CriticalfunctionofBmx/Etkinischemia-mediatedarteriogenesisandangiogenesis
...constitutivelyactiveformofBmxundertheendothelialTie-2enhancer/promoter(Bmx-SK-Tgmice)tostudytheroleofBmxinischemia-mediatedarteriogenesis/angiogenesis.Inresponsetoischemia,Bmx-KOmicehadmarkedlyreduced,whereasBmx-SK-Tgmicehadenhanced,clinicalrecovery,limbperfusion,andischemicreservecapacitywhencompar...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期RenalexpressionandactivityofthegerminalcenterkinaseSK
...inkinases.ThisscreeningdemonstratedexpressionofaproteinkinaseconsistentwithSK2,agroupIIgerminalcenterkinaseandhomologofhumanSte20-likekinase(SLK).SK2mRNA,proteinexpression,andkinaseactivitywereincreasedinratfetalkidneyhomogenates(embryonicdays17-21)comparedwithadultcontrols.Inadultkidneyssubjectedto...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第1期UseofPhylogeneticandPhenotypicAnalysesToIdentifyNonhemolyticStreptococciIsolatedfromBacteremicPatients
...rposes,24typeand9referencestrainswereanalyzed:S.sanguinisstrainsATCC10556T/SK1,SK4,andSK36(S.sanguinisstrainwhosegenomeiscurrentlybeingsequencedatVirginiaCommonwealthUniversity;www.sanguinis.mic.vcu.edu);S.oralisstrainsNCTC11427T/SK23andSK34;S.gordoniistrainsATCC10558T/SK3andChallis/SK7;S.mitisstrai...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期載脂蛋白E在神經細胞中表達對細胞功能的影響
...時,探討apoE4在AD發病中的相關機制。研究方法篩選轉染SK-N-SH定位觀察表達鑑定功能分析構建真核表達質粒重組pEGFP-apoE質粒酶切電泳圖apoE3Query:321cgcaggcccggctgggcgcggacatggaggacgtgtgcggccgcctggtgcagtaccgcg380||||||||||||||||||||||||||||||||||||||||||||||...
醫源資料庫;醫學文檔庫;心血管相關CentralEuropeanDobravaHantavirusIsolatefromaStripedFieldMouse(Apodemusagrarius)
InstituteofVirology,HelmutRuskaHaus,ChariteSchoolofMedicine,HumboldtUniversity,D-10098Berlin,GermanyInstituteofVirologyInstituteofZoology,SlovakAcademyofSciences,84206Bratislava,SlovakiaABSTRACTDobravavirus(DOBV)isahantavirusthatcauseshemorrhagicfeverwithrenalsyndrome(HFRS)inEurope.Itishostedbyatlea...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第6期InhibitoryGatingModulationofSmallConductanceCa2+-ActivatedK+ChannelsbytheSyntheticCompound(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtyla
【關鍵詞】InhibitoryGatingModulationSKchannelsaresmallconductanceCa2+-activatedK+channelsimportantforthecontrolofneuronalexcitability,thefinetuningoffiringpatterns,andtheregulationofsynapticmechanisms.TheclassicSKchannelpharmacologyhaslargelyfocusedonthepeptideapamin,whichactsextracellularlybya...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期Bmi-IsEssentialfortheTumorigenicityofNeuroblastomaCells
...eeoftheMedicalUniversityofOhio.CellCultureHumanneuroblastomacelllinesSHEP1,SK-N-AS,SK-N-F1,SK-N-DZ,andSK-N-SHweregrowninDulbecco??smodifiedEagle??smediumsupplementedwith10%fetalbovineserum(FBS);IMR32,SK-N-BE(2),BE(2)-C,SY5Y,andLA1C55Nina1:1mixtureofDulbecco??smodifiedEagle??smediumandHam??snutrientm...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第4期Incidenceofkeratitisofvaryingseverityamongcontactlenswearers
...ation29August2004ABSTRACTAim:Todeterminetheincidenceofnon-severekeratitis(NSK)andseverekeratitis(SK)amongwearersofcurrentgenerationcontactlenses.Methods:A12month,prospective,hospitalbasedepidemiologicalstudywasconductedbyexaminingallcontactlenswearerspresentingwithacornealinfiltrate/ulcertoahospital...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第4期ReceptorRegulationofGeneExpressionofAxonGuidanceMolecules:ImplicationsforAdaptation
...s)andmodulationofaxonguidancemolecules,weinvestigatedwhetherGPCRactivityinaSK-N-MChumanneuroepitheliomacellline(whichexpresseslowlevelsofD1dopaminereceptors)affectsgeneexpressionofaxonguidancemolecules(semaphorins,ephrins,netrins,andtheirreceptors).Usingreal-timepolymerasechainreaction,weidentified1...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期EndothelialNitricOxideSynthaseActivationbyTumorNecrosisFactorThroughNeutralSphingomyelinase2,SphingosineKinase1,andSphingosine1PhosphateRe
...ialactivationofneutral-sphingomyelinase-2(N-SMase2)andsphingosine-kinase-1(SK1)andgenerationofsphingosine-1-phosphate(Sph1P).InhibitionofN-SMase2inhibitedSph1Pformation,whereasinhibitionofSK1didnotaffectN-SMase2activationbyTNF-.BlockadeofN-SMase2,SK1,ortheSph1PreceptorsS1P1andS1P3,eitherbysilencingo...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第1期