AnessentialroleforSKAP-55inLFA-1clusteringonTcellsthatcannotbesubstitutedbySKAP-55R
...antigen-presentingcell(APC)conjugation.Inthisstudy,down-regulationofSKAP-55bysmallinterferingRNAs(siRNAs)identifiedanessentialroleforthisadaptormoleculeintheTcellreceptor(TCR)–mediated“inside-outsignaling“thatisneededforLFA-1clusteringandTcell–APCconjugation.Incontrast,down-regulationofSKAP-...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第11期外周血細胞膜上CD55和CD59缺陷對鑑別診斷陣發性睡眠性血紅蛋白尿與貧血的意義
【摘要】目的探討患者外周血細胞膜上CD55和CD59缺陷對鑑別診斷陣發性睡眠性血紅蛋白尿(parosysmalnocturnalhemoglobinuria,PNH)與貧血(anemia)的意義。方法採用熒光素標記的CD55和CD59單克隆抗體,流式細胞術檢測30例正常人、32例再生...
醫源資料庫;在線期刊;濱州醫學院學報;2007年第30卷第2期MutationStudiesofSer7.39andSer2.60intheHumanCB1CannabinoidReceptor:EvidenceforaSerine-InducedBendinCB1TransmembraneHelix7
...關鍵詞】Mutation200-fold.Incontrast,thebindingaffinityandpotencyofWIN55,212-2,CP55,940,HU210,andAM4056wereunalteredattheS2.60AmutantcomparedwithWThumanCB1receptors.TheseresultsclearlysuggestthatSer7.39,butnotSer2.60,playsacrucialroleinmediatingligandspecificinteractionsforCP55,940,HU210,andAM405...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期劉新垣院士2011連發兩篇權威刊物癌症研究文章
...毒在正常細胞中複製必需而在腫瘤細胞中複製非必需的E1B55K蛋白,構建了靶向甲胎蛋白(AFP)陽性肝癌的雙調控溶瘤腺病毒載體Ad#8226;AFP#8226;E1A#8226;E1B(Δ55)(簡稱Ad#8226;AFP#8226;D55)。與僅缺失E1B55K蛋白的單調控溶瘤腺病毒ZD55(ONYX-015...
行業資訊;臨牀快報;腫瘤相關StructuralDeterminatesforApolipoproteinE-DerivedPeptideInteractionwiththe7NicotinicAcetylcholineReceptor
...ctedinXenopuslaevisoocytesexpressingwild-typeandmutatednAChRs.MutationofTrp55toalanineblocksapoEpeptide-inducedinhibitionofacetylcholine(ACh)-mediated7nAChRresponses.AdditionalmutationsatTrp55suggestthathydrophobicinteractionsbetweenthereceptorandapoE141–148areessentialforinhibitionof7nAChRfun...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期雄激素受體相關蛋白55在人胎兒前列腺發育中的表達
...這當中涉及間質-上皮的相互作用。雄激素受體相關蛋白55(ARA55)是一種定位於間質細胞的雄激素受體共活化物,可與雄激素(AR)結合,並調節雄激素受體的易位和轉錄活性。美國紐約大學醫學院的CaiG博士及其同事對ARA55是否...
行業資訊;臨牀快報;內分泌代謝SphingosineandItsAnalog,theImmunosuppressant2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol,InteractwiththeCB1CannabinoidReceptor
...-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol([3H]CP55,940)inaconcentration-dependentmannerinbothCB1-expressingcelllinesandmousecerebellum.However,thesecompoundsdidnotsignificantlyalter[3H]CP55,940bindingtoCB2receptors.InG-proteinactivationassays,FTY720andsphingosineinhibitedt...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期AllostericModulationoftheCannabinoidCB1Receptor
...heOrgcompoundssignificantlyincreasedthebindingoftheCB1receptoragonist[3H]CP55,940[(1R,3R,4R)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexan-1-ol],indicativeofapositivelycooperativeallostericeffect.Thesamecompoundscausedasignificant,butincomplete,decreaseinthespecificbinding...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期55株腦膜炎奈瑟菌對12種抗生素體外敏感性試驗
...LSI/NCCLS)推薦的紙片擴散法和最低抑菌濃度法測定深圳市55株Nm對抗生素的敏感性並進行分析。結果所有菌株對青黴素、氨苄西林、頭孢曲松、頭孢噻肟、美洛培南、米諾環素、氯黴素、利福平敏感,而全部菌株對複方新諾明耐...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第2期CannabinoidReceptor-MediatedApoptosisInducedbyR(+)-MethanandamideandWin55,212-2IsAssociatedwithCeramideAccumulationandp38ActivationinMantleC
...sisaftertreatmentwiththesyntheticagonistsR(+)-methanandamide[R(+)-MA]andWin55,212-2(Win55;(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo-[1,2,3-d,e]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone)wasdependentonbothcannabinoidreceptors,becausepretreatmentwithN-(piperidin-1-yl)-5-(4-chlor...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期