EnantiomersofNeuroactiveSteroidsSupportaSpecificInteractionwiththeGABA-CReceptorastheMechanismofSteroidAction
...usstudiesofneuroactivesteroidshaveshownthattheenantiomerofallopregnanolone(35P)ismuchlesseffectiveatpotentiatingresponsesoftheGABA-Areceptor(Wittmeretal.,1996,Coveyetal.,2000),theenantiomerof17-estradiolisineffectiveatpotentiatingthehumannicotinic42receptor(Paradisoetal.,2001),andtheenantiomerof(3,5...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期麥芽凝聚素層析柱純化的肺癌相關抗原
...rmlectin—Sepharose—6MB層析柱和自制抗人肺痛單克隆抗體N—35—Sepharose—4B層析柱純化腫瘤相關抗原,比較純化結果;用免疫印技術測定肺癌相關抗原在肺癌、肝癌、宮頸癌、乳腺痛細胞及正常人心臟及肺組織的存在及分佈情況;...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學CharacterizationofmarginalzoneBcellprecursors
...proposedtooccurbywayofproliferativeintermediatesexpressinghighlevelsofCD21/35andCD23.However,weshowthatCD21/35highCD23+splenocytesarenotenrichedforproliferativecells,anddonotcontributesubstantiallytothegenerationoffollicularBcells.Instead,ontogenicrelationships,steady-statelabelingkinetics,andadopti...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第9期EthanolModulatestheInteractionoftheEndogenousNeurosteroidAllopregnanolonewiththe122LGABAAReceptor
...examined122LGABAAreceptormodulationbytheendogenoussteroidsallopregnanolone(35P),pregnenolonesulfate,and-estradiolintheabsenceandpresenceofethanol.Coapplicationof0.1to1%(17-170mM)ethanolinfluencedreceptormodulationby35Pbutnotthatbypregnenolonesulfateor-estradiol.Oneofthethreekineticeffectsevidentinch...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第2期AspergillusHyphaeinInfectedTissue:EvidenceofPhysiologicAdaptationandEffectonCultureRecovery
...ry.ExperimentswereperformedtocomparetherecoveryofAspergillusspp.incubatedat35°Cin6%O2-10%CO2withthatat25°Cinroomair.ThesamplestestedincludedAspergillus-infectedtissuespecimensfromadogmodelandhumanautopsies,experimentalanaerobicallystressedAspergillusinocula,and10,062consecutiveclinicalspecimens.Cu...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第1期達英-35獲歐洲藥管局肯定治痤瘡多毛利大於弊
針對達英-35先後在法國和荷蘭兩國被認爲存在增加血管性栓塞風險的安全性問題,歐洲藥物管理局藥物風險評估委員會(EMA’sPharmacovigilanceRiskAssessmentCommittee,PRAC)於本月13日至16日進行了集中評估,評估結果認爲,達英-35在激...
醫藥經濟;生物技術;技術要聞UncoveringthePharmacologyoftheGProtein-CoupledReceptorGPR40:HighApparentConstitutiveActivityinGuanosine5‘-O-(3-[35S]thio)triphosphateBindingS
...s.Toalloweffectiveligandequilibration,GPR40-Gqwasusedinguanosine5‘-O-(3-[35S]thio)triphosphate([35S]GTPS)bindingassays.AfterexpressionofGPR40-GqinHEK293cellsandmembranepreparationbasalbindingof[35S]GTPSinGqimmunoprecipitateswashighandnotelevatedsubstantiallybyfattyacids.However,treatmentofmembrane...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期DifferencesinKineticsofXanomelineBindingandSelectivityofActivationofGProteinsatM1andM2MuscarinicAcetylcholineReceptors
...Xanomelinewasapotentfast-actingfullagonistinstimulatingguanosine5‘-O-(3-[35S]thio)triphosphatebindingatM1receptors,whereasatM2receptorsitbehavedasapotentpartialagonist(40%ofcarbacholmaximalresponse)onlyuponpreincubationfor1h.DevelopmentofxanomelineagonisticeffectsattheM2receptorwasslowerthanitsabi...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期35例前置胎盤期待療法臨牀分析
Theexpectanttreatmentfor35casesofplacentaprevia [關鍵詞]前置胎盤;期待療法 前置胎盤是嚴重威協孕產婦、胎兒生命主要疾病之一,降低前置胎盤的發生率,提高新生兒的存活率是醫務人員的共同目標。我院2000年1月至2005...
醫源資料庫;在線期刊;局解手術學雜誌;2006年第15卷第1期IdentificationofaNovelLigandBindingResidueArg38(1.35)intheHumanGonadotropin-ReleasingHormoneReceptor
...eractionbetweentheCterminusofgonadotropin-releasinghormone(GnRH)andArg38(1.35),locatedattheextracellularendoftransmembranedomain1ofthehumanGnRHreceptor.MutationofArg38(1.35)toalanineresultedin989-and1268-foldreductioninaffinityforGnRHIandGnRHII,respectively,thetwoendogenousligands.Conservativemutati...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期