RoleofProteinKinaseCandItsAdaptorProteinp62inVoltage-GatedPotassiumChannelModulationinPulmonaryArteries
...dash;mice.PulmonaryarteriesfromPKC–/–micealsoshowedadiminished[Ca2+]iandcontractileresponse,whereasgeneticinactivationofp62–/–resultedinanabsent[Ca2+]iresponse,butitpreservedcontractileresponsetoU46619.[GenBank]ThesedatademonstratethatPKCanditsadaptorproteinp62playakeyroleint...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期PlasminInducesEndothelium-DependentNitricOxide-MediatedRelaxationinthePorcineCoronaryArtery
...einendothelialcells(HUVECs),plasmininducedatransientelevationinthecytosolicCa2+concentrations([Ca2+]i).Theprecedingstimulationwithplasmininhibitedthesubsequent[Ca2+]ielevationinducedbythrombinbutnotthatinducedbytrypsin.InPCAECs,plasminconcentration-dependentlyinducedNOproduction.Conclusions-Theprese...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第4期L-typecalciumchannelsintherenalmicrocirculatoryresponsetoendothelin
...etweenETAandETBreceptors.ThepurposeofthisstudywastodeterminetheroleofL-typeCa2+channelsinthevasoconstrictorresponsetoET-1andtheETBreceptoragonistsarafotoxin6c(S6c)intheratkidney.Renalbloodflow(RBF)wasmeasuredwithanultrasonicflowprobeinanesthetizedrats,andamicrocatheterwasinsertedintotherenalarteryfo...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期ArrhythmogenicMutation-LinkedDefectsinRyanodineReceptorAutoregulationRevealaNovelMechanismofCa2+ReleaseChannelDysfunction
...dia,frequentlyleadingtosuddencardiacdeath(SCD).ThecausativemechanismsofRyR2Ca2+releasedysregulationarecomplexandremaincontroversial.Weinvestigatedthefunctionalimpactofclinically-severeRyR2mutationsoccurringinthecentraldomain,andtheC-terminalIdomain,akeylocusofRyR2autoregulation,oninterdomaininteract...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第1期活性氧和細胞凋亡
...可逆過程,細胞發生凋亡。 2ROS和凋亡信號傳導分子Ca2+的關係 自從Kaiser等發現糖皮質激素誘導的胸腺細胞凋亡與Ca2+離子內流增加有關以來,越來越多的直接或間接證據表明胞漿Ca2+濃度上升是細胞凋亡的一個重要事...
合作平臺;醫學論文;基礎醫學論文;細胞及分子生物學Rac1RegulationofSurfaceExpressionofProtease-ActivatedReceptor-1andResponsivenesstoThrombininVascularSmoothMuscleCells
...ethyl-glutarylcoenzymeAreductaseinhibitor,for24hoursattenuatedthetransient[Ca2+]ielevationinducedbythrombin.ImmunofluorescencestainingrevealedthatsimvastatindecreasedthesurfaceexpressionofPAR1inamannerdependentonproteingeranylgeranylation.IntroductionofaRac1/Cdc42inhibitoryfragmentbutnotaRhoAinhibit...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期Mitochondria,Calcium,andCalpainareKeyMediatorsofResveratrol-InducedApoptosisinBreastCancer
...causesanearlybiphasicincreaseintheconcentrationoffreeintracellularcalcium([Ca2+]i),probablyresultingfromdepletionoftheendoplasmicreticulumstoresinbreastcancercells.Incaspase-3–deficientMCF-7cells,apoptosisismediatedbytheCa2+-activatedprotease,calpain,leadingtothedegradationofplasmamembraneCa2+...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期RegulationofXanthineOxidoreductaseProteinExpressionbyHydrogenPeroxideandCalcium
...eperformedatroomtemperatureusinganEMXESRspectrometer(Bruker).Measurementof[Ca2+]i[Ca2+]iwasmeasuredaspreviouslydescribed.12CellswereincubatedwithFURA2-AM(2μmol/L)andcelldispersionagentPluronicF-127(0.04%)at37°Cinthedarkfor30minutes.Valuesof[Ca2+]iwereobtainedbydeterminingmaximumFURA2fluorescencera...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期急性胰腺炎患者生化(白蛋白、鈣、糖、C-反應蛋白、鉀)變化和臨牀意義
...期(發病48h內)血漿白蛋白(ALb)、血糖(Glu)、血鈣(Ca2+)、C-反應蛋白(CRP)、血鉀(K+)的變化,預測、評估AP嚴重程度及臨牀意義,以指導臨牀治療。方法隨機抽取既往無特殊病史的急性胰腺炎(發病48h內就診)135例,...
醫源資料庫;在線期刊;中華中西醫雜誌;2007年第8卷第3期SuraminandDisulfonatedStilbeneDerivativesStimulatetheCa2+-InducedCa2+-ReleaseMechanisminA7r5Cells
...CampusGasthuisbergO/N,Leuven,BelgiumAbstractWehavedescribedpreviouslyanovelCa2+-inducedCa2+-release(CICR)mechanisminpermeabilizedA7r5cells(embryonicrataorta)and16HBE14o-cells(humanbronchialmucosa)cells(JBiolChem278:27548eC27555,2003).ThisCICRmechanismwasactivatedupontheelevationofthefreecytosoliccal...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第1期