascell-surfaceangiotensintype1(AT1)...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第6期Intercellularcalciumsignalingandnitricoxidefeedbackduringconstrictionofrabbitrenalafferentarterioles
...要】Vasoconstrictionandincreaseintheintracellularcalciumconcentration([Ca2+]i)ofvascularsmoothmusclecellsmaycauseanincreaseofendothelialcell[Ca2+]i,which,inturn,augmentsnitricoxide(NO)productionandinhibitssmoothmusclecellcontraction.Thishypothesiswastestedinmicroperfusedrabbitrenalafferentarteriol...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第4期SynergisticEffectofThrombinonCollagen-InducedPlateletProcoagulantActivityIsMediatedThroughProtease-ActivatedReceptor-1
...stoelucidatethemechanismofthissynergisticactionwithafocusontheintracellularCa2+concentration([Ca2+]i)andthevariousplateletreceptorsforthrombin.MethodsandResults—Wedemonstratethatprocoagulantactivityisrelatedtoasustainedincreased[Ca2+]i,whichinturndependsonextracellularCa2+influx.IncreasedPtdSerexp...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期Endothelin-Aand-Breceptors,superoxide,andCa2+signalinginafferentarterioles
...fromratkidneyandloadedwithfura2.Endothelin-1(ET-1)rapidlyincreasedcytosolicCa2+concentration([Ca2+]i)by303nM.Thesuperoxidedismutasemimetictempol,theNAD(P)Hoxidaseinhibitorapocynin,andnicotinamide,aninhibitorofADPRcyclase,diminishedtheresponseby60%.TheETBRagonistsarafotoxin6c(S6c)increasedpeak[Ca2+]i...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第1期[Ca2+]iReductionIncreasesCellularProliferationandApoptosisinVascularSmoothMuscleCells
...larsmoothmusclecells(VSMCs)haveanabnormalphenotypeanddefectiveintracellularCa2+([Ca2+]i)regulation.WeexaminedcAMPcontentinvascularsmoothmusclesfromPkd2+/eCmicebecausecAMPiselevatedincysticrenalepithelialcells.WefoundcAMPconcentrationwassignificantlyincreasedinPkd2+/eCvesselscomparedwithwild-typevess...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期PotentiationofNativeandRecombinantP2X7-MediatedCalciumSignalingbyArachidonicAcidinCulturedCorticalAstrocytesandHumanEmbryonicKidney293Cell
...nofextracellularAAinthemodulationofthepurinoceptorP2X7-mediatedelevationof[Ca2+]iinculturedneocorticaltype-1astrocytesandP2X7-,P2X2-transfectedhumanembryonickidney(HEK)293cells.Wereportthatinculturedastrocytes,AA-induced[Ca2+]ielevationiscoupledtodepletionofintracellularCa2+storesandtoasustainednonc...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期Voltage-gatedCa2+entryandryanodinereceptorCa2+-inducedCa2+releaseinpreglomerulararterioles
...(ADPR)cyclase,andamplificationoftheinitialIP3R-stimulatedreleaseofcytosolicCa2+([Ca2+]i)fromthesarcoplasmicreticulum(SR)(FellnerSK,ArendshorstWJ.AmJPhysiolRenalPhysiol288:F785-F791,2004).Theresponseoftheryanodinereceptor(RyR)tolocalincreasesin[Ca2+]iisdefinedascalcium-inducedcalciumrelease(CICR).Toi...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第5期Effectoftyrosinekinaseblockadeonnorepinephrine-inducedcytosoliccalciumresponseinratafferentarterioles
...nnorepinephrine(NE)-inducedchangesinintracellularfreecalciumconcentration([Ca2+]i)inratafferentarterioles.[Ca2+]iwasmeasuredinmicrodissectedarteriolesusingratiometricphotometryoffura2fluorescence.Thecontrol[Ca2+]iresponsetoNE(1µM)consistedofarapidinitialpeakfollowedbyaplateauphasesustainedabov...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第5期鈣穩態與鈣超載
...體重要的元素成分之一,在體內以結合狀態和離子狀態(Ca2+)存在。但只有Ca2+才具有生理活性。體內Ca2+分爲細胞內Ca2+和細胞外Ca2+兩種,其中,胞質鈣作爲第二信使對細胞各種生理活動具有廣泛調控作用。1.2第二信使作...
醫源資料庫;在線期刊;中華醫學研究雜誌;2009年第9卷第3期