小鼠B7-1基因轉染的黑色素瘤細胞免疫原性探討
...16-wt,B16-neo).Thelymphocyteswereexaminedforbothproliferationindices(PI)andspecificlysisactivityagainstB16-wtcellsaftersyngeneicMixedLymphocyteTumorCultures(MLTCs)hadbeenconductedfor6d.Injectedsubcutaneouslyintosyngeneicmice,thegrowthratesofB16-neoandB16-mB7.1cellsweretested.ResultsB16...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學共刺激分子B7-1與IL-6協同誘導T細胞活化的研究①
...公式計算: 1.3 淋巴細胞增殖指數(ProliferationIndices,PI)的測定 混合淋巴細胞腫瘤細胞培養(0.2ml培養液含105淋巴細胞、104滅活的腫瘤細胞、無或400UIL-6,陰性對照只含淋巴細胞或者滅活的腫瘤細胞)6d後,用MTT法測定淋巴細胞...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學VascularEndothelialGrowthFactorActivatesPI3K/Akt/ForkheadSignalinginEndothelialCells
...s.Inthisstudy,weexaminedwhetherVEGFiscoupledtophosphatidylinositol3-kinase(PI3K)/Akt/forkheadinECs.MethodsandResults—WedemonstratethathumanECsexpressmembersoftheforkheadfamily(FKHR,FKHRL1,andAFX)andthatVEGFmodulatesthephosphorylation,subcellularlocalization,andtranscriptionalactivityofoneormoreoft...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第2期Down-RegulationofUbiquitinLigaseCblInducedbyTwistHaploinsufficiencyinSaethre-ChotzenSyndromeResultsinIncreasedPIK/AktSignalingandOsteoblast
...tedwithdecreasedubiquitin-mediateddegradationofphosphatidylinositol3kinase(PI3K)andincreasedPI3KexpressionandPI3K/Aktsignaling.IncreasedPI3KimmunoreactivitywasalsofoundinosteoblastsinhistologicalsectionsofaffectedcranialsuturesfromSCSpatients.TransfectionwithTwistorCblabolishedtheincreasedPI3K/Aktsi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第10期PTENActivityIsModulatedDuringIschemiaandReperfusion
...generatesprofoundbuttransientprotectionagainstasubsequentprolongedischemicepisode.Theserine-threoninekinaseAkthasbeenshowntomediateIPC,andAktactivationisnegativelyregulatedbythephosphatasePTEN,butwhetherPTENactivityismodulatedbyIPChasnotbeeninvestigated.Whenisolated,perfusedratheartsweresubjectedtoa...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第12期慢性阻塞性肺疾病患者肺動脈高壓時肺動脈平滑肌細胞的增殖與凋亡
...的增殖與凋亡,B組和C組肺小動脈平滑肌細胞增殖指數(PI)爲(19±5)和(38±7)%,明顯高於A組的(8±2)%;兩組凋亡指數爲(4.5±1.3)和(3.1±1.3)%,均明顯低於A組的(6.9±1.9)%;B組肺動脈平滑肌細胞增殖指數...
行業資訊;臨牀快報;呼吸系統相關CorrelationbetweenhyperphosphatemiaandtypeIINa-Picotransporteractivityinklothomice
...phatehomeostasis.ThegoalofthepresentstudywastoinvestigatetheregulationofNa-Picotransportersinklothomutant(kl/kl)mice.Thekl/klmicedisplayedhyperphosphatemia,highplasma1,25(OH)2D3levels,increasedactivityoftherenalandintestinalsodium-dependentPicotransporters,andincreasedlevelsofthetypeIIa,typeIIb,andt...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期Glycogen-SynthaseKinase3/-CateninAxisPromotesAngiogenesisThroughActivationofVascularEndothelialGrowthFactorSignalinginEndothelialCells
...ationofAktsignalinghadnoeffectonthisparameter.-CatenintransductioninducedcapillaryformationinaMatrigel-plugassayinvivoandpromotedendothelialcelldifferentiationintonetworkstructuresonMatrigel-coatedplatesinvitro.-Cateninactivatedtheexpressionofvascularendothelialgrowthfactor(VEGF)-AandVEGF-Cinendothe...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第2期CharacterizationoftheregulationofrenalNa+/H+exchangerNHE3byinsulin
...assicphosphatidylinositol3-kinase-serum-andglucocorticoid-dependentkinase1(PI3K-SGK1)pathwayasinsulinstimulatesSGK1phosphorylationandtheinsulineffectcanbeblockedbythePI3Kinhibitorwortmanninoradominant-negativeSGK1.WeshowedthatSGK1transcriptandproteinareexpressedinratproximaltubuleandOKcells.Weprevio...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期Inhibitionofphosphatidylinositol3-kinasestimulatesactivityofthesmall-conductanceKchannelintheCCD
...WeusedWesternblottingtoexaminetheexpressionofphosphatidylinositol3-kinase(PI3K)intherenalcortexandoutermedullaandemployedthepatch-clamptechniquetostudytheeffectofPI3KontheROMK-likesmall-conductanceK(SK)channelsinthecorticalcollectingduct(CCD).LowKintakeincreasedtheexpressionofthe110-kDa-subunit(p110...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第4期