Anti-TNF-therapyforsightthreateninguveitis
...atientswithserioussightthreateninguveitiswereincluded,ofwhomsixhadBeh?et’sdisease,fivehadidiopathicposterioruveitis,onehadsarcoidosis,andonebirdshotretinochoroiditis.Onsetandcourseofocularinflammation,inflammatorysigns,andvisualacuitywereassessed.Patientsweretreatedwith200mg(approximately3mg/kg)in...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第5期WeightlossinAlzheimerdisease
...ionalInstituteofNeurologicalandCommunicativeDisordersandStroke/Alzheimer‘sDiseaseandRelatedDisordersAssociation)whowererecruitedfromtheAlzheimer‘sDiseaseCenterinToulouse.Allsubjectunderwentanutritional,neuropsychologic,andfunctionalevaluation.TheZaritscaleswereusedtoassesscaregiverburdenandcareg...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第2期PesticideExposureExacerbates-SynucleinopathyinanATTransgenicMouseModel
...摘要】ThefactorsinitiatingorcontributingtothepathogenesisofParkinson??sdiseaseandrelatedneurodegenerativesynucleinopathiesarestilllargelyunclear,butenvironmentalfactorssuchaspesticideshavebeenimplicated.Inthisstudy,A53Tmutanthuman-synucleintransgenicmice(M83),whichdevelop-synucleinneuropathology,...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第2期DefectiveFasexpressionexacerbatesneurotoxicityinamodelofParkinson‘sdisease
...ctedlyrendermicehighlysusceptibletoneuraldegenerationinamodelofParkinson‘sdisease.WefoundthatFas-deficientlymphoproliferativemicedevelopadramaticphenotyperesemblingclinicalParkinson‘sdisease,characterizedbyextensivenigrostriataldegenerationaccompaniedbytremor,hypokinesia,andlossofmotorcoordinati...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第5期CultureofTropherymawhippleifromHumanSamples:a3-YearExperience(1999to2002)
...ferencesThecultureofTropherymawhipplei,thebacteriumresponsibleforWhipple‘sdisease,hasbeenestablishedonlyrecently.Ourobjectiveistodescribe,basedonourexperience,thecultureofT.whippleiinHELcellsdetectedbyimmunofluorescencestaining.Over3years,wereceived18samplesforT.whippleiculturefrom15patientswithWh...
醫源資料庫;在線期刊;微生物臨牀雜誌;2003年第41卷第8期ExacerbationofDopaminergicTerminalDamageinaMouseModelofParkinson‘sDiseasebytheG-Protein-CoupledReceptorProtease-ActivatedReceptor1
...emouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)modelofParkinson‘sdisease,aneurodegenerativediseasecharacterizedbynigrostriataldopaminedamageandgliosis.AfterMPTPinjection,PAR1–/–miceshowedsignificantlyhigherresiduallevelsofdopamine,dopaminetransporter,andtyrosinehydroxylaseandd...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期Region-specificDissociationofNeuronalLossandNeurofibrillaryPathologyinaMouseModelofTauopathy
...NeurofibrillarytanglesforminaspecificspatialandtemporalpatterninAlzheimer??sdisease.Althoughtangleformationcorrelateswithdementiaandneuronalloss,itremainsunknownwhetherneurofibrillarypathologycausescelldeath.Recently,amousemodeloftauopathywasdevelopedthatreversiblyexpresseshumantauwiththedementia-as...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第5期ApolipoproteinEpolymorphisminpatientswithcataract
...erg@anatcell.gu.seAcceptedforpublication1September2003Keywords:Alzheimer’sdisease;apolipoproteinE;cataract;polymorphismBasedonsimilaritiesinepidemiologyandbiochemistry,ithasbeensuggestedthatcataractandAlzheimer’sdisease(AD)sharethesameaetiologicalmechanisms.ComorbidityofcataractandADintrisomy21(...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第5期免疫抑制劑治療炎症性腸病
...用AZA1.0mg/kg·d~3.0mg/kg·d和安慰劑治療42例克隆氏病(Crohn'sdisease)4mo其有效率分別爲76%和38%(P<0.03),Candyetal[2]治療45例Crohn's病12mo和安慰劑組對照其有效率分別爲56%和10%(P<0.001),Presentetal應用6-MP1.0mg/kg·d~1.5mg/kg·d和安慰劑治...
合作平臺;醫學論文;內科學論文;消化病學Caspase-MediatedCleavageofGlialFibrillaryAcidicProteinwithinDegeneratingAstrocytesoftheAlzheimer??sDiseaseBrain
...ivationofcaspasesandcleavageofcellularproteinswithinneuronsoftheAlzheimer??sdisease(AD)brain.TodeterminewhetherasimilarroleforcaspasesalsooccurswithinglialcellsinAD,wedesignedasite-directedcaspase-cleavageantibodyspecifictoglialfibrillaryacidicprotein(GFAP),acytoskeletonproteinspecificallyexpressedi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第3期