精神症狀對於早期PD的影響較大
...ysuggeststhatpsychiatricsymptomsthatappearintandemwithadvancingParkinson‘sdisease(PD)haveabiggerimpactonpatients‘qualityoflifeintheearlytomiddlestagesofdiseasecomparedwithlaterstages.KarenE.Anderson,MD,assistantprofessorofpsychiatryandneurologyattheUniversityofMarylandinBaltimoreandtheMarylandPa...
行業資訊;臨牀快報;神經科DifferentialSensitivityofKir2Inward-RectifierPotassiumChannelstoaMitochondrialUncoupler:IdentificationofaRegulatorySite
...iologyofseveralneurologicalandcardiovasculardisorders,includingAlzheimer‘sdisease(Baloyannisetal.,2004),Parkinson‘sdisease(Fiskumetal.,2003),heartfailure(Marin-Garciaetal.,2001),myocardialandcerebralischemia(SimsandAnderson,2002;Sadeketal.,2003),and,potentially,epilepsy(Patel,2002).Alterationofe...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期IdentificationandCharacterizationofaFunctionalTATABoxPolymorphismoftheUDPGlucuronosyltransferase1A7Gene
...ements.UGT1A128isafunctionalUGTpromoterpolymorphismassociatedwithGilbert‘sdiseaseandsevereirinotecantoxicity,whichalsooccursintheabsenceofUGT1A128.TheaimofthisstudywastoidentifyandcharacterizeUGTpromotervariantsrelevantforirinotecandetoxification.RecombinantUGT1Aproteinswereanalyzedforirinotecanme...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期60~80歲老年人血清肌酐值水平調研
...inctlycorrelativewithdiabetesmellitus、coronaryheartdiseaseandAlzheimer‘sdisease.ConclusionTheserumcreatinineleveloftheoldpeoplefrom60to80yearsoldhasnoremarkabledifferencefromserumcreatininerangeofnormaladults. 【Keywords】oldpeople;serumcreatininevalue;Alzheimer‘sdisease 肌酐是...
醫源資料庫;在線期刊;中華中西醫雜誌;2005年第6卷第20期炎症性腸病的非手術治療進展
...ngshape. [Keywords]inflammatoryboweldisease;ulcerativecolitis;Crohn‘sdisease;treatment 炎症性腸病(Inflammatoryboweldisease,IBD)是一組慢性、反覆發作性腸道非特異炎症性疾病,包括潰瘍性結腸炎(ulcerativecolitis,UC)和克羅恩病(Crohn,Sdiseas,CD),...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2012年第10卷第8期IlluminatingtheroleoftypeIIFNsincolitis
...npriortoDSStreatmentwhileadministrationtomicewithchroniccolitisinfactworsensdisease(8,10).Thus,administrationofCpGODNsinchronicallyactiveUCmayaugmentratherthansuppressintestinalinflammation.InadditiontoIFN-/?,CpGODN–TLR9signalingstronglyinducestheNF-B–dependentexpressionofproinflammatorycytokine...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期Binswanger病患者免疫狀態的研究
... 1 BennettDA,WilsonRS,GilleyDWetal.ClinicaldiagnosisofBinswanger‘sdisease.JNeurolNeurosurgPsychiatry,1990;53:961 2 LinkH,TibblingG.PrinciplesofalbuminandIgGanalysesinneurologicaldisorder:III.EvaluationofIgGsynthesiswithinthecentralnervoussysyteminmultiplesclerosis.ScandJClinLabInvest...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學β澱粉樣蛋白對小膠質細胞合成一氧化氮的影響
...NFκB途徑大量合成NO,可能參與阿爾茨海默病(Alzheimer‘sdisease,AD)的致病過程。【關鍵詞】β澱粉樣蛋白小膠質細胞κ輕鏈核因子一氧化氮阿爾茨海默病EffectofamyloidbetapeptideonactivatedmicroglialcellexcretingnitricoxideHANXiaofengLüLiGERul...
醫源資料庫;在線期刊;濱州醫學院學報;2008年第31卷第2期EarlyAxonopathyPrecedingNeurofibrillaryTanglesinMutantTauTransgenicMice
...nreferredtoastauopathies1andincludesomeformsoffrontotemporaldementia,Pick??sdisease,progressivesupranuclearpalsy,corticobasaldegeneration,andAlzheimer??sdisease(AD).Severalofthesetauopathiesarecharacterizedbybothcognitiveandmotordysfunctionandwidespreadtaupathologyinbrain,brainstem,andspinalcord.For...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期UseofShell-VialCellCultureAssayforIsolationofBacteriafromClinicalSpecimens:13YearsofExperience
...classicalagarprocedureandPCRwerenegative.INTRODUCTIONThespectrumofinfectiousdiseasesiswideandchanging.Thereliablediagnosisofinfectiousdiseaseremainsadifficultproblemevenforspecializedlaboratories.Isolationofnewmicroorganismswillallowthedescriptionofclinicalfeaturesofnewdiseasesandthecharacterization...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期