QuantitativeProteomicsIdentifiesSurfactant-Resistant-SynucleininCerebralCortexofParkinsonism-DementiaComplexofGuambutNotAlzheimer??sDiseaseor
...analyzingproteinsresistanttosurfactantextractionfrompatientswithAlzheimer??sdisease(AD)orPDCandtheirmatchedcontrolsusingisobarictagsforrelativeandabsolutequantification.InadditiontotheexpectedincreaseinabnormalfrontalcorticalAßpeptides,tau,ubiquitin,andapolipoproteinEinAD,andtauinPDC,weidentif...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期LithiumReducesTauPhosphorylationbutNotAßorWorkingMemoryDeficitsinaTransgenicModelwithBothPlaquesandTangles
...ynthasekinase3(GSK-3)isamajorkinaseimplicatedinthepathogenesisofAlzheimer??sdisease(AD),andreducingitsactivitymayhavetherapeuticefficacy.Twovariantsexist,referredtoasGSK-3andGSK-3ß.Inadditiontothelatter??swell-describedroleinthephosphorylationoftau,reportsalsosuggestthatGSK-3mayregulateamyloid...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第5期老年性癡呆的藥物治療概況
【摘要】阿爾茨海默病(Alzheimersdisease,AD)是一類比較複雜的認知功能障礙性疾病,其臨牀主要表現爲近期記憶功能障礙,隨後爲持續性智能減退、判斷推理能力喪失、失語、運動障礙等;病理特徵爲神經細胞間存在大量的老年...
合作平臺;在線期刊;中華醫學研究雜誌;2004年第4卷第12期;綜述心臟白塞病
...984,86(4):636.2BradburyAW,MileAA,MurieJA.SurgicalaspectsofBebcet’sdisease.JSurg,1994,81(14):1712.3HuraibS.RightarrialthrombusasaComplicationofsubclavianveinCatheterizationacasereport.Angiology,1992,43(5):439.4HuongDLT,WechslerB,PapoT,etal.EndomgocardialfibrosisinBehcet’...
醫源資料庫;在線期刊;中華中西醫雜誌;2006年第7卷第10期UseofSpecificrRNAOligonucleotideProbesforMicroscopicDetectionofMycobacteriumaviumComplexOrganismsinTissue
...iversityofColorado,Boulder,ColoradoDepartmentofMedicine,DivisionofInfectiousDiseases,UniversityofColoradoHealthSciencesCenter,Denver,ColoradoABSTRACTMembersoftheMycobacteriumaviumcomplex(MAC)areimportantenvironmentalpathogensthatareimplicatedinseveralchronic,idiopathicdiseases.DiagnosisofMAC-baseddi...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期白塞病的心臟表現
....Chest,1984,86(4):636.2ByadburyAW,MileAA,MurieJA.SurgicalaspectsofBebcet’sdisease.JSurg,1994,81(14):1712.3HuraibS.RightarrialthrombusasaComplicationofsubclavianveinCatheterizationacasereport.Angiology,1992,43(5):439.4HuongDLT,WechslerB,PapoT,etal.EndomgocardialfibrosisinBehcet’sdisease.AnnRheD...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2006年第6卷第23期RoleoftheRedoxProteinThioredoxininCytoprotectiveMechanismEvokedby(-)-Deprenyl
...,1983;Murphyetal.,1983).TheinitialuseofselegilineinpatientswithParkinson‘sdiseaseisaimedatincreasingbraindopaminelevelsthroughtheinhibitionofMAO-mediatedoxidativedeaminationofdopamineduringthetreatmentofpatientswithlevodopa.Clinicalobservationsimplythatselegilinemighthaveadditionalneuroprotectivep...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期雙側帶蒂腎上腺背部皮下移位術治療柯興病
... TranspositionofbilateralpedicledadrenalglandforthetreatmentofCushing′sdisease ZHANGWeixing,ZHAOGaoxian,MENGQingjun,etal. (DepartmentofUrology,FirstAffiliatedHospital,HenanMedicalUniversity,Zhengzhou,450052,China.) Abstract:Objective TostudythetherapeuticmethodofCushing′...
合作平臺;醫學論文;外科論文;普通外科學PolyunsaturatedFattyAcidsInduce-Synuclein-RelatedPathogenicChangesinNeuronalCells
...einshasemergedasakeyfeatureofseveralneurodegenerativediseases.InParkinson??sdisease,progressivelossofdopaminergicneuronsisaccompaniedbypolymerizationofthecytoplasmicprotein-synuclein(S)intofilamentousinclusionsfoundinneuronalsomata(Lewybodies)anddendrites(Lewyneurites).SimilarSaggregatesoccurincorti...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第12期75例老年癡呆患者非認知功能損害臨牀分析
...考文獻1BurgioL.InterventionsforthebehavioralcomplicationofAlzheimer’sdisease:behavioralapproaches.IntPsychogeriatr,1996,8(1):45.2張新卿,董會卿,閔寶權,等.阿爾茨海默氏病與血管性癡呆的臨牀特點.中國神經精神疾病雜誌,1999,25(6):349.3HironoN...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第6A期