InactivationofthePRDM1/BLIMP1geneindiffuselargeBcelllymphoma
....Eisen,R.E.Davis,C.Ma,I.S.Lossos,A.Rosenwald,J.C.Boldrick,H.Sabet,T.Tran,X.Yu,etal.2000.DistincttypesofdiffuselargeB-celllymphomaidentifiedbygeneexpressionprofiling.Nature.403:503–511.Shaffer,A.L.,A.Rosenwald,andL.M.Staudt.2002.Lymphoidmalignancies:thedarksideofB-celldifferentiation.Nat.Rev.Immuno...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期GeneticDiversityofMultidrug-ResistantMycobacteriumtuberculosisIsolatesandIdentificationof11NovelrpoBAllelesinTaiwan
...iologyofMDRM.tuberculosisinTaiwanhasnotbeenwellknownandwasthusinvestigatedbyusingspoligotypingandstandardIS6110restrictionfragmentlengthpolymorphism(RFLP)analysisinthisstudy.TheprevalenceofrpoBmutationsassociatedwithRMPresistanceamongMDRisolateswasalsoinvestigated.MDRisolates.Atotalof162MDRisolateso...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期ConstraintsonHIV-1evolutionandimmunodominancerevealedinmonozygoticadulttwinsinfectedwiththesamevirus
...meangeneticdiversityamongrandomlyselectedsequencesfromlocalepidemiologicallyunrelatedHIV-infectedindividualsincludedintheanalysiswas4.4±0.3%.Similarphylogeneticanalysisontheenvgeneestimatedameangeneticdiversityof3.2±0.2%amongthesiblings‘virusesoverthecourseofinfection.Thehighdegreeofgeneticsimil...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期IdentificationofImmunodominantEpitopesontheMembraneProteinoftheSevereAcuteRespiratorySyndrome-AssociatedCoronavirus
...idesM1-31andM132-161wereproducedatCovanceResearchProducts,Inc.(Denver,PA),byusingtheirstandardprotocols.Briefly,NewZealandWhiterabbitswereimmunizedintradermallywith250μgofpurifiedpeptidesresuspendedinphosphate-bufferedsolution(pH7.2)inthepresenceofFreundcompleteadjuvantandboostedwithfreshlyprepared...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期EmergenceofaNephropathogenicAvianInfectiousBronchitisViruswithaNovelGenotypeinIndia
...as5%betweenS1sequencesofIBVcanresultinpoorcross-protectionofferedbycurrentlyusedvaccines(4).Severalvariants,aswellasisolates,relatedtoEuropeanorAmericanstrainshavepreviouslybeenreportedinChinaandotherpartsofAsia,withwhichIndiaeithersharespoliticalbordersortradeexchange(14,16,18,19).Thus,theIndianiso...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第2期Noaudiblewheezing:nuggetsandconundrumsfrommouseasthmamodels
...ributionsofeosinophilsandmastcellsandthesensitivitytoinducedAHRinthecommonlyusedmousestrains.Wesuggestthatthesediscordances,reflectingmethodologicalandgeneticdifferences,maybeinformativeforunderstandingheterogeneityofhumanasthma.Humanbronchialasthmaisheterogeneousintermsofseverity,genetics,andinalll...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期HumanInfectionwithanAvianH9N2InfluenzaAVirusinHongKongin2003
...uencefragmentswereassembledwithLasergene(version6.0;DNASTAR)andthenalignedbyusingBioEdit,version7,andresidueanalysiswasperformedwithBioEdit,version7(9).Phylogenetictreesweregeneratedbyneighbor-joiningbootstrapanalysis(1,000replicates)byusingtheTamura-NeialgorithminMEGA,version2.1(13).Alleightgeneswe...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期生態中心在新型污水處理模式及評估方面取得進展
...。相關研究論文:1.X.Wang,P.L.McCarty,J.Liu*,N.-Q.Ren,D.-J.Lee,H.-Q.Yu,J.Qu,2015.Probabilisticevaluationofintegratingresourcerecoveryintowastewatertreatmenttoimproveenvironmentalsustainability.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica.DOI:10.1073/pnas.1410715112.2.X....
醫藥經濟;生物技術;環保技術TheinvivopatternofAIDtargetingtoimmunoglobulinswitchregionsdeducedfrommutationspectrainmsh2–/–ung–/–mice
...rmutationaccumulateinastepwisemannerwithonlyasmallnumber(onetofour)ofusuallyunlinkedmutationsbeingfixedineachgeneration.Theevidencethatclusteredsame-stranddeamination(compatiblewithprocessiveAIDaction)hasoccurredinsomeSregionsequencesobtainedafterLPSstimulationofsplenicBcellsfrommsh2–/–ung–/...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第9期Bcell–deficientNOD.H-2h4micehaveCD4+CD25+Tregulatorycellsthatinhibitthedevelopmentofspontaneousautoimmunethyroiditis
...micearegivenNaIwaterbeginningat2moofage;lesionsarechronicandremainrelativelyunchangedinseverityforseveralmonths(1,4).Autoantibodydetermination.MTg-specificautoantibodieswereassessedbyELISAusingserumfromindividualmiceasdescribedpreviously(1,5).Flowcytometry.SpleencellsorPBLswereanalyzedforexpressiono...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期