ContributionofGeneSequenceVariationsoftheHepaticCytochromeP4503A4EnzymetoVariabilityinIndividualResponsivenesstoClopidogrel
...beenassociatedwithclopidogrelresponsevariability.BecausemetabolicactivityofCYP3A4isgeneticallyregulated,wehypothesizedthatgeneticvariationsofthisenzymemaycontributetoclopidogrelresponsevariability.MethodsandResults-G,ApolymorphismsoftheCYP3A4genewereassessedin82patientsinasteadyphaseofclopidogrelthe...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期DiscoveryofOsmosensitiveTranscriptionalRegulationofHumanCytochromeP4503AsbytheTonicity-ResponsiveEnhancerBindingProtein(NuclearFactorofActi
...DiscoveryWereportthediscoveryofanosmosensitivetranscriptionalcontrolofhumanCYP3A4,CYP3A7,andCYP3A5.Ambienthypertonicity(350–450mOsmol/kg)increasedmRNAexpressionsoftheCYP3Aby10-to20-foldinhuman-intestinalC2bbe1cells,followedbyanincreaseofCYP3Aprotein.Hypotonicity,ontheotherhand,suppressedCYP3Am...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期基因多態性和股骨頭壞死的相關研究進展
...作用,沒有找到其和ANFH的關係。Tamura等[15]也沒有找到CYP3A4和ANFH的關係。但是最近[16、17]的研究確實發現了P4503A的低活性是ANFH的一個致病因素。因此,關於CYP450的基因多態性的研究值得進一步的開展。轉運蛋白P-糖蛋白(P-g...
醫源資料庫;在線期刊;中國矯形外科雜誌;2008年第16卷第11期ModulationofUDP-GlucuronosyltransferaseFunctionbyCytochromeP450:EvidencefortheAlterationofUGT2B7-CatalyzedGlucuronidationofMorphinebyCYP3A4
...orphine3-hydroxylgroupwereexaminedbysimultaneousexpressionofUGT2B7andeitherCYP3A4,-1A2,or-2C9inCOS-1cells.AlthoughcoexpressionofCYP3A4withUGT2B7hadlittleeffectonVmax,theKmwasincreasedbyabout9.8-foldcomparedwiththeUGT2B7singleexpressionsystem.TheotherP450isozymes(CYP1A2andCYP2C9)hadsomeeffectsonKmand...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期MutualrepressionbetweensteroidandxenobioticreceptorandNF-Bsignalingpathwayslinksxenobioticmetabolismandinflammation
...teractionsbyinducinghepaticdrug-metabolizingenzymessuchascytochromeP4503A4(CYP3A4)(4).RIFalsoactsasanimmunosuppressanttosuppresshumoralandcellularimmunologicalresponsesinlivercells,anditsimmunosuppressiverolehasbeenwelldescribedinhumans(5–9).Callejaetal.suggestedthattheimmunosuppressiveeffectsofRI...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第8期SteroidandxenobioticreceptorandvitaminDreceptorcrosstalkmediatesCYP24expressionanddrug-inducedosteomalacia
...fampicinhadnoeffectonintestinalCYP24expression,despitedemonstrationofmarkedCYP3A4induction.CombinedwithourpreviousfindingsthatCYP3A4,notCYP24,playsthedominantroleinhydroxylationof1,25(OH)2D3inhumanliverandintestine,ourresultsindicatethatSXRhasadualroleinmediatingvitaminDcatabolismanddrug-inducedoste...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期PossibleinvolvementofpregnaneXreceptor–enhancedCYP24expressionindrug-inducedosteomalacia
...tsarealsorecognizedbyVDRafterheterodimerizationwithRXR,asshownwithiNOS(31),CYP3A4(32,33),CYP2B6,andCYP2C9(8).Theseobservationssuggesttousthatthesereceptorsarecapableofregulatingcommongenesthroughthesamecis-actingelements.Thiscouldrepresentanexampleoffunctionalnuclearreceptorcross-talk,suggestingthat...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期DesignofPAP-1,aSelectiveSmallMoleculeKv1.3Blocker,fortheSuppressionofEffectorMemoryTCellsinAutoimmuneDiseases
...yedontheturnoverofcoumarin(CYP2A6)or7-benzyloxy-4-trifluoromethyl-coumarin(CYP3A4)bythedetectionoftheirfluorescentmetabolites(Hendersonetal.,1999),andIC50valuesweredeterminedbytestingmultiplecompoundconcentrationsrangingfrom10nMto200μM.Allexperimentswereconductedinduplicateandresultsarereportedaspe...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期