DoseEscalationofDesmoteplaseforAcuteIschemicStroke(DEDAS)
...double-blind,randomized,dose-escalationstudyinvestigatingdosesof90μg/kgand125μg/kgdesmoteplase.EligibilitycriteriaincludedbaselineNationalInstituteofHealthStrokeScale(NIHSS)scoresof4to20andMRIevidenceofperfusion/diffusionmismatch.Thesafetyendpointwastherateofsymptomaticintracranialhemorrhage.Prima...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第5期Long-TermNicotineTreatmentDecreasesStriatal6NicotinicAcetylcholineReceptorSitesandFunctioninMice
...termittenttreatment.Consistentwithpreviousstudies,nicotineexposureincreased125I-epibatidineand125I-A85380(3-[2-(S)-azetidinylmethoxy]pyridine),butnot125I--bungarotoxin,receptorsincortexandstriatum.Weobservedanunexpectedreduction(30%)instriatal125I--conotoxinMIIsites,whichoccurredbecauseofadecreasein...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期TheDesmoteplaseinAcuteIschemicStrokeTrial(DIAS)
...age(sICH),lowerweight-adjusteddosesescalatingthrough62.5μg/kg,90μg/kg,and125μg/kgweresubsequentlyinvestigatedin57patients(referredtoasPart2).ThesafetyendpointwastherateofsICH.EfficacyendpointsweretherateofreperfusiononMRIafter4to8hoursandclinicaloutcomeasassessedbyNIHSS,modifiedRankinscale,andBar...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第1期InductionofOralTolerancetoHSP60oranHSP60-PeptideActivatesTCellRegulationandReducesAtherosclerosis
...ubatedwithmycobacterialHSP60,aHSP60peptide(253to268),andaHSP70peptide(111to125).ProliferationofTcellswasmeasuredbyincorporationof[6-3H]-thymidine.Subsequently,LDLr–/–miceweretreatedorallywithPBS,HSP60,HSP60(253to268),andHSP70(111to125)4timesin8days.Aftertreatmentthemicewereequippedwithco...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第12期MinimalLipidationofPre-ßHDLbyABCA1ResultsinReducedAbilitytoInteractwithABCA
...BCA1(HEK293-ABCA1)ornon-transfected(control)cellswereincubatedwithlipidfree125I-apoA-Ifor24hours.IncubationofapoA-IwithHEK293-ABCA1cells,butnotcontrolcells,ledtotheformationofheterogeneous-sized,pre-ßmigratingnascentHDLsubpopulations(pre-ß1to-4)thatvariedinsize(7.1to15.7nm),lipid,andapoA...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第8期ABCA1-InducedCellSurfaceBindingSitesforApoA-I
...napoA-ItomouseJ774macrophageswasexamined.Analysisoftotalbindingat37°Cof125I-WTapoA-ItothecellsandspecificallytoABCA1,asdeterminedbycovalentcross-linking,revealedsaturablehighaffinitybindinginbothcases.Determinationofthelevelofcell-surfaceexpressionofABCA1showedthatonlyabout10%oftheapoA-Iassociat...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期SubunitCompositionofNicotinicReceptorsinMonkeyStriatum:EffectofTreatmentswith1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineorL-DOPA
...hthosefromdualimmunoprecipitationandradioligandbindingstudies([3H]cytisine,125I--bungarotoxin,and125I--conotoxinMII)suggestthefollowing:that623,6423,and32nAChRsubtypesarepresentondopaminergicterminalsandthatthe42subtypeislocalizedonbothdopaminergicandnondopaminergicneurons,whereas22and7receptorsarel...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期AnApolipoprotein(a)PeptideDelaysChylomicronRemnantClearanceandIncreasesPlasmaRemnantLipoproteinsandAtherosclerosisInVivo
...nant(CR)clearance,liversfromcontrolorKIV5–8transgenicmicewereperfusedwith125I-labeledratCRsintheabsenceorpresenceofapo(a)peptidesorlipoproteins.AsshowninFigure4,bothKIV5–8peptideandfull-lengthapo(a)significantlydecreasedthepercentremovalofCRsperpassthroughtheliversofnontransgenicmice.Next,wecomp...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期PhoneutrianigriventerToxin1:ANovel,State-DependentInhibitorofNeuronalSodiumChannelsThatInteractswithμConotoxinBindingSites
...pparentaffinityofTx1forthechannelincreasesasthemembraneisdepolarized.Amono[125I]iodo-Tx1derivativedisplayedhigh-affinitybindingtoasingleclassofsites(KD=80pM,Bmax=0.43pmol/mgprotein)inratbrainmembranes.Solubilizedbindingsiteswereimmunoprecipitatedbyantibodiesdirectedagainstaconservedmotifinsodiumchan...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期NigrostriatalDamagePreferentiallyDecreasesaSubpopulationof62*nAChRsinMouse,Monkey,andParkinson‘sDiseaseStriatum
...nAChRsubtypesinmouse,monkey,andhumanstriatum.Receptorcompetitionstudieswith125I--CtxMIIshowedthatE11Ainhibitioncurveswerebiphasic,suggestingthepresenceoftwodistinct62*nAChRsubtypes.Theseincludeaveryhigh(femtomolar)andahigh(picomolar)affinitysite,with40%ofthesitesintheveryhighaffinityform.Itisnotewor...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第7期