T細胞Th1/Th2亞羣與毒性瀰漫性甲狀腺腫相關性研究
...體液免疫應答。本課題旨在對毒性瀰漫性甲狀腺腫(Gravesdisease,GD)患者T細胞Th1/Th2亞羣介導的免疫進行研究,從免疫水平探討GD的免疫病理及發病機制。 1資料與方法 1.1一般資料正常對照組32例(HD)組:男14例,女18例...
醫源資料庫;在線期刊;中國煤炭工業醫學雜誌;2006年第9卷第8期GestationalVitaminBDeficiencyLeadstoHomocysteine-AssociatedBrainApoptosisandAltersNeurobehavioralDevelopmentinRats
...Downsyndromeandintheelderly,andithasbeenidentifiedasapredictorofAlzheimer??sdisease.3,5,29-32OurstudyshowedthatgestationalvitaminBdeficiencyleadstoaccumulationofHcywithconcomitantapoptosisinselectivebrainareasandpersistentlyaltersneurobehavioralcapacitiesindevelopingrats.Physiologically,aprogressive...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第2期Allneuropathiesgreatandsmall
...88.Ye,Y.,andFortini,M.E.1999..Apoptoticactivitiesofwild-typeandAlzheimer’sdisease-relatedmutantpresenilinsinDrosophilamelanogaster.J.CellBiol.146::1351-1364.Chan,Y.B.etal.2003..NeuromusculardefectsinaDrosophilasurvivalmotorneurongenemutant.Hum.Mol.Genet.12::1367-1376.Warrick,J.M.etal.1998..Expande...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期原位肝移植手術併發症的預防和治療
...ion,splenomegalyandhypersplenia(5withhematemesishistory),1Caroli’sdisease,1Wilson’sdisease,1PrimaryBiliaryCirrhosis,1SclerosingCholangitis.Amongthem,16male,7feˉmaleandagedfrom3~49yearsold.Graftfunctionedin21cases,1patientdiedfromprimarygraftnon-function(PGN)theotherone...
合作平臺;在線期刊;中華實用醫藥雜誌;2004年第4卷第4期;論著老年性癡呆臨牀綜合治療療效觀察
...M,FondaraiJ,etal.LongtermandhinghdosepiracˉetamtreatmentofAlzheimer’sdisease.Neurology,1933,43(2):301.7BreiterJCS,GauA,WelshKA,etal.Inverseassociationofanti-inˉflamatorytreatmentsandAlzheier’sdisease:initialresultsofacotwincontrolstudy.Neurology,1944,44(2):227.8張新...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第6B期幹細胞的發育潛能及其在醫學上的應用
...驗中,將大鼠胚胎幹細胞植入大鼠的帕金森病(Pakinson’sdisease)模型中,胚胎幹細胞可以分化形成分泌多巴胺(dopamine)的神經元,並與周圍神經元整合在一起,這一結果爲治療帕金森綜合徵提供了新的思路[3]。 骨髓幹...
合作平臺;在線期刊;中華醫藥雜誌;2004年第4卷第11期;綜述Up-RegulationandIncreasedActivityofKV3.4ChannelsandTheirAccessorySubunitMinK-RelatedPeptide2InducedbyAmyloidPeptideAreInvolvedinApoptotic
...Asawhole,ourdataindicatethatKV3.4channelscouldbeanoveltargetforAlzheimer‘sdiseasepharmacologicaltherapy.AlterationofneuronalK+channelfunction,whichisinvolvedintheregulationofmembraneexcitability—includingsettingtherestingpotential,keepingactionpotentialsshort,andtiminginterspikeintervals(Bir...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期凝血酶及其抑制劑在中樞神經系統的作用
...itordomainaencodedbyanamyloidproteinprecursormRNAassociatedwithAlzheimer‘sdisease[J].Nature,1988,331:5287.Riek-BurchardtF,StriggowF,Henrich-NoackP,etal.Reymann,Increaseofprothrom-bin-mRNAafterglobalischemiainrats,withconstantexpressionofproteasenexin-1andprotease-activatedreceptors[J].Neur...
醫源資料庫;在線期刊;濱州醫學院學報;2005年第28卷第3期VareniclineIsaPartialAgonistat42andaFullAgonistat7NeuronalNicotinicReceptors
...ialtherapeutictargetsforavarietyofconditionsanddisorders,suchasAlzheimer‘sdisease,anxiety,depression,drugaddiction,epilepsy,pain,Parkinson‘sdisease,schizophreniaandTourette‘ssyndrome(Jensenetal.,2005).Thedevelopmentofsubtypeselectiveligandsisanessentialpartofattemptstomakeprogressintheseareas....
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期Birthpangs:thestressfuloriginsoflymphocytes
...CI200216886.Imaizumi,K.etal.2001..TheunfoldedproteinresponseandAlzheimer’sdisease.Biochim.Biophys.Acta.1536::85-96.Ryu,E.J.etal.2002..EndoplasmicreticulumstressandtheunfoldedproteinresponseincellularmodelsofParkinson’sdisease.J.Neurosci.22::10690-10698.Ozcan,U.etal.2004..Endoplasmicreticulumstre...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期