Gadd45andGadd45arecriticalforregulatingautoimmunity
...unity.Here,weshowthattwomembersofthegrowtharrestandDNAdamage-inducible(Gadd45)family,and,arecriticalinthedevelopmentofpathogeniceffectorTcells.CD4+TcellslackingGadd45canrapidlyexpandandinvadethecentralnervoussysteminresponsetomyelinimmunization,provokinganexacerbatedandprolongedautoimmuneencephalomy...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期MyosinIICo-ChaperoneGeneralCellUNC-OverexpressionIsAssociatedwithOvarianCancerRapidProliferationandMotility
...BothtumorcellproliferationandmetastasisaredependentonmyosinII.BecauseUNC-45isrequiredtochaperonetheassemblyofafunctionalmyosinIImotor,weexaminedtheexpressionofthegeneralcell(GC)UNC-45isoforminovariantumors.SerouscarcinomaexpressedelevatedlevelsofGCUNC-45comparedwithnormalovariansurfaceepitheliumandb...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第11期ReplacementofConnexin40byConnexin45intheMouseImpactonCardiacElectricalConduction
FromtheLaboratoiredeGénétiqueetPhysiologieduDéveloppement(UMRCNRS6545)(S.A.,T.J.-G.,D.G.),InstitutdeBiologieduDéveloppementdeMarseille,UniversitédelaMéditerranée,Marseille,France;DepartmentofMedicalPhysiology(H.v.R.,H.J.),UniversityMedicalCenter,Utrecht,TheNetherlands;NeurologiaExperimental(D...
醫源資料庫;在線期刊;循環研究雜誌;2004年第94卷第1期EndothelialOutgrowthCellsAreNotDerivedFromCD133+CellsorCD45+HematopoieticPrecursors
...beenusedtoidentifyputativecirculatingendothelialprecursors.WealsoincludedCD45intheanalysistoassesstherelationbetweenCD34+hematopoieticprogenitors(HPC),CD34+endothelialprecursors,andbothinvitrogeneratedEPCtypes.Addressingthisissuemightleadtoabetterunderstandingofthelineageandphenotypeoftheprecursor(s...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期Effectsofexpressionofp53andGadd45onosmotictoleranceofrenalinnermedullarycells
...y(IM)collectingductcells(mIMCD3)tohighNaClinvolvesincreasedexpressionofGadd45andp53,bothofwhichhaveimportanteffectsongrowthandsurvivalofthecells.However,mIMCD3cells,beingimmortalizedbySV40,proliferaterapidly,whichisknowntosensitizecellstohighNaCl,whereasIMcellsinsituproliferateveryslowlyandsurvivemu...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第8期平肝舒絡丸
...色譜相應的位置上,顯相同顏色的熒光斑點。處方柴胡 45g 青皮(醋炙) 60g 陳皮 45g佛手 45g 烏藥 45g 香附(醋炙) 45g木香 45g 檀香 45g 丁香 60g沉香 150g 廣藿香 45g 砂仁 45g豆蔻仁 45g 厚朴(姜炙)...
藥品天地;專業藥學;中國藥典;2000版一部二、CD45在信號轉導中的調節作用
二、CD45在信號轉導中的調節作用 (一)CD45在活化信號轉導中的調節作用 在確定CD45爲一種PTPase之前就已證實了CD45參於細胞的活化和生長調節。抗CD45抗體可以(1)抑制PHA或CD3交聯所介導的T細胞增殖;(2)抑制NK或細胞...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學StructuralbasisforthefunctionandregulationofthereceptorproteintyrosinephosphataseCD45
...n,MA021153InstituteofMedicalScience,UniversityofTokyo,Tokyo108-8639,JapanCD45istheprototypicmemberoftransmembranereceptor-likeproteintyrosinephosphatases(RPTPs)andhasessentialrolesinimmunefunctions.ThecytoplasmicregionofCD45,likemanyotherRPTPs,containstwohomologousproteintyrosinephosphatasedomains,a...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第3期1HowardHughesMedicalInstitute,UniversityofAlabamaatBirmingham,Birmingham,AL35294
...rrentlyunclear.InthisstudyweinvestigatetheroleofthecellsurfacephosphataseCD45inNKcelldevelopmentandintracellularsignalingfromactivatingreceptors.StimulationviathemajorhistocompatibilitycomplexI–bindingreceptor,Ly49DonCD45–/–primaryNKcellsresultedintheactivationofphosphoinositide-3-kinaseandnor...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期CD45MOLECULEANDGENERATIONOFEPIDERMALγδTCELLSFROMMIC
CD45MOLECULEANDGENERATIONOFEPIDERMALγδTCELLSFROMMIC免疫學雜誌1999年第2期第15卷基礎免疫學作者:CaiQinchao(蔡欽朝)1,WangBinghe(王秉鶴)2關鍵詞:詞CD45蛋白酪氨酸磷酸酶;樹突狀表皮T細胞;γδT細胞;T細胞發育(1DepartmentofBiochemistry,Anhu...
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