Adose-dependentrequirementfortheprolinemotifofCD28incellularandhumoralimmunityrevealedbyatargetedknockinmutant
...nofnaiveTcellsrequirestheintegrationofsignalsthroughtheantigenreceptorandCD28.AlthoughthereisagreementontheimportanceofCD28,thereremainscontroversyonthemechanismbywhichCD28regulatesTcellfunction.Wehavegeneratedagene-targetedknockinmouseexpressingamutationintheC-terminalproline-richregionofthecytopla...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第9期CD28CostimulationIsRequiredforInVivoInductionofPeripheralToleranceinCD8TCells
...troductionMaterialsandMethodsResultsDiscussionReferencesWhereasligationofCD28isknowntoprovideacriticalcostimulatorysignalforactivationofCD4Tcells,therequirementforCD28asacostimulatorysignalduringactivationofCD8cellsislesswelldefined.EvenlessisknownabouttheinvolvementofCD28signalsduringperipheraltole...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第1期CD28CostimulationIsRequiredforInVivoInductionofPeripheralToleranceinCD8TCells
...ductionMaterialsandMethodsResultsDiscussionReferences:WhereasligationofCD28isknowntoprovideacriticalcostimulatorysignalforactivationofCD4Tcells,therequirementforCD28asacostimulatorysignalduringactivationofCD8cellsislesswelldefined.EvenlessisknownabouttheinvolvementofCD28signalsduringperipheraltole...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第1期HighPrevalenceofCirculatingCD4+CD28–T-CellsinPatientsWithSmallAbdominalAorticAneurysms
...er@uibk.ac.atAbstractObjective—ToassessthepossibleroleofproinflammatoryCD28–Tcellsinabdominalaorticaneurysms(AAAs).Animalstudiesandhumantissuestudiessuggestaroleforinterferon(IFN)-–producingTcellsinthedevelopmentandprogressionofAAAs.MethodsandResults—Fluorescence-activatedcellssorteranalysis...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期ARoleofSuppressorofCytokineSignaling3(SOCS3/CIS3/SSI3)inCD28-mediatedInterleukin2Production
...roductioninducedbyTcellreceptorcross-linkingwhenTcellsarecostimulatedwithCD28.DecreasedproteinexpressioninSOCS3+/-miceenhancedCD28-mediatedIL-2production,clearlyindicatingthecorrelationbetweenexpressionlevelofSOCS3andIL-2productionability.TheSOCS3proteininteractedwithphosphorylatedCD28throughitsSH2d...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期乙肝患者外周血T淋巴細胞上CD28表達及臨牀意義
...究乙肝患者外周血CD4+T淋巴細胞亞羣、CD8+T淋巴細胞亞羣CD28分子表達變化。探討外周血T淋巴細胞CD28的表達對乙型肝炎患者的免疫學意義及臨牀意義。方法:應用流式細胞儀檢測乙肝患者。結果:急性乙型肝炎患者CD8+、CD28+T淋巴...
醫源資料庫;在線期刊;中國民康醫學;2007年第19卷第19期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...tTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesTheCD28familymolecules,CD28,andinduciblecostimulator(ICOS)allprovidepositivecostimulatorysignals.However,unlikeCD28,ICOSdoesnotcostimulateIL-2secretion.TheYMNMmotifthatexistsintheCD28cytoplasmicdomainisaknownbindingsiteforphosphat...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第2期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...tTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesTheCD28familymolecules,CD28,andinduciblecostimulator(ICOS)allprovidepositivecostimulatorysignals.However,unlikeCD28,ICOSdoesnotcostimulateIL-2secretion.TheYMNMmotifthatexistsintheCD28cytoplasmicdomainisaknownbindingsiteforphosphat...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第2期VirusAttachmentandReplicationArePromotedafterAcquisitionofHostCD28andCD152byHIV-1
...mmunology,andMedicine,theUniversityofWesternOntario,London,Ontario,CanadaCD28isconstitutivelyexpressedonCD4+cells,butitshomologueCD152isonlyweaklyexpressedaftercellactivation.Todeterminewhetherthese2costimulatorymoleculescanbeinsertedintohumanimmunodeficiencyvirustype1(HIV-1),viruswasproducedinCD28-...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第19期與CD28有關的協同刺激信號轉導
...凋亡,或被誘導至無能狀態。最重要的協同刺激分子是CD28,它與B7結合後轉導的第二信號能增強細胞因子如IL-2基因轉錄,促進T細胞增殖,並保護T細胞免於凋亡。然而,有關此協同刺激信號轉導的確切機制至今未明。本文擬將有...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第3A期