規劃幹細胞研究的準則
...現階段沒有辦法解決的疾病,像是阿茲罕默症(Alzheimer’sdisease)、糖尿病(diabetes)、帕金申氏症(Parkinson’sdisease),或者像是脊椎損傷(spinalcordinjuries)的狀況,就可能因此找到了解藥,不過由於人類胚胎幹細胞代表着是新生命的開始...
行業資訊;臨牀快報;克隆與幹細胞研究中國科學家對阿爾茲海默症血液研究獲進展
...息,該所雷紅星研究員開展的“阿爾茲海默症(Alzheimer‘sDisease,AD)血液轉錄組特徵性擾動研究”取得進展,其研究論文已於近日在《JournalofAlzheimer‘sDisease》雜誌發表。 雷紅星的研究論文通過對5個AD血液轉錄組公共數據進行...
行業資訊;臨牀快報;血液LipoproteinReceptor-RelatedProtein-MediatesAmyloid-??-MediatedCellDeathofCerebrovascularCells
...tion,seemstobeamajorcauseofA??accumulationinthebrainoflate-onsetAlzheimer??sdiseasepatientsandhereditarycerebralhemorrhagewithamyloidosisDutchtype.Weobservedassociationofreceptorforadvancedglycationendproducts,CD36,andlow-densitylipoproteinreceptor(LDLR)withcerebralamyloidangiopathyinbothAlzheimer??...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第12期ASyntheticDerivativeoftheNaturalProductRocaglaolIsaPotentInhibitorofCytokine-MediatedSignalingandShowsNeuroprotectiveActivityinVitroandi
...fbrainsexposedtotraumaandischemiaaswellasinbrainsofpatientswithAlzheimer‘sdisease(AD)andParkinson‘sdisease(PD).BrainhypoxiaandtraumaticbraininjurycauseenhancedAP-1activityandactivationofupstreamactivatingmitogen-activatedproteinkinasecascadesinADandPD(Hunotetal.,1997;Kaltschmidtetal.,1997;Schnei...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期老年性癡呆患者的早期認識與家庭護理
...M,KarlawishJH.CognitivefunctionassessmentinindividualsatriskforAlzheimer‘sdisease.JAmAcadNursePract.2003,15(2):79-86. 4施曉莉.老年癡呆病人的護理.家庭護士,2008,6(7):1844-1845. 5張慶華,趙紅.老年性癡呆患者的護理現狀及進展.白求恩軍醫學院...
醫源資料庫;在線期刊;中華醫學研究雜誌;2009年第9卷第11期ConsequencesofCopperAccumulationintheLiversoftheAtpbC/C(WilsonDiseaseGene)KnockoutMice
...odegenerativedisease.NeurobiolDis1999,6:221-230LoudianosG,GitlinJD:Wilson??sdisease.SeminLiverDis2000,20:353-364RiordanSM,WilliamsR:TheWilson??sdiseasegeneandphenotypicdiversity.JHepatol2001,34:165-171FerenciP,CacaK,LoudianosG,Mieli-VerganiG,TannerS,SternliebI,SchilskyM,CoxD,BerrF:Diagnosisandphenot...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第2期袁鈞英等—細胞死亡研究
...在慢性神經退行性疾病,比如亨廷頓舞蹈病(Huntington‘sdisease,HD,是一種由IT15基因上CAG重複序列異常擴展所致常染色體顯性遺傳的神經退行性疾病),阿爾茨海默病(Alzheimer‘sdisease,AD,即老年癡呆症)中也會出現。爲了探...
行業資訊;臨牀快報;細胞分子與蛋白質組TheThiazolidinedionePioglitazoneAltersMitochondrialFunctioninHumanNeuron-LikeCells
...iazolidinedionesarecurrentlyunderconsiderationforthetreatmentofAlzheimer‘sdisease(AD)(Landreth,2006).Themostproposedrationaleisthatthiazolidinedioneanti-inflammatorypropertiesmayproveusefulformitigatingamyloid-inducedmicroglialactivation,aprocesspotentiallycontributingtoneurodegeneration.Mitochond...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期HomocysteineandfolateasriskfactorsfordementiaandAlzheimerdisease
...epopulation(1).Therefore,itisimportanttoidentifymodifiableriskfactorsforthisdisease.Thesulfuraminoacidhomocysteineisauniquecandidateforthisrolebecauseofitsdirectneurotoxicity(2-4)anditsassociationwithcerebrovasculardisease(5),whichiscurrentlybelievedtoplayasignificantroleinADetiology(6).Moreover,ele...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第3期TransformingGrowthFactor-1ImpairsEndothelin-1-MediatedContractionofBrainVesselsbyInducingMitogen-ActivatedProtein(MAP)KinasePhosphatase-1andI
...ingBrainlevelsoftransforminggrowthfactor-1(TGF-1)areincreasedinAlzheimer‘sdiseaseandhavebeenimplicatedintheassociatedcerebrovascularpathology.WerecentlyreportedthattransgenicmicethatoverexpressTGF-1(TGF+mice)display,withaging,selectivelyreducedendothelin-1(ET-1)-mediatedcontractions.BecauseET-1isa...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期