DesignofPAP-1,aSelectiveSmallMoleculeKv1.3Blocker,fortheSuppressionofEffectorMemoryTCellsinAutoimmuneDiseases
...ifornia,Davis,Davis,California(A.Sa.,P.A.,D.H.,H.W.)AbstractThelymphocyteK+channelKv1.3constitutesanattractivepharmacologicaltargetfortheselectivesuppressionofterminallydifferentiatedeffectormemoryT(TEM)cellsinTcell-mediatedautoimmunediseases,suchasmultiplesclerosisandtype1diabetes.Unfortunately,non...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期ThepolymerasecomplexgenescontributetothehighvirulenceofthehumanH5N1influenzavirusisolateA/Vietnam/1203/04
1DepartmentofInfectiousDiseasesandDepartmentofPathology,St.JudeChildren‘sResearchHospital,Memphis,TN381052DepartmentofPathology,UniversityofTennessee,Memphis,TN38105H5N1influenzavirusestransmittedfrompoultrytohumansinAsiacausehighmortalityandposeapandemicthreat.Viralgenesimportantforcelltropismand...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期NovelCompound2-Methyl-2H-pyrazole-3-carboxylicAcid(2-methyl-4-o-tolylazo-phenyl)-amide(CH-223191)Prevents2,3,7,8-TCDD-InducedToxicitybyAntagonizing
【關鍵詞】ArylHydrocarbonReceptor2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)isawidespreadenvironmentalpollutantwithmanytoxiceffects,includingendocrinedisruption,reproductivedysfunction,immunotoxicity,liverdamage,andcancer.ThesearemediatedbyTCDDbindingtoandactivatingthearylhydrocarbonreceptor(AhR)...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期SimplificationTherapywithOnce-DailyEmtricitabine,Didanosine,andEfavirenzinHIV-1InfectedAdultswithViralSuppressionReceivingaProteaseInhibitorB
Assistance-PubliqueHpitauxdeParis,Paris,InstitutNationaldelaSantéetdelaRechercheMédicaleUBordeauxHpitalSaint-André,Bordeaux,Hpitaldel‘Archet,NiceHpitalSainteMarguerite,Marseille,FranceBackground.Weassessedaonce-dailycombinationtosimplifytherapyinpatientsinfectedwithhumanimmunodeficiencyvirustyp...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第6期麻葉蕁麻葉極性化學成分研究
...學者對裂葉蕁麻(U.fissaPritz.)、狹葉蕁麻(U.angustifoliaFisch.exHomem.)和麻葉蕁麻的化學成分和生物活性也進行了一些研究。藥理實驗研究表明麻葉蕁麻有較好的抑菌作用,亦有明顯的強心作用。麻葉蕁麻葉乙醇提取物經系統溶劑...
醫源資料庫;在線期刊;中華中西醫雜誌;2008年第9卷第12期單組分溶液配製
...listofbuffers(Prof.R.Beynon)onthepageJavabasedMolecularBiologist‘sWorkbenchEMBL.BufferCalculatoronthesiteofLabVelocity.Registrationisnecessary(free).Abouttherecalculationofrecipesforthearbitraryvolumes:Organicsubstances.pKaandtemperaturedependenceofpHforcommonbuffers.BufferMwpKa20oCWorkingrangedel...
藥品天地;專業藥學;實驗技術;基本實驗技術;常用試劑異丙酚複合麻醉下股骨粗隆間骨折切開復位內固定術瑞芬太尼控制性降壓的效果
...普鈉、硝酸甘油、尼卡地平、艾司洛爾等是控制性降壓(CH)常用的藥物,常需輔助其他藥物使降壓平穩,安全。超短效阿片類麻醉性鎮痛藥瑞芬太尼具有很強的降壓作用。本研究擬探討異丙酚複合麻醉下股骨粗隆間骨折切開復...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2008年第6卷第10期FolateintakeoftheDutchpopulationaccordingtonewlyestablishedliquidchromatographydataforfoods
...dPietAvandenBrandt1FromtheInspectorateforHealthProtectionandVeterinaryPublicHealth,‘s-Hertogenbosch,Netherlands;theNutritionandToxicologyResearchInstituteNUTRIMandtheDepartmentsofHumanBiologyandEpidemiology,MaastrichtUniversity,Maastricht,Netherlands;andtheTNONutritionandFoodResearchInstitute,Depa...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年73卷第4期Regulationofphosphatidylinositol3–kinasebypolyisoprenylphosphatesinneutrophil-mediatedtissueinjury
...rapeuticsandReperfusionInjury,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA021152DepartmentofChemistry,UniversityofSouthernCalifornia,CA90089Neutrophilsplayacentralroleinhostdefense,inflammation,andtissueinjury.Recentfindingsindicateanovelroleforpolyisoprenylphosphates(PIPPs)asnatural...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期第二節 水溶性維生素
...作用,硫胺素經氧化後轉變爲脫氫硫胺素(又稱硫色素thiochrome),它在紫外光下呈蘭色熒光,可以利用此特性來檢測生物組織中的維生素B1或進行定量測定。 維生素B1易被小腸吸收,在肝臟中維生素B1被磷酸化成爲焦磷酸硫胺...
醫源資料庫;醫源圖書館;教材類;生物化學與分子生物學