前列腺素E1對離體兔未成熟心肌保護效果的實驗研究
...肌酸激酶同工酶、心肌乾溼比及觀察心肌超微結構變化。結果實驗組左心功能恢復明顯優於對照組,以及冠脈流量比、心肌乾溼比高於對照組,而肌酸激酶同工酶較對照組低,電鏡檢查顯示實驗組心肌線粒體破壞程度低於對照組...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2005年第5卷第2期DirectvasoconstrictoreffectofprostaglandinE2onrenalinterlobulararteries:roleoftheEP3receptor
【摘要】EvidenceindicatesthatprostaglandinE2(PGE2)preferentiallyaffectspreglomerularrenalvessels.However,whetherthisislimitedtosmall-caliberarteriolesorwhetherlargervesselsfartherupstreamalsorespondtoPGE2iscurrentlyunclear.Inthepresentstudy,wefirstinvestigatedtheeffectsofPGE2alongthepreglomerula...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第3期前列腺素E1輔助治療小兒喘息性呼吸道疾病
...PGE1,比較兩者顯效率及總有效率,評價PGE1的治療效果。結果治療組顯效率69.7%,總有效率97%,明顯高於對照組(顯效率38.3%,總有效率88.3%)。結論由於PGE1抑制血小板聚集及血栓素生成,抑制免疫複合物生成,擴張外周及冠狀血...
醫源資料庫;在線期刊;中華現代兒科學雜誌;2006年第3卷第5期SelectivityofcyclooxygenaseisoformactivityandprostanoidproductioninnormalanddiseasedHan:SPRD-cyratkidneys
...anoidproduction[thromboxaneB2(TXB2,stablemetaboliteofTXA2),prostaglandinE2(PGE2),and6-keto-prostaglandinF1(6-keto-PGF1,stablemetaboliteofPGI2)]innormalanddiseasedkidneys.Indiseasedkidneys,COX-1-immunoreactiveproteinandmRNAlevelswerehigherandCOX-2levelswerelowercomparedwithnormalkidneys.Incontrast,CO...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第4期E-Ring8-IsoprostanesAreAgonistsatEP2-andEP4-ProstanoidReceptorsonHumanAirwaySmoothMuscleCellsandRegulatetheReleaseofColony-StimulatingFac
...tively,inaconcentration-dependentmannerby8-iso-prostaglandin(PG)E1and8-iso-PGE2,butnotby8-iso-PGF1,8-iso-PGF2,and8-iso-PGF3.AH6809(6-isopropoxy-9-oxoxanthine-2-carboxylicacid),anEP1-/EP2-/DP-receptorblockingdrug,antagonizedtheinhibitoryeffectof8-iso-PGE1and8-iso-PGE2onGM-CSFoutputwithanaffinityconsi...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第2期霧化吸入前列腺素E1對急性肺損傷豬氧合及肺內分流的影響
...通氣PEEP,霧化吸入PGE1。觀察4h,每1h記錄上述指標一次。結果ALI成功後,三組MAP均降低,但組間差異無統計學意義(P>0.05);三組MPAP升高,C組與A、B組比較差異有統計學意義;C組PaO2較A、B組升高;C組Cdyn高於A組;C組CO高於A組;...
行業資訊;臨牀快報;呼吸系統相關SignalingPathwaysInvolvedinCyclooxygenase-2InductionbyHepatocyteGrowthFactorinNon–Small-CellLungCancer
...ediatedbycyclooxygenase-2(COX-2),resultingintheproductionofprostaglandinE2(PGE2).Weexaminedfourc-Met-positivenon–small-celllungcancer(NSCLC)celllinesforeffectsofHGFonCOX-2.HGFincreasedCOX-2proteinexpression3-foldoverbasallevels.InductionofCOX-2occurredthroughboththeextracellularsignal-regulate...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期ActionofEGFandPGE2onbasolateralorganicanionuptakeinrabbitproximalrenaltubulesandhOAT1expressedinhumankidneyepithelialcells
...AT)viaERK1/2,arachidonicacid,phospholipaseA2,andgenerationofprostaglandins.PGE2bindstheprostanoidreceptorand,thus,activatesadenylatecyclaseandPKA,whichstimulatebasolateralorganicanionuptake.Inthepresentstudy,weinvestigatedwhetherthisregulatorycascadeisalsotrue1)forexvivoconditionsinisolatedrenalprox...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第4期p38MAPkinasemediatesmechanicallyinducedCOX-2andPGEP4receptorexpressioninpodocytes:implicationsfortheactincytoskeleton
...larcapillarypressure(Pgc).However,vasoactivehormones,suchasprostaglandinE2(PGE2),maychallengetheintegrityoftheactincytoskeleton,alterpodocytemorphology,andcompromiseglomerularpermeability.PGE2synthesiscorrelateswiththeonsetofproteinuriaandincreasedPgcfollowingreducednephronmass.Weinvestigatedtheinte...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第4期NicotinicAcid-InducedFlushingIsMediatedbyActivationofEpidermalLangerhansCells
...tal.,1979),andthelevelsofseveralvasodilatoryprostanoidslikeprostaglandinE2(PGE2)andprostaglandinD2(PGD2)andtheirmetabolitesareelevatedafteradministrationofnicotinicacid(Eklundetal.,1979;Nozakietal.,1987;Morrowetal.,1989;Sternetal.,1991).Theseobservationshaveledtothehypothesisthatprostanoidsareinvolv...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期