Factorsaffectingstatisticalpowerinthedetectionofgeneticassociation
...ocus.Thesetofallelesis(A,B,orO)withgenotypesAA,AB,AO,etc.Byhaplotype,wemeanaspecificsetofallelesonaperson’schromosome(7).WeprovideanexampleinFigure1.Figure1Pictorialexampleofrecombination.Left:The2pairsofchromosomes(solidlines,dashedlines)representthe(duplicated)chromosomesinmeiosisbeforerecombina...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第6期IdentificationofaPostendocyticSortingSequenceinCCR5
...L)substrate24haftercoculture,andblue-stainedfociwerecounted.ResultsareshownaspercentageoffusionefficiencyrelativetotheWTreceptor(mean±S.E.M.fromthreeindependenttransfections).ThesameresultswereobtainedinHeLa-P4cells(datanotshown).DetectionofReceptorExpressionattheCellSurface.HEK293(orHeLa-P4)...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期OriginsandevolutionoftheWesterndiet:healthimplicationsforthe21stcentury
...Evolutionactingthroughnaturalselectionrepresentsanongoinginteractionbetweenaspeciesgenomeanditsenvironmentoverthecourseofmultiplegenerations.Genetictraitsmaybepositivelyornegativelyselectedrelativetotheirconcordanceordiscordancewithenvironmentalselectivepressures(1).Whentheenvironmentremainsre...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第2期AutophagyisinvolvedinTcelldeathafterbindingofHIV-1envelopeproteinstoCXCR4
...ganapoptoticpathwaythatinvolvesmitochondrialtransmembranedepolarizationandcaspase-3activationindependentlyofFas-mediatedsignalingandGiproteinactivation(9).ThismechanismmayexplaintheTcelldropthatoftencoincideswiththeemergenceofX4isolatesduringthelaterstagesofthedisease.AsCXCR4isprimarilyexpressedonce...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第8期MutationoftheDRYMotifRevealsDifferentStructuralRequirementsfortheCCChemokineReceptor5-MediatedSignalingandReceptorEndocytosis
...dicCCR5ligandthatinhibitsHIVinfectionandwasfoundtodependontheintegrityoftheAsp-Arg-Tyr(DRY)motif.ChangingArg-126bytheneutralresidueAsn(R126N-CCR5mutant)abolishedCCR5-mediatedactivationofGproteins,eitherconstitutivelyorinresponsetoagonists.Incontrast,R126N-CCR5notonlyretainedagonist-promotedphosphory...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期Casq2deletioncausessarcoplasmicreticulumvolumeincrease,prematureCa2+release,andcatecholaminergicpolymorphicventriculartachycardia
...teinwasloadedperlaneinduplicateandsubjectedtoSDS-PAGE,thenone-halfofthegelwasprocessedfor45Ca2+overlay(left)andtheotherhalfstainedwithStains-all(right).OnemicrogramofpurifiedcanineCasq2wasalsorunasaninternalstandard.(C)ImmunoblotdetectionofSRproteinsinmicrosomesisolatedfrom10Casq2+/+,10Casq2+/–,an...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期Thephosphoinositide-bindingproteinp40phoxactivatestheNADPHoxidaseduringFcIIAreceptor–inducedphagocytosis
...ins,gp91phoxandp22phox,thattogetherformtheoxidaseflavocytochromeb558,aswellasp47phox,p67phox,andRac-GTP,whichtranslocatefromthecytosoltothemembranetoactivateelectrontransportthroughtheflavocytochrome(2,3).Attestingtoitsimportanceinhostdefense,geneticdefectsintheaforementionedphox(phagocyteoxidase)su...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期AllostericInteractionswithMuscarinicAcetylcholineReceptors:ComplexRoleoftheConservedTryptophanM2422TrpinaCriticalClusterofAminoAcidsforBa
...heorthostericradioligand[3H]NMS([3H]N-methylscopolaminechloride,81Ci/mmol)waspurchasedfromNEN-DuPont(Homburg,Germany).MutagenesisandExpressionPoint-mutatedM2andM5receptorsweregeneratedasdescribedpreviously(Voigtländeretal.,2003;Huangetal.,2005)usingtheQuikChangesite-directedmutagenesiskit(Strat...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期Aminoacyl-tRNASynthetase-InteractingMultifunctionalProtein/pControlsEndoplasmicReticulumRetentionofHeatShockProteingp
...cyl-tRNAsynthetase-interactingmultifunctionalprotein1(AIMP1;previouslyknownasp43)isamultifunctionalproteinthatwasinitiallyfoundinmultitRNAsynthetasecomplex.Inthepresentstudy,screeningoftheAIMP1-bindingproteinsrevealedthatAIMP1canformamolecularcomplexwithheatshockproteingp96.AIMP1enhancesgp96dimeriza...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期Rimonabant:JustanAntiobesityDrug?CurrentEvidenceonItsPleiotropicEffects
...eboththeclinicalefficacyandthebiologicalactivityofrimonabantexaminingasmuchaspossiblethemolecularaspectsatthebasisofrimonabant-inducedeffects.First,wediscusstheefficacyandsafetyofrimonabantinreducingbodyweightandcardiometabolicriskfactors.Second,wereviewtheincreasingliteratureontheotherpotentialther...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期