CriticalRoleforSphingosineKinase-1inRegulatingSurvivalofNeuroblastomaCellsExposedtoAmyloid-βPeptide
...vedtoplayacausativeroleintheneurodegenerativeprocessoccurringinAlzheimer‘sdisease(Roheretal.,1993;Selkoe,2001).AlthoughAβ-mediatedneuronalcelldeathdemonstratesbiochemicalcharacteristicsofapoptosis,themolecularmechanismunderlyingAβtoxicityremainslargelyundefined.Itisnoteworthythatincrease...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期成人Still病30例臨牀分析
...【關鍵詞】成人Still病診斷治療成人Still病(adultonsetstillsdisease,AOSD)是一種病因未明的以長期間歇性發熱、一過性多形性皮疹、關節炎或關節痛、咽痛爲主要臨牀表現,並伴有周圍血白細胞總數及粒細胞增高和肝功能受損等系統...
醫源資料庫;在線期刊;中華現代內科學雜誌;2008年第5卷第2期治療老年癡呆藥物研究
...老年癡呆症;治療藥物;藥物研究【Abstract】Alzheimer’sdiseaseisanormaldiseaseintheaged.ThisarticlehassummarizedtheresearchsituationofthedrugsforpreventingAlzheimer’sdiseaseandprovidesreferenceforthedrugdesign.【Keywords】Alzheimer’sdisease;drugtherapy;drugresearch...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2008年第8卷第8期血漿同型半胱氨酸及其相關酶基因多態性與Alzheimer病的關係
...ereductase,MTHFR)的基因多態性與阿爾茨海默病(Alzheimer’sdisease,AD)的關係。方法對68例AD患者和68例健康對照組採用循環酶法測定血漿Hcy水平;多聚酶鏈反應-限制性片段長度多態性(PCR-RFLP)方法檢測MTHFR基因C677T的多態性。...
醫源資料庫;在線期刊;中華現代內科學雜誌;2009年第6卷第1期血管性帕金森綜合徵和帕金森病患者嗅覺障礙的對比研究
...256-258. [3]LiberiniP,ParolaS,SpanoPF,etal.OlfactioninParkinson‘sdisease:methodsofassessmentandclinicalrelevance[J].JNeurol,2000,247(2):88-96. [4]MontgomeryEBJr,KollerWC,LaMantiaTJ,etal.EarlydetectionofprobableidiopathicParkinson‘sdisease:I.Developmentofadiagnostictestb...
醫源資料庫;在線期刊;中國民康醫學;2009年第21卷第9期BrainCholesterol:LongSecretLifeBehindaBarrier
...:160–193.RaffaiRL,WeisgraberKH.Cholesterol:fromheartattackstoAlzheimer’sdisease.JLipidRes.2003;44:1423–1430.SnipesG,SuterU.CholesterolandMyelin.In:BittmanR,ed.Cholesterol.NewYork:PlenumPress;1998.DietschyJM,TurleySD.Cholesterolmetabolisminthebrain.CurrOpinLipidol.2001;12:105–112.Bj?rkhemI,Lu...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第5期調心方不同部位羣和拆方對東莨菪鹼小鼠學習記憶的影響
...ndisassebledprescriptionsMorriswaˉtermaze阿爾茨海默病(Alzhemier’sdisease,AD)是一種中樞神經系統慢性退行性病變,目前本病在病因、診斷和治療上尚無突破性的進展。調心方是林水淼教授多年來治療AD的經驗方,取得了較好的臨牀療效...
合作平臺;在線期刊;中華中西醫雜誌;2004年第5卷第6期;論著Nasalvaccinationwithaproteosome-basedadjuvantandglatirameracetateclears?-amyloidinamousemodelofAlzheimerdisease
...juvant.Ourlaboratoryhasbeeninterestedinvaccinationstrategiesfornoninfectiousdiseasesusingthemucosalimmunesystem,anapproachthatislessinvasivethanparenteraladministrationandthatisclinicallyapplicable(27-29).WehavepreviouslydemonstratedthatnasalvaccinationwithA?1–40peptideresultedina50–60%reduction...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期Alcoholintakeinrelationtobrainmagneticresonanceimagingfindingsinolderpersonswithoutdementia
...ke2002;33:115262.KalariaRN.TheroleofcerebralischemiainAlzheimersdisease.NeurobiolAging2000;21:32130.TruelsenT,ThudiumD,GrønbækM.Amountandtypeofalcoholandriskofdementia:theCopenhagenCityHeartStudy.Neurology2002;59:13139.HennC,LoffelholzK,KleinJ.Stimulatoryandinhibi...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第4期Arolefordocosahexaenoicacid–derivedneuroprotectinD1inneuralcellsurvivalandAlzheimerdisease
...9-30367.McGeer,E.G.,andMcGeer,P.L.2003..InflammatoryprocessesinAlzheimer’sdisease.Prog.Neuropsychopharmacol.Biol.Psychiatry.27::741-749.Marcheselli,V.L.etal.2003..Noveldocosanoidsinhibitbrainischemia-reperfusion-mediatedleukocyteinfiltrationandpro-inflammatorygeneexpression.J.Biol.Chem.278::43807-...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期