肺癌介入治療進展
...、支氣管動脈灌注治療中晚期肺癌 支氣管動脈灌注(BAI)採用Seldinger氏法。經皮股動脈穿刺,在電視透視下利用連續性血管造影技術或數字減影血管造影(DSA),進行支氣管肺動脈造影(BAG)及BAI〔2〕。BAG多用5F導管,亦有...
合作平臺;醫學論文;內科學論文;呼吸病學ModulationofAdiposeTissueDevelopmentbyPharmacologicalInhibitionofPAI-
...】Objective-Theeffectofanovelsmallmoleculeplasminogenactivatorinhibitor(PAI-1)inhibitoronadiposetissuephysiologywasinvestigated.MethodsandResults-Inhumanpreadipocytecultures,PAI-039inhibitedbothbasalandglucose-stimulatedincreasesinactivePAI-1antigen,yethadnoeffectonPAI-1mRNA,suggestingadirectinacti...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第10期HepatocyteGrowthFactorRegulatesEBox-DependentPlasminogenActivatorInhibitorType1GeneExpressioninHepG2LiverCells
...hfactor(HGF),asaregulatorofhepaticsynthesisofplasminogenactivatorinhibitor(PAI)-1,thephysiologicalinhibitoroffibrinolysisandapotentialinducerofatherothrombosis.MethodsandResults-HGFincreasedPAI-1mRNAexpressionandPAI-1proteinaccumulationintheconditionedmediaofhumanliver-derivedHepG2cells,andincreased...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第10期DifferentialCellularMechanismsInvolvingPlasminogenActivatorInhibitorTypeI
...equatebalancebetweenserineproteasesandtheirplasminogenactivatorinhibitor-1(PAI-1)iscriticalforpathologicalangiogenesis.PAI-1deficiencyinmiceisassociatedwithimpairedchoroidalneovascularization(CNV)andtumoralangiogenesis.Inthepresentwork,wedemonstrateunexpecteddifferencesinthecontributionofbonemarrow(...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期DualRoleforPlasminogenActivatorInhibitorTypeasSolubleandasMatricellularRegulatorofEpithelialAlveolarCellWoundHealing
【摘要】Epitheliumrepair,crucialforrestorationofalveolo-capillarybarrierintegrity,isorchestratedbyvariouscytokinesandgrowthfactors.Amongthemkeratinocytegrowthfactorplaysapivotalroleinbothcellproliferationandmigration.Theurokinaseplasminogenactivator(uPA)systemalsoinfluencescellmigrationthroughpr...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第11期Interleukin-6andMevastatinRegulatePlasminogenActivatorInhibitor-1ThroughCCAAT/Enhancer-BindingProtein-
...-6(IL-6),andstatinasregulatorsofsynthesisofplasminogenactivatorinhibitor-1(PAI-1),thephysiologicalfibrinolysisinhibitorandanacute-phasereactant.MethodsandResults—TransienttransfectionandluciferaseassayinHepG2humanhepatoma-derivedcellsdemonstratedthatIL-6increasedPAI-1promoteractivityandmevastatind...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第5期NeutralizationofPlasminogenActivatorInhibitorI(PAI-1)bytheSyntheticAntagonistPAI-749viaaDualMechanismofAction
【關鍵詞】NeutralizationPAI-749isapotentandselectivesyntheticantagonistofplasminogenactivatorinhibitor1(PAI-1)thatpreservedtissue-typeplasminogenactivator(tPA)andurokinase-typeplasminogenactivator(uPA)activitiesinthepresenceofPAI-1(IC50values,157and87nM,respectively).Thefluorescence(Fl)offluoro...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期老年肺癌的支氣管動脈內灌注藥物治療效果分析
...reatmentoflungcancerinsenilitybyadministrationintobronchinalarteryinfusion(BAI).Methods:SelectiveangiograraphofthebronchialarrerywasperformedbySelddingermethod.Afterthetargetarterywasfound.threekindsofthecombinationchemotherapeuticdrugswereadministered.respecitively,thenthecurativeeffectandinfluen...
醫源資料庫;在線期刊;中國民康醫學;2007年第19卷第14期NutritionallyInducedObesityIsAttenuatedinTransgenicMiceOverexpressingPlasminogenActivatorInhibitor-1
...jectiveofthisstudywastoinvestigatetheroleofplasminogenactivatorinhibitor-1(PAI-1)inadiposetissuedevelopmentinvivo.MethodsandResults—Transgenic(Tg)miceoverexpressingmurinePAI-1undercontroloftheadipocytepromoteraP2andwild-type(WT)controlswerekeptonstandardfood(SFD)oronhigh-fatdiet(HFD)for15weeks.The...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2003年第23卷第1期PharmacologicalInhibitionandGeneticDeficiencyofPlasminogenActivatorInhibitor-1AttenuatesAngiotensinII/Salt-InducedAorticRemodeling
...tive—Totestthehypothesisthatpharmacologicalplasminogenactivatorinhibitor(PAI)-1inhibitionprotectsagainstrenin-angiotensin-aldosteronesystem-inducedcardiovascularinjury,theeffectofanovelorallyactivesmall-moleculePAI-1inhibitor,PAI-039,wasexaminedinamousemodelofangiotensin(Ang)II-inducedvascularremo...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第2期