PPAR-ligandamelioratesacuterenalfailurebyreducingcisplatin-inducedincreasedexpressionofrenalendonucleaseG
...ulesincisplatin-treatedmice.PretreatmentofPPAR-wild-typemicewithPPAR-ligandWY-14643reducedsignificantlycisplatin-inducedincreasedproteinexpressionandenzymeactivityofEndoGandpreventedthenucleartranslocationofmitochondrialEndoG.MorphologicalexaminationoftubularinjuryinthePPAR-wild-typemicethatreceived...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期ModulationofPPARExpressionandInflammatoryInterleukin-6ProductionbyChronicGlucoseIncreasesMonocyte/EndothelialAdhesion
...invascularcells,soweexaminedPPAR-associatedsignalinginEC.AknownPPARagonist,Wy14,643,preventedglucose-mediatedIL-6productionbyECandreducedglucose-mediatedmonocyteadhesionby40%.HG-culturedHAEChada50%reductioninexpressionofPPARcomparedwithcontrolEC.PrimaryaorticECisolatedfromPPARknockout(KO)miceshowedi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第5期PPARligandprotectsduringcisplatin-inducedacuterenalfailurebypreventinginhibitionofrenalFAOandPDCactivity
...owreportontheeffectsofperoxisomeproliferator-activatedreceptor-(PPAR)ligandWy-14643(WY)ontheabnormalitiesofmediumchainfattyacidoxidationandpyruvatedehydrogenasecomplex(PDC)activityinkidneytissueofcisplatin-treatedmice.CisplatincausesasignificantreductioninmRNAlevelsandenzymeactivityofmitochondrialme...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第3期ModulationofReceptorPhosphorylationContributestoActivationofPeroxisomeProliferatorActivatedReceptorbyDehydroepiandrosteroneandOtherPeroxisome
...,PPARcanbeactivatedwithperoxisomeproliferators(PP),suchasfibratedrugs(e.g.,Wy-14643,clofibrate),nonfibratedrugs(nafenopin),fattyacids,chlorinatedcompounds,nonsteroidalanti-inflammatorydrugs,andendogenoussteroids,suchasdehydroepiandrosterone(DHEA)(EscherandWhali,2000).MostPPserveasligandsfortherecept...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期FenofibricAcid,anActiveFormofFenofibrate,IncreasesApolipoproteinA-I–MediatedHigh-DensityLipoproteinBiogenesisbyEnhancingTranscriptionofATP-Bi
...iptionofthegeneofapolipoproteinA-I(apoA-I)intheliver.13–15APPARactivator,Wy14643,wasshowntoupregulatethegeneofATP-bindingcassettetransporterA1(ABCA1)16thatmediatesandrate-limitsbiogenesisofHDLbytheinteractionofhelicalapolipoproteinandcells.17–20ABCA1expressionisenhancedbyloadingcholesteroltocell...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第6期ConstitutiveExpressionofPeroxisomeProliferator-ActivatedReceptor-RegulatedGenesinDwarfMice
...dthosealteredbythePP4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thioaceticacid(WY-14,643)in+/dwmice.Thegenesincludedthoseinvolvedin-and-oxidationoffattyacids(Acox1,Cyp4a10,Cyp4a14)andthoseinvolvedinstressresponses(thechaperonin,T-complexprotein1)andcardiovasculardisease(fibrinogen).Thelevelsofsomeofthes...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期ReciprocalandCoordinateRegulationofSerumAmyloidAVersusApolipoproteinA-IandParaoxonase-1byInflammationinMurineHepatocytes
...orafterexposuretotheperoxisomeproliferator-activatedreceptor-(PPAR)ligands(WY-14643andfenofibrate).Consistentwiththesefindings,thebasallevelofSAAwasincreased,whereasapoA-IandPON-1decreasedinprimaryhepatocytesfromPPAR-deficientmiceascomparedwithwild-typemice.Moreover,neitherWY-14643norfenofibratehada...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期ExpressionofHemeOxygenase-1inHumanVascularCellsIsRegulatedbyPeroxisomeProliferator-ActivatedReceptors
...umans.28,29ThereforewedeterminedtheinfluenceofligandsspecificforeitherPPAR(Wy-14,643andfenofibrate)orPPAR(rosiglitazoneandtroglitazone)onHO-1expressioninvascularcells.Westernblotanalysis(Figure1A)andimmunofluorescence(Figure1B)demonstratedthatbothPPARandPPARligandsinducedHO-1expressioninhumanumbilic...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第6期PeroxisomeProliferator-ActivatedReceptorAgonistsIncreaseNitricOxideSynthaseExpressioninVascularEndothelialCells
...Raction,inhibitedthefenofibrate-inducedupregulationofeNOSproteinexpression.WY14643andbezafibratealsoincreasedeNOSproteinlevels,whereasrosiglitazonedidnot.TransienttransfectionexperimentsusinghumaneNOSpromoterconstructshowedthatfenofibratefailedtoenhanceeNOSpromoteractivity.ActinomycinDstudiesdemonst...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期HepaticPGC-1βOverexpressionInducesCombinedHyperlipidemiaandModulatestheResponsetoPPARActivation
...hesetwocoactivatorsinpotentiatingthelipidloweringpropertiesofthePPARagonistWy14,643(Wy).MethodsandResults—C57BL/6micewerefedchoworHFDandtransducedwithadenovirusesencodingPGC-1orPGC-1β.Onchow,hepaticPGC-1βoverexpressioncausedseverecombinedhyperlipidemiaincludingelevatedplasmaapolipopr...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第12期