TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...ecytomegalovirus(MCMV)iscontrolledbyadominantlocus,Cmv1.Cmv1islinkedtotheLy49familyofnaturalkillerreceptorsondistalchromosome6.WhilesomestudieslocalizedCmv1asdistaltotheLy49genecluster,geneticandfunctionalanalysisidentifiedLy49hasapivotalfactorinresistancetoMCMV.Theroleofthesetwoindependentgenomicdo...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...ecytomegalovirus(MCMV)iscontrolledbyadominantlocus,Cmv1.Cmv1islinkedtotheLy49familyofnaturalkillerreceptorsondistalchromosome6.WhilesomestudieslocalizedCmv1asdistaltotheLy49genecluster,geneticandfunctionalanalysisidentifiedLy49hasapivotalfactorinresistancetoMCMV.Theroleofthesetwoindependentgenomicdo...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第3期TheNeurosteroidsDehydroepiandrosteroneSulfateandPregnenoloneSulfateInhibittheUNC-49GABAReceptorthroughaCommonSetofResidues
...id,pregnenolonesulfate(PS),dependsonsixidentifiedM1residuestoinhibittheUNC-49GABAreceptor,ahomomericGABAreceptorfromCaenorhabditiselegansthatishomologoustothemammalianGABAAreceptor.Here,weinvestigatetheinhibitionoftheUNC-49GABAreceptorbyanothersulfatedneurosteroid,dehydroepiandrosteronesulfate(DHEAS...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期NaturalkillercelleducationinmicewithsingleormultiplemajorhistocompatibilitycomplexclassImolecules
...trolledbothbythenumberofNKcellsaffectedandbythestrengthofeachMHCclassI–Ly49receptorinteraction,indicatingthatNKcelleducationmayberegulatedbyacombinationofqualitativeandquantitativeevents.Abbreviationsused:CFSE,5,6-carboxyfluoresceindiacetatesuccinimidylester;DRI,down-regulatingindex;FI,fluorescenc...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期1HowardHughesMedicalInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL35294
...ptors.StimulationviathemajorhistocompatibilitycomplexI–bindingreceptor,Ly49DonCD45–/–primaryNKcellsresultedintheactivationofphosphoinositide-3-kinaseandnormalcytotoxicitybutfailedtoelicitarangeofcytokinesandchemokines.ThisblockageisassociatedwithimpairedphosphorylationofSyk,Vav1,JNK,andp38,whi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期ProatherogenicRoleforNKCellsRevealed
...FN)-,andthesecretionofatheroprotectiveautoantibodies,respectively.Seepage1049Macrophagesareparticularlyimportanttotheatheroscleroticdiseaseprocess.Theyareamongthefirstcellstoinfiltratethearterywallandregulatelesiongrowthfromitsinceptionthroughuptakeofmodifiedlipoproteins,productionofapolipoprotein(a...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第6期異基因骨髓移植中T細胞表達Ly49A與移植物抗宿主病發生相關
異基因骨髓移植中T細胞表達Ly49A與移植物抗宿主病發生相關中國免疫學雜誌2000年第10期第16卷移植免疫學作者:段連寧 郭坤元 劉明 李玉華單位:段連寧(第一軍醫大學珠江醫院血液科,廣州510282);郭坤元(第一軍醫大學...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學VLA-4和LFA-1參與HPP-EPC體內向缺血組織的歸巢
...動脈構建裸鼠後肢缺血模型,移植經功能級別的VLA-4(或CD49d)和LFA-1(或CD11a)中和抗體阻斷後的HPP-EPCs,觀察肢體壞死長度和肢體脫失情況,用放射性核素方法檢測缺血肢體血流恢復程度,組織學方法計數毛細血管密度和歸巢到缺血...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第9期Naturalselectiondrivesrecurrentformationofactivatingkillercellimmunoglobulin-likereceptorandLy49frominhibitoryhomologues
...hibitoryKIR,wetooktheapproachofreconstructingtheirnaturalhistoryandthatofLy49,theanalogoussysteminrodents.Ageneralprincipleisthatinhibitoryreceptorsareancestral,theactivatingreceptorshavingevolvedfromthembymutation.Thisevolutionaryprocessoffunctionalswitchoccursindependentlyindifferentspeciestoyield...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期高處墜落傷49例病例分析
...2004年共收治外科創傷類疾病患者241例,其中高處墜落者49例,佔20.33%,現報告如下。 1臨牀資料 1.1一般資料本組49例中,男44例,女5例,男女比例爲8.8∶1。 1.2年齡最小3歲,最大83歲。≤10歲2例,佔4.08%;11~22歲11例,...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2005年第3卷第15期