NeuronalorGlialExpressionofHumanApolipoproteinEAffectsParenchymalandVascularAmyloidPathologyDifferentiallyinDifferentBrainRegionsofDouble-
【摘要】ApolipoproteinE4(ApoE4)isassociatedwithAlzheimer??sdiseasebyunknownmechanisms.WegeneratedsixtransgenicmicestrainsexpressinghumanApoE4incombinationwithmutantamyloidprecursorprotein(APP)andmutantpresenilin-1(PS1)insingle-,double-,ortriple-transgeniccombinations.Diffuse,butnotdense,amyloidp...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第1期經肛管肌鞘內巨結腸根治術後遠端狹窄病因分析
...TorreDL,Ortega-SalgodlJA.TransanalendorectalPull-tnroughforHischsprung’sdisease.JPediatrSurg,1998,33:1281-1286.2AlbaneseCT,Jennings.RW,Smith,etal.Perinealone-stagePull-throughforHischsprung’sdisease.JPediatrSurg,1999,34:377-380.3LangerJC,MinkesPK,MazziottiMV,etzansanalone-s...
資料庫;在線期刊;中華現代兒科學雜誌;2004年第1卷第1期ANewVisualRatingScaletoAssessStrategicWhiteMatterHyperintensitiesWithinCholinergicPathwaysinDementia
...holinergichypothesisofADhasledtothefirstsuccessfultherapeuticstrategyforthisdisease.18ElectrophysiologicalstudiesandanimalmodelswithspecificcorticopetalcholinergiclesionssuggestthatAChmaybeprimarilyinvolvedinattentionalprocesseswithsecondaryimpactonlearningandmemoryfunctions.19Thehypothesisthatcorti...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第10期VitaminDstatus,1,25-dihydroxyvitaminD3,andtheimmunesystem
...eficiency,orVDRdeficiencydependsonthenatureoftheimmuneresponse(eg,infectiousdisease,asthma,orautoimmunedisease).AnadditionalfactorthatdeterminestheeffectofvitaminDstatusonimmunefunctionisdietarycalcium.DietarycalciumhasindependenteffectsonIBDseverity.VitaminD-deficientmiceonlow-calciumdietsdeveloped...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第6期老年性癡呆中膽鹼能系統研究進展
...1ParnettiL,SeninU,MecocciP.CognitiveenhancementtherapyforAlzheimer’sdisease.Thewayforward.Drugs.1997,53(5):752-768.2LopezOL,HamiltonRL,BeckerJT,etal.SeverityofcognitiveimpairˉmentandtheclinicaldiagnosisofADwithLewybodies.Neurology,2000,54(9):1780-1787.3CoreyBloomJ,Tirabo...
合作平臺;在線期刊;中華醫學研究雜誌;2004年第4卷第4期;綜述喜普妙治療帕金森病合併抑鬱及護理干預
...;喜普妙;護理干預 抑鬱已成爲帕金森病(Parkinsonsdisease,PD)患者的常見症狀,並嚴重影響PD患者的治療效果及生活質量。針對PD患者的抑鬱狀態,本研究採用喜普妙治療聯合全程護理干預取得良好療效,現總結報告如下。 ...
醫源資料庫;在線期刊;中華現代護理學雜誌;2005年第2卷第24期DecreaseintheglyceraldehydederivedadvancedglycationendproductsintheseraofpatientswithVogt-Koyanagi-Haradadisease
...portedthatglyceraldehydederivedAGE(AGE-2)hasastrongbiologicaleffectonvariousdiseases.TheaimofthisstudywastoinvestigatetheserumAGE-2levelsinVogt-Koyanagi-Harada(VKH)disease.Methods:Serawereobtainedfrom31patientswithactiveVKH.20ofthese31patientsweretreatedwithsystemiccorticosteroids.Ascontrols,33healt...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第11期大連醫科大學神經病學試題(碩士)2001年
...檢查的正常值9、EP持續狀態10、LockedinSyndrome11、Alzheimer‘sDisease二、簡答題(50)1、左側T5BrownSequard的臨表2、下運動神經元癱瘓的臨牀特點及其病變部位3、假性球麻痹的臨特及病變部位4、眶上裂Syndrome的臨表5、健忘性失語的損害...
醫源資料庫;醫源習題集;未分類試題西班牙研製診斷腸炎的基因芯片正式通過試驗
...成爲醫生診斷兩種主要的腸炎——節段性迴腸炎(Crohn’sdisease)和潰瘍性結腸炎(ulcerouscolitis)的得力幫手。 在歐洲,有上百萬人忍受着這種慢性疾病的折磨,其中約有10萬西班牙人。這種基因芯片的研究人員說,它可以幫...
醫藥經濟;生物技術;生物芯片GenetherapystudyforParkinson‘sdiseasebeginsinNewYork
ResearchersslippedbillionsofcopiesofageneintothebrainofaParkinson‘sdiseasepatientMonday,markingthefirstattempttotestgenetherapyinapersonwiththatdisease.The55-year-oldpatienthaddinnerafterwardandwasdoingfine,Dr.MichaelKaplittofWeillCornellMedicalCollegesaidafewhoursaftercompletingtheprocedure.Thema...
行業資訊;臨牀快報;遺傳與基因組