烏司他丁對全髖置換患者手術期間免疫功能的影響
...、CD4+以及CD4+/CD8+值明顯低於Ⅰ組(P0.05)。結論烏司他丁能夠改善麻醉和手術對全髖置換患者的免疫抑制。【文獻標識碼】A【文章編號】1680-077X(2005)02-0109-02EffectofulinastatinoncellularimmunityduringtotalhiparthroplastyHuJue,LuXiaohua,ZhouYif...
合作平臺;在線期刊;中華醫藥雜誌;2005年第5卷第2期;論著SuppressionoftumorformationinlymphnodesbyL-selectin–mediatednaturalkillercellrecruitment
...itute,UniversityofCaliforniaSanFrancisco,SanFrancisco,CA94143Naturalkiller(NK)cellsareknowntorejectcertaintumorsinvivo;however,theabilityofNKcellstopreventmetastasisoftumorsintosecondarylymphoidorganshasnotbeenaddressed.Here,wereportthatintumor-bearinghosts,NKcellsarerecruitedtoregionallymphnodesinw...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第12期NaturalKillerCellsandCD4+T-CellsModulateCollateralArteryDevelopment
...hindlimbischemia.MethodsandResults—Lymphocytes,detectedwithmarkersforNK1.1,CD3,andCD4,invadedthecollateralvesselwall.ArteriogenesiswasimpairedinC57BL/6micedepletedforNaturalKiller(NK)-cellsbyanti-NK1.1antibodiesandinNK-cell–deficienttransgenicmice.Arteriogenesiswas,however,unaffectedinJ2...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期ANovelRoleforTachykininNeurokinin-3ReceptorsinRegulationofHumanBronchialGangliaNeurons
...ckedbyexogenouslyappliedtachykininneurokinin-3receptoreCselectiveagonist,senktideanalogue,butnotsignificantlybytachykininneurokinin-1orneurokinin-2receptoreCselectiveagonists.Responsestoendogenoustachykininsorexogenousselectivetachykininneurokinin-3receptoractivationwithsenktideanaloguewereinhibited...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第2期Dendriticcellmaturationbyinnatelymphocytes:coordinatedstimulationofinnateandadaptiveimmunity
...aptiveimmunity.Recentstudieshaveshownthatinnatelymphocytes—naturalkiller(NK),naturalkillerT(NKT),andTcells—alsotriggerDCmaturation.ThisinteractioninturnexpandsandactivatesinnatelymphocytesandinitiatesadaptiveTcellimmunity.Here,wecommentontheevidencethatthesepathwaysareTLRindependentandhavethepot...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第2期SubstancePNeurokinin1ReceptorActivationwithintheDorsalRapheNucleusControlsSerotoninReleaseintheMouseFrontalCortex
...鍵詞】SubstancePPreclinicalstudiessuggestthatsubstanceP(SP)neurokinin1(NK1)receptorantagonistsareefficientinthetreatmentofanxietyanddepression.Thistherapeuticactivitycouldbemediatedviastimulationofserotonin(5-HT)neuronslocatedinthedorsalraphenucleus(DRN),whichreceiveimportantSP-NK1receptorimmunor...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期AnewtypeofradiosensitiveT–B–NK+severecombinedimmunodeficiencycausedbyaLIG4mutation
...ationresultinSCIDcharacterizedbyabsenceofmatureBandTcells.AsubsetofT–B–NK+SCIDpatientsissensitivetoionizingradiation,andthemajorityofthesepatientshavemutationsinArtemis.WepresentapatientwithanewtypeofradiosensitiveT–B–NK+SCIDwithadefectinDNAligaseIV(LIG4).Todate,LIG4mutationshaveonlybeendesc...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第1期NKcellspromotetransplanttolerancebykillingdonorantigen-presentingcells
...raelDeaconessMedicalCenter,HarvardMedicalSchool,BostonMA02215Naturalkiller(NK)cellsareprogrammedtokilltargetcellswithoutpriorantigenpriming.Becauseoftheirpotentcytolyticactivities,NKcellsareoneofthekeycelltypesinvolvedindismantlingallografts.However,incertaintransplantmodels,NKcellsalsoexpresspotent...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期DefectiveNKTcelldevelopmentinmiceandhumanslackingtheadapterSAP,theX-linkedlymphoproliferativesyndromegeneproduct
...ralkillercells.Itplaysacriticalroleinimmunity,asitismutatedinhumanswithX-linkedlymphoproliferativesyndrome(XLP),afatalimmunodeficiencycharacterizedbyanabnormalresponsetoEpstein-Barrvirus(EBV)infection.SAPinteractswiththeSLAMfamilyreceptorsandpromotestransductionsignaleventsbythesereceptorsthroughits...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期CharacterizationoftheearlystagesofthymicNKTcelldevelopment
...rentiationstepsthatleadtotheperipheralinterleukin-4/interferon-–producingNKTphenotype.However,theirmoreimmatureHSAhighprecursorshaveremainedelusive,andithasbeendifficulttodetermineunambiguouslywhetherNKTcellsoriginatefromaCD4+CD8+double-positive(DP)stage,andwhentheCD4+andCD4–CD8–double-negativ...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第4期